LOCUS       NM_018231               4058 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 38 member 7 (SLC38A7),
            transcript variant 1, mRNA.
ACCESSION   NM_018231
VERSION     NM_018231.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Meng,D., Yang,Q., Jeong,M.H., Curukovic,A., Tiwary,S., Melick,C.H.,
            Lama-Sherpa,T.D., Wang,H., Huerta-Rosario,M., Urquhart,G.,
            Zacharias,L.G., Lewis,C., DeBerardinis,R.J. and Jewell,J.L.
  TITLE     SNAT7 regulates mTORC1 via macropinocytosis
  JOURNAL   Proc Natl Acad Sci U S A 119 (20), e2123261119 (2022)
   PUBMED   35561222
  REMARK    GeneRIF: SNAT7 regulates mTORC1 via macropinocytosis.
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Haratake,N., Hu,Q., Okamoto,T., Jogo,T., Toyokawa,G., Kinoshita,F.,
            Takenaka,T., Tagawa,T., Iseda,N., Itoh,S., Yamada,Y., Oda,Y.,
            Shimokawa,M., Kikutake,C., Suyama,M., Unoki,M., Sasaki,H. and
            Mori,M.
  TITLE     Identification of SLC38A7 as a Prognostic Marker and Potential
            Therapeutic Target of Lung Squamous Cell Carcinoma
  JOURNAL   Ann Surg 274 (3), 500-507 (2021)
   PUBMED   34171866
  REMARK    GeneRIF: Identification of SLC38A7 as a Prognostic Marker and
            Potential Therapeutic Target of Lung Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 4058)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4058)
  AUTHORS   Dudenkov,T.M., Liu,D., Cairns,J., Devarajan,S., Zhuang,Y.,
            Ingle,J.N., Buzdar,A.U., Robson,M.E., Kubo,M., Batzler,A.,
            Barman,P., Jenkins,G.D., Carlson,E.E., Goetz,M.P., Northfelt,D.W.,
            Moreno-Aspitia,A., Desta,Z., Reid,J.M., Kalari,K.R., Wang,L. and
            Weinshilboum,R.M.
  TITLE     Anastrozole Aromatase Inhibitor Plasma Drug Concentration
            Genome-Wide Association Study: Functional Epistatic Interaction
            Between SLC38A7 and ALPPL2
  JOURNAL   Clin Pharmacol Ther 106 (1), 219-227 (2019)
   PUBMED   30648747
  REMARK    GeneRIF: GWAS identified a novel gene encoding an anastrozole
            transporter, SLC38A7, as well as epistatic interaction between SNPs
            in that gene and SNPs near ALPPL2 that influenced both the
            expression of the transporter and anastrozole plasma concentrations
REFERENCE   5  (bases 1 to 4058)
  AUTHORS   Verdon,Q., Boonen,M., Ribes,C., Jadot,M., Gasnier,B. and Sagne,C.
  TITLE     SNAT7 is the primary lysosomal glutamine exporter required for
            extracellular protein-dependent growth of cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 114 (18), E3602-E3611 (2017)
   PUBMED   28416685
  REMARK    GeneRIF: Cell fractionation confirmed the lysosomal localization of
            SNAT7, and flux measurements confirmed its substrate selectivity
            and showed a strong activation by the lysosomal pH gradient.
            Interestingly, gene silencing or editing experiments revealed that
            SNAT7 is the primary permeation pathway for glutamine across the
            lysosomal membrane and it is required for growth of cancer cells in
            a low free-glutamine environment.
REFERENCE   6  (bases 1 to 4058)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   7  (bases 1 to 4058)
  AUTHORS   Schioth,H.B., Roshanbin,S., Hagglund,M.G. and Fredriksson,R.
  TITLE     Evolutionary origin of amino acid transporter families SLC32, SLC36
            and SLC38 and physiological, pathological and therapeutic aspects
  JOURNAL   Mol Aspects Med 34 (2-3), 571-585 (2013)
   PUBMED   23506890
  REMARK    Review article
REFERENCE   8  (bases 1 to 4058)
  AUTHORS   Hagglund,M.G., Sreedharan,S., Nilsson,V.C., Shaik,J.H.,
            Almkvist,I.M., Backlin,S., Wrange,O. and Fredriksson,R.
  TITLE     Identification of SLC38A7 (SNAT7) protein as a glutamine
            transporter expressed in neurons
  JOURNAL   J Biol Chem 286 (23), 20500-20511 (2011)
   PUBMED   21511949
REFERENCE   9  (bases 1 to 4058)
  AUTHORS   Newton-Cheh,C., Eijgelsheim,M., Rice,K.M., de Bakker,P.I., Yin,X.,
            Estrada,K., Bis,J.C., Marciante,K., Rivadeneira,F.,
            Noseworthy,P.A., Sotoodehnia,N., Smith,N.L., Rotter,J.I.,
            Kors,J.A., Witteman,J.C., Hofman,A., Heckbert,S.R., O'Donnell,C.J.,
            Uitterlinden,A.G., Psaty,B.M., Lumley,T., Larson,M.G. and
            Stricker,B.H.
