LOCUS       NM_012319               3566 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens solute carrier family 39 member 6 (SLC39A6),
            transcript variant 1, mRNA.
ACCESSION   NM_012319
VERSION     NM_012319.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3566)
  AUTHORS   Saravanan,R., Balasubramanian,V., Sundaram,S., Dev,B.,
            Vittalraj,P., Pitani,R.S., Shanmugasundaram,G., Rayala,S.K. and
            Venkatraman,G.
  TITLE     Expression of cell surface zinc transporter LIV1 in triple negative
            breast cancer is an indicator of poor prognosis and therapy failure
  JOURNAL   J Cell Physiol 239 (4), e31203 (2024)
   PUBMED   38345361
  REMARK    GeneRIF: Expression of cell surface zinc transporter LIV1 in triple
            negative breast cancer is an indicator of poor prognosis and
            therapy failure.
REFERENCE   2  (bases 1 to 3566)
  AUTHORS   Yu,Z., Chen,C., Gu,H., Dong,J., Zhang,Y., Wang,J., Ma,H. and
            Zhang,G.
  TITLE     Suppression of SLC39A6-CREB1 axis in liver cancer causes
            PCK1-mediated mitochondrial dysfunction
  JOURNAL   Cell Prolif 56 (10), e13527 (2023)
   PUBMED   37435980
  REMARK    GeneRIF: Suppression of SLC39A6-CREB1 axis in liver cancer causes
            PCK1-mediated mitochondrial dysfunction.
REFERENCE   3  (bases 1 to 3566)
  AUTHORS   Althobiti,M., El-Sharawy,K.A., Joseph,C., Aleskandarany,M.,
            Toss,M.S., Green,A.R. and Rakha,E.A.
  TITLE     Oestrogen-regulated protein SLC39A6: a biomarker of good prognosis
            in luminal breast cancer
  JOURNAL   Breast Cancer Res Treat 189 (3), 621-630 (2021)
   PUBMED   34453638
  REMARK    GeneRIF: Oestrogen-regulated protein SLC39A6: a biomarker of good
            prognosis in luminal breast cancer.
REFERENCE   4  (bases 1 to 3566)
  AUTHORS   Kim,B., Kim,H.Y. and Lee,W.W.
  TITLE     Zap70 Regulates TCR-Mediated Zip6 Activation at the Immunological
            Synapse
  JOURNAL   Front Immunol 12, 687367 (2021)
   PUBMED   34394081
  REMARK    GeneRIF: Zap70 Regulates TCR-Mediated Zip6 Activation at the
            Immunological Synapse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3566)
  AUTHORS   Nimmanon,T., Ziliotto,S., Ogle,O., Burt,A., Gee,J.M.W.,
            Andrews,G.K., Kille,P., Hogstrand,C., Maret,W. and Taylor,K.M.
  TITLE     The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger
            of mitosis
  JOURNAL   Cell Mol Life Sci 78 (4), 1781-1798 (2021)
   PUBMED   32797246
  REMARK    GeneRIF: The ZIP6/ZIP10 heteromer is essential for the
            zinc-mediated trigger of mitosis.
REFERENCE   6  (bases 1 to 3566)
  AUTHORS   Schaner,M.E., Ross,D.T., Ciaravino,G., Sorlie,T., Troyanskaya,O.,
            Diehn,M., Wang,Y.C., Duran,G.E., Sikic,T.L., Caldeira,S.,
            Skomedal,H., Tu,I.P., Hernandez-Boussard,T., Johnson,S.W.,
            O'Dwyer,P.J., Fero,M.J., Kristensen,G.B., Borresen-Dale,A.L.,
            Hastie,T., Tibshirani,R., van de Rijn,M., Teng,N.N., Longacre,T.A.,
            Botstein,D., Brown,P.O. and Sikic,B.I.
  TITLE     Gene expression patterns in ovarian carcinomas
  JOURNAL   Mol Biol Cell 14 (11), 4376-4386 (2003)
   PUBMED   12960427
  REMARK    GeneRIF: LIV-1 is coregulated with estrogen receptor in some breast
            cancers.
