LOCUS       NM_152346               8133 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens solute carrier family 43 member 2 (SLC43A2),
            transcript variant 2, mRNA.
ACCESSION   NM_152346
VERSION     NM_152346.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8133)
  AUTHORS   Maric,S., Fluchter,P., Guglielmetti,L.C., Staerkle,R.F., Sasse,T.,
            Restin,T., Schneider,C., Holland-Cunz,S.G., Crenn,P. and
            Vuille-Dit-Bille,R.N.
  TITLE     Plasma citrulline correlates with basolateral amino acid
            transporter LAT4 expression in human small intestine
  JOURNAL   Clin Nutr 40 (4), 2244-2251 (2021)
   PUBMED   33077272
  REMARK    GeneRIF: Plasma citrulline correlates with basolateral amino acid
            transporter LAT4 expression in human small intestine.
REFERENCE   2  (bases 1 to 8133)
  AUTHORS   Bian,Y., Li,W., Kremer,D.M., Sajjakulnukit,P., Li,S., Crespo,J.,
            Nwosu,Z.C., Zhang,L., Czerwonka,A., Pawlowska,A., Xia,H., Li,J.,
            Liao,P., Yu,J., Vatan,L., Szeliga,W., Wei,S., Grove,S., Liu,J.R.,
            McLean,K., Cieslik,M., Chinnaiyan,A.M., Zgodzinski,W., Wallner,G.,
            Wertel,I., Okla,K., Kryczek,I., Lyssiotis,C.A. and Zou,W.
  TITLE     Cancer SLC43A2 alters T cell methionine metabolism and histone
            methylation
  JOURNAL   Nature 585 (7824), 277-282 (2020)
   PUBMED   32879489
  REMARK    GeneRIF: Cancer SLC43A2 alters T cell methionine metabolism and
            histone methylation.
REFERENCE   3  (bases 1 to 8133)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8133)
  AUTHORS   Oparija,L., Rajendran,A., Poncet,N. and Verrey,F.
  TITLE     Anticipation of food intake induces phosphorylation switch to
            regulate basolateral amino acid transporter LAT4 (SLC43A2) function
  JOURNAL   J Physiol 597 (2), 521-542 (2019)
   PUBMED   30379325
REFERENCE   5  (bases 1 to 8133)
  AUTHORS   Zevenbergen,C., Meima,M.E., Lima de Souza,E.C., Peeters,R.P.,
            Kinne,A., Krause,G., Visser,W.E. and Visser,T.J.
  TITLE     Transport of Iodothyronines by Human L-Type Amino Acid Transporters
  JOURNAL   Endocrinology 156 (11), 4345-4355 (2015)
   PUBMED   26305885
REFERENCE   6  (bases 1 to 8133)
  AUTHORS   Cleal,J.K., Glazier,J.D., Ntani,G., Crozier,S.R., Day,P.E.,
            Harvey,N.C., Robinson,S.M., Cooper,C., Godfrey,K.M., Hanson,M.A.
            and Lewis,R.M.
  TITLE     Facilitated transporters mediate net efflux of amino acids to the
            fetus across the basal membrane of the placental
            syncytiotrophoblast
  JOURNAL   J Physiol 589 (Pt 4), 987-997 (2011)
   PUBMED   21224231
REFERENCE   7  (bases 1 to 8133)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 8133)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 8133)
  AUTHORS   Broer,S.
  TITLE     Amino acid transport across mammalian intestinal and renal
            epithelia
  JOURNAL   Physiol Rev 88 (1), 249-286 (2008)
   PUBMED   18195088
  REMARK    Review article
REFERENCE   10 (bases 1 to 8133)
  AUTHORS   Bodoy,S., Martin,L., Zorzano,A., Palacin,M., Estevez,R. and
            Bertran,J.
