LOCUS       NM_001135146            3152 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens solute carrier family 39 member 8 (SLC39A8),
            transcript variant 2, mRNA.
ACCESSION   NM_001135146
VERSION     NM_001135146.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3152)
  AUTHORS   Seidelin,A.S., Nordestgaard,B.G., Tybjaerg-Hansen,A. and Stender,S.
  TITLE     Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver Disease?
  JOURNAL   Antioxid Redox Signal 41 (10-12), 591-596 (2024)
   PUBMED   38687342
  REMARK    GeneRIF: Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver
            Disease?
REFERENCE   2  (bases 1 to 3152)
  AUTHORS   Liu,Z., Huang,J., Li,D., Zhang,C., Wan,H., Zeng,B., Tan,Y.,
            Zhong,F., Liao,H., Liu,M., Chen,Z.S., Zou,C., Liu,D. and Qin,B.
  TITLE     Targeting ZIP8 mediated ferroptosis as a novel strategy to protect
            against the retinal pigment epithelial degeneration
  JOURNAL   Free Radic Biol Med 214, 42-53 (2024)
   PUBMED   38309537
  REMARK    GeneRIF: Targeting ZIP8 mediated ferroptosis as a novel strategy to
            protect against the retinal pigment epithelial degeneration.
REFERENCE   3  (bases 1 to 3152)
  AUTHORS   Zhang,T., Wang,S., Hua,D., Shi,X., Deng,H., Jin,S. and Lv,X.
  TITLE     Identification of ZIP8-induced ferroptosis as a major type of cell
            death in monocytes under sepsis conditions
  JOURNAL   Redox Biol 69, 102985 (2024)
   PUBMED   38103342
  REMARK    GeneRIF: Identification of ZIP8-induced ferroptosis as a major type
            of cell death in monocytes under sepsis conditions.
REFERENCE   4  (bases 1 to 3152)
  AUTHORS   Steimle,B.L., Bailey,D.K., Smith,F.M., Rosenblum,S.L. and
            Kosman,D.J.
  TITLE     Calcium and the Ca-ATPase SPCA1 modulate plasma membrane abundance
            of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain microvascular
            endothelial cells
  JOURNAL   J Biol Chem 298 (8), 102211 (2022)
   PUBMED   35787370
  REMARK    GeneRIF: Calcium and the Ca-ATPase SPCA1 modulate plasma membrane
            abundance of ZIP8 and ZIP14 to regulate Mn(II) uptake in brain
            microvascular endothelial cells.
REFERENCE   5  (bases 1 to 3152)
  AUTHORS   Foster,P.S., Tay,H.L. and Oliver,B.G.
  TITLE     Deficiency in the zinc transporter ZIP8 impairs epithelia renewal
            and enhances lung fibrosis
  JOURNAL   J Clin Invest 132 (11) (2022)
   PUBMED   35642632
  REMARK    GeneRIF: Deficiency in the zinc transporter ZIP8 impairs epithelia
            renewal and enhances lung fibrosis.
REFERENCE   6  (bases 1 to 3152)
  AUTHORS   Kim,J.E., Tannenbaum,S.R. and White,F.M.
  TITLE     Global phosphoproteome of HT-29 human colon adenocarcinoma cells
  JOURNAL   J Proteome Res 4 (4), 1339-1346 (2005)
   PUBMED   16083285
REFERENCE   7  (bases 1 to 3152)
  AUTHORS   Taylor,K.M., Morgan,H.E., Johnson,A., Hadley,L.J. and
            Nicholson,R.I.
  TITLE     Structure-function analysis of LIV-1, the breast cancer-associated
            protein that belongs to a new subfamily of zinc transporters
  JOURNAL   Biochem J 375 (Pt 1), 51-59 (2003)
   PUBMED   12839489
REFERENCE   8  (bases 1 to 3152)
  AUTHORS   Taylor,K.M. and Nicholson,R.I.
  TITLE     The LZT proteins; the LIV-1 subfamily of zinc transporters
  JOURNAL   Biochim Biophys Acta 1611 (1-2), 16-30 (2003)
   PUBMED   12659941
  REMARK    Review article
REFERENCE   9  (bases 1 to 3152)
  AUTHORS   Begum,N.A., Kobayashi,M., Moriwaki,Y., Matsumoto,M., Toyoshima,K.
            and Seya,T.
  TITLE     Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a
            novel gene, BIGM103, encoding a 7-TM protein: identification of a
            new protein family having Zn-transporter and Zn-metalloprotease
            signatures
  JOURNAL   Genomics 80 (6), 630-645 (2002)
   PUBMED   12504855
REFERENCE   10 (bases 1 to 3152)
  AUTHORS   Park,J.H.
