LOCUS       NM_001013251            1885 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens solute carrier family 3 member 2 (SLC3A2), transcript
            variant 6, mRNA.
ACCESSION   NM_001013251
VERSION     NM_001013251.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Yaga,M., Hasegawa,K., Ikeda,S., Matsubara,M., Hiroshima,T.,
            Kimura,T., Shirai,Y., Tansri,W., Uehara,H., Tachikawa,M.,
            Okairi,Y., Sone,M., Mori,H., Kogue,Y., Akamine,H., Okuzaki,D.,
            Kawagishi,K., Kawanaka,S., Yamato,H., Takeuchi,Y., Okura,E.,
            Kanzaki,R., Okami,J., Nakamichi,I., Nakane,S., Kobayashi,A.,
            Iwazawa,T., Tokunaga,T., Yokouchi,H., Yano,Y., Uchida,J., Mori,M.,
            Komuta,K., Tachi,T., Kuroda,H., Kijima,N., Kishima,H., Ichii,M.,
            Futami,S., Naito,Y., Shiroyama,T., Miyake,K., Koyama,S., Hirata,H.,
            Takeda,Y., Funaki,S., Shintani,Y., Kumanogoh,A. and Hosen,N.
  TITLE     CD98 heavy chain protein is overexpressed in non-small cell lung
            cancer and is a potential target for CAR T-cell therapy
  JOURNAL   Sci Rep 14 (1), 17917 (2024)
   PUBMED   39095551
  REMARK    GeneRIF: CD98 heavy chain protein is overexpressed in non-small
            cell lung cancer and is a potential target for CAR T-cell therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Lai,W.Y., Chuang,T.P., Borenas,M., Lind,D.E., Hallberg,B. and
            Palmer,R.H.
  TITLE     Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression
            via MARCH11 to promote neuroblastoma cell growth
  JOURNAL   Cell Death Differ 31 (7), 910-923 (2024)
   PUBMED   38858548
  REMARK    GeneRIF: Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2
            expression via MARCH11 to promote neuroblastoma cell growth.
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Rullo-Tubau,J., Martinez-Molledo,M., Bartoccioni,P., Puch-Giner,I.,
            Arias,A., Saen-Oon,S., Stephan-Otto Attolini,C., Artuch,R.,
            Diaz,L., Guallar,V., Errasti-Murugarren,E., Palacin,M. and
            Llorca,O.
  TITLE     Structure and mechanisms of transport of human Asc1/CD98hc amino
            acid transporter
  JOURNAL   Nat Commun 15 (1), 2986 (2024)
   PUBMED   38582862
  REMARK    GeneRIF: Structure and mechanisms of transport of human Asc1/CD98hc
            amino acid transporter.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Zhang,J., Xiang,F., Ding,Y., Hu,W., Wang,H., Zhang,X., Lei,Z.,
            Li,T., Wang,P. and Kang,X.
  TITLE     Identification and validation of RNA-binding protein SLC3A2
            regulates melanocyte ferroptosis in vitiligo by integrated analysis
            of single-cell and bulk RNA-sequencing
  JOURNAL   BMC Genomics 25 (1), 236 (2024)
   PUBMED   38438962
  REMARK    GeneRIF: Identification and validation of RNA-binding protein
            SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated
            analysis of single-cell and bulk RNA-sequencing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Wu,P., Zhao,L., Kong,G. and Song,B.
  TITLE     Study on the Role and Mechanism of SLC3A2 in Tumor-Associated
            Macrophage Polarization and Bladder Cancer Cells Growth
  JOURNAL   Technol Cancer Res Treat 23, 15330338241246649 (2024)
   PUBMED   38656249
  REMARK    GeneRIF: Study on the Role and Mechanism of SLC3A2 in
            Tumor-Associated Macrophage Polarization and Bladder Cancer Cells
            Growth.
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Lindsten,T., June,C.H., Thompson,C.B. and Leiden,J.M.
  TITLE     Regulation of 4F2 heavy-chain gene expression during normal human
            T-cell activation can be mediated by multiple distinct molecular
            mechanisms
  JOURNAL   Mol Cell Biol 8 (9), 3820-3826 (1988)
   PUBMED   3265471
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Gottesdiener,K.M., Karpinski,B.A., Lindsten,T., Strominger,J.L.,
            Jones,N.H., Thompson,C.B. and Leiden,J.M.