REFERENCE   7  (bases 1 to 3566)
  AUTHORS   Taylor,K.M., Morgan,H.E., Johnson,A., Hadley,L.J. and
            Nicholson,R.I.
  TITLE     Structure-function analysis of LIV-1, the breast cancer-associated
            protein that belongs to a new subfamily of zinc transporters
  JOURNAL   Biochem J 375 (Pt 1), 51-59 (2003)
   PUBMED   12839489
  REMARK    GeneRIF: Structure-function analysis of LIV-1.
            GeneRIF: LIV-1, a member of the ZIP family of zinc transporters, is
            an integral plasma membrane protein that transports zinc into
            cells.
REFERENCE   8  (bases 1 to 3566)
  AUTHORS   Taylor,K.M. and Nicholson,R.I.
  TITLE     The LZT proteins; the LIV-1 subfamily of zinc transporters
  JOURNAL   Biochim Biophys Acta 1611 (1-2), 16-30 (2003)
   PUBMED   12659941
  REMARK    GeneRIF: Review of LIV-1 and other LZT proteins.
            Review article
REFERENCE   9  (bases 1 to 3566)
  AUTHORS   Dressman,M.A., Walz,T.M., Lavedan,C., Barnes,L., Buchholtz,S.,
            Kwon,I., Ellis,M.J. and Polymeropoulos,M.H.
  TITLE     Genes that co-cluster with estrogen receptor alpha in microarray
            analysis of breast biopsies
  JOURNAL   Pharmacogenomics J 1 (2), 135-141 (2001)
   PUBMED   11911440
  REMARK    GeneRIF: LIV-1 co-clusters with estrogen receptor alpha in
            microarray analysis of breast cancer biopsies.
REFERENCE   10 (bases 1 to 3566)
  AUTHORS   Manning,D.L., Daly,R.J., Lord,P.G., Kelly,K.F. and Green,C.D.
  TITLE     Effects of oestrogen on the expression of a 4.4 kb mRNA in the
            ZR-75-1 human breast cancer cell line
  JOURNAL   Mol Cell Endocrinol 59 (3), 205-212 (1988)
   PUBMED   2903103
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091060.10.
            
            On Nov 23, 2018 this sequence version replaced NM_012319.3.
            
            Summary: Zinc is an essential cofactor for hundreds of enzymes. It
            is involved in protein, nucleic acid, carbohydrate, and lipid
            metabolism, as well as in the control of gene transcription,
            growth, development, and differentiation. SLC39A6 belongs to a
            subfamily of proteins that show structural characteristics of zinc
            transporters (Taylor and Nicholson, 2003 [PubMed
            12659941]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.159982.1,
                                           SRR1660805.53290.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269187.10/ ENSP00000269187.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC091060.10        189473-189699       c
            228-1025            AC091060.10        186578-187375       c
            1026-1206           AC091060.10        184879-185059       c
            1207-1376           AC091060.10        183854-184023       c
            1377-1595           AC091060.10        182411-182629       c
            1596-1701           AC091060.10        177033-177138       c
            1702-2079           AC091060.10        174456-174833       c
            2080-2160           AC091060.10        172860-172940       c
            2161-2351           AC091060.10        171418-171608       c
            2352-3566           AC091060.10        168890-170104       c
FEATURES             Location/Qualifiers
     source          1..3566
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..3566
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /note="solute carrier family 39 member 6"
                     /db_xref="GeneID:25800"
                     /db_xref="HGNC:HGNC:18607"
                     /db_xref="MIM:608731"
     exon            1..227
