LOCUS       NM_001128225            2330 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens solute carrier family 39 member 13 (SLC39A13),
            transcript variant 1, mRNA.
ACCESSION   NM_001128225
VERSION     NM_001128225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Shoji,M., Ohashi,T., Nagase,S., Yuri,H., Ichihashi,K.,
            Takagishi,T., Nagata,Y., Nomura,Y., Fukunaka,A., Kenjou,S.,
            Miyake,H., Hara,T., Yoshigai,E., Fujitani,Y., Sakurai,H., Dos
            Santos,H.G., Fukada,T. and Kuzuhara,T.
  TITLE     Possible involvement of zinc transporter ZIP13 in myogenic
            differentiation
  JOURNAL   Sci Rep 14 (1), 8052 (2024)
   PUBMED   38609428
  REMARK    GeneRIF: Possible involvement of zinc transporter ZIP13 in myogenic
            differentiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   Cheng,X., Wang,J., Liu,C., Jiang,T., Yang,N., Liu,D., Zhao,H. and
            Xu,Z.
  TITLE     Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human
            ovarian cancer cells via activating Src/FAK signaling pathway
  JOURNAL   J Exp Clin Cancer Res 40 (1), 199 (2021)
   PUBMED   34154618
  REMARK    GeneRIF: Zinc transporter SLC39A13/ZIP13 facilitates the metastasis
            of human ovarian cancer cells via activating Src/FAK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2330)
  AUTHORS   Kumps,C., Campos-Xavier,B., Hilhorst-Hofstee,Y., Marcelis,C.,
            Kraenzlin,M., Fleischer,N., Unger,S. and Superti-Furga,A.
  TITLE     The Connective Tissue Disorder Associated with Recessive Variants
            in the SLC39A13 Zinc Transporter Gene (Spondylo-Dysplastic
            Ehlers-Danlos Syndrome Type 3): Insights from Four Novel Patients
            and Follow-Up on Two Original Cases
  JOURNAL   Genes (Basel) 11 (4), 420 (2020)
   PUBMED   32295219
  REMARK    GeneRIF: The Connective Tissue Disorder Associated with Recessive
            Variants in the SLC39A13 Zinc Transporter Gene (Spondylo-Dysplastic
            Ehlers-Danlos Syndrome Type 3): Insights from Four Novel Patients
            and Follow-Up on Two Original Cases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2330)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2330)
  AUTHORS   Lee,M.G. and Bin,B.H.
  TITLE     Different Actions of Intracellular Zinc Transporters ZIP7 and ZIP13
            Are Essential for Dermal Development
  JOURNAL   Int J Mol Sci 20 (16), 3941 (2019)
   PUBMED   31412620
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2330)
  AUTHORS   Bin,B.H., Fukada,T., Hosaka,T., Yamasaki,S., Ohashi,W., Hojyo,S.,
            Miyai,T., Nishida,K., Yokoyama,S. and Hirano,T.
  TITLE     Biochemical characterization of human ZIP13 protein: a
            homo-dimerized zinc transporter involved in the spondylocheiro
            dysplastic Ehlers-Danlos syndrome
  JOURNAL   J Biol Chem 286 (46), 40255-40265 (2011)
   PUBMED   21917916
  REMARK    GeneRIF: Biochemical characterization of human ZIP13 protein: a
            homo-dimerized zinc transporter involved in the spondylocheiro
            dysplastic Ehlers-Danlos syndrome.
REFERENCE   7  (bases 1 to 2330)
  AUTHORS   Walker,L.C., Ju,E.M. and Yeowell,H.N.
  TITLE     Mutational analysis of 12 patients with the phenotype of
            Ehlers-Danlos syndrome type VIB shows no linkage to the zinc
            transporter gene SLC39A13
  JOURNAL   Am J Med Genet A 155A (8), 2011-2014 (2011)
   PUBMED   21739577
  REMARK    GeneRIF: mutations in the SLC39A13 gene do not account for the
            Ehlers-Danlos syndrome type VIB phenotype
REFERENCE   8  (bases 1 to 2330)
  AUTHORS   Giunta,C., Elcioglu,N.H., Albrecht,B., Eich,G., Chambaz,C.,
            Janecke,A.R., Yeowell,H., Weis,M., Eyre,D.R., Kraenzlin,M. and
            Steinmann,B.
