LOCUS       NM_020342               5222 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens solute carrier family 39 member 10 (SLC39A10),
            transcript variant 2, mRNA.
ACCESSION   NM_020342 XM_047707
VERSION     NM_020342.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5222)
  AUTHORS   Ren,X., Feng,C., Wang,Y., Chen,P., Wang,S., Wang,J., Cao,H., Li,Y.,
            Ji,M. and Hou,P.
  TITLE     SLC39A10 promotes malignant phenotypes of gastric cancer cells by
            activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways
  JOURNAL   Exp Mol Med 55 (8), 1757-1769 (2023)
   PUBMED   37524874
  REMARK    GeneRIF: SLC39A10 promotes malignant phenotypes of gastric cancer
            cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT
            pathways.
REFERENCE   2  (bases 1 to 5222)
  AUTHORS   Irfan Afridi,M., Zheng,Z., Liu,J., Liu,L., Zhang,S., Zhu,Z.,
            Peng,Y., Zhou,D. and Tu,H.
  TITLE     The bZIP transcription factor BATF3/ZIP-10 suppresses innate
            immunity by attenuating PMK-1/p38 signaling
  JOURNAL   Int Immunol 35 (4), 181-196 (2023)
   PUBMED   36409527
  REMARK    GeneRIF: The bZIP transcription factor BATF3/ZIP-10 suppresses
            innate immunity by attenuating PMK-1/p38 signaling.
REFERENCE   3  (bases 1 to 5222)
  AUTHORS   Polesel,M., Ingles-Prieto,A., Christodoulaki,E., Ferrada,E.,
            Doucerain,C., Altermatt,P., Knecht,M., Kuhn,M., Steck,A.L.,
            Wilhelm,M. and Manolova,V.
  TITLE     Functional characterization of SLC39 family members ZIP5 and ZIP10
            in overexpressing HEK293 cells reveals selective copper transport
            activity
  JOURNAL   Biometals 36 (1), 227-237 (2023)
   PUBMED   36454509
  REMARK    GeneRIF: Functional characterization of SLC39 family members ZIP5
            and ZIP10 in overexpressing HEK293 cells reveals selective copper
            transport activity.
            Erratum:[Biometals. 2024 Aug;37(4):1037-1038. doi:
            10.1007/s10534-024-00615-z.. PMID: 38913288]
REFERENCE   4  (bases 1 to 5222)
  AUTHORS   Li,H., Shen,X., Ma,M., Liu,W., Yang,W., Wang,P., Cai,Z., Mi,R.,
            Lu,Y., Zhuang,J., Jiang,Y., Song,Y., Wu,Y. and Shen,H.
  TITLE     ZIP10 drives osteosarcoma proliferation and chemoresistance through
            ITGA10-mediated activation of the PI3K/AKT pathway
  JOURNAL   J Exp Clin Cancer Res 40 (1), 340 (2021)
   PUBMED   34706747
  REMARK    GeneRIF: ZIP10 drives osteosarcoma proliferation and
            chemoresistance through ITGA10-mediated activation of the PI3K/AKT
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5222)
  AUTHORS   Nimmanon,T., Ziliotto,S., Ogle,O., Burt,A., Gee,J.M.W.,
            Andrews,G.K., Kille,P., Hogstrand,C., Maret,W. and Taylor,K.M.
  TITLE     The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger
            of mitosis
  JOURNAL   Cell Mol Life Sci 78 (4), 1781-1798 (2021)
   PUBMED   32797246
  REMARK    GeneRIF: The ZIP6/ZIP10 heteromer is essential for the
            zinc-mediated trigger of mitosis.
REFERENCE   6  (bases 1 to 5222)
  AUTHORS   Pal,D., Sharma,U., Singh,S.K. and Prasad,R.
  TITLE     Association between ZIP10 gene expression and tumor aggressiveness
            in renal cell carcinoma
  JOURNAL   Gene 552 (1), 195-198 (2014)
   PUBMED   25200496
  REMARK    GeneRIF: A significant correlation between ZIP10 mRNA expressions
            with aggressiveness of RCC.