  TITLE     SLC39A8-CDG
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37023243
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR006301.1, BC012125.1,
            AP002023.1 and BC001320.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001135146.1.
            
            Summary: This gene encodes a member of the SLC39 family of
            solute-carrier genes, which show structural characteristics of zinc
            transporters. The encoded protein is glycosylated and found in the
            plasma membrane and mitochondria, and functions in the cellular
            import of zinc at the onset of inflammation. It is also thought to
            be the primary transporter of the toxic cation cadmium, which is
            found in cigarette smoke. Multiple transcript variants encoding
            different isoforms have been found for this gene. Additional
            alternatively spliced transcript variants of this gene have been
            described, but their full-length nature is not known. [provided by
            RefSeq, Oct 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012125.1, SRR11853563.25601.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356736.5/ ENSP00000349174.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 DR006301.1         23-30
            9-1885              BC012125.1         1-1877
            1886-2757           AP002023.1         52369-53240
            2758-3152           BC001320.1         1278-1672
FEATURES             Location/Qualifiers
     source          1..3152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..3152
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /note="solute carrier family 39 member 8"
                     /db_xref="GeneID:64116"
                     /db_xref="HGNC:HGNC:20862"
                     /db_xref="MIM:608732"
     exon            1..138
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            139..610
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1774
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; solute carrier family 39 (metal ion
                     transporter), member 8; BCG induced integral membrane
                     protein BIGM103; Zrt- and Irt-like protein 8; zinc
                     transporter ZIP8; LIV-1 subfamily of ZIP zinc transporter
                     6; ZIP-8; BCG-induced integral membrane protein in
                     monocyte clone 103 protein; metal cation symporter ZIP8;
                     ZRT/IRT-like protein 8; Zinc transporter 8"
                     /codon_start=1
                     /product="metal cation symporter ZIP8 isoform a precursor"
                     /protein_id="NP_001128618.1"
                     /db_xref="CCDS:CCDS3656.1"
                     /db_xref="GeneID:64116"
                     /db_xref="HGNC:HGNC:20862"
                     /db_xref="MIM:608732"
                     /translation="MAPGRAVAGLLLLAAAGLGGVAEGPGLAFSEDVLSVFGANLSLS
                     AAQLQHLLEQMGAASRVGVPEPGQLHFNQCLTAEEIFSLHGFSNATQITSSKFSVICP
                     AVLQQLNFHPCEDRPKHKTRPSHSEVWGYGFLSVTIINLASLLGLILTPLIKKSYFPK
                     ILTFFVGLAIGTLFSNAIFQLIPEAFGFDPKVDSYVEKAVAVFGGFYLLFFFERMLKM
                     LLKTYGQNGHTHFGNDNFGPQEKTHQPKALPAINGVTCYANPAVTEANGHIHFDNVSV
                     VSLQDGKKEPSSCTCLKGPKLSEIGTIAWMITLCDALHNFIDGLAIGASCTLSLLQGL
                     STSIAILCEEFPHELGDFVILLNAGMSTRQALLFNFLSACSCYVGLAFGILVGNNFAP
                     NIIFALAGGMFLYISLADMFPEMNDMLREKVTGRKTDFTFFMIQNAGMLTGFTAILLI
                     TLYAGEIELE"
     exon            611..773
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            774..943
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1066
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1231
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1439
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1624
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..3152
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /note="hexamer: AGTAAA"
     polyA_site      3152
                     /gene="SLC39A8"