  TITLE     Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome--an
            autosomal-recessive entity caused by mutations in the zinc
            transporter gene SLC39A13
  JOURNAL   Am J Hum Genet 82 (6), 1290-1305 (2008)
   PUBMED   18513683
  REMARK    GeneRIF: clinical features of 6 patients from 2 consanguineous
            families with Ehlers-Danlos syndrome-like features caused by a
            mutation in the zinc transporter gene SLC39A13
REFERENCE   9  (bases 1 to 2330)
  AUTHORS   Fukada,T., Civic,N., Furuichi,T., Shimoda,S., Mishima,K.,
            Higashiyama,H., Idaira,Y., Asada,Y., Kitamura,H., Yamasaki,S.,
            Hojyo,S., Nakayama,M., Ohara,O., Koseki,H., Dos Santos,H.G.,
            Bonafe,L., Ha-Vinh,R., Zankl,A., Unger,S., Kraenzlin,M.E.,
            Beckmann,J.S., Saito,I., Rivolta,C., Ikegawa,S., Superti-Furga,A.
            and Hirano,T.
  TITLE     The zinc transporter SLC39A13/ZIP13 is required for connective
            tissue development; its involvement in BMP/TGF-beta signaling
            pathways
  JOURNAL   PLoS One 3 (11), e3642 (2008)
   PUBMED   18985159
  REMARK    Erratum:[PLoS One. 2008;3(11). doi:
            10.1371/annotation/a6c35a12-e8eb-43a0-9d00-5078fa6da1bb]
REFERENCE   10 (bases 1 to 2330)
  AUTHORS   Taylor,K.M. and Nicholson,R.I.
  TITLE     The LZT proteins; the LIV-1 subfamily of zinc transporters
  JOURNAL   Biochim Biophys Acta 1611 (1-2), 16-30 (2003)
   PUBMED   12659941
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090559.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001128225.2.
            
            Summary: This gene encodes a member of the LIV-1 subfamily of the
            ZIP transporter family. The encoded transmembrane protein functions
            as a zinc transporter. Mutations in this gene have been associated
            with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome.
            Alternate transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008853.2, SRR1803617.36625.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362021.9/ ENSP00000354689.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC090559.7         33062-33134
            74-382              AC090559.7         34559-34867
            383-496             AC090559.7         36398-36511
            497-618             AC090559.7         36818-36939
            619-726             AC090559.7         37872-37979
            727-816             AC090559.7         38069-38158
            817-867             AC090559.7         38897-38947
            868-1000            AC090559.7         39249-39381
            1001-1121           AC090559.7         39511-39631
            1122-2330           AC090559.7         39760-40968
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..2330
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /note="solute carrier family 39 member 13"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
     exon            1..73
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            74..382
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1197
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; solute carrier family 39 (metal ion
                     transporter), member 13; zinc transporter ZIP13; zrt- and
                     Irt-like protein 13; LIV-1 subfamily of ZIP zinc
                     transporter 9; ZRT/IRT-like protein 13; solute carrier
                     family 39 (zinc transporter), member 13; LIV-1 subfamily
                     of ZIP zinc transporters human member 9; zinc transporter
                     13"
                     /codon_start=1
                     /product="zinc transporter ZIP13 isoform a precursor"
                     /protein_id="NP_001121697.2"
                     /db_xref="CCDS:CCDS44592.1"
                     /db_xref="GeneID:91252"
                     /db_xref="HGNC:HGNC:20859"
                     /db_xref="MIM:608735"
                     /translation="MPGCPCPGCGMAGPRLLFLTALALELLERAGGSQPALRSRGTAT
                     ACRLDNKESESWGALLSGERLDTWICSLLGSLMVGLSGVFPLLVIPLEMGTMLRSEAG