  TITLE     Common variants at ten loci influence QT interval duration in the
            QTGEN Study
  JOURNAL   Nat Genet 41 (4), 399-406 (2009)
   PUBMED   19305408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001677.1 and AC010287.9.
            
            On Nov 23, 2018 this sequence version replaced NM_018231.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001677.1, SRR1803614.8376.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219320.9/ ENSP00000219320.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2243              AK001677.1         1-2243
            2244-4058           AC010287.9         159754-161568       c
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..4058
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /note="solute carrier family 38 member 7"
                     /db_xref="GeneID:55238"
                     /db_xref="HGNC:HGNC:25582"
                     /db_xref="MIM:614236"
     exon            1..54
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            55..278
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            279..663
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..1782
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /note="isoform 1 is encoded by transcript variant 1; amino
                     acid transporter; putative sodium-coupled neutral amino
                     acid transporter 7; Sodium-coupled neutral amino acid
                     transporter 7"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 7
                     isoform 1"
                     /protein_id="NP_060701.1"
                     /db_xref="CCDS:CCDS10800.1"
                     /db_xref="GeneID:55238"
                     /db_xref="HGNC:HGNC:25582"
                     /db_xref="MIM:614236"
                     /translation="MAQVSINNDYSEWDLSTDAGERARLLQSPCVDTAPKSEWEASPG
                     GLDRGTTSTLGAIFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVI
                     LAYCSQASNERTYQEVVWAVCGKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAV
                     MAKEPEGASGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYASFLSVVGTWYVTAIV
                     IIKYIWPDKEMTPGNILTRPASWMAVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTW
                     GGVVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLT
                     SYPILHFCGRAVVEGLWLRYQGVPVEEDVGRERRRRVLQTLVWFLLTLLLALFIPDIG
                     KVISVIGGLAACFIFVFPGLCLIQAKLSEMEEVKPASWWVLVSYGVLLVTLGAFIFGQ
                     TTANAIFVDLLA"
     exon            664..862
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1004
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1103
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1161
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1276
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1424
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1624
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1679
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..4058
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4035..4040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /note="hexamer: AATAAA"
     polyA_site      4058
                     /gene="SLC38A7"
                     /gene_synonym="SNAT7"
                     /note="major polyA site"
ORIGIN      
        1 atgtgatgca tgctcacgtg tctccgcagc cggctcggga aagaatcccc caagctccat
       61 ttcatgagta agcgtgagag ccgctcagtt tcctccagct ctgctgaagc cagcacagaa
      121 gtagcccaaa ctcttccctc tgctgacagc aaattttagg caaagtcttg agaaagaaga
      181 aattgggtcc agaaagggaa gtgaggagaa tcagatccca gacctttggg gagaaggagc
      241 aaccgcctct ggcacagccc atcagggaga aagagcaggt tgagaagagt cctaagctaa
      301 cagccccaaa caggtgggtg ttgctcagct ccctgaggca tgtggttgta aggcagaacc
      361 cacagacctt gcaggaagaa ggctctcggg gccatggccc aggtcagcat caacaatgac
      421 tacagcgagt gggacttgag cacggatgcc ggggagcggg ctcggctgct gcagagtccc
      481 tgtgtggaca cagcccccaa gagtgagtgg gaagcctctc ctgggggtct ggacagaggc
      541 accacttcca cacttggggc catcttcatc gtcgtcaacg cgtgcctggg tgcagggtta
      601 ctcaacttcc cagcagcctt cagcactgcg gggggcgtgg cagcaggcat cgcactgcag
      661 atgggtatgc tggttttcat catcagtggc cttgtcatcc tggcctactg ctcccaggcc
