LOCUS       NM_001114106            2381 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 44 member 3 (SLC44A3),
            transcript variant 1, mRNA.
ACCESSION   NM_001114106
VERSION     NM_001114106.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2381)
  AUTHORS   Ren,M., Sambuughin,N., Mungunshukh,O., Edgeworth,D.B., Hupalo,D.,
            Zhang,X., Wilkerson,M.D., Dalgard,C.L., O'Connor,F.G. and
            Deuster,P.A.
  TITLE     Genome-Wide Analysis of Exertional Rhabdomyolysis in Sickle Cell
            Trait Positive African Americans
  JOURNAL   Genes (Basel) 15 (4), 408 (2024)
   PUBMED   38674343
  REMARK    GeneRIF: Genome-Wide Analysis of Exertional Rhabdomyolysis in
            Sickle Cell Trait Positive African Americans.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2381)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2381)
  AUTHORS   Traiffort,E., Ruat,M., O'Regan,S. and Meunier,F.M.
  TITLE     Molecular characterization of the family of choline
            transporter-like proteins and their splice variants
  JOURNAL   J Neurochem 92 (5), 1116-1125 (2005)
   PUBMED   15715662
REFERENCE   4  (bases 1 to 2381)
  AUTHORS   O'Regan,S., Traiffort,E., Ruat,M., Cha,N., Compaore,D. and
            Meunier,F.M.
  TITLE     An electric lobe suppressor for a yeast choline transport mutation
            belongs to a new family of transporter-like proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1835-1840 (2000)
   PUBMED   10677542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC311042.1, BC033858.1, AY358659.1 and DB331517.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001114106.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033858.1, SRR1803617.91127.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271227.11/ ENSP00000271227.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DC311042.1         13-34
            23-1406             BC033858.1         1-1384
            1407-2188           AY358659.1         876-1657
            2189-2381           DB331517.1         2-194               c
FEATURES             Location/Qualifiers
     source          1..2381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3"
     gene            1..2381
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /note="solute carrier family 44 member 3"
                     /db_xref="GeneID:126969"
                     /db_xref="HGNC:HGNC:28689"
                     /db_xref="MIM:620328"
     exon            1..122
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2057
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     choline transporter-like protein 3"
                     /codon_start=1
                     /product="choline transporter-like protein 3 isoform 1"
                     /protein_id="NP_001107578.1"
                     /db_xref="CCDS:CCDS44176.1"
                     /db_xref="GeneID:126969"
                     /db_xref="HGNC:HGNC:28689"
                     /db_xref="MIM:620328"
                     /translation="MHCLGAEYLVSAEGAPRQREWRPQIYRKCTDTAWLFLFFLFWTG
                     LVFIMGYSVVAGAAGRLLFGYDSFGNMCGKKNSPVEGAPLSGQDMTLKKHVFFMNSCN
                     LEVKGTQLNRMALCVSNCPEEQLDSLEEVQFFANTSGSFLCVYSLNSFNYTHSPKADS
                     LCPRLPVPPSKSFPLFNRCVPQTPECYSLFASVLINDVDTLHRILSGIMSGRDTILGL
                     CILALALSLAMMFTFRFITTLLVHIFISLVILGLLFVCGVLWWLYYDYTNDLSIELDT
                     ERENMKCVLGFAIVSTGITAVLLVLIFVLRKRIKLTVELFQITNKAISSAPFLLFQPL
                     WTFAILIFFWVLWVAVLLSLGTAGAAQVMEGGQVEYKPLSGIRYMWSYHLIGLIWTSE
                     FILACQQMTIAGAVVTCYFNRSKNDPPDHPILSSLSILFFYHQGTVVKGSFLISVVRI
                     PRIIVMYMQNALKEQQHGALSRYLFRCCYCCFWCLDKYLLHLNQNAYTTTAINGTDFC
                     TSAKDAFKILSKNSSHFTSINCFGDFIIFLGKVLVVCFTVFGGLMAFNYNRAFQVWAV
                     PLLLVAFFAYLVAHSFLSVFETVLDALFLCFAVDLETNDGSSEKPYFMDQEFLSFVKR
                     SNKLNNARAQQDKHSLRNEEGTELQAIVR"
     exon            123..230
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            231..373
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            374..510
