LOCUS       NM_014579               1376 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 39 member 2 (SLC39A2),
            transcript variant 1, mRNA.
ACCESSION   NM_014579
VERSION     NM_014579.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1376)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1376)
  AUTHORS   Gyimesi,G., Albano,G., Fuster,D.G., Hediger,M.A. and
            Pujol-Gimenez,J.
  TITLE     Unraveling the structural elements of pH sensitivity and substrate
            binding in the human zinc transporter SLC39A2 (ZIP2)
  JOURNAL   J Biol Chem 294 (20), 8046-8063 (2019)
   PUBMED   30914478
  REMARK    GeneRIF: results provide the first structural evidence for the
            previously observed pH and voltage modulation of ZIP2-mediated
            metal transport, identify the substrate-binding site, and suggest a
            structure-based transport mechanism for the ZIP2 transporter.
            Erratum:[J Biol Chem. 2020 Mar 27;295(13):4369. doi:
            10.1074/jbc.AAC120.013245.. PMID: 32221034]
REFERENCE   3  (bases 1 to 1376)
  AUTHORS   Franz,M.C., Pujol-Gimenez,J., Montalbetti,N., Fernandez-Tenorio,M.,
            DeGrado,T.R., Niggli,E., Romero,M.F. and Hediger,M.A.
  TITLE     Reassessment of the Transport Mechanism of the Human Zinc
            Transporter SLC39A2
  JOURNAL   Biochemistry 57 (26), 3976-3986 (2018)
   PUBMED   29791142
  REMARK    GeneRIF: Reassessment of the Transport Mechanism of the Human Zinc
            Transporter SLC39A2.
REFERENCE   4  (bases 1 to 1376)
  AUTHORS   Kamei,S., Fujikawa,H., Nohara,H., Ueno-Shuto,K., Maruta,K.,
            Nakashima,R., Kawakami,T., Matsumoto,C., Sakaguchi,Y., Ono,T.,
            Suico,M.A., Boucher,R.C., Gruenert,D.C., Takeo,T., Nakagata,N.,
            Li,J.D., Kai,H. and Shuto,T.
  TITLE     Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2
            Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway
            Epithelial Cells
  JOURNAL   EBioMedicine 27, 304-316 (2018)
   PUBMED   29289532
  REMARK    GeneRIF: the splice switch to DeltaC-ZIP2 as well as decreased
            expression of other ZIPs caused zinc deficiency, which is
            sufficient for induction of MUC5AC.
REFERENCE   5  (bases 1 to 1376)
  AUTHORS   Pfaender,S., Sauer,A.K., Hagmeyer,S., Mangus,K., Linta,L.,
            Liebau,S., Bockmann,J., Huguet,G., Bourgeron,T., Boeckers,T.M. and
            Grabrucker,A.M.
  TITLE     Zinc deficiency and low enterocyte zinc transporter expression in
            human patients with autism related mutations in SHANK3
  JOURNAL   Sci Rep 7, 45190 (2017)
   PUBMED   28345660
  REMARK    GeneRIF: Results showed decreased expression of Zn uptake
            transporters ZIP2 and ZIP4 on mRNA and protein level correlating
            with SHANK3 expression levels, and found reduced levels of ZIP4
            protein co-localizing with SHANK3 at the plasma membrane. ZIP4
            exists in a complex with SHANK3. Further results confirmed a link
            between enterocytic SHANK3, ZIP2 and ZIP4.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1376)
  AUTHORS   Harris,E.D.
  TITLE     Cellular transporters for zinc
  JOURNAL   Nutr Rev 60 (4), 121-124 (2002)
   PUBMED   12002684
  REMARK    Review article
REFERENCE   7  (bases 1 to 1376)
  AUTHORS   Cao,J., Bobo,J.A., Liuzzi,J.P. and Cousins,R.J.
  TITLE     Effects of intracellular zinc depletion on metallothionein and ZIP2
            transporter expression and apoptosis
  JOURNAL   J Leukoc Biol 70 (4), 559-566 (2001)
   PUBMED   11590192
REFERENCE   8  (bases 1 to 1376)
  AUTHORS   Gaither,L.A. and Eide,D.J.
  TITLE     Eukaryotic zinc transporters and their regulation
  JOURNAL   Biometals 14 (3-4), 251-270 (2001)
   PUBMED   11831460
  REMARK    Review article
REFERENCE   9  (bases 1 to 1376)
  AUTHORS   Gaither,L.A. and Eide,D.J.
  TITLE     Functional expression of the human hZIP2 zinc transporter
  JOURNAL   J Biol Chem 275 (8), 5560-5564 (2000)
   PUBMED   10681536
REFERENCE   10 (bases 1 to 1376)
  AUTHORS   Yamaguchi,S.
