LOCUS       NM_001352171            5443 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 41 member 2 (SLC41A2),
            transcript variant 4, mRNA.
ACCESSION   NM_001352171 XM_005269176
VERSION     NM_001352171.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5443)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5443)
  AUTHORS   Sahni,J., Nelson,B. and Scharenberg,A.M.
  TITLE     SLC41A2 encodes a plasma-membrane Mg2+ transporter
  JOURNAL   Biochem J 401 (2), 505-513 (2007)
   PUBMED   16984228
REFERENCE   3  (bases 1 to 5443)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Functional characterization of the mouse [corrected] solute
            carrier, SLC41A2
  JOURNAL   Biochem Biophys Res Commun 330 (3), 701-705 (2005)
   PUBMED   15809054
  REMARK    Erratum:[Biochem Biophys Res Commun. 2007 May 11;356(3):822]
REFERENCE   4  (bases 1 to 5443)
  AUTHORS   Wabakken,T., Rian,E., Kveine,M. and Aasheim,H.C.
  TITLE     The human solute carrier SLC41A1 belongs to a novel eukaryotic
            subfamily with homology to prokaryotic MgtE Mg2+ transporters
  JOURNAL   Biochem Biophys Res Commun 306 (3), 718-724 (2003)
   PUBMED   12810078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090051.8 and AC089985.14.
            
            On Sep 24, 2020 this sequence version replaced NM_001352171.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. Variants 1-8 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3644041.1,
                                           SRR14038191.1781153.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258538.8/ ENSP00000258538.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AC090051.8         36710-36912         c
            204-925             AC089985.14        133732-134453       c
            926-1033            AC089985.14        115414-115521       c
            1034-1105           AC089985.14        101033-101104       c
            1106-1250           AC089985.14        94792-94936         c
            1251-1397           AC089985.14        92052-92198         c
            1398-1545           AC089985.14        72191-72338         c
            1546-1625           AC089985.14        67050-67129         c
            1626-1757           AC089985.14        51602-51733         c
            1758-1906           AC089985.14        50231-50379         c
            1907-5443           AC089985.14        7560-11096          c
FEATURES             Location/Qualifiers
     source          1..5443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..5443
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="solute carrier family 41 member 2"
                     /db_xref="GeneID:84102"
                     /db_xref="HGNC:HGNC:31045"
                     /db_xref="MIM:610802"
     exon            1..203
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            204..925
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..2092
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="isoform a is encoded by transcript variant 4;
                     SLC41A1-like 1; solute carrier family 41 (magnesium
                     transporter), member 2"
                     /codon_start=1
                     /product="solute carrier family 41 member 2 isoform a"
                     /protein_id="NP_001339100.1"
                     /db_xref="CCDS:CCDS9100.2"
                     /db_xref="GeneID:84102"
                     /db_xref="HGNC:HGNC:31045"
                     /db_xref="MIM:610802"
                     /translation="MTNSKGRSITDKTSGGPSSGGGFVDWTLRLNTIQSDKFLNLLLS
                     MVPVIYQKNQEDRHKKANGIWQDGLSTAVQTFSNRSEQHMEYHSFSEQSFHANNGHAS
                     SSCSQKYDDYANYNYCDGRETSETTAMLQDEDISSDGDEDAIVEVTPKLPKESSGIMA
                     LQILVPFLLAGFGTVSAGMVLDIVQHWEVFRKVTEVFILVPALLGLKGNLEMTLASRL
                     STAVNIGKMDSPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLDHSI
                     LLCSSSVATAFIASLLQGIIMVGVIVGSKKTGINPDNVATPIAASFGDLITLAILAWI
                     SQGLYSCLETYYYISPLVGVFFLALTPIWIIIAAKHPATRTVLHSGWEPVITAMVISS
                     IGGLILDTTVSDPNLVGIVVYTPVINGIGGNLVAIQASRISTYLHLHSIPGELPDEPK