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..604
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            605..765
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..855
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            856..980
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1167
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1333
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1490
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1577
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1715
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1952
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2381
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2168..2173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /note="major polyA site"
     regulatory      2359..2364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
                     /note="hexamer: AATAAA"
     polyA_site      2381
                     /gene="SLC44A3"
                     /gene_synonym="CTL3"
ORIGIN      
        1 agccccggcc ccggccccgg ctcgcgggcg ctgcgtctcc gcgtacagga ggcggcggcg
       61 gctcccagtc accggccccc gccggcgagc gcacgatgca ctgcctgggc gccgagtacc
      121 tggtttctgc agaaggagcc cctaggcaaa gggagtggcg accccagatt tataggaaat
      181 gcacagatac ggcatggtta ttcctgttct ttctcttttg gactggtttg gtgtttatca
      241 tgggctactc ggtggtggct ggagccgcgg gaagactcct ctttggctat gacagctttg
      301 gcaacatgtg tggcaagaag aactcccccg tggaaggggc ccctctttca gggcaggaca
      361 tgaccctaaa aaaacacgtg ttctttatga attcctgcaa cctggaagtc aaaggtacgc
      421 agctcaaccg catggccctc tgtgtatcca actgccctga agagcagctt gactccctgg
      481 aagaggtcca gttctttgca aacaccagtg ggtccttcct gtgtgtttat agtttgaatt
      541 ccttcaacta tacccacagt ccaaaagcag actcactgtg tcccaggcta ccagttcctc
      601 caagcaagtc atttccctta tttaaccgat gtgtccctca aacacctgag tgctactccc
      661 tatttgcatc tgttttgata aatgatgttg acaccctcca ccgaattcta agtggaatca
      721 tgtcgggaag agatacaatc cttggcctgt gtatcctcgc attagccttg tctttggcca
      781 tgatgtttac cttcagattc atcaccaccc ttctggttca cattttcatt tcattggtta
      841 ttttgggatt gttgtttgtc tgcggtgttt tatggtggct gtattatgac tataccaacg
      901 acctcagcat agaattggac acagaaaggg aaaatatgaa gtgcgtgctg gggtttgcta
      961 tcgtatccac aggcatcacg gcagtgctgc tcgtcttgat ttttgttctc agaaagagaa
     1021 taaaattgac agttgagctt ttccaaatca caaataaagc catcagcagt gctcccttcc
     1081 tgctgttcca gccactgtgg acatttgcca tcctcatttt cttctgggtc ctctgggtgg
     1141 ctgtgctgct gagcctggga actgcaggag ctgcccaggt tatggaaggc ggccaagtgg
     1201 aatataagcc cctttcgggc attcggtaca tgtggtcgta ccatttaatt ggcctcatct
     1261 ggactagtga attcatcctt gcgtgccagc aaatgactat agctggggca gtggttactt
     1321 gttatttcaa cagaagtaaa aatgatcctc ctgatcatcc catcctttcg tctctctcca
     1381 ttctcttctt ctaccatcaa ggaaccgttg tgaaagggtc atttttaatc tctgtggtga
     1441 ggattccgag aatcattgtc atgtacatgc aaaacgcact gaaagaacag cagcatggtg
     1501 cattgtccag gtacctgttc cgatgctgct actgctgttt ctggtgtctt gacaaatacc
     1561 tgctccatct caaccagaat gcatatacta caactgctat taatgggaca gatttctgta
     1621 catcagcaaa agatgcattc aaaatcttgt ccaagaactc aagtcacttt acatctatta
     1681 actgctttgg agacttcata atttttctag gaaaggtgtt agtggtgtgt ttcactgttt
     1741 ttggaggact catggctttt aactacaatc gggcattcca ggtgtgggca gtccctctgt
     1801 tattggtagc tttttttgcc tacttagtag cccatagttt tttatctgtg tttgaaactg
     1861 tgctggatgc acttttcctg tgttttgctg ttgatctgga aacaaatgat ggatcgtcag
     1921 aaaagcccta ctttatggat caagaatttc tgagtttcgt aaaaaggagc aacaaattaa
     1981 acaatgcaag ggcacagcag gacaagcact cattaaggaa tgaggaggga acagaactcc
     2041 aggccattgt gagatagata cccatttagg tatctgtacc tggaaaacat ttccttctaa
     2101 gagccattta cagaatagaa gatgagacca ctagagaaaa gttagtgaat ttttttttaa
     2161 aagacctaat aaaccctatt cttcctcatt gtctttgtca ttattgtttg accaggtaac
     2221 aatactggaa ctatattagt ttaccttttt ttgtacaaat taggacagaa aaactcttct
     2281 aaaaccatgt ttatatgcat caacttacaa agtacactat gtaagaactg aggtaagttt
     2341 gtaagtgcac aactaataaa taaacctttt taagataagg a
//