  TITLE     Identification of LAT4, a novel amino acid transporter with system
            L activity
  JOURNAL   J Biol Chem 280 (12), 12002-12011 (2005)
   PUBMED   15659399
  REMARK    GeneRIF: In situ hybridization experiments show that LAT4 mRNA is
            restricted to the epithelial cells of the distal tubule and the
            collecting duct in the kidney. In the intestine, LAT4 is mainly
            present in the cells of the crypt.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC027923.1, AC130343.7 and
            AC100748.2.
            
            On Jun 2, 2019 this sequence version replaced NM_152346.2.
            
            Summary: This gene encodes a member of the L-amino acid
            transporter-3 or SLC43 family of transporters. The encoded protein
            mediates sodium-, chloride-, and pH-independent transport of
            L-isomers of neutral amino acids, including leucine, phenylalanine,
            valine and methionine. This protein may contribute to the transfer
            of amino acids across the placental membrane to the fetus.
            [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon in the coding region compared to
            variant 1. It encodes isoform 2 which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005642.1, BC027923.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301335.10/ ENSP00000301335.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2633              BC027923.1         3-2635
            2634-7428           AC130343.7         19487-24281         c
            7429-8133           AC100748.2         1-705
FEATURES             Location/Qualifiers
     source          1..8133
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..8133
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="solute carrier family 43 member 2"
                     /db_xref="GeneID:124935"
                     /db_xref="HGNC:HGNC:23087"
                     /db_xref="MIM:610791"
     exon            1..41
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            42..247
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1797
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     L-type amino acid transporter 4; large neutral amino acids
                     transporter small subunit 4; solute carrier family 43
                     (amino acid system L transporter), member 2"
                     /codon_start=1
                     /product="large neutral amino acids transporter small
                     subunit 4 isoform 2"
                     /protein_id="NP_689559.1"
                     /db_xref="CCDS:CCDS11006.1"
                     /db_xref="GeneID:124935"
                     /db_xref="HGNC:HGNC:23087"
                     /db_xref="MIM:610791"
                     /translation="MAPTLATAHRRRWWMACTAVLENLLFSAVLLGWGSLLIMLKSEG
                     FYSYLCTEPENVTNGTVGGTAEPGHEEVSWMNGWLSCQAQDEMLNLAFTVGSFLLSAI
                     TLPLGIVMDKYGPRKLRLLGSACFAVSCLLIAYGASKPNALSVLIFIALALNGFGGMC
                     MTFTSLTLPNMFGDLRSTFIALMIGSYASSAVTFPGIKLIYDAGVSFIVVLVVWAGCS
