LOCUS       NM_173514               2522 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 38 member 9 (SLC38A9),
            transcript variant 1, mRNA.
ACCESSION   NM_173514
VERSION     NM_173514.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2522)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   2  (bases 1 to 2522)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2522)
  AUTHORS   Fromm,S.A., Lawrence,R.E. and Hurley,J.H.
  TITLE     Structural mechanism for amino acid-dependent Rag GTPase nucleotide
            state switching by SLC38A9
  JOURNAL   Nat Struct Mol Biol 27 (11), 1017-1023 (2020)
   PUBMED   32868926
  REMARK    GeneRIF: Structural mechanism for amino acid-dependent Rag GTPase
            nucleotide state switching by SLC38A9.
REFERENCE   4  (bases 1 to 2522)
  AUTHORS   Heinz,L.X., Lee,J., Kapoor,U., Kartnig,F., Sedlyarov,V.,
            Papakostas,K., Cesar-Razquin,A., Essletzbichler,P., Goldmann,U.,
            Stefanovic,A., Bigenzahn,J.W., Scorzoni,S., Pizzagalli,M.D.,
            Bensimon,A., Muller,A.C., King,F.J., Li,J., Girardi,E., Mbow,M.L.,
            Whitehurst,C.E., Rebsamen,M. and Superti-Furga,G.
  TITLE     TASL is the SLC15A4-associated adaptor for IRF5 activation by
            TLR7-9
  JOURNAL   Nature 581 (7808), 316-322 (2020)
   PUBMED   32433612
REFERENCE   5  (bases 1 to 2522)
  AUTHORS   Scalise,M., Galluccio,M., Pochini,L., Cosco,J., Trotta,M.,
            Rebsamen,M., Superti-Furga,G. and Indiveri,C.
  TITLE     Insights into the transport side of the human SLC38A9 transceptor
  JOURNAL   Biochim Biophys Acta Biomembr 1861 (9), 1558-1567 (2019)
   PUBMED   31295473
REFERENCE   6  (bases 1 to 2522)
  AUTHORS   Rebsamen,M., Pochini,L., Stasyk,T., de Araujo,M.E., Galluccio,M.,
            Kandasamy,R.K., Snijder,B., Fauster,A., Rudashevskaya,E.L.,
            Bruckner,M., Scorzoni,S., Filipek,P.A., Huber,K.V., Bigenzahn,J.W.,
            Heinz,L.X., Kraft,C., Bennett,K.L., Indiveri,C., Huber,L.A. and
            Superti-Furga,G.
  TITLE     SLC38A9 is a component of the lysosomal amino acid sensing
            machinery that controls mTORC1
  JOURNAL   Nature 519 (7544), 477-481 (2015)
   PUBMED   25561175
  REMARK    GeneRIF: SLC38A9 is a physical and functional component of the
            amino acid sensing machinery that controls the activation of mTOR
REFERENCE   7  (bases 1 to 2522)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   8  (bases 1 to 2522)
  AUTHORS   Uchiyama,K., Takagi,T., Iwamoto,Y., Kondo,N., Okayama,T.,
            Yoshida,N., Kamada,K., Katada,K., Handa,O., Ishikawa,T., Yasuda,H.,
            Sakagami,J., Konishi,H., Yagi,N., Naito,Y. and Itoh,Y.
  TITLE     New genetic biomarkers predicting azathioprine blood concentrations
            in combination therapy with 5-aminosalicylic acid
  JOURNAL   PLoS One 9 (4), e95080 (2014)
   PUBMED   24762746
  REMARK    GeneRIF: SNPs within SLC38A9 are correlated with inflammatory bowel
            disease patients' 6-thioguanine nucleotide blood concentrations.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2522)
  AUTHORS   Schioth,H.B., Roshanbin,S., Hagglund,M.G. and Fredriksson,R.
