LOCUS       NM_173854               5017 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 41 member 1 (SLC41A1), mRNA.
ACCESSION   NM_173854
VERSION     NM_173854.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5017)
  AUTHORS   Cibulka,M., Brodnanova,M., Grendar,M., Necpal,J., Benetin,J.,
            Han,V., Kurca,E., Nosal,V., Skorvanek,M., Vesely,B., Stanclova,A.,
            Lasabova,Z., Pos,Z., Szemes,T., Stuchlik,S., Grofik,M. and
            Kolisek,M.
  TITLE     Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase
            Risk for Parkinson's Disease: Report from Enlarged Slovak Study
  JOURNAL   Int J Mol Sci 23 (3), 1604 (2022)
   PUBMED   35163527
  REMARK    GeneRIF: Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May
            Increase Risk for Parkinson's Disease: Report from Enlarged Slovak
            Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5017)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5017)
  AUTHORS   Tsao,Y.T., Shih,Y.Y., Liu,Y.A., Liu,Y.S. and Lee,O.K.
  TITLE     Knockdown of SLC41A1 magnesium transporter promotes mineralization
            and attenuates magnesium inhibition during osteogenesis of
            mesenchymal stromal cells
  JOURNAL   Stem Cell Res Ther 8 (1), 39 (2017)
   PUBMED   28222767
  REMARK    GeneRIF: Knockdown of SLC41A1 magnesium transporter promotes
            mineralization and attenuates magnesium inhibition during
            osteogenesis of mesenchymal stromal cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5017)
  AUTHORS   Madadi,F., Khaniani,M.S., Shandiz,E.E., Ayromlou,H., Najmi,S.,
            Emamalizadeh,B., Taghavi,S., Jamshidi,J., Tafakhori,A.,
            Shahidi,G.A. and Darvish,H.
  TITLE     Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms
            in Parkinson's Disease in the Iranian Population
  JOURNAL   Genet Test Mol Biomarkers 20 (10), 629-632 (2016)
   PUBMED   27612022
  REMARK    GeneRIF: The association of rs11240569 polymorphism in SLC41A1 gene
            with reduced risk of Parkinson's Disease was replicated in our
            population.
REFERENCE   5  (bases 1 to 5017)
  AUTHORS   Mastrototaro,L., Tietjen,U., Sponder,G., Vormann,J.,
            Aschenbach,J.R. and Kolisek,M.
  TITLE     Insulin Modulates the Na+/Mg2+ Exchanger SLC41A1 and Influences
            Mg2+ Efflux from Intracellular Stores in Transgenic HEK293 Cells
  JOURNAL   J Nutr 145 (11), 2440-2447 (2015)
   PUBMED   26355001
  REMARK    GeneRIF: Na+-dependent Mg2+ efflux conducted by Na+/Mg2+ exchanger
            SLC41A1 is regulated by insulin.
REFERENCE   6  (bases 1 to 5017)
  AUTHORS   Tucci,A., Nalls,M.A., Houlden,H., Revesz,T., Singleton,A.B.,
            Wood,N.W., Hardy,J. and Paisan-Ruiz,C.
  TITLE     Genetic variability at the PARK16 locus
  JOURNAL   Eur J Hum Genet 18 (12), 1356-1359 (2010)
   PUBMED   20683486
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5017)
  AUTHORS   Satake,W., Nakabayashi,Y., Mizuta,I., Hirota,Y., Ito,C., Kubo,M.,
            Kawaguchi,T., Tsunoda,T., Watanabe,M., Takeda,A., Tomiyama,H.,
            Nakashima,K., Hasegawa,K., Obata,F., Yoshikawa,T., Kawakami,H.,
            Sakoda,S., Yamamoto,M., Hattori,N., Murata,M., Nakamura,Y. and
            Toda,T.
  TITLE     Genome-wide association study identifies common variants at four
            loci as genetic risk factors for Parkinson's disease
  JOURNAL   Nat Genet 41 (12), 1303-1307 (2009)
   PUBMED   19915576
REFERENCE   8  (bases 1 to 5017)
  AUTHORS   Kolisek,M., Launay,P., Beck,A., Sponder,G., Serafini,N.,
            Brenkus,M., Froschauer,E.M., Martens,H., Fleig,A. and Schweigel,M.
  TITLE     SLC41A1 is a novel mammalian Mg2+ carrier
  JOURNAL   J Biol Chem 283 (23), 16235-16247 (2008)
   PUBMED   18367447
  REMARK    GeneRIF: SLC41A1 is a novel mammalian Mg2+ carrier
REFERENCE   9  (bases 1 to 5017)
  AUTHORS   Goytain,A. and Quamme,G.A.