            Erratum:[Gene. 2022 Apr 20;819:146311. doi:
            10.1016/j.gene.2022.146311.. PMID: 35219547]
REFERENCE   7  (bases 1 to 5222)
  AUTHORS   Takatani-Nakase,T., Matsui,C., Maeda,S., Kawahara,S. and
            Takahashi,K.
  TITLE     High glucose level promotes migration behavior of breast cancer
            cells through zinc and its transporters
  JOURNAL   PLoS One 9 (2), e90136 (2014)
   PUBMED   24587242
  REMARK    GeneRIF: Zinc and its transporters, ZIP6 and ZIP10, are required
            for the breast cancer cells motility stimulated with high glucose
            level, such as in diabetes.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5222)
  AUTHORS   Service,S.K., Verweij,K.J., Lahti,J., Congdon,E., Ekelund,J.,
            Hintsanen,M., Raikkonen,K., Lehtimaki,T., Kahonen,M., Widen,E.,
            Taanila,A., Veijola,J., Heath,A.C., Madden,P.A., Montgomery,G.W.,
            Sabatti,C., Jarvelin,M.R., Palotie,A., Raitakari,O., Viikari,J.,
            Martin,N.G., Eriksson,J.G., Keltikangas-Jarvinen,L., Wray,N.R. and
            Freimer,N.B.
  TITLE     A genome-wide meta-analysis of association studies of Cloninger's
            Temperament Scales
  JOURNAL   Transl Psychiatry 2 (5), e116 (2012)
   PUBMED   22832960
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5222)
  AUTHORS   Wang,L., McDonnell,S.K., Hebbring,S.J., Cunningham,J.M., St
            Sauver,J., Cerhan,J.R., Isaya,G., Schaid,D.J. and Thibodeau,S.N.
  TITLE     Polymorphisms in mitochondrial genes and prostate cancer risk
  JOURNAL   Cancer Epidemiol Biomarkers Prev 17 (12), 3558-3566 (2008)
   PUBMED   19064571
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5222)
  AUTHORS   Taylor,K.M. and Nicholson,R.I.
  TITLE     The LZT proteins; the LIV-1 subfamily of zinc transporters
  JOURNAL   Biochim Biophys Acta 1611 (1-2), 16-30 (2003)
   PUBMED   12659941
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291241.1, AC013274.6 and AI693720.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020342.2.
            
            Summary: Zinc is an essential cofactor for hundreds of enzymes. It
            is involved in protein, nucleic acid, carbohydrate, and lipid
            metabolism, as well as in the control of gene transcription,
            growth, development, and differentiation. SLC39A10 belongs to a
            subfamily of proteins that show structural characteristics of zinc
            transporters (Taylor and Nicholson, 2003 [PubMed
            12659941]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.264484.1, AB033091.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359634.10/ ENSP00000352655.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2645              AK291241.1         11-2655
            2646-5137           AC013274.6         97212-99703
            5138-5222           AI693720.1         18-102              c
FEATURES             Location/Qualifiers
     source          1..5222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.3"
     gene            1..5222
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /note="solute carrier family 39 member 10"