  TITLE     Evolutionary origin of amino acid transporter families SLC32, SLC36
            and SLC38 and physiological, pathological and therapeutic aspects
  JOURNAL   Mol Aspects Med 34 (2-3), 571-585 (2013)
   PUBMED   23506890
  REMARK    Review article
REFERENCE   10 (bases 1 to 2522)
  AUTHORS   Januchowski,R., Zawierucha,P., Andrzejewska,M., Rucinski,M. and
            Zabel,M.
  TITLE     Microarray-based detection and expression analysis of ABC and SLC
            transporters in drug-resistant ovarian cancer cell lines
  JOURNAL   Biomed Pharmacother 67 (3), 240-245 (2013)
   PUBMED   23462296
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC371481.1, BC066891.1, AK075190.1 and AI580489.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173514.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1 6, 7 and 8 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066891.1, SRR1660803.15636.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396865.7/ ENSP00000380074.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               DC371481.1         12-451
            441-1958            BC066891.1         441-1958
            1959-2520           AK075190.1         1902-2463
            2521-2522           AI580489.1         11-12               c
FEATURES             Location/Qualifiers
     source          1..2522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..2522
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /note="solute carrier family 38 member 9"
                     /db_xref="GeneID:153129"
                     /db_xref="HGNC:HGNC:26907"
                     /db_xref="MIM:616203"
     exon            1..108
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            109..156
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            157..303
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1876
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative sodium-coupled neutral amino acid transporter 9;
                     up-regulated in lung cancer 11"
                     /codon_start=1
                     /product="neutral amino acid transporter 9 isoform 1"
                     /protein_id="NP_775785.2"
                     /db_xref="CCDS:CCDS3968.1"
                     /db_xref="GeneID:153129"
                     /db_xref="HGNC:HGNC:26907"
                     /db_xref="MIM:616203"
                     /translation="MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSKRPFCIEP
                     TNIVNVNHVIQRVSDHASAMNKRIHYYSRLTTPADKALIAPDHVVPAPEECYVYSPLG
                     SAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLL
                     TLYCCYRVVKSRTMMFSLDTTSWEYPDVCRHYFGSFGQWSSLLFSLVSLIGAMIVYWV
                     LMSNFLFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDT
                     GAQQFEKWWDKSRTVPFYLVGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFLVTFKAV
                     RLGFHLEFHWFIPTEFFVPEIRFQFPQLTGVLTLAFFIHNCIITLLKNNKKQENNVRD
                     LCIAYMLVTLTYLYIGVLVFASFPSPPLSKDCIEQNFLDNFPSSDTLSFIARIFLLFQ
                     MMTVYPLLGYLARVQLLGHIFGDIYPSIFHVLILNLIIVGAGVIMACFYPNIGGIIRY
                     SGAACGLAFVFIYPSLIYIISLHQEERLTWPKLIFHVFIIILGVANLIVQFFM"
     exon            304..436
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            437..558
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            559..622
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            623..716
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            717..887
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            888..947
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1142
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1250