                     GCYYPFRTFFGPGVNNKSAQVLLLLVIPGHLIFLYTIHLMKSGHTSLTIIFIVVYLFG
                     AVLQVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLIGD
                     RDGDVGD"
     exon            926..1033
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1105
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1250
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1397
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1545
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1625
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1757
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1906
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..5443
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4670..4675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="hexamer: AATAAA"
     polyA_site      4691
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="major polyA site"
     regulatory      5288..5293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="hexamer: AATAAA"
     polyA_site      5306
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="major polyA site"
     regulatory      5422..5427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
                     /note="hexamer: AATAAA"
     polyA_site      5443
                     /gene="SLC41A2"
                     /gene_synonym="SLC41A1-L1"
ORIGIN      
        1 gtcagcttgg ggccgcagcc gcgcgaggag gcgcgggagc aggaaggagc tgtgggctgg
       61 gagccgctgt cctccccgcc accaccggtg ccgggcacca ggtgaatgcc ccttccatcc
      121 cccgcccctg gtgtctcggt ctggtctgag gagacgggga cccttctcac accggccgct
      181 gccgccgccg cgctccggaa cagatccagt ccttctgtgg aacttctgaa catcttttat
      241 tagtggaaat attttctaca caatgaagtc aacaacttaa tttaaaccag tgtttgtgcg
      301 gttctgattc atctgctgtg gttcccgaag cttgagatct aaggagtaca gggtcttttg
      361 tgatgacaat atgactaata gtaaaggaag atctattacc gataaaacaa gtggtggtcc
      421 aagtagtgga ggaggttttg tagattggac tttacgttta aacacaattc aatccgacaa
      481 gtttttaaat ttactcttga gtatggttcc agtgatttac cagaaaaacc aagaagacag
      541 gcacaaaaaa gcaaacggca tttggcaaga tggattatca actgcagtac agacttttag
      601 taatagatct gagcaacaca tggagtatca cagtttctca gagcagtctt ttcatgccaa
      661 taatgggcac gcatcatcaa gctgcagcca aaagtatgat gactatgcca attataatta
      721 ctgtgatgga agggagactt cagaaaccac tgccatgtta caagatgaag atatatctag
      781 tgatggtgat gaagatgcta ttgtagaagt gaccccaaaa ttaccaaagg aatccagtgg
      841 catcatggca ttgcaaatac ttgtgccctt tttgctagct ggttttggaa cagtttcagc
      901 tggcatggta ctggatatag tacagcactg ggaggtgttc agaaaagtta cagaagtttt
      961 cattttagtc cctgcacttc ttggtctcaa agggaacttg gaaatgacat tggcatccag
     1021 attatccact gcagtaaata ttgggaagat ggattcaccc attgaaaagt ggaacctaat
     1081 aattggcaac ttggctttaa agcaggttca ggcaacagta gtgggttttc tagcagctgt
     1141 ggcagcaatt atattgggct ggattccaga aggaaaatat taccttgatc attccatact
     1201 tctgtgctct agcagtgtgg caactgcctt cattgcatct cttctgcagg gaataataat
     1261 ggttggggtt atcgttggtt caaagaagac tggtataaat cctgataatg ttgctacacc
     1321 cattgctgct agttttggcg accttataac tcttgccata ttggcttgga taagtcaggg
     1381 cttatactcc tgtcttgaga cctattacta catttctcca ttagttggtg tatttttctt
     1441 ggctctaacc cctatttgga ttataatagc tgccaaacat ccagccacaa gaacagttct
     1501 ccactcaggc tgggagcctg tcataacagc tatggttata agtagcattg ggggccttat
     1561 tctggacaca actgtatcag acccaaactt ggttgggatt gttgtttaca cgccagttat
     1621 taatggtatt ggtggtaatt tggtggccat tcaggctagc aggatttcta cctacctcca
     1681 tttacatagc attccaggag aattgcctga tgaacccaaa ggttgttact acccatttag
     1741 aactttcttt ggtccaggag taaataataa gtctgctcaa gttctactgc ttttagtgat
     1801 tcctggacat ttaattttcc tctacactat tcatttgatg aaaagtggtc atacttcttt
     1861 aactataatc ttcatagtag tgtatttatt tggcgctgtg ttacaggtat ttaccttgct
     1921 gtggattgct gactggatgg tccatcactt ctggaggaaa ggaaaggacc cggatagttt
     1981 ctccatcccc tacctaacag cattgggtga tctgctcggg acagctctgt tagccttaag
     2041 ttttcatttt ctttggctta ttggagatcg agatggagat gttggagact aataaattct
     2101 acaaactgct ctcaagttac caaggaagaa aatacacgac aaccacttat ggctcttttt