  TITLE     Functional characterization of human SLC41A1, a Mg2+ transporter
            with similarity to prokaryotic MgtE Mg2+ transporters
  JOURNAL   Physiol Genomics 21 (3), 337-342 (2005)
   PUBMED   15713785
  REMARK    GeneRIF: The SLC41A1 transcript is present in many tissues, notably
            renal epithelial cells, and is upregulated in some tissues with
            magnesium deficiency.
REFERENCE   10 (bases 1 to 5017)
  AUTHORS   Wabakken,T., Rian,E., Kveine,M. and Aasheim,H.C.
  TITLE     The human solute carrier SLC41A1 belongs to a novel eukaryotic
            subfamily with homology to prokaryotic MgtE Mg2+ transporters
  JOURNAL   Biochem Biophys Res Commun 306 (3), 718-724 (2003)
   PUBMED   12810078
  REMARK    GeneRIF: Data report the identification and structural
            characterization of solute carrier family 41 member 1 (SLC41A1), a
            eukaryotic protein with homology to the bacterial MgtE family of
            potential Mg(2+) transporters.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119673.3, HY148928.1, DA496198.1, BX641054.1, BC136303.1 and
            BX648979.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173854.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832001.1, AL831974.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367137.4/ ENSP00000356105.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC119673.3         139976-139977       c
            3-77                HY148928.1         3-77
            78-409              DA496198.1         40-371
            410-521             BX641054.1         246-357
            522-4416            BC136303.1         1-3895
            4417-5017           BX648979.1         4289-4889
FEATURES             Location/Qualifiers
     source          1..5017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..5017
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /note="solute carrier family 41 member 1"
                     /db_xref="GeneID:254428"
                     /db_xref="HGNC:HGNC:19429"
                     /db_xref="MIM:610801"
     exon            1..391
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            392..1409
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1038..2579
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /note="solute carrier family 41 (magnesium transporter),
                     member 1"
                     /codon_start=1
                     /product="solute carrier family 41 member 1"
                     /protein_id="NP_776253.3"
                     /db_xref="CCDS:CCDS30988.1"
                     /db_xref="GeneID:254428"
                     /db_xref="HGNC:HGNC:19429"
                     /db_xref="MIM:610801"
                     /translation="MSSKPEPKDVHQLNGTGPSASPCSSDGPGREPLAGTSEFLGPDG
                     AGVEVVIESRANAKGVREEDALLENGSQSNESDDVSTDRGPAPPSPLKETSFSIGLQV
                     LFPFLLAGFGTVAAGMVLDIVQHWEVFQKVTEVFILVPALLGLKGNLEMTLASRLSTA
                     ANIGHMDTPKELWRMITGNMALIQVQATVVGFLASIAAVVFGWIPDGHFSIPHAFLLC
                     ASSVATAFIASLVLGMIMIGVIIGSRKIGINPDNVATPIAASLGDLITLALLSGISWG
                     LYLELNHWRYIYPLVCAFFVALLPVWVVLARRSPATREVLYSGWEPVIIAMAISSVGG
                     LILDKTVSDPNFAGMAVFTPVINGVGGNLVAVQASRISTFLHMNGMPGENSEQAPRRC
                     PSPCTTFFSPDVNSRSARVLFLLVVPGHLVFLYTISCMQGGHTTLTLIFIIFYMTAAL
                     LQVLILLYIADWMVHWMWGRGLDPDNFSIPYLTALGDLLGTGLLALSFHVLWLIGDRD
                     TDVGD"
     exon            1410..1517
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1589
