LOCUS       NM_014585               3330 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens solute carrier family 40 member 1 (SLC40A1), mRNA.
ACCESSION   NM_014585
VERSION     NM_014585.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3330)
  AUTHORS   Chen,J., Yang,X., Li,Q., Ma,J., Li,H., Wang,L., Chen,Z. and Quan,Z.
  TITLE     Inhibiting DNA methyltransferase DNMT3B confers protection against
            ferroptosis in nucleus pulposus and ameliorates intervertebral disc
            degeneration via upregulating SLC40A1
  JOURNAL   Free Radic Biol Med 220, 139-153 (2024)
   PUBMED   38705495
  REMARK    GeneRIF: Inhibiting DNA methyltransferase DNMT3B confers protection
            against ferroptosis in nucleus pulposus and ameliorates
            intervertebral disc degeneration via upregulating SLC40A1.
REFERENCE   2  (bases 1 to 3330)
  AUTHORS   Debbiche,R., Elbahnsi,A., Uguen,K., Ka,C., Callebaut,I. and Le
            Gac,G.
  TITLE     Insights into the role of glycerophospholipids on the iron export
            function of SLC40A1 and the molecular mechanisms of ferroportin
            disease
  JOURNAL   FASEB J 38 (13), e23725 (2024)
   PUBMED   38959016
  REMARK    GeneRIF: Insights into the role of glycerophospholipids on the iron
            export function of SLC40A1 and the molecular mechanisms of
            ferroportin disease.
REFERENCE   3  (bases 1 to 3330)
  AUTHORS   Jiang,J., Duan,R., Zhu,J., Yan,J., Ye,J. and Luo,C.
  TITLE     Influence of SLC40A1 on Cytokine Interactions and Immune
            Infiltration in Glioblastoma
  JOURNAL   Neuromolecular Med 26 (1), 21 (2024)
   PUBMED   38750318
  REMARK    GeneRIF: Influence of SLC40A1 on Cytokine Interactions and Immune
            Infiltration in Glioblastoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3330)
  AUTHORS   Zhang,G., Zhang,W., Dan,M., Zou,F., Qiu,C. and Sun,C.
  TITLE     PRPF19 promotes the proliferation, migration, and inhibits
            autophagy in prostate cancer by suppressing SLC40A1
  JOURNAL   Chin J Physiol 66 (5), 379-387 (2023)
   PUBMED   37929350
  REMARK    GeneRIF: PRPF19 promotes the proliferation, migration, and inhibits
            autophagy in prostate cancer by suppressing SLC40A1.
REFERENCE   5  (bases 1 to 3330)
  AUTHORS   Ohta,K., Ito,M., Chida,T., Nakashima,K., Sakai,S., Kanegae,Y.,
            Kawasaki,H., Aoshima,T., Takabayashi,S., Takahashi,H., Kawata,K.,
            Shoji,I., Sawasaki,T., Suda,T. and Suzuki,T.
  TITLE     Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation
  JOURNAL   PLoS Pathog 19 (8), e1011591 (2023)
   PUBMED   37585449
  REMARK    GeneRIF: Role of hepcidin upregulation and proteolytic cleavage of
            ferroportin 1 in hepatitis C virus-induced iron accumulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3330)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   7  (bases 1 to 3330)
  AUTHORS   Abboud,S. and Haile,D.J.
  TITLE     A novel mammalian iron-regulated protein involved in intracellular
            iron metabolism
  JOURNAL   J Biol Chem 275 (26), 19906-19912 (2000)
   PUBMED   10747949
REFERENCE   8  (bases 1 to 3330)
  AUTHORS   Donovan,A., Brownlie,A., Zhou,Y., Shepard,J., Pratt,S.J.,
            Moynihan,J., Paw,B.H., Drejer,A., Barut,B., Zapata,A., Law,T.C.,
            Brugnara,C., Lux,S.E., Pinkus,G.S., Pinkus,J.L., Kingsley,P.D.,
            Palis,J., Fleming,M.D., Andrews,N.C. and Zon,L.I.
  TITLE     Positional cloning of zebrafish ferroportin1 identifies a conserved
            vertebrate iron exporter
  JOURNAL   Nature 403 (6771), 776-781 (2000)
   PUBMED   10693807
REFERENCE   9  (bases 1 to 3330)
  AUTHORS   McKie,A.T., Marciani,P., Rolfs,A., Brennan,K., Wehr,K., Barrow,D.,
            Miret,S., Bomford,A., Peters,T.J., Farzaneh,F., Hediger,M.A.,
            Hentze,M.W. and Simpson,R.J.
