LOCUS       NM_003627               2514 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens solute carrier family 43 member 1 (SLC43A1),
            transcript variant 1, mRNA.
ACCESSION   NM_003627
VERSION     NM_003627.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2514)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2514)
  AUTHORS   Zevenbergen,C., Meima,M.E., Lima de Souza,E.C., Peeters,R.P.,
            Kinne,A., Krause,G., Visser,W.E. and Visser,T.J.
  TITLE     Transport of Iodothyronines by Human L-Type Amino Acid Transporters
  JOURNAL   Endocrinology 156 (11), 4345-4355 (2015)
   PUBMED   26305885
REFERENCE   3  (bases 1 to 2514)
  AUTHORS   Sekine,Y., Nishibori,Y., Akimoto,Y., Kudo,A., Ito,N., Fukuhara,D.,
            Kurayama,R., Higashihara,E., Babu,E., Kanai,Y., Asanuma,K.,
            Nagata,M., Majumdar,A., Tryggvason,K. and Yan,K.
  TITLE     Amino acid transporter LAT3 is required for podocyte development
            and function
  JOURNAL   J Am Soc Nephrol 20 (7), 1586-1596 (2009)
   PUBMED   19443642
REFERENCE   4  (bases 1 to 2514)
  AUTHORS   Broer,S.
  TITLE     Amino acid transport across mammalian intestinal and renal
            epithelia
  JOURNAL   Physiol Rev 88 (1), 249-286 (2008)
   PUBMED   18195088
  REMARK    Review article
REFERENCE   5  (bases 1 to 2514)
  AUTHORS   Babu,E., Kanai,Y., Chairoungdua,A., Kim,D.K., Iribe,Y.,
            Tangtrongsup,S., Jutabha,P., Li,Y., Ahmed,N., Sakamoto,S.,
            Anzai,N., Nagamori,S. and Endou,H.
  TITLE     Identification of a novel system L amino acid transporter
            structurally distinct from heterodimeric amino acid transporters
  JOURNAL   J Biol Chem 278 (44), 43838-43845 (2003)
   PUBMED   12930836
  REMARK    GeneRIF: LAT3 is a transporter subserving system L2 and should
            denote a new family of organic solute transporters
REFERENCE   6  (bases 1 to 2514)
  AUTHORS   Skotheim,R.I., Monni,O., Mousses,S., Fossa,S.D., Kallioniemi,O.P.,
            Lothe,R.A. and Kallioniemi,A.
  TITLE     New insights into testicular germ cell tumorigenesis from gene
            expression profiling
  JOURNAL   Cancer Res 62 (8), 2359-2364 (2002)
   PUBMED   11956097
REFERENCE   7  (bases 1 to 2514)
  AUTHORS   Cole,K.A., Chuaqui,R.F., Katz,K., Pack,S., Zhuang,Z., Cole,C.E.,
            Lyne,J.C., Linehan,W.M., Liotta,L.A. and Emmert-Buck,M.R.
  TITLE     cDNA sequencing and analysis of POV1 (PB39): a novel gene
            up-regulated in prostate cancer
  JOURNAL   Genomics 51 (2), 282-287 (1998)
   PUBMED   9722952
REFERENCE   8  (bases 1 to 2514)
  AUTHORS   Chuaqui,R.F., Englert,C.R., Strup,S.E., Vocke,C.D., Zhuang,Z.,
            Duray,P.H., Bostwick,D.G., Linehan,W.M., Liotta,L.A. and
            Emmert-Buck,M.R.
  TITLE     Identification of a novel transcript up-regulated in a clinically
            aggressive prostate carcinoma
  JOURNAL   Urology 50 (2), 302-307 (1997)
   PUBMED   9255310
REFERENCE   9  (bases 1 to 2514)
  AUTHORS   Shuangshoti,S. and Viratchai,C.
  TITLE     Encephalomalacia unrelated to vascular occlusion
  JOURNAL   J Med Assoc Thai 59 (9), 421-425 (1976)
   PUBMED   972295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM147085.1, AB103033.1 and BQ029981.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003627.5.
