LOCUS       NM_001271958            2038 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 39 member 1 (SLC39A1),
            transcript variant 3, mRNA.
ACCESSION   NM_001271958
VERSION     NM_001271958.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2038)
  AUTHORS   Zhang,Q., Pan,J., An,F., Nie,H. and Zhan,Q.
  TITLE     Decreased SLC39A1 (Solute carrier family 39 member 1) expression
            predicts unfavorable prognosis in patients with early-stage
            hepatocellular carcinoma
  JOURNAL   Bioengineered 12 (1), 8147-8156 (2021)
   PUBMED   34615436
  REMARK    GeneRIF: Decreased SLC39A1 (Solute carrier family 39 member 1)
            expression predicts unfavorable prognosis in patients with
            early-stage hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 2038)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2038)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2038)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2038)
  AUTHORS   Cho,H.M., Ryu,J.R., Jo,Y., Seo,T.W., Choi,Y.N., Kim,J.H.,
            Chung,J.M., Cho,B., Kang,H.C., Yu,S.W., Yoo,S.J., Kim,H. and Sun,W.
  TITLE     Drp1-Zip1 Interaction Regulates Mitochondrial Quality Surveillance
            System
  JOURNAL   Mol Cell 73 (2), 364-376 (2019)
   PUBMED   30581142
  REMARK    GeneRIF: Mitochondrial membrane potential is reduced focally at a
            fission site by the Drp1 recruitment, which is initiated by the
            interaction of Drp1 with mitochondrial zinc transporter Zip1 and
            Zn(2+) entry through the Zip1-MCU complex. After division, healthy
            mitochondria restore MMP levels and participate in the
            fusion-fission cycle again, but mitochondria that fail to restore
            MMP undergo mitophagy.
REFERENCE   6  (bases 1 to 2038)
  AUTHORS   Franklin,R.B., Ma,J., Zou,J., Guan,Z., Kukoyi,B.I., Feng,P. and
            Costello,L.C.
  TITLE     Human ZIP1 is a major zinc uptake transporter for the accumulation
            of zinc in prostate cells
  JOURNAL   J Inorg Biochem 96 (2-3), 435-442 (2003)
   PUBMED   12888280
  REMARK    GeneRIF: zip1 mechanism of transport appears to involve the
            transport of zinc from low molecular weight ligands that exist in
            circulation as relatively loosely bound complexes with zinc
REFERENCE   7  (bases 1 to 2038)
  AUTHORS   Milon,B., Dhermy,D., Pountney,D., Bourgeois,M. and Beaumont,C.
  TITLE     Differential subcellular localization of hZip1 in adherent and
            non-adherent cells
  JOURNAL   FEBS Lett 507 (3), 241-246 (2001)
   PUBMED   11696349
REFERENCE   8  (bases 1 to 2038)
  AUTHORS   Gaither,L.A. and Eide,D.J.
  TITLE     The human ZIP1 transporter mediates zinc uptake in human K562
            erythroleukemia cells
  JOURNAL   J Biol Chem 276 (25), 22258-22264 (2001)
   PUBMED   11301334
REFERENCE   9  (bases 1 to 2038)
  AUTHORS   Gaither,L.A. and Eide,D.J.
  TITLE     Functional expression of the human hZIP2 zinc transporter
  JOURNAL   J Biol Chem 275 (8), 5560-5564 (2000)
   PUBMED   10681536
REFERENCE   10 (bases 1 to 2038)
  AUTHORS   Lioumi,M., Ferguson,C.A., Sharpe,P.T., Freeman,T., Marenholz,I.,
            Mischke,D., Heizmann,C. and Ragoussis,J.
  TITLE     Isolation and characterization of human and mouse ZIRTL, a member
            of the IRT1 family of transporters, mapping within the epidermal
            differentiation complex
  JOURNAL   Genomics 62 (2), 272-280 (1999)
   PUBMED   10610721
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075257.1, BC014303.2 and
            AF132942.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001271958.1.
