LOCUS       NM_199329               2619 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens solute carrier family 43 member 3 (SLC43A3),
            transcript variant 3, mRNA.
ACCESSION   NM_199329
VERSION     NM_199329.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Kim,C.S., Sayler,A.L., Dean,H., Ruel,N.M. and Hammond,J.R.
  TITLE     Functional comparison of human and murine equilibrative nucleobase
            transporter 1
  JOURNAL   PLoS One 19 (10), e0311519 (2024)
   PUBMED   39361655
  REMARK    GeneRIF: Functional comparison of human and murine equilibrative
            nucleobase transporter 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Ruel,N.M., Nguyen,K.H., Kim,C.S., Andrade,L.P.S. and Hammond,J.R.
  TITLE     Impact of SLC43A3/ENBT1 Expression and Function on 6-Mercaptopurine
            Transport and Cytotoxicity in Human Acute Lymphoblastic Leukemia
            Cells
  JOURNAL   J Pharmacol Exp Ther 382 (3), 335-345 (2022)
   PUBMED   35798387
  REMARK    GeneRIF: Impact of SLC43A3/ENBT1 Expression and Function on
            6-Mercaptopurine Transport and Cytotoxicity in Human Acute
            Lymphoblastic Leukemia Cells.
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Takenaka,R., Yasujima,T., Furukawa,J., Hishikawa,Y., Yamashiro,T.,
            Ohta,K., Inoue,K. and Yuasa,H.
  TITLE     Functional Analysis of the Role of Equilibrative Nucleobase
            Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in HepG2 Cells
  JOURNAL   J Pharm Sci 109 (8), 2622-2628 (2020)
   PUBMED   32339528
  REMARK    GeneRIF: Functional Analysis of the Role of Equilibrative
            Nucleobase Transporter 1 (ENBT1/SLC43A3) in Adenine Transport in
            HepG2 Cells.
REFERENCE   5  (bases 1 to 2619)
  AUTHORS   Hasbargen,K.B., Shen,W.J., Zhang,Y., Hou,X., Wang,W., Shuo,Q.,
            Bernlohr,D.A., Azhar,S. and Kraemer,F.B.
  TITLE     Slc43a3 is a regulator of free fatty acid flux
  JOURNAL   J Lipid Res 61 (5), 734-745 (2020)
   PUBMED   32217606
  REMARK    GeneRIF: Slc43a3 is a regulator of free fatty acid flux.
REFERENCE   6  (bases 1 to 2619)
  AUTHORS   Shimozono,N., Jinnin,M., Masuzawa,M., Masuzawa,M., Wang,Z.,
            Hirano,A., Tomizawa,Y., Etoh-Kira,T., Kajihara,I., Harada,M.,
            Fukushima,S. and Ihn,H.
  TITLE     NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma
  JOURNAL   Cancer Res 75 (21), 4458-4465 (2015)
   PUBMED   26527604
  REMARK    GeneRIF: transcriptome sequencing of patient-derived angiosarcoma
            cells, identified a novel fusion gene NUP160-SLC43A3 found to be
            expressed in 9 of 25 human angiosarcoma specimens that were
            examined.
REFERENCE   7  (bases 1 to 2619)
  AUTHORS   Furukawa,J., Inoue,K., Maeda,J., Yasujima,T., Ohta,K., Kanai,Y.,
            Takada,T., Matsuo,H. and Yuasa,H.
  TITLE     Functional identification of SLC43A3 as an equilibrative nucleobase
            transporter involved in purine salvage in mammals
  JOURNAL   Sci Rep 5, 15057 (2015)
   PUBMED   26455426
  REMARK    GeneRIF: SLC43A3 is an equilibrative nucleobase transporter
            involved in purine salvage in mammals.
            Erratum:[Sci Rep. 2016 Mar 04;6:22175. doi: 10.1038/srep22175..
            PMID: 26940463]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2619)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   9  (bases 1 to 2619)
  AUTHORS   Stuart,R.O., Pavlova,A., Beier,D., Li,Z., Krijanovski,Y. and
            Nigam,S.K.