  TITLE     [Subtraction cloning of growth arrest inducible genes in normal
            human epithelial cells]
  JOURNAL   Kokubyo Gakkai Zasshi 62 (1), 78-93 (1995)
   PUBMED   7751801
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314974.1 and D83039.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014579.3.
            
            Summary: This gene encodes a member of the ZIP family of metal ion
            transporters. The encoded protein functions as a zinc transporter.
            Mutations in this gene may be associated with susceptibility to
            carotid artery disease. Multiple transcript variants have been
            described. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF186081.1, D83039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298681.5/ ENSP00000298681.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-512               AK314974.1         3-514
            513-1376            D83039.1           489-1352
FEATURES             Location/Qualifiers
     source          1..1376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1376
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /note="solute carrier family 39 member 2"
                     /db_xref="GeneID:29986"
                     /db_xref="HGNC:HGNC:17127"
                     /db_xref="MIM:612166"
     exon            1..269
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1084
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /note="isoform a is encoded by transcript variant 1; Zrt-
                     and Irt-like protein 2; zinc transporter ZIP2; zinc uptake
                     transporter 2; solute carrier family 39 (zinc
                     transporter), member 2; zinc transporter 2; ZRT/IRT-like
                     protein 2"
                     /codon_start=1
                     /product="zinc transporter ZIP2 isoform a"
                     /protein_id="NP_055394.2"
                     /db_xref="CCDS:CCDS9563.1"
                     /db_xref="GeneID:29986"
                     /db_xref="HGNC:HGNC:17127"
                     /db_xref="MIM:612166"
                     /translation="MEQLLGIKLGCLFALLALTLGCGLTPICFKWFQIDAARGHHRLV
                     LRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFMVQNRSASERNSSGDADSAHMEY
                     PYGELIISLGFFFVFFLESLALQCCPGAAGGSTVQDEEWGGAHIFELHSHGHLPSPSK
                     GPLRALVLLLSLSFHSVFEGLAVGLQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLG
                     TSSRWAVFSILLLALMSPLGLAVGLAVTGGDSEGGRGLAQAVLEGVAAGTFLYVTFLE
                     ILPRELASPEAPLAKWSCVAAGFAFMAFIALWA"
     exon            270..400
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..451
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            452..1376
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1354..1359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /note="hexamer: AATAAA"
     polyA_site      1376
                     /gene="SLC39A2"
                     /gene_synonym="6A1; ETI-1; ZIP-2; ZIP2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcagaa gcaacacaga aagaagatac caacagcctc ctgaaactca cgagagtgga
       61 cactccagtg ttgaccacct aagataccac tcctgctcca aagattacag ctcccttgtc
      121 attctgactc ctgggcttac cctacacccc agagatggag caactactag gaataaaact
      181 tggctgcctg tttgccctgt tggctctcac tctgggctgt ggccttactc ccatctgctt
      241 caaatggttc cagattgatg cagccagagg tcatcaccgg ctagtcctca gactcctggg
      301 ctgtatttct gctggtgttt tcctgggagc agggttcatg catatgactg ctgaagccct
      361 ggaggaaatt gaatcacaga ttcagaagtt catggtgcag aacagatcag caagtgagag
      421 aaattcttct ggtgatgctg attcagctca tatggagtat ccctatggag agctcatcat
      481 ctccctgggc ttcttttttg tcttcttttt ggagtcgctg gcattgcagt gctgtcctgg
      541 ggctgctgga ggatcgacag tgcaggacga agaatggggt ggggctcata tcttcgaact
      601 ccacagccat ggacatttac cctcaccctc aaagggtccc ctccgagccc ttgtcctctt
      661 gctgtcactc tcctttcact cagtgtttga agggctagct gtggggctgc agccgacagt
      721 agcagctacc gtgcagctct gccttgctgt cctggctcat aaggggcttg tggtgtttgg
      781 tgtaggaatg cggctagtgc atttaggtac cagctcacga tgggcagtgt tctccatact
      841 attattagct ctcatgtccc ccctgggcct agccgtaggg ctggctgtga ctggagggga
      901 ctctgaagga gggcggggct tagcccaggc tgtgttagag ggtgtggcag ctggtacctt
      961 cctgtatgtc accttcctag aaattcttcc acgggagcta gctagtcctg aggcccctct
     1021 agctaagtgg agctgtgtag ccgctggttt tgccttcatg gcctttattg ccttgtgggc
     1081 ctgagagatt cctggctttt ctgatggacc tatttaggac aacctctcta tccccaggga
     1141 gacctcccaa atggctttga ccctcagaca tttctttact cagactaaat agcattcagt
     1201 aggactggac tggaccccag gtttccttta catgagatcc catttctcac cctggactaa
     1261 gacaaagata tttaggttga gcagctatta attggagaat tggtacagag acgctccaga
     1321 ttttattctt atcccattta tgctactgtg tgtaataaaa tgcccatttt accctc
//