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1734
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1881
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..2029
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2109
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2244
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2393
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..5017
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4997..5002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /note="hexamer: AATAAA"
     polyA_site      5017
                     /gene="SLC41A1"
                     /gene_synonym="MgtE; NPHPL2"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcccc agatcacgtt tgccaccggc agccaaccag ttgggcccga gtccgcgggc
       61 aagaagcgat tgggggcgcg tgagctcggc tccccggtcc cccgtccggg tgcccccccg
      121 ccgggcccga agcgatatat cctgccctcc ccggccacct cccccgcgtg gaagcggagc
      181 ggcggcctcg ctgtaacgca gaagcgaaat gtagcgagcc gggtgtcgcg gctggacgct
      241 cgccttggct gggggtgtgg gggggcacgc cgggggccaa ggaggactgt cgaggaggag
      301 tgatgagaag agggggtgcc ctgcaccccc cgagaccacg ggccacgctg ccacttgcca
      361 ggcgcccccc ttcctcccag gcgaggggca ggtgttccac actgattctc gtgactttaa
      421 ggaccaggga tttgaagagg tattagctct tcccaggaag ggaggaagtt tctggaagag
      481 aagggaaaga cggcagacgc tgcgctggga ccagcagagc ctgaggagct gtgggaagct
      541 gacagagccc agccaaagga gcgggaagga gccgcagccc caggctggca ctgtgttctg
      601 aaagatttga actcaagctg ctttttacgg aagaggggcc acttcagagg gcaccccaga
      661 atttggttga gctcttctac tctggatgcc ccctgctctg aggagcctgc cactgagaac
      721 caaagaagat aagaggacag atactttttc ttcaagcaca gagctggtgg gttggagtca
      781 ggcatctgca cccctagtgg ctgtctggtg aggaatttct tgtttcttcc cagcttgcgg
      841 cttcagtgct tgatggggct gcctgttggt ggatcagttt ttgcagtgcc tggtaggagt
      901 ggagagccgt gggaagaggt cctgcggcgc ccaagcctgg gttcacccca agactaagtt
      961 ctttcccaag ttagagaaga agagagaaag caaaaagaag agaggaaagt tctcccttcc
     1021 cctcctccgt gcctgtcatg tcctctaagc cagagccgaa ggacgtccac caactgaacg
     1081 ggactggccc ttctgcctct ccctgctctt cagatggccc agggagagag cccttggctg
     1141 ggacctcaga gttcctgggg cctgatgggg ctggggtaga ggtggtgatt gagtctcggg
     1201 ccaacgccaa gggggttcgg gaggaggacg ccctgctgga gaacgggagc cagagcaacg
     1261 aaagtgacga cgtcagcaca gaccgtggcc ctgcgccacc ttccccgctc aaggagacct
     1321 ccttttccat cgggctgcaa gtactgtttc cattcctcct ggcaggcttt gggaccgtgg
     1381 ctgctggcat ggtgttggac atcgtgcagc actgggaagt cttccagaag gtgacagagg
     1441 tcttcatcct agtgcctgcg ctgctggggc tcaaagggaa cctggaaatg accctggcat
     1501 caaggctttc cactgcagcc aacattggac acatggacac acccaaggag ctctggcgga
     1561 tgatcactgg gaacatggcc ctcatccagg tgcaggccac ggtggtgggc ttcctggcgt
     1621 ccatcgcagc cgtcgtcttt ggctggatcc ctgatggcca cttcagtatt ccgcacgcct
     1681 tcctgctctg tgctagcagc gtggccacag ccttcattgc ctccctggta ctgggtatga
     1741 tcatgattgg agtcatcatt ggctctcgca agattgggat caacccagac aacgtggcca
     1801 cacccattgc tgccagcctg ggcgacctca tcaccttggc gctgctctca ggcatcagct
     1861 ggggactcta cctggaactg aatcactggc gatacatcta cccactggtg tgtgctttct
     1921 ttgtggccct gctgcctgtc tgggtggtgc tggcccgacg aagtccagcc acaagggagg
     1981 tgttgtactc gggctgggag cctgttatca ttgccatggc catcagcagt gtgggaggcc
     2041 tcatcttgga caagactgtc tcagacccca actttgctgg gatggctgtc ttcacgcctg
     2101 tgattaatgg tgttgggggc aatctggtgg cagtgcaggc cagccgcatc tccaccttcc
     2161 tgcacatgaa tggaatgccc ggagagaact ctgagcaagc tcctcgccgc tgtcccagtc