  TITLE     EEG1, a putative transporter expressed during epithelial
            organogenesis: comparison with embryonic transporter expression
            during nephrogenesis
  JOURNAL   Am J Physiol Renal Physiol 281 (6), F1148-F1156 (2001)
   PUBMED   11704567
REFERENCE   10 (bases 1 to 2619)
  AUTHORS   Li,M.S., Sun,L., Satoh,T., Fisher,L.M. and Spry,C.J.
  TITLE     Human eosinophil major basic protein, a mediator of allergic
            inflammation, is expressed by alternative splicing from two
            promoters
  JOURNAL   Biochem J 305 (Pt 3) (Pt 3), 921-927 (1995)
   PUBMED   7531438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC347054.1, BC003163.1 and AL157431.1.
            
            On Jun 2, 2019 this sequence version replaced NM_199329.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2, 3 and 4 encode the same
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075552.1, SRR5189661.173995.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395124.6/ ENSP00000378556.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               DC347054.1         28-557
            531-1891            BC003163.1         510-1870
            1892-2619           AL157431.1         1939-2666
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..2619
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /note="solute carrier family 43 member 3"
                     /db_xref="GeneID:29015"
                     /db_xref="HGNC:HGNC:17466"
                     /db_xref="MIM:618034"
     exon            1..60
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..125
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            126..489
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1781
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /note="isoform 1 is encoded by transcript variant 3;
                     likely ortholog of mouse embryonic epithelial gene 1;
                     equilibrative nucleobase transporter 1"
                     /codon_start=1
                     /product="equilibrative nucleobase transporter 1 isoform
                     1"
                     /protein_id="NP_955361.1"
                     /db_xref="CCDS:CCDS7956.1"
                     /db_xref="GeneID:29015"
                     /db_xref="HGNC:HGNC:17466"
                     /db_xref="MIM:618034"
                     /translation="MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFK
                     DLCGPDAGPIGNATGQADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARL
                     IAIFFYTTATLIIAFTSAGSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIIT
                     LYNGAFDSSSAVFLIIKLLYEKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLP
                     PNYSYGLCPGNGTTKEEKETAEHENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFS
                     RRFAWHLVWLSVIQLWHYLFIGTLNSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPW
                     NGLLMDRLKQKYQKEARKTGSSTLAVALCSTVPSLALTSLLCLGFALCASVPILPLQY
                     LTFILQVISRSFLYGSNAAFLTLAFPSEHFGKLFGLVMALSAVVSLLQFPIFTLIKGS
                     LQNDPFYVNVMFMLAILLTFFHPFLVYRECRTWKESPSAIA"
     exon            490..619
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..666
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            667..743
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..836
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            837..976
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1074
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1248
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1365