  TITLE     A novel duodenal iron-regulated transporter, IREG1, implicated in
            the basolateral transfer of iron to the circulation
  JOURNAL   Mol Cell 5 (2), 299-309 (2000)
   PUBMED   10882071
REFERENCE   10 (bases 1 to 3330)
  AUTHORS   Haile,D.J.
  TITLE     Assignment of Slc11a3 to mouse chromosome 1 band 1B and SLC11A3 to
            human chromosome 2q32 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 328-329 (2000)
   PUBMED   10828623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA806565.1 and BC037733.1.
            
            On Dec 4, 2019 this sequence version replaced NM_014585.5.
            
            Summary: The protein encoded by this gene is a cell membrane
            protein that may be involved in iron export from duodenal
            epithelial cells. Defects in this gene are a cause of
            hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037733.1, AL136944.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261024.7/ ENSP00000261024.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-470               DA806565.1         26-495
            471-3330            BC037733.1         575-3434
FEATURES             Location/Qualifiers
     source          1..3330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.2"
     gene            1..3330
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /note="solute carrier family 40 member 1"
                     /db_xref="GeneID:30061"
                     /db_xref="HGNC:HGNC:10909"
                     /db_xref="MIM:604653"
     exon            1..369
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2042
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /note="solute carrier family 11 (proton-coupled divalent
                     metal ion transporters), member 3; iron regulated gene 1;
                     solute carrier family 40 (iron-regulated transporter),
                     member 1; SLC40 iron transporter"
                     /codon_start=1
                     /product="ferroportin"
                     /protein_id="NP_055400.1"
                     /db_xref="CCDS:CCDS2299.1"
                     /db_xref="GeneID:30061"
                     /db_xref="HGNC:HGNC:10909"
                     /db_xref="MIM:604653"
                     /translation="MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHF
                     AVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVS
                     VILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIV
                     VVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCV
                     EYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHEL
                     EHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYT
                     QGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVF
                     MPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESV
                     PIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHF
                     IMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQA
                     NTSVV"
     exon            370..437
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     exon            438..597
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..713
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..840
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1086
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1728
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..3330
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3306..3311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /note="hexamer: TATAAA"
     polyA_site      3330
                     /gene="SLC40A1"
                     /gene_synonym="FPN; FPN1; HFE4; IREG1; MST079; MSTP079;
                     MTP1; SLC11A3"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggcg gcggcggaga gagctggctc agggcgtccg ctaggctcgg acgacctgct
       61 gagcctccca aaccgcttcc ataaggcttt gcctttccaa cttcagctac agtgttagct
