LOCUS       NM_173596               1980 bp    mRNA    linear   PRI 12-MAR-2023
DEFINITION  Homo sapiens solute carrier family 39 member 5 (SLC39A5),
            transcript variant 1, mRNA.
ACCESSION   NM_173596
VERSION     NM_173596.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Polesel M, Ingles-Prieto A, Christodoulaki E, Ferrada E, Doucerain
            C, Altermatt P, Knecht M, Kuhn M, Steck AL, Wilhelm M and Manolova
            V.
  TITLE     Functional characterization of SLC39 family members ZIP5 and ZIP10
            in overexpressing HEK293 cells reveals selective copper transport
            activity
  JOURNAL   Biometals 36 (1), 227-237 (2023)
   PUBMED   36454509
  REMARK    GeneRIF: Functional characterization of SLC39 family members ZIP5
            and ZIP10 in overexpressing HEK293 cells reveals selective copper
            transport activity.
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Lin E, Tsai SJ, Kuo PH, Liu YL, Yang AC, Conomos MP and Thornton
            TA.
  TITLE     Genome-wide association study in the Taiwan Biobank identifies four
            novel genes for human height: NABP2, RASA2, RNF41 and SLC39A5
  JOURNAL   Hum Mol Genet 30 (23), 2362-2369 (2021)
   PUBMED   34270706
  REMARK    GeneRIF: Genome-wide association study in the Taiwan Biobank
            identifies four novel genes for human height: NABP2, RASA2, RNF41
            and SLC39A5.
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Dong S, Tian Q, Zhu T, Wang K, Lei G, Liu Y, Xiong H, Shen L, Wang
            M, Zhao R, Wu H, Li B, Zhang Q, Yao Y, Guo H, Xia K, Xia L and Hu
            Z.
  TITLE     SLC39A5 dysfunction impairs extracellular matrix synthesis in high
            myopia pathogenesis
  JOURNAL   J Cell Mol Med 25 (17), 8432-8441 (2021)
   PUBMED   34302427
  REMARK    GeneRIF: SLC39A5 dysfunction impairs extracellular matrix synthesis
            in high myopia pathogenesis.
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Liu Z, Hu Z, Cai X and Liu S.
  TITLE     SLC39A5 promotes lung adenocarcinoma cell proliferation by
            activating PI3K/AKT signaling
  JOURNAL   Pathol Res Pract 224, 153541 (2021)
   PUBMED   34252710
  REMARK    GeneRIF: SLC39A5 promotes lung adenocarcinoma cell proliferation by
            activating PI3K/AKT signaling.
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Li Q, Jin J, Liu J, Wang L and He Y.
  TITLE     Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits
            Esophageal Cancer Growth In Vivo
  JOURNAL   Oncol Res 24 (3), 205-214 (2016)
   PUBMED   27458102
  REMARK    GeneRIF: we found that downregulation of ZIP5 by RNA interference
            inhibited esophageal cancer growth in vivo, reduced the expression
            of COX2, and promoted the expression of E-cadherin.
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Guo H, Jin X, Zhu T, Wang T, Tong P, Tian L, Peng Y, Sun L, Wan A,
            Chen J, Liu Y, Li Y, Tian Q, Xia L, Zhang L, Pan Y, Lu L, Liu Q,
            Shen L, Li Y, Xiong W, Li J, Tang B, Feng Y, Zhang X, Zhang Z, Pan
            Q, Hu Z and Xia K.
  TITLE     SLC39A5 mutations interfering with the BMP/TGF-beta pathway in
            non-syndromic high myopia
  JOURNAL   J Med Genet 51 (8), 518-525 (2014)
   PUBMED   24891338
REFERENCE   7  (bases 1 to 1980)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1980)
  AUTHORS   Wang F, Kim BE, Petris MJ and Eide DJ.