                     GLVFLNCFFNWPLEPFPGPEDMDYSVKIKFSWLGFDHKITGKQFYKQVTTVGRRLSVG
                     SSMRSAKEQVALQEGHKLCLSTVDLEVKCQPDAAVAPSFMHSVFSPILLLSLVTMCVT
                     QLRLIFYMGAMNNILKFLVSGDQKTVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKEC
                     EDASEEPEEKDANQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQ
                     ILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISALFALLQQPLFLAMMG
                     PLQGDPLWVNVGLLLLSLLGFCLPLYLICYRRQLERQLQQRQEDDKLFLKINGSSNQE
                     AFV"
     exon            248..455
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            456..511
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            512..588
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            589..681
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..815
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1018
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1165
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1304
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1437
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1511
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1635
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..8133
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="hexamer: AATAAA"
     polyA_site      2999
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="major polyA site"
     regulatory      3607..3612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="hexamer: AATAAA"
     polyA_site      3624
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="hexamer: GATAAA"
     polyA_site      3814
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
     regulatory      8112..8117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
                     /note="hexamer: AATAAA"
     polyA_site      8133
                     /gene="SLC43A2"
                     /gene_synonym="LAT4"
ORIGIN      
        1 aaaaggcgcc gggcgggccc gacacacgcc ggaggagccg ggtggtgcag agccggagcc
       61 ggagccggag ccgcgccgcg ccgcaccatg gcgcccaccc tggccactgc ccatcggcgc
      121 cgctggtgga tggcctgcac ggccgtgctg gagaacctcc tcttctcggc agtcctcctg
      181 ggctggggct cgctgctcat catgctcaag tcagagggct tttactccta cctgtgtacc
      241 gagccagaga atgtcaccaa tggcacagtg ggcggcacag cagagccggg gcacgaggag
      301 gtgagctgga tgaacggctg gctcagctgc caggcccagg acgagatgct aaatttggcc
      361 ttcactgtgg gctcctttct gctcagtgcc atcaccctgc ccctgggtat cgtcatggac
      421 aagtatggcc cgaggaagct caggctgctg ggcagcgcct gcttcgcggt ttcctgcttg
      481 ctgattgcgt acggagcaag taaaccaaac gctctctccg tgctcatctt catcgccctg
      541 gctctgaatg gctttggtgg gatgtgtatg accttcacct cattaacact gcccaacatg
      601 ttcggcgacc ttcggtccac gtttattgcc ttgatgattg ggtcctacgc ctcctcggca
      661 gtcacctttc caggaatcaa gctcatctat gatgctggtg tctccttcat cgtcgtcctc
      721 gtggtctggg ccggctgctc cgggctggtt ttcctcaact gcttctttaa ctggcccctt
      781 gagcccttcc cggggccgga ggacatggac tactcggtga agatcaagtt cagctggctg