                     AWRLKQLLSFALGGLLGNVFLHLLPEAWAYTCSASPGGEGQSLQQQQQLGLWVIAGIL
                     TFLALEKMFLDSKEEGTSQAPNKDPTAAAAALNGGHCLAQPAAEPGLGAVVRSIKVSG
                     YLNLLANTIDNFTHGLAVAASFLVSKKIGLLTTMAILLHEIPHEVGDFAILLRAGFDR
                     WSAAKLQLSTALGGLLGAGFAICTQSPKGVVGCSPAAEETAAWVLPFTSGGFLYIALV
                     NVLPDLLEEEDPWRSLQQLLLLCAGIVVMVLFSLFVD"
     exon            383..496
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            497..618
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            619..726
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            727..816
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            817..867
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1000
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1121
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..2330
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2312..2317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /note="hexamer: AATAAA"
     polyA_site      2330
                     /gene="SLC39A13"
                     /gene_synonym="EDSSPD3; LZT-Hs9; SCDEDS; ZIP13"
                     /note="major polyA site"
ORIGIN      
        1 agagcctggg cggggcgcgg caccgcagct ggatggctgg ggccgcccgg atcgccgccg
       61 ccgccgccgc acgtacgtgg catgcctgga tgtccctgcc ctggctgtgg catggcgggc
      121 ccaaggctcc tcttcctcac tgcccttgcc ctggagctct tggaaagggc tgggggttcc
      181 cagccggccc tccggagccg ggggactgcg acggcctgtc gcctggacaa caaggaaagc
      241 gagtcctggg gggctctgct gagcggagag cggctggaca cctggatctg ctccctcctg
      301 ggttccctca tggtggggct cagtggggtc ttcccgttgc ttgtcattcc cctagagatg
      361 gggaccatgc tgcgctcaga agctggggcc tggcgcctga agcagctgct cagcttcgcc
      421 ctggggggac tcttgggcaa tgtgtttctg catctgctgc ccgaagcctg ggcctacacg
      481 tgcagcgcca gccctggtgg tgaggggcag agcctgcagc agcagcaaca gctggggctg
      541 tgggtcattg ctggcatcct gaccttcctg gcgttggaga agatgttcct ggacagcaag
      601 gaggagggga ccagccaggc ccccaacaaa gaccccactg ctgctgccgc cgcgctcaat
      661 ggaggccact gtctggccca gccggctgca gagcccggcc tcggtgccgt ggtccggagc
      721 atcaaagtca gcggctacct caacctgctg gccaacacca tcgataactt cacccacggg
      781 ctggctgtgg ctgccagctt ccttgtgagc aagaagatcg ggctcctgac aaccatggcc
      841 atcctcctgc atgagatccc ccatgaggtg ggcgactttg ccatcctgct ccgggccggc
      901 tttgaccgat ggagcgcagc caagctgcaa ctctcaacag cgctgggggg cctactgggc
      961 gctggcttcg ccatctgtac ccagtccccc aagggagtag ttgggtgttc tcccgctgca
     1021 gaggagacgg cagcctgggt cctgcccttc acctctggcg gctttctcta catcgccttg
     1081 gtgaacgtgc tccctgacct cttggaagaa gaggacccgt ggcgctccct gcagcagctg
     1141 cttctgctct gtgcgggcat cgtggtaatg gtgctgttct cgctcttcgt ggattaactt
     1201 tccctgatgc cgacgcccct gccccctgca gcaataagat gctcggattc actctgtgac
     1261 cgcatatgtg agaggcagag agggcgagtg gctgcgagag agaatgagcc tcccgccaga
     1321 caggagggag gtgcgtgtgg atgtatgtgg tgtgcacatg tggccagagg tgtgtgcgcg
     1381 agaccgacac tgtgatccct gtgctgggtc cggggcccag tgtagcgcct gtccccagcc
     1441 atgctgtggt tacctctcct tgccgccctg tcaccttcac ctcccggagt aagcagcgag
     1501 gaagagcagc actggtccca agcagaggcc ttgccctgct gggaccccgg gagtgagagc
     1561 agcccaagga tccagggtgc agggaactcc agagctgccc acctcccact gccccctcag
     1621 cacacacaca gtccccaggc ggcctagggg ccaaggctgg ggcggctttg gtcccttttc
     1681 ctggcccttc cttccccact tctaagccaa agaaaggaga ggcaggtgct cctgtacccc
     1741 agccccactc agcactgaca gtccccagct cctagtagtg agctgggagg cgcttcctaa
     1801 gaccctttcc tcagggctgc cctgggagct cattcctggc caacacgccc tggcagcacc
     1861 agcagctctt gccacctcca gctgccaaac agcagcctgc cgggcaggga gcagccccag
     1921 gccagagagg cctcccggtc cagctcaggg atgctcctgc cagcacaggg gccagggact
     1981 cctggagcag gcacatagtg agcccgggca gccctgccca gctcaggccc ctttccttcc
     2041 ccattgaggt tggggtaggt gggggcggtg agggctccac gttgtcagcg ctcaggaatg
     2101 tgctccggca gagtgctgaa gccataatcc ccaaccattt cccttggctg acgcccaggt
     2161 actcagctgg cccactccac agccaggcct ggccctgccc ttcaccgtgg atgttttcag
     2221 aagtggccat cgagaggtct ggatggtttt atagcaactt tgctgtgatt ccgtttgtat
     2281 ctgtaaatat ttgttctata gataagatac aaataaatat tatccacata
//