                     /gene_synonym="BIGM103; CDG2N; LZT-Hs6; PP3105; ZIP8"
                     /note="major polyA site"
ORIGIN      
        1 gagtttcacc gcggacctgt cagagataca gaggttgtgg gggcgggaga cagaaagaga
       61 gagagatcca gagaccgagt cttacgttga cacgcagaga gaaagacgca gagacagaca
      121 aacaaacaga taggagaggc tctccaggag gccggggggc ccactccgcc tatcgctccc
      181 ctcggctacg ctgccacttc aatgccccgc aggtcgcgag ctgctgttct ttcgaaggcg
      241 tcggagaacc aggggcgtcc cgcgccacct ctgactcgga gcagcgccga gcactgacgc
      301 tcccgccctt gggcaaggac gccagtgcgc ccgcgcgcgt ccctctgcgc ggcagcccgt
      361 cgcgggccct caaggggaag cccaggccag gatggccccg ggtcgcgcgg tggccgggct
      421 cctgttgctg gcggccgccg gcctcggagg agtggcggag gggccagggc tagccttcag
      481 cgaggatgtg ctgagcgtgt tcggcgcgaa tctgagcctg tcggcggcgc agctccagca
      541 cttgctggag cagatgggag ccgcctcccg cgtgggcgtc ccggagcctg gccagctgca
      601 cttcaaccag tgtttaactg ctgaagagat cttttccctt catggctttt caaatgctac
      661 ccaaataacc agctccaaat tctctgtcat ctgtccagca gtcttacagc aattgaactt
      721 tcacccatgt gaggatcggc ccaagcacaa aacaagacca agtcattcag aagtttgggg
      781 atatggattc ctgtcagtga cgattattaa tctggcatct ctcctcggat tgattttgac
      841 tccactgata aagaaatctt atttcccaaa gattttgacc ttttttgtgg ggctggctat
      901 tgggactctt ttttcaaatg caattttcca acttattcca gaggcatttg gatttgatcc
      961 caaagtcgac agttatgttg agaaggcagt tgctgtgttt ggtggatttt acctactttt
     1021 cttttttgaa agaatgctaa agatgttatt aaagacatat ggtcagaatg gtcataccca
     1081 ctttggaaat gataactttg gtcctcaaga aaaaactcat caacctaaag cattacctgc
     1141 catcaatggt gtgacatgct atgcaaatcc tgctgtcaca gaagctaatg gacatatcca
     1201 ttttgataat gtcagtgtgg tatctctaca ggatggaaaa aaagagccaa gttcatgtac
     1261 ctgtttgaag gggcccaaac tgtcagaaat agggacgatt gcctggatga taacgctctg
     1321 cgatgccctc cacaatttca tcgatggcct ggcgattggg gcttcctgca ccttgtctct
     1381 ccttcaggga ctcagtactt ccatagcaat cctatgtgag gagtttcccc acgagttagg
     1441 agactttgtg atcctactca atgcagggat gagcactcga caagccttgc tattcaactt
     1501 cctttctgca tgttcctgct atgttgggct agcttttggc attttggtgg gcaacaattt
     1561 cgctccaaat attatatttg cacttgctgg aggcatgttc ctctatattt ctctggcaga
     1621 tatgtttcca gagatgaatg atatgctgag agaaaaggta actggaagaa aaaccgattt
     1681 caccttcttc atgattcaga atgctggaat gttaactgga ttcacagcca ttctactcat
     1741 taccttgtat gcaggagaaa tcgaattgga gtaatagaaa atggaagatg gtgttgttaa
     1801 taaaggcatt taatagataa aaacatctcc aaaaaggatt ttgaagctga tcctatttag
     1861 ttaaaaagat aattttgctt tcaactgtag gtccagaaaa ctaattattg gcatcagtct
     1921 gtgaaatagt ccattatttg ttgttaaaaa tgcttcaaaa ggttttcagt gtcagtctga
     1981 gatgcctggt atataggagc ctttgggaaa tacctatttt tcagtattcc atgcatatta
     2041 gatatcacca tgaagcaaga gacatgcatt ctataatcat gtagacactc agactcaggg
     2101 gaaaatacaa gttatatcct gaaagccttt aaaactctat ggtaggatca aagattcaaa
     2161 tggtttcaga gaggttttat ttcaattaat ttgttctagt gctttcaaga gcaagtacat
     2221 caaaatgtag aaggtaaaat gtatgcaaca ctaatataaa ttattccaag tctttaagga
     2281 gccaaagaaa aaaaagattt ctcacagctt tttgttctgt tttgtatttc aattaggaac
     2341 ttgcagtatt attttgaaaa ccattctaaa ataataggag ttaggaaata aataaagttt
     2401 tgctagccct gctaagttca ggcttagagg cttatcgcta agtataaact tcaccagatt
     2461 ccacgaaaag ctggatagct ttttttctga cttatgttgt ggttgcaccc ctcacaaatg
     2521 gcagaacagt atgtaaagct ggtaacacct cggtttcagt gcaccatgtg tttgctttgt
     2581 gaaggtgaag aatatgttgg tttagagaaa gaaattggat gtaattttat gcaatttact
     2641 tttaaagaca aacataacta tttagcagag aatattttaa taaatgcaaa acaacagctg
     2701 gactgctgta catcaaggac agattaactg gaaaacatat gttccttatg tgtgatcgag
     2761 agccattcag aaaagacttc ctttgtgttc agcctatact tttccatatg gtataccttg
     2821 aaaaaaatta gcacaccatg gttatttttc taccttttat aaaagacaga gcctgtttac
     2881 tcatttagaa gatagagaaa attggtctaa aattgaacat cctagattca cactcccaag
     2941 tcacttaagg tgatttgatg gtgaggaaaa tgattgacaa agcccaacaa tgatctcagg
     3001 aattacattt tccaacagac caaaaaatgt tttcatgtag cagcaatgca gatttggtga
     3061 atatttaata tatattttag tatgtatttc actttatgac tgacaattaa aaaatattgt
     3121 ttggccaaat agtaaacacc cttttgaaac ca
//