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1025
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2504
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LIV-1 protein, estrogen regulated; solute
                     carrier family 39 (metal ion transporter), member 6; zinc
                     transporter ZIP6; ZIP-6; zrt- and Irt-like protein 6;
                     estrogen-regulated protein LIV-1; solute carrier family 39
                     (zinc transporter), member 6; zinc transporter 6;
                     ZRT/IRT-like protein 6"
                     /codon_start=1
                     /product="zinc transporter ZIP6 isoform 1 precursor"
                     /protein_id="NP_036451.4"
                     /db_xref="CCDS:CCDS42428.1"
                     /db_xref="GeneID:25800"
                     /db_xref="HGNC:HGNC:18607"
                     /db_xref="MIM:608731"
                     /translation="MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGI
                     NVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDH
                     EHHSDHERHSDHEHHSEHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRN
                     SQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDV
                     SSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGM
                     GIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISI
                     ISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDAFLHLLPHSHASHHHSHSHE
                     EPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDK
                     KKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRADSQEPSHFDSQQ
                     PAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILH
                     HHHHQNHHPHSHSQRYSREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSS
                     GLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYA
                     ENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGMLLGFGIML
                     LISIFEHKIVFRINF"
     exon            1026..1206
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1376
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1595
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1701
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..2079
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2160
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2351
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..3566
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /note="hexamer: AATAAA"
     polyA_site      3566
                     /gene="SLC39A6"
                     /gene_synonym="LIV-1; LIV1; ZIP6"
                     /note="major polyA site"
ORIGIN      
        1 agtgattgtc ttccagcttc gcgaaggcta ggggcgcggc tgccgggtgg ctgcgcggcg
       61 ctgcccccgg accgaggggc agccaaccca atgaaaccac cgcgtgttcg cgcctggtag
      121 agatttctcg aagacaccag tgggcccgtt ccgagccctc tggaccgccc gtgtggaacc
      181 aaacctgcgc gcgtggccgg gccgtgggac aacgaggccg cggagacgaa ggcgcaatgg
      241 cgaggaagtt atctgtaatc ttgatcctga cctttgccct ctctgtcaca aatccccttc
      301 atgaactaaa agcagctgct ttcccccaga ccactgagaa aattagtccg aattgggaat
      361 ctggcattaa tgttgacttg gcaatttcca cacggcaata tcatctacaa cagcttttct
      421 accgctatgg agaaaataat tctttgtcag ttgaagggtt cagaaaatta cttcaaaata
      481 taggcataga taagattaaa agaatccata tacaccatga ccacgaccat cactcagacc
      541 acgagcatca ctcagaccat gagcgtcact cagaccatga gcatcactca gagcacgagc
      601 atcactctga ccatgatcat cactctcacc ataatcatgc tgcttctggt aaaaataagc
      661 gaaaagctct ttgcccagac catgactcag atagttcagg taaagatcct agaaacagcc