            
            Summary: This gene encodes a member of the zinc-iron permease
            family. The encoded protein is localized to the cell membrane and
            acts as a zinc uptake transporter. This gene has been linked to
            prostate cancer, breast cancer, and Alzheimer's disease.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2012].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, 4 and 5 encode the same protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.22776.1,
                                           SRR1660805.136069.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356205.9/ ENSP00000348535.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               AK075257.1         36-289
            255-2036            BC014303.2         646-2427
            2037-2038           AF132942.1         1998-1999
FEATURES             Location/Qualifiers
     source          1..2038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2038
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /note="solute carrier family 39 member 1"
                     /db_xref="GeneID:27173"
                     /db_xref="HGNC:HGNC:12876"
                     /db_xref="MIM:604740"
     exon            1..43
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /inference="alignment:Splign:2.1.0"
     exon            44..262
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1050
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /note="isoform a is encoded by transcript variant 3;
                     solute carrier family 39 (zinc transporter), member 3;
                     zrt- and Irt-like protein 1; solute carrier family 39
                     (zinc transporter), member 1; zinc transporter 1;
                     ZRT/IRT-like protein 1"
                     /codon_start=1
                     /product="zinc transporter ZIP1 isoform a"
                     /protein_id="NP_001258887.1"
                     /db_xref="CCDS:CCDS1055.1"
                     /db_xref="GeneID:27173"
                     /db_xref="HGNC:HGNC:12876"
                     /db_xref="MIM:604740"
                     /translation="MGPWGEPELLVWRPEAVASEPPVPVGLEVKLGALVLLLVLTLLC
                     SLVPICVLRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAA
                     LHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPSPLEETRALLGTVNGGPQHWH
                     DGPGVPQASGAPATPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHK
                     GILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLE
                     GMAAGTFLYITFLEILPQELASSEQRILKVILLLAGFALLTGLLFIQI"
     exon            263..393
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /inference="alignment:Splign:2.1.0"
     exon            394..2038
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="SLC39A1"
                     /gene_synonym="ZIP1; ZIRTL"
                     /note="major polyA site"
ORIGIN      
        1 aggccggaag cgcgcggaga ccatgtagtg agaccctcgc gaggtctgag agtcactgga
       61 gctaccagaa gcatcatggg gccctgggga gagccagagc tcctggtgtg gcgccccgag
      121 gcggtagctt cagagcctcc agtgcctgtg gggctggagg tgaagttggg ggccctggtg
      181 ctgctgctgg tgctcaccct cctctgcagc ctggtgccca tctgtgtgct gcgccggcca
      241 ggagctaacc atgaaggctc agcttcccgc cagaaagccc tgagcctagt aagctgtttc
      301 gcggggggcg tctttttggc cacttgtctc ctggacctgc tgcctgacta cctggctgcc
      361 atagatgagg ccctggcagc cttgcacgtg acgctccagt tcccactgca agagttcatc
      421 ctggccatgg gcttcttcct ggtcctggtg atggagcaga tcacactggc ttacaaggag
      481 cagtcagggc cgtcacctct ggaggaaaca agggctctgc tgggaacagt gaatggtggg
      541 ccgcagcatt ggcatgatgg gccaggggtc ccacaggcga gtggagcccc agcaaccccc
      601 tcagccttgc gtgcctgtgt actggtgttc tccctggccc tccactccgt gttcgagggg
      661 ctggcggtag ggctgcagcg agaccgggct cgggccatgg agctgtgcct ggctttgctg
      721 ctccacaagg gcatcctggc tgtcagcctg tccctgcggc tgttgcagag ccaccttagg
      781 gcacaggtgg tggctggctg tgggatcctc ttctcatgca tgacacctct aggcatcggg
      841 ctgggtgcag ctctggcaga gtcggcagga cctctgcacc agctggccca gtctgtgcta
      901 gagggcatgg cagctggcac ctttctctat atcacctttc tggaaatcct gccccaggag
      961 ctggccagtt ctgagcaaag gatcctcaag gtcattctgc tcctagcagg ctttgccctg
     1021 ctcactggcc tgctcttcat ccaaatctag ggggcttcaa gagaggggca ggggagattg
     1081 atgatcaggt gcccctgttc tcccttccct cccccagttg tggggaatag gaaggaaagg
     1141 ggaagggaaa tactgaggac caaaaagttc tctgggagct aaagatagag cctttggggc
     1201 tatctgacta atgagaggga agtgggcaga caagaggctg gccccagtcc caaggaacaa
     1261 gagatggtca agtcgctaga gacatatcag gggacattag gattggggaa gacacttgac
     1321 tgctagaatc agaggttgga cactatacat aaggacaggc tcacatggga ggctggaggt
     1381 gggtacccag ctgctgtgga acgggtatgg acaggtcata aacctagagt cagtgtcctg
     1441 ttggtcctag cccatttcag caccctgcca cttggagtgg acccctccta ctcttcttag
     1501 cgcctaccct catacctatc tccctcctcc catctcctag gggactggcg ccaaatggtc
     1561 tctccctgcc aattttggta tcttctctgg cctctccagt cctgcttact cctctatttt
     1621 taaagtgcca aacaaatccc cttcctcttt ctcaaagcac agtaatgtgg cactgagccc
     1681 tacccagcac ctcagtgaag ggggcctgct tgctctttat tttggtcccg gatcctgggg
     1741 tggggcagaa atattttctg ggctggggta ggaggaaggt tgttgcagcc atctactgct
     1801 gctgtaccct aggaatatgg ggacatggac atggtgtccc atgcccagat gataaacact
     1861 gagctgccaa aacatttttt taaatacacc cgaggagccc aagggggaag ggcaatgcct
     1921 acccccagcg ttatttttgg ggagggaggg ctgtgcatag ggacatattc tttagaatct
     1981 attttattaa ctgacctgtt ttgggacctg ttacccaaat aaaagatgtt tctagaca
//