      721 agcaatgaga ggacctacca ggaggtggta tgggctgtgt gtggcaagct gacaggtgtg
      781 ctatgtgagg tggccatcgc tgtctacacc tttggcacct gcattgcctt cctaatcatc
      841 attggcgacc agcaggacaa gattatagct gtgatggcga aagagccgga gggggccagc
      901 ggcccttggt acacagaccg caagttcacc atcagcctca ctgccttcct cttcatcctg
      961 cccctctcca tccccaggga gattggtttc cagaaatatg ccagcttcct gagcgtcgtg
     1021 ggtacctggt acgtcacagc catcgttatc atcaagtaca tctggccaga taaagagatg
     1081 accccaggga acatcctgac caggccggct tcctggatgg ctgtgttcaa tgccatgccc
     1141 accatctgct tcggatttca gtgccacgtc agcagtgtgc ccgtcttcaa cagcatgcag
     1201 cagcctgaag tgaagacctg gggtggagtg gtgacagctg ccatggtcat agccctcgct
     1261 gtctacatgg ggacaggcat ctgtggcttc ctgacctttg gagctgctgt ggatcctgac
     1321 gtgctcctgt cctatccctc ggaggacatg gccgtggccg ttgcccgagc cttcatcatc
     1381 ctgagcgtgc tcacctccta ccctatcctg cacttctgtg ggcgggcggt ggtggaaggc
     1441 ctgtggctgc gctaccaggg ggtgccagtg gaggaggacg tggggcggga gcggcggcgg
     1501 cgagtgctgc agacgctggt ctggttcctg ctcaccctgc tgctggcgct cttcatccct
     1561 gacatcggca aggtgatctc agtcattgga ggcctggccg cctgcttcat cttcgtcttc
     1621 ccagggctgt gcctcattca agccaaactc tctgagatgg aagaggtcaa accagccagc
     1681 tggtgggtgc tggtcagcta cggagtcctc ttggtcaccc tgggagcctt catcttcggc
     1741 cagaccacag ccaacgccat ctttgtggat ctcttggcat aaccactgcc tcccagggaa
     1801 cacaaggcct ttgccattgg tcgcaggaac ccatctctta gagctatggg gccattctta
     1861 gtccacgatc attccaactg gtgggatgac atccggacat cctcttccag ggactggggc
     1921 aaactcaggc cccacacctc tggacagctc aaatccagtc cccttcctgc tccccagtcc
     1981 tggcagtgcc gtggatggcg gcaggaagtc tcacatcata gaggacccct cctcctctcc
     2041 cagttctcaa cttctccatg cctggaatcc acgggtgaag agagtcggta gatctcataa
     2101 gaaagaatcc agtctgactt ccctctggag aatgactatg gacagaaggc caccatcctc
     2161 cacagagcac cctgtcctga gtaggggttg tgctcattac cccaggccag tggtagcttc
     2221 ctcaggagcc tggccacttc caacggtagc actgaagtca tgcaaatgca tagtcaggta
     2281 gattcagacc ttgtccacac cttcctgggc aacccccacc atgaacctgt cagcctcttt
     2341 cccatagcta atagacattt cccaggcctt gaggggcccc accctgtctc tttcatcaaa
     2401 cctgatggtc caggctgggc atccctctcc tcctccatcc ccagacatca ccaggtctaa
     2461 tgtttacaaa cggtgccagc ccggctctga agccaagggc cgtcccgtgc cacggtgctg
     2521 tgagtattcc tccgttagct ttccccataa ggttgggagt atctgctttt gtgtctgaga
     2581 tgggcccctc ttttcagagg ccgcagggtg ggtgatggag aaggctgaga acctttcaga
     2641 ccctctgtgt gggctgggct ggtcagaatc agggtgtacc tccccgacac cttctttttc
     2701 agtgatgttt tctcttcttc ctgcctttcc tctgcctcct cccctgccag ccctagcgtg
     2761 actacccaga gacaaaaaaa aaaaaaaaaa aaaaaggcag ggctgggcgc agtggctcac
     2821 gcctgtaatc ccagcacttt gggaggccaa ggcgggcaga tgacttgagg tcaggagttc
     2881 gagaccagcc tggccaacac ggcaaaaccc catctctact aaaaatacaa aaaattaacc
     2941 gggcatggtg gcgggcacct gtaatcccag ctacttggga ggctgaggca gcagagccgc
     3001 ttaaacccag gaggcagaga ctgcaatgag ctgagatcgt gccattgcac tccagcttgg
     3061 gcaacaagag tgaaacttca tctcaaaaaa acagaaacaa acaaaaaggc agctgggttg
     3121 tcactgatgg gcagcatttg agcctgccac actggcctgg aagtttccct tccagtctgg
     3181 attttgtctg ctccttcctt ccccctcacc ccgttacctc ttcacctccc atctcacttc
     3241 actgtgtagc tcagtctctc ccacgcacat aattggggac agtgggggct ctcttaccag
     3301 cctcctcagc aacgcacgtc catcaggcct ggcctcagtg gccagccaca ttgatgtcac
     3361 actggaattg ttaccccaga gagggcgaag agataggcta tctccccacc tcccacccta
     3421 ctccccacta tattcccgtt ttgaccacct cagcccctca gctgccccct ctcactttgg
     3481 ccaatcccag gcaccaatca gacttcctcc tccacctgga gcccctagca tttccttgtc
     3541 ccctcttccc caaaacctct gtaaagggta cgagagggac cccctgccga gccgcccgcc
     3601 actcagggca gtccgatcta agaagcagaa gctggttgga ggctggctgg gcctctgtcc
     3661 agtccccaga tggataaact gccttttctc acatcccctc ttggtgcctg atcttctctg
     3721 cccccggggc cagacccact gtgctgtttt ctgtcagtct gtggcacagc accaagctct
     3781 gccagcacca gtccctgaca gggctaggag gacagcctgg tcagcagggc tgcagtcccc
     3841 cagtgccgtg tttcgggggt caagggatgt aagtggagtc attgcacaga gacagaccag
     3901 tcaggagaag gagctggaat ctggcctctt gtcctaacct caggagcccc ctcccatcct
     3961 ctccccaccc tccctatcgg ggtacttcac tgtttctttt ctacttgtgt atactcgaga
     4021 aagggaagat ggttaataaa agggatttgt gctgctga
//