      721 aggggaaagg agctcaccga ccagaacatg ccagtggtag aaggaatgtc aaggacagtg
      781 ttagtgctag tgaagtgacc tcaactgtgt acaacactgt ctctgaagga actcactttc
      841 tagagacaat agagactcca agacctggaa aactcttccc caaagatgta agcagctcca
      901 ctccacccag tgtcacatca aagagccggg tgagccggct ggctggtagg aaaacaaatg
      961 aatctgtgag tgagccccga aaaggcttta tgtattccag aaacacaaat gaaaatcctc
     1021 aggagtgttt caatgcatca aagctactga catctcatgg catgggcatc caggttccgc
     1081 tgaatgcaac agagttcaac tatctctgtc cagccatcat caaccaaatt gatgctagat
     1141 cttgtctgat tcatacaagt gaaaagaagg ctgaaatccc tccaaagacc tattcattac
     1201 aaatagcctg ggttggtggt tttatagcca tttccatcat cagtttcctg tctctgctgg
     1261 gggttatctt agtgcctctc atgaatcggg tgtttttcaa atttctcctg agtttccttg
     1321 tggcactggc cgttgggact ttgagtggtg atgctttttt acaccttctt ccacattctc
     1381 atgcaagtca ccaccatagt catagccatg aagaaccagc aatggaaatg aaaagaggac
     1441 cacttttcag tcatctgtct tctcaaaaca tagaagaaag tgcctatttt gattccacgt
     1501 ggaagggtct aacagctcta ggaggcctgt atttcatgtt tcttgttgaa catgtcctca
     1561 cattgatcaa acaatttaaa gataagaaga aaaagaatca gaagaaacct gaaaatgatg
     1621 atgatgtgga gattaagaag cagttgtcca agtatgaatc tcaactttca acaaatgagg
     1681 agaaagtaga tacagatgat cgaactgaag gctatttacg agcagactca caagagccct
     1741 cccactttga ttctcagcag cctgcagtct tggaagaaga agaggtcatg atagctcatg
     1801 ctcatccaca ggaagtctac aatgaatatg tacccagagg gtgcaagaat aaatgccatt
     1861 cacatttcca cgatacactc ggccagtcag acgatctcat tcaccaccat catgactacc
     1921 atcatattct ccatcatcac caccaccaaa accaccatcc tcacagtcac agccagcgct
     1981 actctcggga ggagctgaaa gatgccggcg tcgccactct ggcctggatg gtgataatgg
     2041 gtgatggcct gcacaatttc agcgatggcc tagcaattgg tgctgctttt actgaaggct
     2101 tatcaagtgg tttaagtact tctgttgctg tgttctgtca tgagttgcct catgaattag
     2161 gtgactttgc tgttctacta aaggctggca tgaccgttaa gcaggctgtc ctttataatg
     2221 cattgtcagc catgctggcg tatcttggaa tggcaacagg aattttcatt ggtcattatg
     2281 ctgaaaatgt ttctatgtgg atatttgcac ttactgctgg cttattcatg tatgttgctc
     2341 tggttgatat ggtacctgaa atgctgcaca atgatgctag tgaccatgga tgtagccgct
     2401 gggggtattt ctttttacag aatgctggga tgcttttggg ttttggaatt atgttactta
     2461 tttccatatt tgaacataaa atcgtgtttc gtataaattt ctagttaagg tttaaatgct
     2521 agagtagctt aaaaagttgt catagtttca gtaggtcata gggagatgag tttgtatgct
     2581 gtactatgca gcgtttaaag ttagtgggtt ttgtgatttt tgtattgaat attgctgtct
     2641 gttacaaagt cagttaaagg tacgttttaa tatttaagtt attctatctt ggagataaaa
     2701 tctgtatgtg caattcaccg gtattaccag tttattatgt aaacaagaga tttggcatga
     2761 catgttctgt atgtttcagg gaaaaatgtc tttaatgctt tttcaagaac taacacagtt
     2821 attcctatac tggattttag gtctctgaag aactgctggt gtttaggaat aagaatgtgc
     2881 atgaagccta aaataccaag aaagcttata ctgaatttaa gcaaagaaat aaaggagaaa
     2941 agagaagaat ctgagaattg gggaggcata gattcttata aaaatcacaa aatttgttgt
     3001 aaattagagg ggagaaattt agaattaagt ataaaaaggc agaattagta tagagtacat
     3061 tcattaaaca tttttgtcag gattatttcc cgtaaaaacg tagtgagcac ttttcatata
     3121 ctaatttagt tgtacattta actttgtata atacagaaat ctaaatatat ttaatgaatt
     3181 caagcaatat atcacttgac caagaaattg gaatttcaaa atgttcgtgc gggtatatac
     3241 cagatgagta cagtgagtag ttttatgtat caccagactg ggttattgcc aagttatata
     3301 tcaccaaaag ctgtatgact ggatgttctg gttacctggt ttacaaaatt atcagagtag
     3361 taaaactttg atatatatga ggatattaaa actacactaa gtatcatttg attcgattca
     3421 gaaagtactt tgatatctct cagtgcttca gtgctatcat tgtgagcaat tgtcttttat
     3481 atacggtact gtagccatac taggcctgtc tgtggcattc tctagatgtt tcttttttac
     3541 acaataaatt ccttatatca gcttga
//