  TITLE     The mammalian Zip5 protein is a zinc transporter that localizes to
            the basolateral surface of polarized cells
  JOURNAL   J Biol Chem 279 (49), 51433-51441 (2004)
   PUBMED   15322118
  REMARK    GeneRIF: Zip5 protein is a zinc transporter that localizes to the
            basolateral surface of polarized cells
REFERENCE   9  (bases 1 to 1980)
  AUTHORS   Taylor KM, Morgan HE, Johnson A, Hadley LJ and Nicholson RI.
  TITLE     Structure-function analysis of LIV-1, the breast cancer-associated
            protein that belongs to a new subfamily of zinc transporters
  JOURNAL   Biochem J 375 (Pt 1), 51-59 (2003)
   PUBMED   12839489
REFERENCE   10 (bases 1 to 1980)
  AUTHORS   Taylor KM and Nicholson RI.
  TITLE     The LZT proteins; the LIV-1 subfamily of zinc transporters
  JOURNAL   Biochim Biophys Acta 1611 (1-2), 16-30 (2003)
   PUBMED   12659941
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073896.41.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_173596.2.
            
            Summary: The protein encoded by this gene belongs to the ZIP family
            of zinc transporters that transport zinc into cells from outside,
            and play a crucial role in controlling intracellular zinc levels.
            Zinc is an essential cofactor for many enzymes and proteins
            involved in gene transcription, growth, development and
            differentiation. Mutations in this gene have been associated with
            autosomal dominant high myopia (MYP24). Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313188.1, SRR11853567.7274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000454355.7/ ENSP00000405360.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC073896.41        103660-103731       c
            73-128              AC073896.41        103487-103542       c
            129-171             AC073896.41        102909-102951       c
            172-529             AC073896.41        102221-102578       c
            530-713             AC073896.41        100910-101093       c
            714-876             AC073896.41        98796-98958         c
            877-1046            AC073896.41        98456-98625         c
            1047-1187           AC073896.41        98082-98222         c
            1188-1284           AC073896.41        97290-97386         c
            1285-1449           AC073896.41        97036-97200         c
            1450-1530           AC073896.41        96771-96851         c
            1531-1721           AC073896.41        96442-96632         c
            1722-1980           AC073896.41        95936-96194         c
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..1980
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /note="solute carrier family 39 member 5"
                     /db_xref="GeneID:283375"
                     /db_xref="HGNC:HGNC:20502"
                     /db_xref="MIM:608730"
     exon            1..72
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            73..128
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            129..171
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            172..529
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1865
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /note="zinc transporter ZIP5; zrt- and Irt-like protein 5;
                     solute carrier family 39 (zinc transporter), member 5;
                     solute carrier family 39 (metal ion transporter), member
                     5; zinc transporter 5; ZRT/IRT-like protein 5"
                     /codon_start=1
                     /product="zinc transporter ZIP5 precursor"
                     /protein_id="NP_775867.2"
                     /db_xref="CCDS:CCDS8912.2"
                     /db_xref="GeneID:283375"
                     /db_xref="HGNC:HGNC:20502"
                     /db_xref="MIM:608730"
                     /translation="MMGSPVSHLLAGFCVWVVLGWVGGSVPNLGPAEQEQNHYLAQLF
