LOCUS       NM_139177               2732 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens solute carrier family 39 member 11 (SLC39A11),
            transcript variant 2, mRNA.
ACCESSION   NM_139177
VERSION     NM_139177.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2732)
  AUTHORS   Kim,E.Y., Verdejo-Torres,O., Diaz-Rodriguez,K., Hasanain,F.,
            Caromile,L. and Padilla-Benavides,T.
  TITLE     Single nucleotide polymorphisms and Zn transport by ZIP11 shape
            functional phenotypes of HeLa cells
  JOURNAL   Metallomics 16 (2) (2024)
   PUBMED   38285610
  REMARK    GeneRIF: Single nucleotide polymorphisms and Zn transport by ZIP11
            shape functional phenotypes of HeLa cells.
REFERENCE   2  (bases 1 to 2732)
  AUTHORS   Zhu,B., Huo,R., Zhi,Q., Zhan,M., Chen,X. and Hua,Z.C.
  TITLE     Increased expression of zinc transporter ZIP4, ZIP11, ZnT1, and
            ZnT6 predicts poor prognosis in pancreatic cancer
  JOURNAL   J Trace Elem Med Biol 65, 126734 (2021)
   PUBMED   33631610
  REMARK    GeneRIF: Increased expression of zinc transporter ZIP4, ZIP11,
            ZnT1, and ZnT6 predicts poor prognosis in pancreatic cancer.
REFERENCE   3  (bases 1 to 2732)
  AUTHORS   Ha,E. and Bae,J.H.
  TITLE     Zinc transporter SLC39A11 polymorphisms are associated with chronic
            gastritis in the Korean population: the possible effect on spicy
            food intake
  JOURNAL   Nutr Res 57, 78-85 (2018)
   PUBMED   30122198
  REMARK    GeneRIF: We found 8 different single nucleotide polymorphisms
            (SNPs) that are significantly different between subjects without
            gastritis and those with gastritis...  In conclusion, we found that
            zinc transporter gene ZIP11 is associated with chronic gastritis in
            the Korean population and it may interact with spicy food, which
            suggests ZIP11 as a therapeutic target for precision nutrition.
REFERENCE   4  (bases 1 to 2732)
  AUTHORS   Wu,L., Chaffee,K.G., Parker,A.S., Sicotte,H. and Petersen,G.M.
  TITLE     Zinc transporter genes and urological cancers: integrated analysis
            suggests a role for ZIP11 in bladder cancer
  JOURNAL   Tumour Biol 36 (10), 7431-7437 (2015)
   PUBMED   25900876
  REMARK    GeneRIF: Polymorphisms within ZIP11 gene were significantly
            associated with bladder cancer risk.
REFERENCE   5  (bases 1 to 2732)
  AUTHORS   Kang,X., Chen,R., Zhang,J., Li,G., Dai,P.G., Chen,C. and Wang,H.J.
  TITLE     Expression Profile Analysis of Zinc Transporters (ZIP4, ZIP9,
            ZIP11, ZnT9) in Gliomas and their Correlation with IDH1 Mutation
            Status
  JOURNAL   Asian Pac J Cancer Prev 16 (8), 3355-3360 (2015)
   PUBMED   25921144
  REMARK    GeneRIF: In glioma tumors, low ZIP11 expression was significantly
            associated with higher grade. Higher ZIP11 expression was weakly
            correlated with IDH1 mutation status.
REFERENCE   6  (bases 1 to 2732)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   7  (bases 1 to 2732)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 2732)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2732)
  AUTHORS   Landers,J.E., Melki,J., Meininger,V., Glass,J.D., van den
            Berg,L.H., van Es,M.A., Sapp,P.C., van Vught,P.W.,
            McKenna-Yasek,D.M., Blauw,H.M., Cho,T.J., Polak,M., Shi,L.,
            Wills,A.M., Broom,W.J., Ticozzi,N., Silani,V., Ozoguz,A.,
            Rodriguez-Leyva,I., Veldink,J.H., Ivinson,A.J., Saris,C.G.,
            Hosler,B.A., Barnes-Nessa,A., Couture,N., Wokke,J.H.,
            Kwiatkowski,T.J. Jr., Ophoff,R.A., Cronin,S., Hardiman,O.,
            Diekstra,F.P., Leigh,P.N., Shaw,C.E., Simpson,C.L., Hansen,V.K.,
            Powell,J.F., Corcia,P., Salachas,F., Heath,S., Galan,P.,
            Georges,F., Horvitz,H.R., Lathrop,M., Purcell,S., Al-Chalabi,A. and
            Brown,R.H. Jr.
