LOCUS       NM_144564               1367 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens solute carrier family 39 member 3 (SLC39A3),
            transcript variant 1, mRNA.
ACCESSION   NM_144564
VERSION     NM_144564.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1367)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1367)
  AUTHORS   Costello,L.C., Zou,J., Desouki,M.M. and Franklin,R.B.
  TITLE     Evidence for changes in RREB-1, ZIP3, and Zinc in the early
            development of pancreatic adenocarcinoma
  JOURNAL   J Gastrointest Cancer 43 (4), 570-578 (2012)
   PUBMED   22427155
  REMARK    GeneRIF: These results support a concept that downregulation of
            RREB-1 causes downregulation of ZIP3, which results in decreased
            zinc in pancreatic premalignant and carcinoma cells
REFERENCE   3  (bases 1 to 1367)
  AUTHORS   dos Santos Rocha,P.B., de Castro Amorim,A., de Sousa,A.F., do
            Monte,S.J., da Mata Sousa,L.C., do Nascimento Nogueira,N.,
            Neto,J.M. and do Nascimento Marreiro,D.
  TITLE     Expression of the zinc transporters genes and metallothionein in
            obese women
  JOURNAL   Biol Trace Elem Res 143 (2), 603-611 (2011)
   PUBMED   21053094
  REMARK    GeneRIF: The metallothionein gene had a higher expression in the
            blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3
            (p=0.01 in obese patients.
REFERENCE   4  (bases 1 to 1367)
  AUTHORS   Costello,L.C., Levy,B.A., Desouki,M.M., Zou,J., Bagasra,O.,
            Johnson,L.A., Hanna,N. and Franklin,R.B.
  TITLE     Decreased zinc and downregulation of ZIP3 zinc uptake transporter
            in the development of pancreatic adenocarcinoma
  JOURNAL   Cancer Biol Ther 12 (4), 297-303 (2011)
   PUBMED   21613827
  REMARK    GeneRIF: Data show that the combination of concurrent zinc, ZIP3,
            and RREB-1 changes represent early events in the development of
            adenocarcinoma.
REFERENCE   5  (bases 1 to 1367)
  AUTHORS   Ollila,H.M., Soronen,P., Silander,K., Palo,O.M., Kieseppa,T.,
            Kaunisto,M.A., Lonnqvist,J., Peltonen,L., Partonen,T. and Paunio,T.
  TITLE     Findings from bipolar disorder genome-wide association studies
            replicate in a Finnish bipolar family-cohort
  JOURNAL   Mol Psychiatry 14 (4), 351-353 (2009)
   PUBMED   19308021
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1367)
  AUTHORS   Kahmann,L., Uciechowski,P., Warmuth,S., Plumakers,B.,
            Gressner,A.M., Malavolta,M., Mocchegiani,E. and Rink,L.
  TITLE     Zinc supplementation in the elderly reduces spontaneous
            inflammatory cytokine release and restores T cell functions
  JOURNAL   Rejuvenation Res 11 (1), 227-237 (2008)
   PUBMED   18279033
  REMARK    GeneRIF: Gene expression regulation of ZIPs after zinc
            supplementation.
REFERENCE   7  (bases 1 to 1367)
  AUTHORS   Desouki,M.M., Geradts,J., Milon,B., Franklin,R.B. and Costello,L.C.
  TITLE     hZip2 and hZip3 zinc transporters are down regulated in human
            prostate adenocarcinomatous glands
  JOURNAL   Mol Cancer 6, 37 (2007)
   PUBMED   17550612
  REMARK    GeneRIF: ZiP2 and Zip3 are down regulated in malignant cells
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1367)
  AUTHORS   Wang,F., Dufner-Beattie,J., Kim,B.E., Petris,M.J., Andrews,G. and
            Eide,D.J.
  TITLE     Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and
            ZIP3 zinc uptake transporters
  JOURNAL   J Biol Chem 279 (23), 24631-24639 (2004)
   PUBMED   15054103
REFERENCE   9  (bases 1 to 1367)
  AUTHORS   Dufner-Beattie,J., Langmade,S.J., Wang,F., Eide,D. and Andrews,G.K.
  TITLE     Structure, function, and regulation of a subfamily of mouse zinc
            transporter genes
  JOURNAL   J Biol Chem 278 (50), 50142-50150 (2003)
   PUBMED   14525987
  REMARK    GeneRIF: ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc
            homeostasis rather than primary roles in the acquisition of dietary
            zinc
REFERENCE   10 (bases 1 to 1367)
  AUTHORS   Gaither,L.A. and Eide,D.J.
  TITLE     Functional expression of the human hZIP2 zinc transporter
  JOURNAL   J Biol Chem 275 (8), 5560-5564 (2000)
   PUBMED   10681536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ898834.1 and BC005869.2.
