LOCUS       NM_017836               2182 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 41 member 3 (SLC41A3),
            transcript variant 2, mRNA.
ACCESSION   NM_017836
VERSION     NM_017836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Chang,Q., Xu,Y., Wang,J., Jing,H., Rao,L., Tang,W., Zhang,Z. and
            Wu,X.
  TITLE     SLC41A3 Exhibits as a Carcinoma Biomarker and Promoter in Liver
            Hepatocellular Carcinoma
  JOURNAL   Comput Math Methods Med 2021, 8556888 (2021)
   PUBMED   34819993
  REMARK    GeneRIF: SLC41A3 Exhibits as a Carcinoma Biomarker and Promoter in
            Liver Hepatocellular Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Mastrototaro,L., Smorodchenko,A., Aschenbach,J.R., Kolisek,M. and
            Sponder,G.
  TITLE     Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux
            system
  JOURNAL   Sci Rep 6, 27999 (2016)
   PUBMED   27302215
  REMARK    GeneRIF: Data identify SLC41A3 as the first mammalian mitochondrial
            Mg(2+) efflux system, which greatly enhances the understanding of
            intracellular Mg(2+) homeostasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Wabakken,T., Rian,E., Kveine,M. and Aasheim,H.C.
  TITLE     The human solute carrier SLC41A1 belongs to a novel eukaryotic
            subfamily with homology to prokaryotic MgtE Mg2+ transporters
  JOURNAL   Biochem Biophys Res Commun 306 (3), 718-724 (2003)
   PUBMED   12810078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079848.16, AC117422.5 and AC092903.11.
            
            On May 21, 2020 this sequence version replaced NM_017836.3.
            
            Transcript Variant: This variant (2) uses alternate splicing in the
            3' coding region, compared to variant 1, resulting in a shorter
            protein (isoform 2) with a unique C-terminus.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009444.1, SRR11853566.20052.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360370.9/ ENSP00000353533.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC079848.16        148496-148527
            33-332              AC117422.5         4382-4681
            333-440             AC117422.5         21578-21685
            441-512             AC092903.11        9264-9335
            513-657             AC092903.11        16463-16607
            658-804             AC092903.11        20010-20156
            805-949             AC092903.11        26067-26211
            950-1029            AC092903.11        27369-27448
            1030-1164           AC092903.11        30193-30327
            1165-1313           AC092903.11        34062-34210
            1314-2182           AC092903.11        35717-36585
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.2-q21.3"
     gene            1..2182
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /note="solute carrier family 41 member 3"
                     /db_xref="GeneID:54946"
                     /db_xref="HGNC:HGNC:31046"
                     /db_xref="MIM:610803"
     exon            1..32
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            33..332
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1523
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     SLC41A1-like 2"
                     /codon_start=1
                     /product="solute carrier family 41 member 3 isoform 2"
                     /protein_id="NP_060306.4"
                     /db_xref="CCDS:CCDS43144.1"
                     /db_xref="GeneID:54946"
                     /db_xref="HGNC:HGNC:31046"
                     /db_xref="MIM:610803"
                     /translation="MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPE
                     SQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDL
                     LTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLL
                     AAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPD
                     NIATPIAASLGDLITLSILALVSSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSP
                     PIVKILKFGWFPIILAMVISSFGGLILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQT
                     SRISTYLHMWSAPGVLPLQMKKFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYI
                     IYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPYLTG
                     LGDLLGTGLLALCFFTDWLLKSKAELGGISELASGPP"
     exon            333..440
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..512
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..657
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..804
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..949
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1029
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1164
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1313
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..2182
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /note="hexamer: AATAAA"
     polyA_site      2182
                     /gene="SLC41A3"
                     /gene_synonym="SLC41A1-L2"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcccg ccgccgcctg ggaggggacc cgggctgcca ggcgcccagc tgtgcccaga
       61 tggatgggac agagacccgg cagcggaggc tggacagctg tggcaagcca ggggagctgg
      121 ggcttcctca ccccctcagc acaggaggac tccctgtagc ctcagaagat ggagctctca
      181 gggcccctga gagccaaagc gtgaccccca agccactgga gactgagcct agcagggaga
      241 ccacctggtc cataggcctt caggtgaccg tgcccttcat gtttgcaggc ctgggactgt
      301 cctgggccgg catgcttctg gactatttcc agcactggcc tgtgtttgtg gaggtgaaag
      361 accttttgac attggtgccg cccctggtgg gcctgaaggg gaacctggag atgacactgg
      421 catccagact ctccacagct gccaacactg gacaaattga tgacccccag gagcagcaca
      481 gagtcatcag cagcaacctg gccctcatcc aggtgcaggc cactgtcgtg gggctcttgg
      541 ctgctgtggc tgcgctgctg ttgggcgtgg tgtctcgaga ggaagtggat gtcgccaagg
      601 tggagttgct gtgtgccagc agtgtcctca ctgccttcct tgcagccttt gccctggggg
      661 tgctgatggt ctgtatagtg attggtgctc gaaagctcgg ggtcaaccca gacaacattg
      721 ccacgcccat tgcagccagc ctgggagacc tcatcacact gtccattctg gctttggtta
      781 gcagcttctt ctacagacac aaagatagtc ggtatctgac gccgctggtc tgcctcagct
      841 ttgcggctct gaccccagtg tgggtcctca ttgccaagca gagcccaccc atcgtgaaga
      901 tcctgaagtt tggctggttc ccaatcatcc tggccatggt catcagcagt ttcggaggac
      961 tcatcttgag caaaaccgtt tctaaacagc agtacaaagg catggcgata tttacccccg
     1021 tcatatgtgg tgttggtggc aatctggtgg ccattcagac cagccgaatc tcaacctacc
     1081 tgcacatgtg gagtgcacct ggcgtcctgc ccctccagat gaagaaattc tggcccaacc
     1141 cgtgttctac tttctgcacg tcagaaatca attccatgtc agctcgagtc ctgctcttgc
     1201 tggtggtccc aggccatctg attttcttct acatcatcta cctggtggag ggtcagtcag
     1261 tcataaacag ccagaccttt gtggtgctct acctgctggc aggcctgatc caggtgacaa
     1321 tcctgctgta cctcgcagaa gtgatggttc ggctgacttg gcaccaggcc ctggatcctg
     1381 acaaccactg catcccctac cttacagggc tgggggacct gctcggtact ggcctcctgg
     1441 cactctgctt tttcactgac tggctactga agagcaaggc agagctgggt ggcatctcag
     1501 aactggcatc tggacctccc taactgggcc ccgctggtcc catttgctca ttagaatttc
     1561 ctctcacatc agtgggatac agaattcagt ttctcccttg ccaggtcctt gggatggttg
     1621 acccctgcct ctgcagtagc cttttgtgag tctgctaagg tagctctcac acacctcggc
     1681 tctggggttg atacctgagc ctgcaataga gccctgaaat caagagcatg gcttgagtgt
     1741 gtgaatatga tgtgtgcaca tgcttaatga gcgtgcaagt gtgcacacgt ttgtggagag
     1801 gagggtgttc tggcctgaga aggtaaagaa gaggcatgtc cagtatgctt tgcagggtgt
     1861 gtttgctctt ttccatgccc atgcaaccca gattggggtg gagcaggaag gagctctttt
     1921 ctgttcccaa gcctcagaac tcttgagctg tggcttactt gctgtcttca ccaggttcaa
     1981 gctccgtggg ccacactgct gctgtgccaa gaaggtgtac agcctcccca ggatggggcc
     2041 tcatacaacc cttcatctgc actcaacatt taatcgtgtc cttgctgtct ttttattttc
     2101 ctttttgttt gttagcaaaa acctctattt agatttcaat aatcagagaa gtgtaaaata
     2161 aaacagatta tattgtactt ga
//