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1357
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1471
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1620
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1710
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..2522
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2392..2397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
                     /note="hexamer: AATAAA"
     polyA_site      2413
                     /gene="SLC38A9"
                     /gene_synonym="SNAT9; URLC11"
ORIGIN      
        1 gcttcctgtt tggactagga gccccgcggt cgcaaattgc gagaatttgg gaagggaatc
       61 tttatcttct cgtctagttc tccgaggttg aaggctcggc ctgctcagag aaggaaactg
      121 aggtccaccg agttggagaa acctactcaa caccaggact aacttcttca gtgcttagag
      181 tgtgagaaaa atggcaaata tgaatagtga ttctaggcat cttggcacct ctgaggtaga
      241 tcatgaaaga gatcctggac ctatgaatat ccagtttgag ccatcggatc taagatccaa
      301 aaggcctttc tgtatagagc ccacaaacat cgtgaatgtg aatcatgtca ttcagagggt
      361 tagtgaccat gcctctgcca tgaacaagag aattcattac tacagccggc tcaccactcc
      421 tgcagacaag gcactgattg ccccagacca tgtagttcca gctccagaag agtgctatgt
      481 gtatagtcca ttgggctctg cttataaact tcaaagttac actgaaggat acggtaaaaa
      541 caccagttta gtaaccattt ttatgatttg gaataccatg atgggaacat ctatactaag
      601 cattccttgg ggcataaaac aggctggatt tactactgga atgtgtgtca tcatactgat
      661 gggcctttta acactttatt gctgctacag agtagtgaaa tcacggacta tgatgttttc
      721 gttggatacc actagctggg aatatccaga tgtctgcaga cattatttcg gctcctttgg
      781 gcagtggtcg agtctccttt tctccttggt gtctctcatt ggagcaatga tagtttattg
      841 ggtgcttatg tcaaattttc tttttaatac tggaaagttt atttttaatt ttattcatca
      901 cattaatgac acagacacta tactgagtac caataatagc aaccctgtga tttgtccaag
      961 tgccgggagt ggaggccatc ctgacaacag ctctatgatt ttctatgcca atgacacagg
     1021 agcccaacag tttgaaaagt ggtgggataa gtccaggaca gtcccctttt atcttgtagg
     1081 gctcctcctc ccactgctca atttcaagtc tccttcattt ttttcaaaat ttaatatcct
     1141 aggcacagtg tctgtccttt atttgatttt ccttgtcacc tttaaggctg ttcgcttggg
     1201 atttcatttg gaatttcatt ggtttatacc aacagaattt tttgtaccag agataagatt
     1261 tcagtttcca cagctgactg gagtgcttac ccttgctttt tttattcata attgtatcat
     1321 cacactcttg aagaacaaca agaaacaaga aaacaatgtg agggacttgt gcattgctta
     1381 tatgctggtg acattaactt atctctatat tggagtcctg gtttttgctt catttccttc
     1441 accaccatta tccaaagatt gtattgagca gaatttttta gacaacttcc ctagcagtga
     1501 caccctgtcc ttcattgcaa ggatattcct gctgttccag atgatgactg tatacccact
     1561 cttaggctac ctggctcgtg tccagctttt gggccatatc ttcggtgaca tttatcctag
     1621 cattttccat gtgctgattc ttaatctaat tattgtggga gctggagtga tcatggcctg
     1681 tttctaccca aacataggag ggatcataag atattcagga gcagcatgtg gactggcctt
     1741 tgtattcata tacccatctc tcatctatat aatttccctc caccaagaag agcgtctgac
     1801 atggcctaaa ttaatcttcc acgttttcat catcattttg ggcgtggcta acctgattgt
     1861 tcagtttttt atgtgaaata cctcaactgt ttttttcaag agctctcatg atattttgag
     1921 ccttgacaac agttctatat aaattcactt gtaaatgctg ctgttgtgta attctaaata
     1981 ttttctaaga taatttgaaa gcaagggaaa tagtggcccc ttaatgagta tttttttatt
     2041 ggggtgggga aaggggcaaa aagaatgatc ttagtgtctt tacctttctc atattaactc
     2101 acctctttat tctgtggtct tttctgaata gaaatgtatg ccctaggaag aaatcatgct
     2161 gggttttgct tttagagata aaaggtggtg gatttatttt gcctgcagta aagattctca
     2221 gggtgtcaga gcagcatatt gtcaaatcct gcttctgttt tatgtttcag tgtattcact
     2281 ttcattttct tacttactag accatttctg cagtttgccc aaacctctac tgtttgggac
     2341 agtaagccaa atacctcatt tttaaaaaga agttttcatg gcatcagtgt taataaagta
     2401 catttttaac tgagtcttaa tctctatttg aagaaaaagt agagacaaaa gtaatgtcaa
     2461 tgtaatcccc aggatcatga aatgtataca aaataaataa agtaggagag tttgttgctg
     2521 tc
//