            
            Summary: SLC43A1 belongs to the system L family of plasma membrane
            carrier proteins that transports large neutral amino acids (Babu et
            al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB103033.1, SRR1803611.171760.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278426.8/ ENSP00000278426.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               BM147085.1         85-213
            130-2192            AB103033.1         114-2176
            2193-2514           BQ029981.1         16-337              c
FEATURES             Location/Qualifiers
     source          1..2514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..2514
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /note="solute carrier family 43 member 1"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
     exon            1..259
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            260..426
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1952
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /note="L-type amino acid transporter 3; prostate cancer
                     overexpressed gene 1 protein; solute carrier family 43
                     (amino acid system L transporter), member 1"
                     /codon_start=1
                     /product="large neutral amino acids transporter small
                     subunit 3"
                     /protein_id="NP_003618.1"
                     /db_xref="CCDS:CCDS7958.1"
                     /db_xref="GeneID:8501"
                     /db_xref="HGNC:HGNC:9225"
                     /db_xref="MIM:603733"
                     /translation="MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEG
                     FYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFG
                     PRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMF
                     GNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWP
                     IEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFM
                     SPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVT
                     GGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGT
                     VLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFV
                     LHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGE
                     PFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA"
     exon            427..604
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            605..660
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            661..737
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            738..830
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            831..964
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1143
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1290
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1326
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1465
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1607
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1681
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1805
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2514
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /note="hexamer: AATAAA"
     polyA_site      2514
                     /gene="SLC43A1"
                     /gene_synonym="LAT3; PB39; POV1; R00504"
                     /note="major polyA site"
ORIGIN      
        1 acttcatcca agcccagctt cgcagacctc tggcgcccgg cgggttccca gttcccccgc
       61 ttcttccgag gagacagcgg aggcgaggcc accgggctgt caggctgaag ctccgtggcc
      121 gccgggtcct gcacgcagag aagaccccag cgccggcgcg gctcagggct gggcccacgg
      181 gactccggac gcgccgcgaa agcgttgcgc tcccggaggc gtccgcagct gctggctgct
      241 catttgccgg tgaccggagg ctcggggcca gcatggcccc cacgctgcaa caggcgtacc
      301 ggaggcgctg gtggatggcc tgcacggctg tgctggagaa cctcttcttc tctgctgtac
      361 tcctgggctg gggctccctg ttgatcattc tgaagaacga gggcttctat tccagcacgt
      421 gcccagctga gagcagcacc aacaccaccc aggatgagca gcgcaggtgg ccaggctgtg
      481 accagcagga cgagatgctc aacctgggct tcaccattgg ttccttcgtg ctcagcgcca
      541 ccaccctgcc actggggatc ctcatggacc gctttggccc ccgacccgtg cggctggttg
      601 gcagtgcctg cttcactgcg tcctgcaccc tcatggccct ggcctcccgg gacgtggaag
      661 ctctgtctcc gttgatattc ctggcgctgt ccctgaatgg ctttggtggc atctgcctaa
      721 cgttcacttc actcacgctg cccaacatgt ttgggaacct gcgctccacg ttaatggccc
      781 tcatgattgg ctcttacgcc tcttctgcca ttacgttccc aggaatcaag ctgatctacg
      841 atgccggtgt ggccttcgtg gtcatcatgt tcacctggtc tggcctggcc tgccttatct
      901 ttctgaactg caccctcaac tggcccatcg aagcctttcc tgcccctgag gaagtcaatt
      961 acacgaagaa gatcaagctg agtgggctgg ccctggacca caaggtgaca ggtgacctct
     1021 tctacaccca tgtgaccacc atgggccaga ggctcagcca gaaggccccc agcctggagg
     1081 acggttcgga tgccttcatg tcaccccagg atgttcgggg cacctcagaa aaccttcctg
     1141 agaggtctgt ccccttacgc aagagcctct gctcccccac tttcctgtgg agcctcctca
     1201 ccatgggcat gacccagctg cggatcatct tctacatggc tgctgtgaac aagatgctgg
     1261 agtaccttgt gactggtggc caggagcatg agacaaatga acagcaacaa aaggtggcag
     1321 agacagttgg gttctactcc tccgtcttcg gggccatgca gctgttgtgc cttctcacct
     1381 gccccctcat tggctacatc atggactggc ggatcaagga ctgcgtggac gccccaactc
     1441 agggcactgt cctcggagat gccagggacg gggttgctac caaatccatc agaccacgct
     1501 actgcaagat ccaaaagctc accaatgcca tcagtgcctt caccctgacc aacctgctgc
     1561 ttgtgggttt tggcatcacc tgtctcatca acaacttaca cctccagttt gtgacctttg
     1621 tcctgcacac cattgttcga ggtttcttcc actcagcctg tgggagtctc tatgctgcag
     1681 tgttcccatc caaccacttt gggacgctga caggcctgca gtccctcatc agtgctgtgt
     1741 tcgccttgct tcagcagcca cttttcatgg cgatggtggg acccctgaaa ggagagccct
     1801 tctgggtgaa tctgggcctc ctgctattct cactcctggg attcctgttg ccttcctacc
     1861 tcttctatta ccgtgcccgg ctccagcagg agtacgccgc caatgggatg ggcccactga
     1921 aggtgcttag cggctctgag gtgaccgcat agacttctca gaccaaggga cctggatgac
     1981 aggcaatcaa ggcctgagca accaaaagga gtgccccata tggcttttct acctgtaaca
     2041 tgcacataga gccatggccg tagatttata aataccaaga gaagttctat ttttgtaaag
     2101 actgcaaaaa ggaggaaaaa aaaccttcaa aaacgccccc taagtcaacg ctccattgac
     2161 tgaagacagt ccctatccta gaggggttga gccttcttcc tccttgggtt ggaggagacc
     2221 agggtgcctc ttatctcctt ctagcggtct gcctcctggt acctcttggg gggatcggca
     2281 aacaggctac ccctgaggtc ccatgtgcca tgagtgtgca cacatgcatg tgtctgtgta
     2341 tgtgtgaatg tgagagagac acagccctcc tttcagaagg aaaggggcct gaggtgccag
     2401 ctgtgtcctg ggttaggggt tgggggtcgg ccccttccag ggccaggagg gcaggttccc
     2461 tctctggtgc tgctgcttgc aagtcttaga ggaaataaaa agggaagtga gaga
//