     2161 caaaactctt aaatcagtag tttgactttt gccagggtaa tcttcagttg gccctgattc
     2221 aattaaatgg ccttaatttt tttttaagga atttgtgtca aaaccagaat gaagagtatt
     2281 cgtgctgctt ttcatagaat aaatgataat ttgacataga catagatata agttccagct
     2341 ctgaaattaa ttaggaaaga atataggatg tttacagtga ataattttaa aaccacaaac
     2401 atagcagaaa tgtactttat tattaaattt gtaatgcagg attagaagaa gcagagctct
     2461 agtttagcct ttcttgtctc acagatgtgc tgtatcccag gcatactata aaacgaagag
     2521 tgcccaacca agctttgaat cgtattaaca atgcccacct ctatgctagc tgaggataaa
     2581 tttaccagtt gctcatattt aaactgacct aaatatgttt tgctgagcat aagataaact
     2641 cacttttacc tccatctaaa attatcctgt tctgatgcca attcaatttc agctctgcaa
     2701 gttcttgtca ggctaatctt taaacattga gtgatcttga gagattgtta atgaaagcag
     2761 tgagtcattt tttgatgatt gatttgttgg aaaaatgttg atgtgtttta aaaaatgtaa
     2821 tcttcaaaaa cagaatataa cctgagatgc atttgtagag acaagacggt acgagaatgt
     2881 gtgtgtgtgt gtgtgtgaga gagagagact tttgatgaag aactaaatct tggattgctg
     2941 atagcaaaga tcatagtgct gttggaatat cagcaatata gagttattct taaacacatt
     3001 ctattaacat gtttttgtca ttgggtccaa aaattttgct gctgaccaga atttactatt
     3061 tgttacctat attctttttt tttttttttt tttttttttt tgagacagag tcttgctctg
     3121 tcgcccaggc tggaatgcag tggtgtgatc tcggctcact gctacctcca cctcctggat
     3181 tcaagtgatt ctcctgcctc agcctcccga gtagctggga ttacaggaat gcgccacaac
     3241 gcccagctaa tttgttacct acactctaat taataattaa taatttctta ttttaaaaag
     3301 tagtactatt taatataatc aagataggag atttaaaatg agcaagtgat tcatttgctc
     3361 ttttaaagaa gcccgttgac ttacgctttt aaaaaagaag ttggtgggtt acctcaatta
     3421 ttgttcatgc ttaaacatat ccatttgtac aggcttattt ctacgtggga cccaatcata
     3481 tatactatat ttctcaaata atttttctaa aactctggcc tatattctaa acacttgacc
     3541 aacaccttag ttattgaata ggtaaccatt tttaaagtac atgtggttca ttttttaaaa
     3601 ttcaatctct caagaccgtt agatatttaa taatttaagc tgataagggt atcaaaatgc
     3661 acattaactt tgatcatcat gatttaagtt gtaactttgt gttattatat aaatattagg
     3721 ttgtttataa atatattgca gaaagtattc ttgttaagct cttttaaatg aggggactgt
     3781 ggtttagagt tatatatttt tgcttatttt taaacttcaa ttattccatt cttctgcctt
     3841 ataataaaac ttttaaggca gagaactgaa ctaattatag aatttctcct ttggagagtt
     3901 ataatgttac atagtgaaca ttcttataaa agaaagaata agtttaagtt gatgaatatt
     3961 tagctgcaaa gattttttac ttaaaaaaat ccatgaatat ctttgatttt attataaagc
     4021 atttgtaaat tatttgcatt tgagctgtaa gattcataaa catttacatt tcccaatgat
     4081 ttctattttg atttttaaaa aatatacagg gcaagctaca tttttaaagc attaatcaac
     4141 aactttatta tattacacat tccagtgcac aaacacacaa tatcatttaa tactcacagt
     4201 agtacctgtg aaatatatca gatggatatt cctatctcta ttttacagca gaggaaaccg
     4261 aaattcagag aacttacatt tctaaggttg tacagctgca aaatgaccaa attgtgaagt
     4321 ccctaacatc caggttttca taatgccagt actctttcta tgacatgttt atgaccctcc
     4381 aaatgtacca aaactaccta actaattcac tgagaggaag ccaactgcaa aaataggatt
     4441 tttaaaagta caatagagta ttactacatt ttatggattt cagacaaaga aacctccgtt
     4501 tattatatcc tgatggtgag tattgccagc tctaaattat tcatatttct aagaccaagg
     4561 aaaatatagg taaatgaaaa ttttgaaata aagaacaatg ccttaatttg taaaatctat
     4621 cattgctacc accctgccca ggtctggcca tttgccataa atgctggtaa ataaatacaa
     4681 tgactgatag agttctgtct cctttctctt ttgctaccca accttggtta gagcaaccaa
     4741 atgtctaaaa ggcatgtaac aggagaaaaa aataaaaaca ttagtcacca attcgccgat
     4801 tataaaaggg atgtagattc ctttaaatta ttactgacct tttgaaagcc ttcacgtaag
     4861 tatgcaacag ataaaatgac tcatttaccc acaacaataa tctattatca gtcttaagta
     4921 atgtgaattc actgtatttc tttttataca acataaaaac ttctgctttc caaacttctt
     4981 ccttttcact aatttatcag ccactttatt tatacacaga taacactttt agaaacattt
     5041 ttctttcttg tccatttttt tctttcaaaa ataaagtttc ttagaacctg ataaaatgga
     5101 aacttatggt aatatgtgtt ctggtaggtg tccaaaaatt ccacaccata gactatcaat
     5161 gatatagcca aataaaggcc attcaaaaaa atcagtaatt gggattcctt gccttatatc
     5221 tatggtatag tgtacccatt tataacgggg ttctgccatc ttcgaattgt tttaaactca
     5281 aataaagaat aaaatttaag aaataattat ccagtcttgt tatgcttact tcttgatgaa
     5341 ctagagaaca tcaagccagt gtggaaatct cccagaagag actggggtaa tttatgtata
     5401 catatgatat ttatgaatta taataaattg ggctttgacc ata
//
