LOCUS       NM_025257               2585 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 44 member 4 (SLC44A4),
            transcript variant 1, mRNA.
ACCESSION   NM_025257 NM_032794
VERSION     NM_025257.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Sabui,S., Anthonymuthu,S., Ramamoorthy,K., Skupsky,J.,
            Jennings,T.S.K., Rahmatpanah,F., Fleckenstein,J.M. and Said,H.M.
  TITLE     Effect of knocking out mouse Slc44a4 on colonic uptake of the
            microbiota-generated thiamine pyrophosphate and colon physiology
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (1), G36-G46 (2024)
   PUBMED   38713615
  REMARK    GeneRIF: Effect of knocking out mouse Slc44a4 on colonic uptake of
            the microbiota-generated thiamine pyrophosphate and colon
            physiology.
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Wu,J., Cheng,Y., Zhang,R., Shen,H., Ma,L., Yang,J., Zhang,Y. and
            Zhang,J.
  TITLE     Evaluating the Association of Common Variants of the SLC44A4 Gene
            with Ulcerative Colitis Susceptibility in the Han Chinese
            Population
  JOURNAL   Genet Test Mol Biomarkers 21 (9), 555-559 (2017)
   PUBMED   28753073
  REMARK    GeneRIF: We found that rs2736428 was significantly associated with
            UC risk (allelic p = 0.0004), and the CT and TT genotypes of
            rs2736428 had a higher distribution compared with the CC genotypes
            (genotypic p = 0.001), suggesting that the T allele was a risk
            allele (odds ratio = 1.45, 95% confidence interval = 1.18-1.78).
            Moreover, one haplotype block that included rs2736428 was found to
            be strongly associated with UC risk as well
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Ma,Z., Xia,W., Liu,F., Ma,J., Sun,S., Zhang,J., Jiang,N., Wang,X.,
            Hu,J. and Ma,D.
  TITLE     SLC44A4 mutation causes autosomal dominant hereditary postlingual
            non-syndromic mid-frequency hearing loss
  JOURNAL   Hum Mol Genet 26 (2), 383-394 (2017)
   PUBMED   28013291
  REMARK    GeneRIF: Whole-exome sequencing revealed SLC44A4, which encodes the
            choline transport protein, as the pathogenic gene in this family.
            In the zebrafish model, downregulation of slc44a4 using morpholinos
            led to significant abnormalities in the zebrafish inner ear and
            lateral line neuromasts and contributed, to some extent, to
            disabilities in hearing and balance.
            Erratum:[Hum Mol Genet. 2017 Aug 15;26(16):3234. doi:
            10.1093/hmg/ddx232.. PMID: 28859437]
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Nabokina,S.M., Ramos,M.B. and Said,H.M.
  TITLE     Mechanism(S) Involved in the Colon-Specific Expression of the
            Thiamine Pyrophosphate (Tpp) Transporter
  JOURNAL   PLoS One 11 (2), e0149255 (2016)
   PUBMED   26901654
  REMARK    GeneRIF: epigenetic mechanisms (histone modifications) play a role
            in determining the tissue-specific pattern of expression of the
            TPPT along the GI tract.
            Erratum:[PLoS One. 2017 Oct 11;12(10):e0186550. doi:
            10.1371/journal.pone.0186550.. PMID: 29020075]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Gupta,A., Juyal,G., Sood,A., Midha,V., Yamazaki,K., Vich Vila,A.,
            Esaki,M., Matsui,T., Takahashi,A., Kubo,M., Weersma,R.K. and
            Thelma,B.K.
  TITLE     A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis
            GWAS hits, underscores their potential role in disease
            susceptibility
  JOURNAL   Eur J Hum Genet 25 (1), 111-122 (2016)
   PUBMED   27759029
  REMARK    GeneRIF: These results suggest (i) apparent allelic heterogeneity
            in CFB and genetic heterogeneity in SLC44A4 across different ethnic
            groups; (ii) shared ulcerative colitis genetic etiological factors
            among Asians
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Xie,T., Rowen,L., Aguado,B., Ahearn,M.E., Madan,A., Qin,S.,
            Campbell,R.D. and Hood,L.
  TITLE     Analysis of the gene-dense major histocompatibility complex class
            III region and its comparison to mouse
  JOURNAL   Genome Res 13 (12), 2621-2636 (2003)
   PUBMED   14656967
REFERENCE   7  (bases 1 to 2585)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 2585)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2585)
  AUTHORS   Uhl,J., Penzel,R., Sergi,C., Kopitz,J., Otto,H.F. and Cantz,M.