                     /db_xref="GeneID:57181"
                     /db_xref="HGNC:HGNC:20861"
                     /db_xref="MIM:608733"
     exon            1..56
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            57..1075
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2563
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /note="solute carrier family 39 (metal ion transporter),
                     member 10; zinc transporter ZIP10; ZIP-10; zrt- and
                     Irt-like protein 10; solute carrier family 39 (zinc
                     transporter), member 10; zinc transporter 10; ZRT/IRT-like
                     protein 10"
                     /codon_start=1
                     /product="zinc transporter ZIP10 precursor"
                     /protein_id="NP_065075.1"
                     /db_xref="CCDS:CCDS33353.1"
                     /db_xref="GeneID:57181"
                     /db_xref="HGNC:HGNC:20861"
                     /db_xref="MIM:608733"
                     /translation="MKVHMHTKFCLICLLTFIFHHCNHCHEEHDHGPEALHRQHRGMT
                     ELEPSKFSKQAAENEKKYYIEKLFERYGENGRLSFFGLEKLLTNLGLGERKVVEINHE
                     DLGHDHVSHLDILAVQEGKHFHSHNHQHSHNHLNSENQTVTSVSTKRNHKCDPEKETV
                     EVSVKSDDKHMHDHNHRLRHHHRLHHHLDHNNTHHFHNDSITPSERGEPSNEPSTETN
                     KTQEQSDVKLPKGKRKKKGRKSNENSEVITPGFPPNHDQGEQYEHNRVHKPDRVHNPG
                     HSHVHLPERNGHDPGRGHQDLDPDNEGELRHTRKREAPHVKNNAIISLRKDLNEDDHH
                     HECLNVTQLLKYYGHGANSPISTDLFTYLCPALLYQIDSRLCIEHFDKLLVEDINKDK
                     NLVPEDEANIGASAWICGIISITVISLLSLLGVILVPIINQGCFKFLLTFLVALAVGT
                     MSGDALLHLLPHSQGGHDHSHQHAHGHGHSHGHESNKFLEEYDAVLKGLVALGGIYLL
                     FIIEHCIRMFKHYKQQRGKQKWFMKQNTEESTIGRKLSDHKLNNTPDSDWLQLKPLAG
                     TDDSVVSEDRLNETELTDLEGQQESPPKNYLCIEEEKIIDHSHSDGLHTIHEHDLHAA
                     AHNHHGENKTVLRKHNHQWHHKHSHHSHGPCHSGSDLKETGIANIAWMVIMGDGIHNF
                     SDGLAIGAAFSAGLTGGISTSIAVFCHELPHELGDFAVLLKAGMTVKQAIVYNLLSAM
                     MAYIGMLIGTAVGQYANNITLWIFAVTAGMFLYVALVDMLPEMLHGDGDNEEHGFCPV
                     GQFILQNLGLLFGFAIMLVIALYEDKIVFDIQF"
     exon            1076..1283
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1453
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1642
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1763
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2132
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2213
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2404
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..5222
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5198..5203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /note="hexamer: AATAAA"
     polyA_site      5222
                     /gene="SLC39A10"
                     /gene_synonym="LZT-Hs2; ZIP10"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgggg tttggtaccg agcggagagg agatgcacac ggcactcgag tgtgaggaaa
       61 aatagaaatg aaggtacata tgcacacaaa attttgcctc atttgtttgc tgacatttat
      121 ttttcatcat tgcaaccatt gccatgaaga acatgaccat ggccctgaag cgcttcacag
      181 acagcatcgt ggaatgacag aattggagcc aagcaaattt tcaaagcaag ctgctgaaaa