  TITLE     Isolation and structural characterization of the human 4F2
            heavy-chain gene, an inducible gene involved in T-lymphocyte
            activation
  JOURNAL   Mol Cell Biol 8 (9), 3809-3819 (1988)
   PUBMED   3265470
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Quackenbush,E., Clabby,M., Gottesdiener,K.M., Barbosa,J.,
            Jones,N.H., Strominger,J.L., Speck,S. and Leiden,J.M.
  TITLE     Molecular cloning of complementary DNAs encoding the heavy chain of
            the human 4F2 cell-surface antigen: a type II membrane glycoprotein
            involved in normal and neoplastic cell growth
  JOURNAL   Proc Natl Acad Sci U S A 84 (18), 6526-6530 (1987)
   PUBMED   3476959
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1987 Dec;84(23):8618]
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Teixeira,S., Di Grandi,S. and Kuhn,L.C.
  TITLE     Primary structure of the human 4F2 antigen heavy chain predicts a
            transmembrane protein with a cytoplasmic NH2 terminus
  JOURNAL   J Biol Chem 262 (20), 9574-9580 (1987)
   PUBMED   3036867
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Michalak,M., Quackenbush,E.J. and Letarte,M.
  TITLE     Inhibition of Na+/Ca2+ exchanger activity in cardiac and skeletal
            muscle sarcolemmal vesicles by monoclonal antibody 44D7
  JOURNAL   J Biol Chem 261 (1), 92-95 (1986)
   PUBMED   2416754
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX443653.2 and AB018010.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001013251.2.
            
            Summary: This gene is a member of the solute carrier family and
            encodes a cell surface, transmembrane protein. The protein exists
            as the heavy chain of a heterodimer, covalently bound through
            di-sulfide bonds to one of several possible light chains. The
            encoded transporter plays a role in regulation of intracellular
            calcium levels and transports L-type amino acids. Alternatively
            spliced transcript variants, encoding different isoforms, have been
            characterized. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (6) differs in the 5' UTR and
            lacks several in-frame exons of the 5' coding region, compared to
            variant 2. These differences cause translation initiation at a
            downstream ATG and an isoform (f) with a shorter N-terminus
            compared to isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.44312.1,
                                           SRR3476690.380893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338663.12/ ENSP00000340815.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BX443653.2         25-41
            18-1885             AB018010.1         1-1868
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1885
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /note="solute carrier family 3 member 2"
                     /db_xref="GeneID:6520"
                     /db_xref="HGNC:HGNC:11026"
                     /db_xref="MIM:158070"
     exon            1..552
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1718
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /note="isoform f is encoded by transcript variant 6;
                     antigen identified by monoclonal antibodies 4F2, TRA1.10,
                     TROP4, and T43; solute carrier family 3 (amino acid
                     transporter heavy chain), member 2; solute carrier family
                     3 (activators of dibasic and neutral amino acid
                     transport), member 2; antigen defined by monoclonal
                     antibody 4F2, heavy chain; CD98 heavy chain; monoclonal
                     antibody 44D7; 4F2 cell-surface antigen heavy chain;
                     lymphocyte activation antigen 4F2 large subunit; amino
                     acid transporter heavy chain SLC3A2"
                     /codon_start=1
                     /product="amino acid transporter heavy chain SLC3A2
                     isoform f"
                     /protein_id="NP_001013269.1"
                     /db_xref="CCDS:CCDS31590.1"