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1552
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1676
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..2619
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="SLC43A3"
                     /gene_synonym="EEG1; ENBT1; FOAP-13; PRO1659; SEEEG-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgaatgcga acctggcccg tgcggaaagg gcgcggagag ccccggcgcg gagcaggcgg
       61 gggacggtat tcagaattcg agcgcaggag ctccgcttct ccacctgctc ccggggagct
      121 attgggatcc agagaatcac ccgctgatgg tttttgccca ggcctgaaac aaccagagag
      181 ctacgggaaa ggaagggctt ggcttgccag aggaattttc caagtgctca aacgccaggc
      241 ttacggcgcc tgtgatccgt ccaggaggac aaagtgggat ttgaagatcc actccacttc
      301 tgctcatggc gggccagggc ctgcccctgc acgtggccac actgctgact gggctgctgg
      361 aatgcctggg ctttgctggc gtcctctttg gctggccttc actagtgttt gtcttcaaga
      421 atgaagatta ctttaaggat ctgtgtggac cagatgctgg gccgattggc aatgccacag
      481 ggcaggctga ctgcaaagcc caggatgaga ggttctcact catcttcacc ctggggtcct
      541 tcatgaacaa cttcatgaca ttccccactg gctacatctt tgaccggttc aagaccaccg
      601 tggcacgcct catagccata tttttctaca ccaccgccac actcatcata gccttcacct
      661 ctgcaggctc agccgtgctg ctcttcctgg ccatgccaat gctcaccatt gggggaatcc
      721 tgtttctcat caccaacctg cagattggga acctatttgg ccaacaccgt tcgaccatca
      781 tcactctgta caatggagca tttgactctt cctcggcagt cttccttatt attaagcttc
      841 tttatgaaaa aggcatcagc ctcagggcct ccttcatctt catctctgtc tgcagtacct
      901 ggcatgtagc acgcactttc ctcctgatgc cccgggggca catcccatac ccactgcccc
      961 ccaactacag ctatggcctg tgccctggga atggcaccac aaaggaagag aaggaaacag
     1021 ctgagcatga aaacagggag ctacagtcaa aggagttcct ttcagcgaag gaagagaccc
     1081 caggggcagg gcagaagcag gaactccgct ccttctggag ctacgctttc tctcggcgct
     1141 ttgcctggca cctggtgtgg ctgtctgtga tacagttgtg gcactacctc ttcattggca
     1201 ctctcaactc cttgctgacc aacatggccg gtggggacat ggcacgagtc agcacctaca
     1261 caaatgcctt tgccttcact cagttcggag tgctgtgtgc cccctggaat ggcctgctca
     1321 tggaccggct taaacagaag taccagaagg aagcaagaaa gacaggttcc tccactttgg
     1381 cggtggccct ctgctcgacg gtgccttcgc tggccctgac atccctgctg tgcctgggct
     1441 tcgccctctg tgcctcagtc cccatcctcc ctctccagta cctcaccttc atcctgcaag
     1501 tgatcagccg ctccttcctc tatgggagca acgcggcctt cctcaccctt gctttccctt
     1561 cagagcactt tggcaagctc tttgggctgg tgatggcctt gtcggctgtg gtgtctctgc
     1621 tccagttccc catcttcacc ctcatcaaag gctcccttca gaatgaccca ttttacgtga
     1681 atgtgatgtt catgcttgcc attcttctga cattcttcca cccctttctg gtatatcggg
     1741 aatgccgtac ttggaaagaa agtccctctg caattgcata gttcagaagc cctcactttt
     1801 cagccccgag gatggttttg ttcatcttcc accacctttg aggacctcgt gtcccaaaag
     1861 actttgccta tcccagcaaa acacacacac acacacacac acacacaaaa taaagacaca
     1921 caaggacgtc tgcgcagcaa gaaaagaatc tcagttgcca agcagattga tatcacacag
     1981 actcaaagca aaggcatgtg gaacttcttt atttcaaaac agaagtgtct ccttgcactt
     2041 agccttggca gacccttgac tccaggggag atgacctggg ggaggaagtg tgtcaactat
     2101 ttctttaggc ctgtttggct ccgaagccta tatgtgcctg gatcctctgc cacgggttaa
     2161 attttcaggt gaagagtgag gttgtcatgg cctcagctat gcttcctggc tctccctcaa
     2221 gagtgcagcc ttggctagag aactcacagc tctgggaaaa agaggagcag acagggttcc
     2281 ctgggcccag tctcagccca gccactgatg ctggatgacc ttggcctgac cctggtctgg
     2341 tctcagaatc acttttccca tctgtaaaat tgagatgaat tttggtgttg aaagttcttc
     2401 ctggagcaga tgtcctagaa ggttttagga atagtgacag agtcaggcca ccccaagggc
     2461 catgggagcc agctgacctg cttgaccgaa ggatttctga cagactatct ttggggatgt
     2521 tttcaagaag ggatataagt tatttacttt gggcatttaa aagaaaattt ctctcgggaa
     2581 taattttata gaaaaataaa gcttctgtgt ctaaggcaa
//
