LOCUS       NM_001145195            2722 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 39 member 12 (SLC39A12),
            transcript variant 1, mRNA.
ACCESSION   NM_001145195
VERSION     NM_001145195.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2722)
  AUTHORS   Strong,M.D., Hart,M.D., Tang,T.Z., Ojo,B.A., Wu,L., Nacke,M.R.,
            Agidew,W.T., Hwang,H.J., Hoyt,P.R., Bettaieb,A., Clarke,S.L.,
            Smith,B.J., Stoecker,B.J., Lucas,E.A., Lin,D. and Chowanadisai,W.
  TITLE     Role of zinc transporter ZIP12 in susceptibility-weighted brain
            magnetic resonance imaging (MRI) phenotypes and mitochondrial
            function
  JOURNAL   FASEB J 34 (9), 10702-12725 (2020)
   PUBMED   32716562
  REMARK    GeneRIF: Role of zinc transporter ZIP12 in susceptibility-weighted
            brain magnetic resonance imaging (MRI) phenotypes and mitochondrial
            function.
REFERENCE   2  (bases 1 to 2722)
  AUTHORS   Chiasserini,D., van Weering,J.R., Piersma,S.R., Pham,T.V.,
            Malekzadeh,A., Teunissen,C.E., de Wit,H. and Jimenez,C.R.
  TITLE     Proteomic analysis of cerebrospinal fluid extracellular vesicles: a
            comprehensive dataset
  JOURNAL   J Proteomics 106, 191-204 (2014)
   PUBMED   24769233
REFERENCE   3  (bases 1 to 2722)
  AUTHORS   Chowanadisai,W., Graham,D.M., Keen,C.L., Rucker,R.B. and
            Messerli,M.A.
  TITLE     Neurulation and neurite extension require the zinc transporter
            ZIP12 (slc39a12)
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9903-9908 (2013)
   PUBMED   23716681
  REMARK    GeneRIF: Data indicate that the zinc transporter ZIP12 (slc39a12)
            is highly expressed in brain.
REFERENCE   4  (bases 1 to 2722)
  AUTHORS   Wang,L., McDonnell,S.K., Hebbring,S.J., Cunningham,J.M., St
            Sauver,J., Cerhan,J.R., Isaya,G., Schaid,D.J. and Thibodeau,S.N.
  TITLE     Polymorphisms in mitochondrial genes and prostate cancer risk
  JOURNAL   Cancer Epidemiol Biomarkers Prev 17 (12), 3558-3566 (2008)
   PUBMED   19064571
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2722)
  AUTHORS   Bly,M.
  TITLE     Examination of the zinc transporter gene, SLC39A12
  JOURNAL   Schizophr Res 81 (2-3), 321-322 (2006)
   PUBMED   16311021
  REMARK    GeneRIF: Examination of the zinc transporter gene, SLC39A12.
REFERENCE   6  (bases 1 to 2722)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2722)
  AUTHORS   Taylor,K.M. and Nicholson,R.I.
  TITLE     The LZT proteins; the LIV-1 subfamily of zinc transporters
  JOURNAL   Biochim Biophys Acta 1611 (1-2), 16-30 (2003)
   PUBMED   12659941
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB469365.1, BC094700.1 and AL360231.16.
            
            On Nov 22, 2018 this sequence version replaced NM_001145195.1.