      841 ggctttgacc acaagatcac agggaagcag ttctacaagc aggtgaccac ggtgggccgg
      901 cgcctgagtg tgggcagctc catgaggagt gccaaggagc aggtggcgct gcaggagggc
      961 cacaagctgt gcctgtccac cgtcgacctg gaggtgaagt gccagccgga tgccgcagtg
     1021 gccccctcct tcatgcacag cgtgttcagc cccatcctgc tgctcagcct ggtcaccatg
     1081 tgcgtcacgc agctgcggct catcttctac atgggggcta tgaacaacat cctcaagttc
     1141 ctggtcagcg gcgaccagaa gacagttggc ctctacacct ccatcttcgg cgtgctccag
     1201 ctgctgtgcc tgctgacggc ccccgtcatt ggctacatca tggactggag gctgaaggag
     1261 tgtgaagacg cctccgagga gcccgaggag aaagacgcca accaaggcga gaagaaaaag
     1321 aagaagcggg accggcagat ccagaagatc actaatgcca tgcgggcctt cgccttcacc
     1381 aacctgctgc tcgtgggctt tggggtgacc tgcctcattc ccaacctgcc tctccagatc
     1441 ctctccttca tcctgcacac aatcgtgcga ggattcatcc actccgctgt cgggggcctg
     1501 tacgctgccg tgtacccctc cacccagttc ggcagcctca cgggactgca gtctctgatc
     1561 agcgcgctct tcgcccttct gcagcagccg ctgtttctgg ccatgatggg tcctctccag
     1621 ggagaccctc tgtgggtgaa cgtggggctg ctccttctca gcctgctggg cttctgcctc
     1681 ccgctctacc tgatctgcta ccggcgccag ctggagcggc agctgcagca gaggcaggag
     1741 gatgacaaac tcttcctcaa aatcaacggc tcgtccaacc aggaggcctt cgtgtagtgg
     1801 ctgccgcctc ggaactgcgg tctcctgcct gtgcttcagt gactgacccc tgtcctgccc
     1861 ctccagagta ccccacgcac ccccaggacc ttcgccgtct ccgtgccagc gttcacgctc
     1921 cctcccgggg ccctgcctcg gagctctgtg gtggaaggac gggagagggc cccggacacg
     1981 cgcgttttct cctgccgaac gcaggggctg ccctgacttt gctctgccgc cccccgggga
     2041 cccggggcct ggggtctctg tggtgcctgc agcaggagcc aggaacgccc ggcaggcagg
     2101 cgctctcccg ccagtgtctg gattctgcct cttgccaaag cagagggggc tgccatcccc
     2161 tgcctgccac ctgcccctcg gctgcatgcc cacagccgta cctgcctgag gacaaaggct
     2221 tgcactgtct cgcccgcgcc tggcccccac cccctccccg gccagcctga ggctgcctga
     2281 ggaaggaagg acccgcttcc tgttgtcggt gctaattcct ttgtaattcc agccccctgt
     2341 cgcctgtcca gggcctgccc acccgttgga ggccggtgga gaagccccac ctggcttatg
     2401 ccctggagag ggtttagcgg gctgggtgga cccctcgcct cctccccgag ggccaatgcc
     2461 gcggacacgt tttcactgtc accctcgttc tgtctgccac ctgaagggaa tttgaggacc
     2521 gccgccaggg caccccgtac atacacacag ctgcttttgt ggaggtggac gaaaggctgt
     2581 ggccggcaga cgtggaggtc caggccgggg tggggacgtg ggtgggtccg aggtgtgtgt
     2641 ggggtcgggg tgggctctag gagttagccc ttatccccac tgaccaggcg ggagccgcca
     2701 ggcctgcagc tgggccagtg cccaggagcc atcctggcgt ggggccagga gcttgtccaa
     2761 ggccacaggc ccacagcacc ccctgccggc gggctccgtg gggccctgga gctgatgacg
     2821 ggggaggccc gtccgcctgg cccaccaacc cgcccacctt gactgccccc agaagtgtgt
     2881 cttgagacct cctgggcgtg cttagagggg tgagttgtgt ttggattttt agttattttc
     2941 tcttcagttt tattagactt cttttttata aagcaataaa tccattttcc tccgggtaag
     3001 ggatgcccct tctggcatat cagttaatag ctgcatgtgc ctattttgag cttgagaaga
     3061 aaaggcagga caagattctc tgccaccgac cagctccagc cgtgcccagc tgctcttcgt
     3121 ctctctgggg gactgctgac tcgggaggga cagtgggcca ggaaaagacc ttcctcccca
     3181 acccccaaac aaactgggct tgtgcagaca tcttagaagt gtgagccacc ctcctctacc
     3241 gattttccca gccaaacagg cgaatcctgg tccctttcca tccctacacc cttccacaac