  TITLE     Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3)
            gene increases survival in sporadic amyotrophic lateral sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 106 (22), 9004-9009 (2009)
   PUBMED   19451621
REFERENCE   10 (bases 1 to 2732)
  AUTHORS   Bagheri-Fam,S., Ferraz,C., Demaille,J., Scherer,G. and Pfeifer,D.
  TITLE     Comparative genomics of the SOX9 region in human and Fugu rubripes:
            conservation of short regulatory sequence elements within large
            intergenic regions
  JOURNAL   Genomics 78 (1-2), 73-82 (2001)
   PUBMED   11707075
  REMARK    GeneRIF: This paper describes the genomic region surrounding the
            SOX9 gene which includes SLC39A11 (C17orf26).
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC035631.1 and AC025198.12.
            
            On Jun 2, 2019 this sequence version replaced NM_139177.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 3. Variants 2, 3, and 5 encode the same isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035631.1, AF331643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255559.8/ ENSP00000255559.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-419               BC035631.1         6-424
            420-420             AC025198.12        25003-25003         c
            421-2732            BC035631.1         426-2737
FEATURES             Location/Qualifiers
     source          1..2732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.3-q25.1"
     gene            1..2732
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /note="solute carrier family 39 member 11"
                     /db_xref="GeneID:201266"
                     /db_xref="HGNC:HGNC:14463"
                     /db_xref="MIM:616508"
     exon            1..78
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            79..197
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1097
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     transporter ZIP11; Zrt- and Irt-like protein 11; solute
                     carrier family 39 (metal ion transporter), member 11; zinc
                     transporter 11; ZRT/IRT-like protein 11"
                     /codon_start=1
                     /product="zinc transporter ZIP11 isoform 2"
                     /protein_id="NP_631916.2"
                     /db_xref="CCDS:CCDS11690.1"
                     /db_xref="GeneID:201266"
                     /db_xref="HGNC:HGNC:14463"
                     /db_xref="MIM:616508"
                     /translation="MLQGHSSVFQALLGTFFTWGMTAAGAALVFVFSSGQRRILDGSL
                     GFAAGVMLAASYWSLLAPAVEMATSSGGFGAFAFFPVAVGFTLGAAFVYLADLLMPHL
                     GAAEDPQTTLALNFGSTLMKKKSDPEGPALLFPESELSIRIDKSENGEAYQRKKAAAT
                     GLPEGPAVPVPSRGNLAQPGGSSWRRIALLILAITIHNVPEGLAVGVGFGAIEKTASA
                     TFESARNLAIGIGIQNFPEGLAVSLPLRGAGFSTWRAFWYGQLSGMVEPLAGVFGAFA
                     VVLAEPILPYALAFAAGAMVYVVMDDIIPEAQISGNGKLASWASILGFVVMMSLDVGL
                     G"
     exon            198..236
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            237..395
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            396..519
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            520..690
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            691..760
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            761..859
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1018
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..2732
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /note="hexamer: AATAAA"
     polyA_site      2732