            
            Summary: Zinc is an essential cofactor for hundreds of enzymes. It
            is involved in protein, nucleic acid, carbohydrate, and lipid
            metabolism, as well as in the control of gene transcription,
            growth, development, and differentiation. SLC39A12 belongs to a
            subfamily of proteins that show structural characteristics of zinc
            transporters (Taylor and Nicholson, 2003 [PubMed
            12659941]).[supplied by OMIM, Aug 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.25699.1,
                                           SRR1660803.22014.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377369.7/ ENSP00000366586.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DB469365.1         82-126
            46-2473             BC094700.1         1-2428
            2474-2722           AL360231.16        41965-42213
FEATURES             Location/Qualifiers
     source          1..2722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.33"
     gene            1..2722
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /note="solute carrier family 39 member 12"
                     /db_xref="GeneID:221074"
                     /db_xref="HGNC:HGNC:20860"
                     /db_xref="MIM:608734"
     exon            1..108
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            109..455
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2270
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; solute carrier family 39 (metal ion
                     transporter), member 12; zinc transporter ZIP12; zrt- and
                     Irt-like protein 12; LIV-1 subfamily of ZIP zinc
                     transporter 8; solute carrier family 39 (zinc
                     transporter), member 12; zinc transporter 12; ZRT/IRT-like
                     protein 12"
                     /codon_start=1
                     /product="zinc transporter ZIP12 isoform 1 precursor"
                     /protein_id="NP_001138667.1"
                     /db_xref="CCDS:CCDS44362.1"
                     /db_xref="GeneID:221074"
                     /db_xref="HGNC:HGNC:20860"
                     /db_xref="MIM:608734"
                     /translation="MCFRTKLSVSWVPLFLLLSRVFSTETDKPSAQDSRSRGSSGQPA
                     DLLQVLSAGDHPPHNHSRSLIKTLLEKTGCPRRRNGMQGDCNLCFEPDALLLIAGGNF
                     EDQLREEVVQRVSLLLLYYIIHQEEICSSKLNMSNKEYKFYLHSLLSLRQDEDSSFLS
                     QNETEDILAFTRQYFDTSQSQCMETKTLQKKSGIVSSEGANESTLPQLAAMIITLSLQ
                     GVCLGQGNLPSPDYFTEYIFSSLNRTNTLRLSELDQLLNTLWTRSTCIKNEKIHQFQR
                     KQNNIITHDQDYSNFSSSMEKESEDGPVSWDQTCFSARQLVEIFLQKGLSLISKEDFK
                     QMSPGIIQQLLSCSCHLPKDQQAKLPPTTLEKYGYSTVAVTLLTLGSMLGTALVLFHS
                     CEENYRLILQLFVGLAVGTLSGDALLHLIPQVLGLHKQEAPEFGHFHESKGHIWKLMG
                     LIGGIHGFFLIEKCFILLVSPNDKQGLSLVNGHVGHSHHLALNSELSDQAGRGKSAST
                     IQLKSPEDSQAAEMPIGSMTASNRKCKAISLLAIMILVGDSLHNFADGLAIGAAFSSS
                     SESGVTTTIAILCHEIPHEMGDFAVLLSSGLSMKTAILMNFISSLTAFMGLYIGLSVS
                     ADPCVQDWIFTVTAGMFLYLSLVEMLPEMTHVQTQRPWMMFLLQNFGLILGWLSLLLL
                     AIYEQNIKI"
     exon            456..737
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            738..945
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1118
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1290
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1463
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1616
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1727
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1794
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1953
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2141
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2722