      241 tgaaaaaaaa tactatattg aaaaactttt tgagcgttat ggtgaaaatg gaagattatc
      301 cttttttggt ttggagaaac ttttaacaaa cttgggcctt ggagagagaa aagtagttga
      361 gattaatcat gaggatcttg gccacgatca tgtttctcat ttagatattt tggcagttca
      421 agagggaaag cattttcact cacataacca ccagcattcc cataatcatt taaattcaga
      481 aaatcaaact gtgaccagtg tatccacaaa aagaaaccat aaatgtgatc cagagaaaga
      541 gacagttgaa gtgtctgtaa aatctgatga taaacatatg catgaccata atcaccgcct
      601 acgtcatcac catcgtttgc atcatcatct tgatcataac aacactcacc attttcataa
      661 tgattccatt actcccagtg agcgtgggga gcctagcaat gaaccttcaa cagagaccaa
      721 taaaacccag gaacaatctg atgttaaact accgaaagga aagaggaaga aaaaagggag
      781 gaaaagtaat gaaaattctg aggttattac accaggtttt ccccctaacc atgatcaggg
      841 tgaacagtat gagcataatc gggtccacaa acctgatcgt gtacataacc caggtcattc
      901 tcatgtacat cttccagaac gtaatggtca tgatcctggt cgtggacacc aagatcttga
      961 tcctgataat gaaggtgaac ttcgacatac tagaaagaga gaagcaccac atgttaaaaa
     1021 taatgcaata atttctttga gaaaagatct aaatgaagat gaccatcatc atgaatgttt
     1081 gaacgtcact cagttattaa aatactatgg tcatggtgcc aactctccca tctcaactga
     1141 tttatttaca tacctttgcc ctgcattgtt atatcaaatc gacagcagac tttgtattga
     1201 gcattttgac aaacttttag ttgaagatat aaataaggat aaaaacctgg ttcctgaaga
     1261 tgaggcaaat ataggggcat cagcctggat ttgtggtatc atttctatca ctgtcattag
     1321 cctgctttcc ttgctaggcg tgatcttggt tcctatcatt aaccaaggat gcttcaaatt
     1381 ccttcttaca ttccttgttg cattagctgt aggaacaatg agtggagacg cccttcttca
     1441 tctactgccc cattctcagg gtggacatga tcacagtcac caacatgcac atgggcatgg
     1501 acattctcat ggacatgaat ctaacaagtt tttggaagaa tatgatgctg tattgaaagg
     1561 acttgttgct ctaggaggca tttacttgct atttatcatt gaacactgca ttagaatgtt
     1621 taagcactac aaacaacaaa gaggaaaaca gaaatggttt atgaaacaga acacagaaga
     1681 atcaactatt ggaagaaagc tttcagatca caagttaaac aatacaccag attctgactg
     1741 gcttcaactc aagcctcttg ccggaactga tgactcggtt gtttctgaag atcgacttaa
     1801 tgaaactgaa ctgacagatt tagaaggcca acaagaatcc cctcctaaaa attacctttg
     1861 tatagaagag gagaaaatca tagaccattc tcacagtgat ggattacata ccattcatga
     1921 gcatgatctc catgctgctg cacataacca ccacggcgag aacaaaactg tgctgaggaa
     1981 gcataatcac cagtggcacc acaagcattc tcatcattcc catggcccct gtcattctgg
     2041 atccgatctg aaagaaacag gaatagctaa tatagcctgg atggtgatca tgggggatgg
     2101 catccacaac ttcagtgatg ggctcgcaat tggtgcagct ttcagtgctg gattgacagg
     2161 aggaatcagt acttctatag ccgtcttctg tcatgaactg ccacatgaat taggagattt
     2221 tgcagttctt cttaaagcag gcatgactgt aaagcaagca attgtataca acctcctctc
     2281 tgccatgatg gcttacatag gcatgctcat aggcacagct gttggtcagt atgccaataa
     2341 catcacactt tggatctttg cagtcactgc aggcatgttc ctctatgtag ccttggtgga
     2401 tatgcttcca gaaatgttgc atggtgatgg tgacaatgaa gaacatggct tttgtcctgt
     2461 ggggcaattc atccttcaga atttaggatt gctctttgga tttgccatta tgctggtgat
     2521 tgccctctat gaagataaaa ttgtgtttga catccagttt tgacctttcc cagtaatcac
     2581 tgttgattac gagaatgtta ccatgcagct ttgcatctgt tccttgtact gtatgcacat
     2641 tgctcaaagg aaagtcagtg gcttgcacta cttacaagtt tcatagattt gagcctaacc