     3301 cctgaagatt cccgctgggt tcttctgcag gctcagagca gttcaggatg tgggcggcag
     3361 ggagggggat gaaaggagaa gaggaaaggg caggtccagg ccacattcaa gctccacatt
     3421 aacagcttgg gcgcctggaa cacatatctc ctaggcttta tttcactcaa atatttaaaa
     3481 aaagactggg cgtggtggct cacgcctata atcccagcac tttgggaggc caaggcagga
     3541 ggctcacctg aggtcaggag ttcgagacca tcctgaccaa catggagaaa ccccgtctgt
     3601 actaaaaata aacattaatc gggcgtggtg gcgtgcgcct gtaatcccaa ctactcggga
     3661 gcctgaggca ggagaatcgc ttgaaccggg gagacggaga ttgccgtgag tcgagatcgc
     3721 accattgcac tccagcctgg gcaacagagc gaggctccgt ctcaaaaaga aaaaaaaaaa
     3781 gagaacgaga taaacatgcc cactcctgag aacactcgtt ttgtgatgtt agtggttatt
     3841 ctgattttca agaaagtatt atagtcaagt ttgggaaagg ctgagttaaa agtcaagcct
     3901 gtttccttac agccagcact gacagcactt tgccaacgct catgagctcc gtggctcctc
     3961 aggagcgggt gtgctgtgct gccgaggaac ggctcgaacc atcagagcca ccagcctcca
     4021 cgtgcggctc catgatcacc cccagcagag gctcccgggt gctggttcca aatggagact
     4081 ccaggtcttg ccgctgaccg gtgactctgc tgccagcatt tgagacccgc catcacacag
     4141 gagttgcaga ttcggagaaa ccctaactag ccagggtgct gccagctggg aaaaggccgc
     4201 cttttttttt tttttttttt ttttgagttg gggtcttgct ctgccatcca ggctggagtg
     4261 cagtggtgca actgatagct caccacggcc tccaactcat gggctcaagg gatcctccca
     4321 cctcggcctc ctaagtatct gggactataa gtgtgtgcca ccatgcctgg ctaatttttt
     4381 ttttcttttt cataaagatg aattcttgct attttgccca ggctggtctg gaactcctgg
     4441 gctgaagcaa ttctcccacc tcagcctccc aaagtgctga gattacaggc gtgagtcaca
     4501 atgcctagcc aaaaagccag tcttgagatg gggaagacgt ggcccgtgct gtccccagca
     4561 gtgcccagtc ccagccaaag tgggcagtgc tgcctcactc tcccacccac cctcagggtg
     4621 tggcacttac tgggaagaag caggcattga gaaacagaat tgaggggggg aaacagtcca
     4681 gggccaacag tgcttgggga ttgaggcctg aaaatgcgag cagggtacag aggctgtggc
     4741 tggccagatg ggtcgggtgc cccctgcact cccaccccct agtcaggggt cacccatcct
     4801 actttgcctt gtgtggagct gacaggtgac atgttttcct attgttgtcc ttgacttgat
     4861 aacaatctgg gagttaaaca catatgatca tccctgcttt acaactgaaa aacgaggcct
     4921 agagatacta tcatcatata cacctgaaaa acgaggcctg gagcgatgga ggagcttgtt
     4981 caaggtcaga gccagcactc atatatgggt cttaagacac tggagcagcc aagggcctct
     5041 agaccaggac attccactcg gagcagcagc tcaggggcca ccaggcctct gtggcagggg
     5101 gacctctgtg gcagggggga cctctgtggc gggggggggg cctctgtggc aggggggtca
     5161 cagcccaagg aaggggagca ggcccaggca tggtttccgt ttctgggagc caagagcctt
     5221 ctcagaagag ggggagagag ctactgcatg gaatcatttg ggccctggag gctgatgggt
     5281 acttggggga gcaatccctg gtgaccccaa ccagcaagac aagtgccctg tgaaggggaa
     5341 gggactacag ctgatcaaag gagcaggcac cagtggccgg gcctcccgtc tgcccctcat
     5401 cctccaggct ctggcgggaa ggagcaggaa gggctccctg cccttggggt tttgatcagt
     5461 gaggaggggg gcttgggtct gagtctgggt ctgggtctgc tgccgaaaca ctgcccccag
     5521 tccctctcct cactagactc tggggtctag gcgtgtcttt gtggtcggcc ttctccaaac
     5581 cctctaggcc tctgtctgca gctgctgctg cctggaccta tacacaaggt cccacccctc
     5641 accggggcca aagacgtggt tgcaggccct ggtggatcct ttctgttttg ctccatcccc