  TITLE     Identification of a CTL4/Neu1 fusion transcript in a sialidosis
            patient
  JOURNAL   FEBS Lett 521 (1-3), 19-23 (2002)
   PUBMED   12067718
REFERENCE   10 (bases 1 to 2585)
  AUTHORS   O'Regan,S., Traiffort,E., Ruat,M., Cha,N., Compaore,D. and
            Meunier,F.M.
  TITLE     An electric lobe suppressor for a yeast choline transport mutation
            belongs to a new family of transporter-like proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1835-1840 (2000)
   PUBMED   10677542
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300771.1, BC014659.1,
            AK222998.1, DA924720.1 and AI560195.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025257.2.
            
            Summary: The protein encoded by this gene may be a sodium-dependent
            transmembrane transport protein involved in the uptake of choline
            by cholinergic neurons. Defects in this gene can cause sialidosis,
            a lysosomal storage disease. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, May 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027397.1, BC014659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229729.11/ ENSP00000229729.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DC300771.1         50-61
            13-399              BC014659.1         1-387
            400-553             AK222998.1         400-553
            554-1120            DA924720.1         7-573
            1121-2406           AK222998.1         1121-2406
            2407-2585           AI560195.1         10-188              c
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..2585
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /note="solute carrier family 44 member 4"
                     /db_xref="GeneID:80736"
                     /db_xref="HGNC:HGNC:13941"
                     /db_xref="MIM:606107"
     exon            1..57
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..2150
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /note="isoform 1 is encoded by transcript variant 1;
                     choline transporter-like protein 4; testicular tissue
                     protein Li 48; thiamine pyrophosphate transporter 1"
                     /codon_start=1
                     /product="choline transporter-like protein 4 isoform 1"
                     /protein_id="NP_079533.2"
                     /db_xref="CCDS:CCDS4724.2"
                     /db_xref="GeneID:80736"
                     /db_xref="HGNC:HGNC:13941"
                     /db_xref="MIM:606107"
                     /translation="MGGKQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLF
                     ILGYIVVGIVAWLYGDPRQVLYPRNSTGAYCGMGENKDKPYLLYFNIFSCILSSNIIS
                     VAENGLQCPTPQVCVSSCPEDPWTVGKNEFSQTVGEVFYTKNRNFCLPGVPWNMTVIT
                     SLQQELCPSFLLPSAPALGRCFPWTNVTPPALPGITNDTTIQQGISGLIDSLNARDIS
                     VKIFEDFAQSWYWILVALGVALVLSLLFILLLRLVAGPLVLVLILGVLGVLAYGIYYC
                     WEEYRVLRDKGASISQLGFTTNLSAYQSVQETWLAALIVLAVLEAILLLMLIFLRQRI
                     RIAIALLKEASKAVGQMMSTMFYPLVTFVLLLICIAYWAMTALYLATSGQPQYVLWAS
                     NISSPGCEKVPINTSCNPTAHLVNSSCPGLMCVFQGYSSKGLIQRSVFNLQIYGVLGL
                     FWTLNWVLALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFIRTLRYHTGSLAFGALI
                     LTLVQIARVILEYIDHKLRGVQNPVARCIMCCFKCCLWCLEKFIKFLNRNAYIMIAIY
                     GKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIPG
                     LGKDFKSPHLNYYWLPIMTSILGAYVIASGFFSVFGMCVDTLFLCFLEDLERNNGSLD
                     RPYYMSKSLLKILGKKNEAPPDNKKRKK"
     exon            58..106
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            107..180
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            181..259
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            260..359
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            360..485
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            486..546
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            547..634
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            635..718
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            719..954