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2705..2710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /note="hexamer: AATAAA"
     polyA_site      2722
                     /gene="SLC39A12"
                     /gene_synonym="bA570F3.1; LZT-Hs8; ZIP-12; ZIP12"
                     /note="major polyA site"
ORIGIN      
        1 acagtcaaag aattttaaaa acagggaact ttgtaactgt gaaatactct ccaggattta
       61 aaaggctgtg gagctccaga taaagaatcg tttatctttc ttctgaagaa attcctttgg
      121 ttacaagttt accccataaa cggcaacaca ctcacctcca tccaagacag actcaaggtg
      181 gaggaagcgt ggaaatgtgc ttccggacaa agctctcagt atcctgggtg ccattgtttc
      241 ttctactcag ccgtgttttt tctactgaga cagacaaacc ctcagcccag gatagcagaa
      301 gccgtgggag ttcaggccaa ccggcagacc tgctacaggt tctctctgct ggtgaccacc
      361 caccccacaa ccactcaaga agcctcatca aaacattgtt ggagaaaact gggtgcccac
      421 ggaggagaaa cggaatgcaa ggagattgca atctgtgctt tgaaccagat gcactattac
      481 taatagctgg aggaaatttt gaagatcagc ttagagaaga agtggtccag agagtttctc
      541 ttctccttct ctattacatt attcatcagg aagagatctg ttcttcaaag ctcaacatga
      601 gtaataaaga gtataaattt tacctacaca gcctactgag cctcaggcag gatgaagatt
      661 cctctttcct ttcacagaat gagacagaag atatcttggc tttcaccagg cagtactttg
      721 acacttctca aagccagtgt atggaaacca aaacgctgca gaaaaaatct ggaatagtga
      781 gcagtgaagg tgctaatgaa agtacgcttc ctcagttggc agccatgatc attactttgt
      841 ccctccaggg tgtttgtctg ggacaaggaa acttgccttc cccagactac tttacagaat
      901 atattttcag ttccttgaat cgtacgaata ccctccgcct atcagaacta gaccaactcc
      961 tcaacactct ctggaccaga agtacttgta tcaaaaatga gaaaatccat caatttcaaa
     1021 ggaaacaaaa caacataata acccatgatc aggactattc taatttctct tcatccatgg
     1081 aaaaagagtc tgaggatggt ccagtttcct gggatcagac ctgcttctct gctaggcagc
     1141 tggtggagat atttctacag aagggcctct cactcatttc taaggaggac tttaagcaaa
     1201 tgagtccagg gatcatccag cagctcctca gctgctcctg ccacttaccc aaggaccaac
     1261 aagcaaagct gccacctacc actctggaga aatacggcta cagcacggtg gctgtcaccc
     1321 ttctcacact gggctccatg ctggggacag cgctggtcct tttccatagc tgtgaggaga
     1381 actacaggct tatcttacag ctgtttgtgg gcttggccgt cgggacactg tctggggacg
     1441 ctctgctcca ccttatccct caggttcttg gtttacataa gcaggaagcc ccagaatttg
     1501 ggcatttcca tgaaagcaaa ggtcatattt ggaaactgat gggattaatt ggaggcatcc
     1561 atggattttt cttgatagaa aaatgtttta ttcttcttgt atcaccaaat gacaagcagg
     1621 gcctgtcatt ggttaatggg cacgtgggtc attcccacca tcttgcactc aactctgaat
     1681 taagtgacca ggcaggcaga ggcaaatctg cttcaactat ccagttgaaa agcccagaag
     1741 attcacaggc agctgaaatg cctataggca gtatgacagc ctccaacaga aaatgtaaag
     1801 ccattagctt gttagcaatc atgattctgg ttggggacag cctgcataat tttgcagatg
     1861 gcctagccat aggagcagcc ttctcatcat catccgagtc aggagtgacc actacgattg
     1921 ctatcttgtg tcatgaaatc ccacatgaaa tgggagactt tgccgtgctc ttaagctctg
     1981 gactttctat gaagactgcc atcctgatga attttataag ctccctaact gccttcatgg
     2041 gattatacat tggcctttcc gtgtcagctg atccatgtgt tcaagactgg atcttcacag
     2101 tcactgctgg gatgttctta tatttatcct tggttgaaat gcttcctgaa atgactcatg
     2161 ttcaaacaca acgaccctgg atgatgtttc tcctgcaaaa ctttggattg atcctaggtt
     2221 ggctttctct cctgctcttg gctatatatg agcaaaatat taaaatataa gtgaggatct
     2281 tcaacatctt tcaaaaatgc atttatatag tcttactttg tttctttcat tgcactctat
     2341 aatgattttt aaattaagaa ttttttatct taggcaaagt gtgtctcttt caattcatta
     2401 acttattaat tttataatgc agttttattt ttggaaacat ataaatatca gactgtcctt
     2461 aattgaaatt ttgtctttgg tttccaacac catgatgaag ctcttgcttt ttaaaaagta
     2521 gttagtaaat tctgcatgaa ttttagtaaa ctttaaaaaa tagatttttt ccctaagaaa
     2581 gaatgtttgt agaatttaaa gtggacagat gcctgttgga gtaaaatcaa ctgcaacttt
     2641 ttgatgttaa tttttttccc tgtgcaatta taaactataa gcaagttaag tgacaagcaa
     2701 atgtaataaa gactagtttt aa
//