     5701 gtcccctctt gcacccagca tcgtcctggt cagaacttcc gtttaaacct tccttgcctg
     5761 ccgtgcactc cgaggggggc gtcactttgc cataggcccc agggctgaaa atggcgggac
     5821 atccagtatt gggctcacgt gcataagact gtcccagaca gcagcacaat cacgttcagc
     5881 caagtggagt ttccgacgca cttgtgtggc agccgcgtga atgtgagccg atatgcagct
     5941 gggaggggtt gtgggcctcc tgcggtgagg ggctcctgcc aggagctctg agaagcctcc
     6001 acagaatcag ccgtcgggct ccttcagcag cagctcccct tatctgtgcc aacgactggg
     6061 ggcctaactc aagggtgcca gcccgtcttc cgccaataca gactgtggga ttctgagagt
     6121 taggagcctg gggtcccctg gggtggggtg gtcagggtga gcaggtgggc tctgtgagcc
     6181 tgtttcccca tgccctgact caccccaatc cctgggtgag gacagagctc ctgaaggcca
     6241 ctgaaggagg tgcagcacac tccacctggg tggccttccg cagctcagcc ctcttcctgc
     6301 cagcaggaag cctctgcctg tgctccttaa gttagccatc ctcaccccct ccgggcagct
     6361 ctgagactga gccagggcca ctagcagcac ccagacctcg acccttctca gaccgaggcg
     6421 ccaccacccc aggccgagga ggcaaggagg gaagaccaaa gtctagagga ctgtcttggt
     6481 ggccctgggc gagtcttgaa ctttggtgcc atcatctgca aaagggagga aagaatgcct
     6541 gcgtggtgca gctacgtgga tacgcagtga agacccgcat ggtgggacgc ctggcactta
     6601 acaatggtag catttggccg ggcgcggtgg ctcacgcctg taatcccagc actttgggag
     6661 gccgaggcgg gcggatcacg aggtcaggag atcaagacca tcccggctaa aacggtgaaa
     6721 ccccgtctct actaaaaata caaaaaatta gccgggcgta gtggcgggcg cctgtagtcc
     6781 cagctacttg ggaggctgag gcaggagaat ggtgtgaacc cgggaggcgg agcttgcagt
     6841 gagccgagat cccgccactg cactccagcc tgggcgacag agcgagactc cgtctcaaaa
     6901 aaaaaaaaaa aaacaatggt agcatcgttt tcagtgccca ggaagaaggc agctgggaca
     6961 gggaaagggc caccacacca cacccaagcc catacaacag gagagccact ttcagcagct
     7021 ctgagcagga cagacttgtg gccaagtcaa gaaagtaagg tctggtccca gcgaggtggc
     7081 tcatccctgt aatcccagtg ctttgggagg ccgaagcggg ggcggggtgg atcacttgag
     7141 gtcaggggtt tgagaccagc ctgaccaaca tggtgaaacc tcaactctac taaaaataca
     7201 aaaattaggg ccgggcgcag tggctcacgc ctgtaatccc agcactttgg gaggctgagg
     7261 cgggcggatc acaaggtcag gagatcgaga ccaacgtggc taacacagtg aaaccccatc
     7321 tctactaaaa atacgaaaaa aaaaaattag ctgggcgtgg tggtgggtac ctgtagtccc
     7381 agctacttgg gaggctgagg caggagaatg gcatgaaccc gggaggtgaa gcttgcagtg
     7441 agccgagatt gtgccactgc actccagcct gggcgacaga gcaagactcc gtctcaaaaa
     7501 aaaaaaaaaa aaaaaaaaaa gtaaggtctg tatctgctga ccccaccctt ctccgaagcc
     7561 ctctccgagc aaagccttaa gaaactcttc tctcgttcac ttttcttttg tggctttcac
     7621 gttttggtaa gacttggcca aatagctgct cgagataatc aatcactggt ggacaagttt
     7681 ctgctgagtg aggtttctgc tgagtggggc gactcaaggc acggtcacgt aggcagcacc
     7741 tgtacaccgc atcctcatac agctgcggga ccgtgcctct gactgtgtgc gtgtgtgttt
     7801 atctaagtgt gagatgcatc cgggcatgtc agggtgtgta catgttggga agactgtgta
     7861 gatttcttgt gtgccgctct ctgaatggag gagaggggaa gcgtcttacc tcgctgaatc
     7921 cctttccatt gctggaaaga acacctgggc aggagcggcc ccaagacccc gcccaggccc
     7981 tcggaaggga gcctgaaggg ttaatccgta ccctgtatta accagggtca acccagcggc
     8041 tgacccgcct cttccctgct cctttgccgt ttctagcacc tggcttactt cctggcacac
     8101 agtgagcact caataaatgt atgctgagaa tga
//