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1054
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1147
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1250
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1504
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1599
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1703
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1777
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1848
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1943
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2028
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2585
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2558..2563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /note="hexamer: ATTAAA"
     polyA_site      2585
                     /gene="SLC44A4"
                     /gene_synonym="C6orf29; CTL4; DFNA72; hTPPT1; NG22; TPPT"
                     /note="major polyA site"
ORIGIN      
        1 actccggaga ctgagccatg gggggaaagc agcgggacga ggatgacgag gcctacggga
       61 agccagtcaa atacgacccc tcctttcgag gccccatcaa gaacagaagc tgcacagatg
      121 tcatctgctg cgtcctcttc ctgctcttca ttctaggtta catcgtggtg gggattgtgg
      181 cctggttgta tggagacccc cggcaagtcc tctaccccag gaactctact ggggcctact
      241 gtggcatggg ggagaacaaa gataagccgt atctcctgta cttcaacatc ttcagctgca
      301 tcctgtccag caacatcatc tcagttgctg agaacggcct acagtgcccc acaccccagg
      361 tgtgtgtgtc ctcctgcccg gaggacccat ggactgtggg aaaaaacgag ttctcacaga
      421 ctgttgggga agtcttctat acaaaaaaca ggaacttttg tctgccaggg gtaccctgga
      481 atatgacggt gatcacaagc ctgcaacagg aactctgccc cagtttcctc ctcccctctg
      541 ctccagctct ggggcgctgc tttccatgga ccaacgttac tccaccggcg ctcccaggga
      601 tcaccaatga caccaccata cagcagggga tcagcggtct tattgacagc ctcaatgccc
      661 gagacatcag tgttaagatc tttgaagatt ttgcccagtc ctggtattgg attcttgttg
      721 ccctgggggt ggctctggtc ttgagcctac tgtttatctt gcttctgcgc ctggtggctg
      781 ggcccctggt gctggtgctg atcctgggag tgctgggcgt gctggcatac ggcatctact
      841 actgctggga ggagtaccga gtgctgcggg acaagggcgc ctccatctcc cagctgggtt
      901 tcaccaccaa cctcagtgcc taccagagcg tgcaggagac ctggctggcc gccctgatcg
      961 tgttggcggt gcttgaagcc atcctgctgc tgatgctcat cttcctgcgg cagcggattc
     1021 gtattgccat cgccctcctg aaggaggcca gcaaggctgt gggacagatg atgtctacca
     1081 tgttctaccc actggtcacc tttgtcctcc tcctcatctg cattgcctac tgggccatga
     1141 ctgctctgta cctggctaca tcggggcaac cccagtatgt gctctgggca tccaacatca
     1201 gctcccccgg ctgtgagaaa gtgccaataa atacatcatg caaccccacg gcccaccttg
     1261 tgaactcctc gtgcccaggg ctgatgtgcg tcttccaggg ctactcatcc aaaggcctaa
     1321 tccaacgttc tgtcttcaat ctgcaaatct atggggtcct ggggctcttc tggaccctta
     1381 actgggtact ggccctgggc caatgcgtcc tcgctggagc ctttgcctcc ttctactggg
     1441 ccttccacaa gccccaggac atccctacct tccccttaat ctctgccttc atccgcacac
     1501 tccgttacca cactgggtca ttggcatttg gagccctcat cctgaccctt gtgcagatag
     1561 cccgggtcat cttggagtat attgaccaca agctcagagg agtgcagaac cctgtagccc
     1621 gctgcatcat gtgctgtttc aagtgctgcc tctggtgtct ggaaaaattt atcaagttcc
     1681 taaaccgcaa tgcatacatc atgatcgcca tctacgggaa gaatttctgt gtctcagcca
     1741 aaaatgcgtt catgctactc atgcgaaaca ttgtcagggt ggtcgtcctg gacaaagtca
     1801 cagacctgct gctgttcttt gggaagctgc tggtggtcgg aggcgtgggg gtcctgtcct
     1861 tctttttttt ctccggtcgc atcccggggc tgggtaaaga ctttaagagc ccccacctca
     1921 actattactg gctgcccatc atgacctcca tcctgggggc ctatgtcatc gccagcggct
     1981 tcttcagcgt tttcggcatg tgtgtggaca cgctcttcct ctgcttcctg gaagacctgg
     2041 agcggaacaa cggctccctg gaccggccct actacatgtc caagagcctt ctaaagattc
     2101 tgggcaagaa gaacgaggcg cccccggaca acaagaagag gaagaagtga cagctccggc
     2161 cctgatccag gactgcaccc cacccccacc gtccagccat ccaacctcac ttcgccttac
     2221 aggtctccat tttgtggtaa aaaaaggttt taggccaggc gccgtggctc acgcctgtaa
     2281 tccaacactt tgagaggctg aggcgggcgg atcacctgag tcaggagttc gagaccagcc
     2341 tggccaacat ggtgaaacct ccgtctctat taaaaataca aaaattagcc gagagtggtg
     2401 gcatgcacct gtcatcccag ctactcggga ggctgaggca ggagaatcgc ttgaacccgg
     2461 gaggcagagg ttgcagtgag ccgagatcgc gccactgcac tccaacctgg gtgacagact
     2521 ctgtctccaa aacaaaacaa acaaacaaaa agattttatt aaagatattt tgttaactca
     2581 gtaaa
//