      121 aagtttggaa agaaggaaaa aagaaaatcc ctgggcccct tttcttttgt tctttgccaa
      181 agtcgtcgtt gtagtctttt tgcccaaggc tgttgtgttt ttagaggtgc tatctccagt
      241 tccttgcact cctgttaaca agcacctcag cgagagcagc agcagcgata gcagccgcag
      301 aagagccagc ggggtcgcct agtgtcatga ccagggcggg agatcacaac cgccagagag
      361 gatgctgtgg atccttggcc gactacctga cctctgcaaa attccttctc taccttggtc
      421 attctctctc tacttgggga gatcggatgt ggcactttgc ggtgtctgtg tttctggtag
      481 agctctatgg aaacagcctc cttttgacag cagtctacgg gctggtggtg gcagggtctg
      541 ttctggtcct gggagccatc atcggtgact gggtggacaa gaatgctaga cttaaagtgg
      601 cccagacctc gctggtggta cagaatgttt cagtcatcct gtgtggaatc atcctgatga
      661 tggttttctt acataaacat gagcttctga ccatgtacca tggatgggtt ctcacttcct
      721 gctatatcct gatcatcact attgcaaata ttgcaaattt ggccagtact gctactgcaa
      781 tcacaatcca aagggattgg attgttgttg ttgcaggaga agacagaagc aaactagcaa
      841 atatgaatgc cacaatacga aggattgacc agttaaccaa catcttagcc cccatggctg
      901 ttggccagat tatgacattt ggctccccag tcatcggctg tggctttatt tcgggatgga
      961 acttggtatc catgtgcgtg gagtacgttc tgctctggaa ggtttaccag aaaaccccag
     1021 ctctagctgt gaaagctggt cttaaagaag aggaaactga attgaaacag ctgaatttac
     1081 acaaagatac tgagccaaaa cccctggagg gaactcatct aatgggtgtg aaagactcta
     1141 acatccatga gcttgaacat gagcaagagc ctacttgtgc ctcccagatg gctgagccct
     1201 tccgtacctt ccgagatgga tgggtctcct actacaacca gcctgtgttt ctggctggca
     1261 tgggtcttgc tttcctttat atgactgtcc tgggctttga ctgcatcacc acagggtacg
     1321 cctacactca gggactgagt ggttccatcc tcagtatttt gatgggagca tcagctataa
     1381 ctggaataat gggaactgta gcttttactt ggctacgtcg aaaatgtggt ttggttcgga
     1441 caggtctgat ctcaggattg gcacagcttt cctgtttgat cttgtgtgtg atctctgtat
     1501 tcatgcctgg aagccccctg gacttgtccg tttctccttt tgaagatatc cgatcaaggt
     1561 tcattcaagg agagtcaatt acacctacca agatacctga aattacaact gaaatataca
     1621 tgtctaatgg gtctaattct gctaatattg tcccggagac aagtcctgaa tctgtgccca
     1681 taatctctgt cagtctgctg tttgcaggcg tcattgctgc tagaatcggt ctttggtcct
     1741 ttgatttaac tgtgacacag ttgctgcaag aaaatgtaat tgaatctgaa agaggcatta
     1801 taaatggtgt acagaactcc atgaactatc ttcttgatct tctgcatttc atcatggtca
     1861 tcctggctcc aaatcctgaa gcttttggct tgctcgtatt gatttcagtc tcctttgtgg
     1921 caatgggcca cattatgtat ttccgatttg cccaaaatac tctgggaaac aagctctttg
     1981 cttgcggtcc tgatgcaaaa gaagttagga aggaaaatca agcaaataca tctgttgttt
     2041 gagacagttt aactgttgct atcctgttac tagattatat agagcacatg tgcttatttt
     2101 gtactgcaga attccaataa atggctgggt gttttgctct gtttttacca cagctgtgcc
     2161 ttgagaacta aaagctgttt aggaaaccta agtcagcaga aattaactga ttaatttccc
     2221 ttatgttgag gcatggaaaa aaaattggaa aagaaaaact cagtttaaat acggagacta
     2281 taatgataac actgaattcc cctatttctc atgagtagat acaatcttac gtaaaagagt
     2341 ggttagtcac gtgaattcag ttatcatttg acagattctt atctgtacta gaattcagat
     2401 atgtcagttt tctgcaaaac tcactcttgt tcaagactag ctaatttatt tttttgcatc
     2461 ttagttattt ttaaaaacaa attcttcaag tatgaagact aaattttgat aactaatatt
     2521 atccttattg atcctattga tcttaaggta tttacatgta tgtggaaaaa caaaacactt
     2581 aactagaatt ctctaataag gtttatggtt tagcttaaag agcacctttg tatttttatt
     2641 atcagatggg gcaacatatt gtatgaagca tatgtagcac ttcacagcat ggttatcatg
     2701 taagctgcag gtagaagcaa agctgtaaag tagatttatc acacaatgac tgcatacaga
     2761 cttcaaatat gtcaatagtt tggtcataga acctagaagc caaaagccac acagaagggc
     2821 aagaatccca atttaactca tgttatcatc attagtgatc tgtgttgtag aacatgaggg
     2881 tgtaagcctt cagcctggca agttacatgt agaaagccca cacttgtgaa ggttttgttt
     2941 tacaaatcac ttgatttaac acactcaggt agaatatttt tatttttact gttttatacc
     3001 cagaagttat ttctacattg ttctacagca agaatattca taaaagtatc cctttcaaat
     3061 gcctttgaga agaatagaag aaaaaaagtt tgtatatatt ttaaaaaatt gttttaaaag
     3121 tcagtttgca acatgtctgt accaagatgg tactttgcct taaccgttta tatgcacttt
     3181 catggagact gcaatacgtt gctatgagca ctttctttat ccttggagtt taatcctttg
     3241 cttcatcttt ctacagtatg acataatgat ttgctatgtt gtaaaatctt tgtaaaaaat
     3301 ttctatataa aaatattttg aaaatcttaa
//