                     /gene="SLC39A11"
                     /gene_synonym="C17orf26; ZIP-11; ZIP11"
                     /note="major polyA site"
ORIGIN      
        1 gactgcggga gtggagccgg cgagagagtg gcagcggggg ctgatggaag tgcagtgggg
       61 gctggagagg gcaccctact gtatccagca tgctccaagg ccacagctct gtgttccagg
      121 ccttgctggg gaccttcttc acctggggga tgacagcagc tggggcagct ctcgtgttcg
      181 tattctctag tggacagagg cggatcttag atggaagtct tggctttgct gcaggggtca
      241 tgttggcagc ttcctattgg tctcttctgg ccccagcagt tgagatggcc acgtcctctg
      301 ggggcttcgg tgcctttgcc ttcttccctg tggctgttgg cttcaccctt ggagcggctt
      361 ttgtctactt ggctgacctc ctgatgcctc acttgggtgc agcagaagac ccccagacga
      421 ccctggcact gaacttcggc tctacgttga tgaagaagaa gtctgatcct gagggtcccg
      481 cgctgctctt ccctgagagt gaactttcca tccggataga caagagtgag aatggtgagg
      541 catatcagag aaagaaggcg gcagccactg gccttccaga gggtcctgct gtccctgtgc
      601 cttctcgagg gaatctggca cagcccggcg gcagcagctg gaggaggatc gcactgctca
      661 tcttggccat cactatacac aacgttccag agggtctcgc tgttggagtt ggatttgggg
      721 ctatagaaaa gacggcatct gctacctttg agagtgccag gaatttggcc attggaatcg
      781 ggatccagaa tttccccgag ggcctggctg tcagccttcc cttgcgaggg gcaggcttct
      841 ccacctggag agctttctgg tatgggcagc tgagcggcat ggtggagccc ctggccgggg
      901 tctttggtgc ctttgccgtg gtgctggctg agcccatcct gccctacgct ctggcctttg
      961 ctgccggtgc catggtctac gtggtcatgg acgacatcat ccccgaagcc cagatcagtg
     1021 gtaatgggaa actggcatcc tgggcctcca tcctgggatt tgtagtgatg atgtcactgg
     1081 acgttggcct gggctagggc tgagacgctt cggaccccgg gaaaggccat acgaagaaac
     1141 agcagtggtt ggcttctatg ggacaacaag cttctttctt cacattaaaa cttttttcct
     1201 tcctctcttc ttcatctcat tatcctgatt gactctgatt ataatagaac catttttact
     1261 ttgctttgag ggagattttt gatttaatgg ggaattttaa ggtgtcatgg aaatacagat
     1321 tctttgtttt ggccactgaa tggactctct cttcagtggg attatcaagg aacttcagat
     1381 cagggaaatc tccacttcgg gaccttctat ctgcctccca actcctcaag gtcacctata
     1441 gaagcgagct accaaaagac gtctcctaag cattttggtg gcctagtgac tcagggcaga
     1501 gtggccagca cacctctcat ccgcccctcc tgctccatca ctgctgagcc tctccccatc
     1561 tagaatgttg gaactggagc atcataaaga tagcaagcta ccttccaagg ccgagccagc
     1621 ccagagagga gcatgtcttc ctttacctcc ccctaaggag atactacatg ggagggggac
     1681 acagaaaaag ggaaggaaat tggctagtct ggcttttttt tttttttttt ttaaaggcaa
     1741 agattgacat tattgaagga aaggggatga ggacaactgt gaactcacag tgagccctgt
     1801 ggaaagaaga gacagacaga gtgtgggttt gttcggaggc ctctgctgtc aatggattcc
     1861 aggagcaagg ccatttgtcg cgctttccaa atttcttagg catttatttt gataagttta
     1921 tagccatcat gtttctaaga gacttggaga caccagcaaa ctgctagaac tcaaactctt
     1981 caattactca aagaaggagc catttcagtt aactcaagtg aatgaaagag ttttggaatc
     2041 tgctgtgggt ccttccctgt tgaccatttg gtaacttata atctgacaaa aactcttgag
     2101 ctgcaacagg ccttgccaga gggctcagga tgggaaagga agaaggggat aggaaaagaa
     2161 gaggtaattt tacatttccc ctttaaagta aattttagcc aactcatcat tctgaaatgt
     2221 ccctataaag aatgagtcga actagaccag aagccagcct actccttctt acatagcttc
     2281 tccaacaggg gtagcaatga cctgtccact tcaaacacag ataaggcctg ccatcctcat
     2341 tggttaaagg cacacgtgag actttcagtg ggctctgctg agaaggaagg cagcccagga
     2401 gtcaggtatg caggcattgc attgtcagtg tctgctctca gagtttacac attcaattgc
     2461 ttccaagggt gaatctcctg ctctgtgaat gctatcagac cccaaaggcc aaccttgggc
     2521 tgggtctatg tacgttcttc cgaagcactg atgatcaaaa ttgaagacac attcagaggt
     2581 ttgattggtt gagattaact ggtgtggtgg ttggtgtatg tatgttttat ttttatgtct
     2641 ttgtatgtag ttctacataa tgcaaattgt gctttctgat ggacaagacc tcataactgt
     2701 gattaatatc aataaaaagg ggatgttgtg ga
//