     2221 cttgtaccac cttcttcagc cctgatgtga attctcgctc agcccgggtc ctcttcctcc
     2281 tcgtggtccc aggacacctg gtgttcctct acaccatcag ctgtatgcag ggcgggcaca
     2341 ccaccctcac actcatcttc atcatcttct atatgacagc tgcactgctc caggtgctga
     2401 ttctcctgta catcgcagac tggatggtgc actggatgtg gggccggggc ctggacccgg
     2461 acaacttctc catcccatac ttgactgctc tgggggacct gcttggcact gggctcctag
     2521 cactcagctt ccatgttctc tggctcatag gggaccgaga cacggatgtc ggggactagc
     2581 ttggtcactc aacattttcc ccatccctct gcactttcta tttgaaattt ttcttttgtt
     2641 cccctgtccc tcctccaccc cacactccca cctctttcta ggacttcact ttgataccaa
     2701 attctcatta ttttcaatgg gaatttttat acattgagcc aagtttgtat agcaagaatt
     2761 tgggaaacac agatggcctg agataagcag tacaagtagg tttttgagac aatcaccaag
     2821 tgcagtttca tggtgggtgc ctccaggtga tgtggactgg agcaggggag ttttgtctgg
     2881 aatctgggga catggggttt ggctttagca acctgtcttg gccctaatga gaaacccttt
     2941 gtaagtgggc tctggatttt tggttttgtt ttctttttat ctgttttgtt ttatttttgg
     3001 ttttggttga acagagggac agaagaataa gtaacactcc caaacacaga catacttttg
     3061 tagaagtgga ccaacttcaa agctctggac aggagacacc tgctccaggc ccctgtgatc
     3121 ccagttctgt tctcttgccc tctggaccta agcgttccca ctcgcagaaa gagtaaggtg
     3181 gactgacttt tcaatttgtg cacatgcctc ttgttcaatg gcctggtcaa catcaacaac
     3241 ccctccctct gatcatttcc agttgattgt catatccagg aaaaaatgga acagtgcact
     3301 cttctccctg ttgacccatg tccacctatt ggttccccaa aatccacatt ctccctgggc
     3361 ccaaatgact ttgtctccct gggcccagat tctttgtctc tcttcaacct tcatctcaaa
     3421 ttgtctctaa gcactacctt ccccagagct tgccaggttg ggttttgaga ttagggtcag
     3481 gtcatgggta tgtggagaat ggtttggagg ttgaggacaa ccacaggtgt ctcattgctg
     3541 ccatttctcc tgaggacata atcacttggt caccttggac cctgtcactt cctaaaatta
     3601 ctcgttctgt catgccatag aggtcagttt tcctctttct tggcttctac ccacaaacat
     3661 tcaccaatca tttattcgtt catttagcaa atatgcagcc tccgcaagat gagctctcct
     3721 gcagacaagc atggtctgaa acattctttg agcaatattt attgagtgcc tactatgtgt
     3781 taggtactgt gccaggcact gataagccag tggtaaggga aacacagctc taacctcacc
     3841 tcattctcca ggttacaaag gccatgtgcc cctttgaatc tggcagagaa agtttcctcg
     3901 ttgtaagtat ttgcatctac ttcaagccag attcttctgc ctctttctcc tttccagacc
     3961 cctactctgt gcagtgctga ccacagctag agccaccgcc ccattgctca accagtattt
     4021 atttccctaa acgacccttc ctcacattcc cttccctcca cctctcctta ccaagcaccc
     4081 aaaagaggat ttagaactag cagggtggac atcatctggt tgtttctact tttctctgcc
     4141 tagcacaaaa ttgggagaaa actggagcct ccatccgcag tcacacgtgt acagatctgg
     4201 ggatttggat gtaggctttt tctaacttct ctctcagaag cttctacaga aacccttcca
     4261 tctgtagcct caagggccca cctccaaggg aaggcttagg caatgatcct gtttctacca
     4321 acactgcacc ttatcccagg aacctgccct agacctccag agaccatatt ttctctccct
     4381 ccatttctac ccagacctcc aggcctcctt ctggaatcat agaaccgtag aattggaagg
     4441 aattttagag gttttctagt tggagttgtg tccaacagaa ttcattaaca ccagcctggg
     4501 cttgtttttc ctcctccctc tggacttttt tcatcttttc ctccacctca aaaaatactt
     4561 acacacagat tcttcttgta caggcatcaa aaccaactcc tctgccccta aggctgtgtc
     4621 cctgtggtct ccagccaccc ctaccccagt cactcgcccc ttcctcatct ctggaatttg
     4681 gccaggcagt cccagaagac tctggagtga cctcctttgc ctaaaaagca gacagatagg
     4741 catgccccag gccctgagtg agcagaggag gactgtaggg tgagagggaa agaaaatgaa
     4801 ggtgactttc atggaagttt catttctttt ccccgattgt accaactgca tgtacttttg
     4861 gcctggctgc aaggagcaat attggtttac tctcgtatcc ttaaaaagtt acagaactgt
     4921 gtcttaagag aattatttat agttactata actgaattga caaatgtcaa cttaactgat
     4981 aaattatatt tggtaaaata aagaggacgt ttattta
//