     2701 acaagaggct ggtgcttagt actgttttcc ctgcacgtag gggtctttta aaaatataaa
     2761 gcttgtgata aagagaggag aatatgggac tccatgaacc agtgttgata tgtttgatta
     2821 agacttttca caaaataatc atataaaaca ctagtctctt tattagtaga aacttctgtg
     2881 gctatgcaga aatagagatc gaaccaaaaa aaatcattta aactttaaaa atattttaaa
     2941 tggactttgg ggagacattt tttgtgtgtt ttaagaatga attgtagtgc tctttaattc
     3001 agctacatat attcatgtgg tgatagggat caacttgaca caactttgaa actgcataaa
     3061 gtagacatag gaactagagg aaagctcagg ctgcattaga gtatgaattt agcattggga
     3121 aaagccctta ttcttgaatc tagagttact atttttgtat atatttgcat agtgtttaaa
     3181 cctgcagcct aaactactga aatttgtgat tgtatgtttg tgtgagcttc agtttaatga
     3241 aagattcata atggttcttt gtattattat aatacttggt gttggggtgt tctttctgtt
     3301 ttgtttttta ctttaatttt gttttgattt tttttttttt tttttggcgg gggtaggtga
     3361 gggtttggag catgtggtct ttttaaaaaa ttgtaaccct ctagaaaata tcaaagaaat
     3421 gaaccagacg tggtttaaat agttgatttt cctattttaa cagtaccaac tagttaattg
     3481 ggaaatgtaa gttctgaatg ttcacattgc tttaccagtt tggcactgga accaagagca
     3541 catgtcgtgg ctggctacaa ggttgtaaag cagaaaatcg aagtttacca tgtctgtaat
     3601 gtgtacatga agtgtcaatt tagaacagtt actaggataa actccattat tgccatggct
     3661 gtcatggtac ccaagtgact tggaagatgc atttaaatta ctcagctgaa atcacttgat
     3721 catcttgtgc caagatatgc tgttggtgcc tgatagggat tagtctttta ggtgccctgt
     3781 tctcctacca taattgtgaa tgatttgtga gaagtgcaag ccatgtttat cctgaatttt
     3841 tacttaataa tttgtattac tagtcatatg catgtagctt tctgtttaca tcctatgcca
     3901 catggtcttc atttatgcca ggtaaactgt atttgaacta tgtgcagcta gctttgtttt
     3961 aatctgcttg gcaaccagtg tagctgctgt aacaatctat cttattgttc aaatatataa
     4021 gagccaaact cttttccatt ccatctaaaa tgttttcatt tagtactctt ctttcctcct
     4081 actctatgaa cttcaaaaca aaaacaaaac tttgagagca gcacatgcat ccaggtattt
     4141 atagattatt gccagtgtct tttctgtatg ctataagcaa gggagcttag gtgttatttc
     4201 tttaatttat gcttgaatct gaaaaattat ttctgactta ctccatggcc tccttataat
     4261 aagtagaagt tttatatata attaattttc agcattgggc actgaattag gacagtcctc
     4321 atctcattgc ttggcccttc aagcaaccta gctaaaaggt gctgatattt tatttagtac
     4381 tgccaacttc aagtgattta gatatctatc tatctagatt tctgaaccaa gatatattta
     4441 tagttcactt ttgggttttt atacccacgg taggattctg cattccagca ttaaatctgc
     4501 ttcattttag aacctttata aaagcaatag ctggaatata ctcccagttt taaaataaat
     4561 gcctgattga tttaaagcaa gtaggttatg ctgaagtata taaagaagtt ttatattctc
     4621 tcaaaaatgg tattatcttt ctttatttgc tagattctta caaatctttt aagagggctg
     4681 taacagttgc tgctagtatt agggttccac atcattctaa tgtatagttt caagtcttaa
     4741 tagacaatct gaattccact acatttcttt tggctccaac attcctttta gcttgaccag
     4801 tctaatttaa aatgtgtttg ttggaggtca ttaacgttac ttgtacaatg ctgtcactgt
     4861 gtgacatcca tatgaatttt ggtatatatc aatcaatcaa tcaatcacat tgcattcaat
     4921 caatcagctg tgattgattg attatgctta gaaatactat agtaactaga tgcagtgtga
     4981 attttttcca ttaacaaaca aacaagtcag tggcttaaat gtgattatgg tcctgcaagg
     5041 tgattcttgc taaaatatct aaacttttgt tttgttttaa ctgaatcatt ttttaactta
     5101 aaaagctgga aaatatcaaa tgctgttttt tttttttcat tgtcaacagt ggtgtgtcat
     5161 tttatgtatg ttcctaatgc ttatggaact cctccaaaat aaagttactc aaagagagca
     5221 aa
//