                     /db_xref="GeneID:6520"
                     /db_xref="HGNC:HGNC:11026"
                     /db_xref="MIM:158070"
                     /translation="MSQDTEVDMKEVELNELEPEKQPMNAASGAAMSLAGAEKNGLVK
                     IKVAEDEAEAAAAAKFTGLSKEELLKVAGSPGWVRTRWALLLLFWLGWLGMLAGAVVI
                     IVRAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGLVL
                     GPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWF
                     STQVDTVATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLI
                     AGTNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLVTQYLNATGNRWCSWSL
                     SQARLLTSFLPAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDE
                     SSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHGDFHAFSAGPGLF
                     SYIRHWDQNERFLVVLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPL
                     ELERLKLEPHEGLLLRFPYAA"
     exon            553..726
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            727..818
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            819..887
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            888..946
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1127
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1271
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1355
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1885
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1860..1865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /note="hexamer: AATAAA"
     polyA_site      1885
                     /gene="SLC3A2"
                     /gene_synonym="4F2; 4F2HC; 4T2HC; CD98; CD98HC; MDU1;
                     NACAE"
                     /note="major polyA site"
ORIGIN      
        1 agatgcagta gccgaaactg cgcggaggca cagaggccgg ggagagcgtt ctgggtccga
       61 gggtccaggt aggggttgag ccaccatctg accgcaagct gcgtcgtgtc gccggttctg
      121 caggcaccat gagccaggac accgaggtgg atatgaagga ggtggagctg aatgagttag
      181 agcccgagaa gcagccgatg aacgcggcgt ctggggcggc catgtccctg gcgggagccg
      241 agaagaatgg tctggtgaag atcaaggtgg cggaagacga ggcggaggcg gcagccgcgg
      301 ctaagttcac gggcctgtcc aaggaggagc tgctgaaggt ggcaggcagc cccggctggg
      361 tacgcacccg ctgggcactg ctgctgctct tctggctcgg ctggctcggc atgcttgctg
      421 gtgccgtggt cataatcgtg cgagcgccgc gttgtcgcga gctaccggcg cagaagtggt
      481 ggcacacggg cgccctctac cgcatcggcg accttcaggc cttccagggc cacggcgcgg
      541 gcaacctggc gggtctgaag gggcgtctcg attacctgag ctctctgaag gtgaagggcc
      601 ttgtgctggg tccaattcac aagaaccaga aggatgatgt cgctcagact gacttgctgc
      661 agatcgaccc caattttggc tccaaggaag attttgacag tctcttgcaa tcggctaaaa
      721 aaaagagcat ccgtgtcatt ctggacctta ctcccaacta ccggggtgag aactcgtggt
      781 tctccactca ggttgacact gtggccacca aggtgaagga tgctctggag ttttggctgc
      841 aagctggcgt ggatgggttc caggttcggg acatagagaa tctgaaggat gcatcctcat
      901 tcttggctga gtggcaaaat atcaccaagg gcttcagtga agacaggctc ttgattgcgg
      961 ggactaactc ctccgacctt cagcagatcc tgagcctact cgaatccaac aaagacttgc
     1021 tgttgactag ctcatacctg tctgattctg gttctactgg ggagcataca aaatccctag
     1081 tcacacagta tttgaatgcc actggcaatc gctggtgcag ctggagtttg tctcaggcaa
     1141 ggctcctgac ttccttcttg ccggctcaac ttctccgact ctaccagctg atgctcttca
     1201 ccctgccagg gacccctgtt ttcagctacg gggatgagat tggcctggat gcagctgccc
     1261 ttcctggaca gcctatggag gctccagtca tgctgtggga tgagtccagc ttccctgaca
     1321 tcccaggggc tgtaagtgcc aacatgactg tgaagggcca gagtgaagac cctggctccc
     1381 tcctttcctt gttccggcgg ctgagtgacc agcggagtaa ggagcgctcc ctactgcatg
     1441 gggacttcca cgcgttctcc gctgggcctg gactcttctc ctatatccgc cactgggacc
     1501 agaatgagcg ttttctggta gtgcttaact ttggggatgt gggcctctcg gctggactgc
     1561 aggcctccga cctgcctgcc agcgccagcc tgccagccaa ggctgacctc ctgctcagca
     1621 cccagccagg ccgtgaggag ggctcccctc ttgagctgga acgcctgaaa ctggagcctc
     1681 acgaagggct gctgctccgc ttcccctacg cggcctgact tcagcctgac atggacccac
     1741 tacccttctc ctttccttcc caggcccttt ggcttctgat ttttctcttt tttaaaaaca
     1801 aacaaacaaa ctgttgcaga ttatgagtga acccccaaat agggtgtttt ctgccttcaa
     1861 ataaaagtca cccctgcatg gtgaa
//