                     GLYGENGTLTAGGLARLLHSLGLGRVQGLRLGQHGPLTGRAASPAADNSTHRPQNPEL
                     SVDVWAGMPLGPSGWGDLEESKAPHLPRGPAPSGLDLLHRLLLLDHSLADHLNEDCLN
                     GSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCIGAPAPAPPGDLLSALLQSAL
                     AVLLLSLPSPLSLLLLRLLGPRLLRPLLGFLGALAVGTLCGDALLHLLPHAQEGRHAG
                     PGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNLETRNLDPEN
                     GSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTDITWMVLLGDG
                     LHNLTDGLAIGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSL
                     VSGALGLGGAVLGVGLSLGPVPLTPWVFGVTAGVFLYVALVDMLPALLRPPEPLPTPH
                     VLLQGLGLLLGGGLMLAITLLEERLLPVTTEG"
     exon            530..713
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            714..876
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1046
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1187
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1284
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1449
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1530
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1721
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1980
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="SLC39A5"
                     /gene_synonym="LZT-Hs7; MYP24; ZIP5"
                     /note="major polyA site"
ORIGIN      
        1 gcctgccccc ccagctggaa ccaagaaggt tgtgtccccc ttcctctggg tgtccttgtc
       61 tcctgctatc agggcttccc ctttcttggt catcgatccc tagagctctg gctctttctc
      121 ttcttgggga actgcttaac gtctacagca aggcctaata ggggacctga gggcacagtc
      181 ctcaggatgt ttcggggaga ataggagcca gaacctgagc ccctaagcta ttcccctcac
      241 caatgatggg gtccccagtg agtcatctgc tggccggctt ctgtgtgtgg gtcgtcttgg
      301 gctgggtagg gggctcagtc cccaacctgg gccctgctga gcaggagcag aaccattacc
      361 tggcccagct gtttggcctg tacggcgaga atgggacgct gactgcaggg ggcttggcgc
      421 ggcttctcca cagcctgggg ctaggccgag ttcaggggct tcgcctggga cagcatgggc
      481 ctctgactgg acgggctgca tccccagctg cagacaattc cacacacagg ccacagaacc
      541 ctgagctgag tgtggatgtc tgggcaggga tgcctctggg tccctcaggg tggggtgacc
      601 tggaagagtc aaaggcccct cacctacccc gtgggccagc cccctcgggc ctggacctcc
      661 ttcacaggct tctgttgctg gaccactcat tggctgacca cctgaatgag gattgtctga
      721 acggctccca gctgctggtc aattttggct tgagccccgc tgctcctctg acccctcgtc
      781 agtttgctct gctgtgccca gccctgcttt atcagatcga cagccgcgtc tgcatcggcg
      841 ctccggcccc tgcaccccca ggggatctac tatctgccct gcttcagagt gccctggcag
      901 tcctgttgct cagcctccct tctcccctat ccctgctgct gctgcggctc ctgggacctc
      961 gtctactacg gcccttgctg ggcttcctgg gggccctggc ggtgggcact ctttgtgggg
     1021 atgcactgct acatctgcta ccgcatgcac aagaagggcg gcacgcagga cctggcggac
     1081 taccagagaa ggacctgggc ccggggctgt cagtgctcgg aggcctcttc ctgctctttg
     1141 tgctggagaa catgctgggg cttttgcggc accgagggct caggccaaga tgctgcaggc
     1201 gaaaacgaag gaatctcgaa acacgcaact tggatccgga gaatggcagt gggatggccc
     1261 ttcagcccct acaggcagct ccagagccag gggctcaggg ccagagggag aagaacagcc
     1321 agcacccacc agctctggcc cctcctgggc accaaggcca cagtcatggg caccagggtg
     1381 gcactgatat cacgtggatg gtcctcctgg gagatggtct acacaacctc actgatgggc
     1441 tggccatagg tgctgccttc tctgatggct tctccagcgg cctcagtacc accttagcgg
     1501 tcttctgcca tgagctgccc cacgaactgg gtgactttgc catgctgctc cagtcagggc
     1561 tgtcctttcg gcggctgctg ctgctgagcc tcgtgtctgg agccctggga ttggggggtg
     1621 cagtcctggg ggtggggctc agcctgggcc ctgtccccct cactccctgg gtgtttgggg
     1681 tcactgctgg ggtcttcctc tatgtggccc ttgtggacat gctaccagcc ctgcttcgtc
     1741 ctccggagcc cctgcctacg ccccatgtgc tcctgcaggg gctggggctg ctgctggggg
     1801 gcggcctcat gcttgccata accctgctgg aggagcggct actgcccgtg accactgagg
     1861 gctgatgggg ccagtggaaa ggggtcgggt tgcccttcct tccccccaac cacaggaatg
     1921 gaggcgggac acagggccag taggagcaat aggattttaa taaacagaac ccatcccaaa
//