            
            On Nov 23, 2018 this sequence version replaced NM_144564.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This sequence has been modified as follows: removed
            29 bp suspected to be vector contamination from the 5' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.132326.1,
                                           SRR3476690.63538.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269740.9/ ENSP00000269740.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BQ898834.1         136-144
            10-1367             BC005869.2         1-1358
FEATURES             Location/Qualifiers
     source          1..1367
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1367
                     /gene="SLC39A3"
                     /gene_synonym="ZIP-3; ZIP3"
                     /note="solute carrier family 39 member 3"
                     /db_xref="GeneID:29985"
                     /db_xref="HGNC:HGNC:17128"
                     /db_xref="MIM:612168"
     exon            1..73
                     /gene="SLC39A3"
                     /gene_synonym="ZIP-3; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            74..405
                     /gene="SLC39A3"
                     /gene_synonym="ZIP-3; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1140
                     /gene="SLC39A3"
                     /gene_synonym="ZIP-3; ZIP3"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     transporter ZIP3; zrt- and Irt-like protein 3; solute
                     carrier family 39 (zinc transporter), member 3; zinc
                     transporter 3; ZRT/IRT-like protein 3"
                     /codon_start=1
                     /product="zinc transporter ZIP3 isoform a"
                     /protein_id="NP_653165.2"
                     /db_xref="CCDS:CCDS12093.1"
                     /db_xref="GeneID:29985"
                     /db_xref="HGNC:HGNC:17128"
                     /db_xref="MIM:612168"
                     /translation="MVKLLVAKILCMVGVFFFMLLGSLLPVKIIETDFEKAHRSKKIL
                     SLCNTFGGGVFLATCFNALLPAVREKLQKVLSLGHISTDYPLAETILLLGFFMTVFLE
                     QLILTFRKEKPSFIDLETFNAGSDVGSDSEYESPFMGGARGHALYVEPHGHGPSLSVQ
                     GLSRASPVRLLSLAFALSAHSVFEGLALGLQEEGEKVVSLFVGVAVHETLVAVALGIS
                     MARSAMPLRDAAKLAVTVSAMIPLGIGLGLGIESAQGVPGSVASVLLQGLAGGTFLFI
                     TFLEILAKELEEKSDRLLKVLFLVLGYTVLAGMVFLKW"
     exon            406..1367
                     /gene="SLC39A3"
                     /gene_synonym="ZIP-3; ZIP3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1367
                     /gene="SLC39A3"
                     /gene_synonym="ZIP-3; ZIP3"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtgggg tcgagactgc gcggccgttg ggcgtgcagc ggcgccagtc ggcggacgag
       61 gggcccccgg gagttgctgg actgagacat gagcctccaa ctgtgtggtt gggctcggta
      121 gcacatcgtg ggacttgggt gtgcgcccac agatggtttg gccctgcagt gaccagagca
      181 gcccaagccg ccaccatggt gaaattgcta gtggccaaaa tcctgtgcat ggtgggcgtg
      241 ttcttcttca tgctgctcgg ctccctgctc cccgtgaaga tcatcgagac agattttgag
      301 aaggcccatc gctcgaaaaa gatcctctct ctctgcaaca cctttggagg aggggtgttt
      361 ctggccacgt gcttcaacgc tctgctgccc gctgtgaggg aaaagctcca gaaggtcctg
      421 agcctcggcc acatcagcac cgactacccg ctggccgaaa ccatcctcct gctgggcttc
      481 ttcatgaccg tcttcctgga gcagctgatc ctgaccttcc gcaaggagaa gccgtccttc
      541 atcgacctgg agaccttcaa cgccggatcg gacgtgggca gcgactcgga gtatgagagc
      601 cccttcatgg ggggcgcgcg gggccacgcg ctgtacgtgg agccccacgg ccacggcccc
      661 agcctgagcg tgcagggcct ctcgcgcgcc agccccgtgc gcctgctcag cctggccttc
      721 gcgctgtcgg cccactcggt ctttgagggc ctggccctgg gcctgcagga ggagggggag
      781 aaagtggtga gcctgttcgt gggggtggcc gtccacgaga cactggtggc cgtggccctg
      841 ggcatcagca tggcccggag tgccatgccc ctgcgggacg cggccaagct ggcggtcacc
      901 gtaagcgcca tgatccccct gggcatcggc ctgggcctgg gcattgagag cgcccagggc
      961 gtgccgggca gcgtggcgtc cgtgctgctg cagggcctgg cgggcggcac cttcctcttc
     1021 atcaccttcc tggagatcct ggccaaggag ctggaggaga agagtgaccg tctgctcaag
     1081 gtcctcttcc tggtgctggg ctacaccgtc ctggccggga tggtcttcct caagtggtga
     1141 gcggcctcgc cattgtccct gccgccggag cccgccggga gccccgggcc ggacacaggc
     1201 cgcgtccccc ggccgcgcgt cccccaagag cgagcactgt ggccctgggc caccacctgt
     1261 gcacaagggg cctcccggga ccaggctgtg cccccgatcc tacaccctga gcctcagagc
     1321 actgctactt tttaaaatac ttctttctct taaaagtctt taccaaa
//
