LOCUS       NM_153811               1605 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 38 member 6 (SLC38A6),
            transcript variant 2, mRNA.
ACCESSION   NM_153811
VERSION     NM_153811.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Fekete,J.T. and Gyorffy,B.
  TITLE     New Transcriptomic Biomarkers of 5-Fluorouracil Resistance
  JOURNAL   Int J Mol Sci 24 (2), 1508 (2023)
   PUBMED   36675023
  REMARK    GeneRIF: New Transcriptomic Biomarkers of 5-Fluorouracil
            Resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Huang,L., Li,L., Cheng,B. and Xing,T.
  TITLE     SLC38A6, regulated by EP300-mediated modifications of H3K27ac,
            promotes cell proliferation, glutamine metabolism and mitochondrial
            respiration in hepatocellular carcinoma
  JOURNAL   Carcinogenesis 43 (9), 885-894 (2022)
   PUBMED   35901507
  REMARK    GeneRIF: SLC38A6, regulated by EP300-mediated modifications of
            H3K27ac, promotes cell proliferation, glutamine metabolism and
            mitochondrial respiration in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Bagchi,S., Baomar,H.A., Al-Walai,S., Al-Sadi,S. and Fredriksson,R.
  TITLE     Histological analysis of SLC38A6 (SNAT6) expression in mouse brain
            shows selective expression in excitatory neurons with high
            expression in the synapses
  JOURNAL   PLoS One 9 (4), e95438 (2014)
   PUBMED   24752331
  REMARK    GeneRIF: SLC38A6 is primarily expressed in excitatory neurons and
            is not expressed in the astrocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Schioth,H.B., Roshanbin,S., Hagglund,M.G. and Fredriksson,R.
  TITLE     Evolutionary origin of amino acid transporter families SLC32, SLC36
            and SLC38 and physiological, pathological and therapeutic aspects
  JOURNAL   Mol Aspects Med 34 (2-3), 571-585 (2013)
   PUBMED   23506890
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648332.1, BC110378.1 and AL160234.3.
            
            On Feb 27, 2020 this sequence version replaced NM_153811.2.
            
            Transcript Variant: This variant (2) uses a distinct splice pattern
            in the 3' coding region and 3' UTR, compared to variant 1. The
            resulting isoform (2) has a shorter and distinct C-terminus,
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110378.1, AF543422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267488.9/ ENSP00000267488.4
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1393              BX648332.1         6-1398
            1394-1520           BC110378.1         1386-1512
            1521-1605           AL160234.3         121605-121689       c
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.1"
     gene            1..1605
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="solute carrier family 38 member 6"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
     exon            1..138
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1404
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="isoform 2 is encoded by transcript variant 2; N
                     system amino acid transporter NAT-1; probable
                     sodium-coupled neutral amino acid transporter 6; N-system
                     amino acid transporter 1; Na(+)-coupled neutral amino acid
                     transporter 6; Sodium-coupled neutral amino acid
                     transporter 6; amino acid transporter SLC38A6"
                     /codon_start=1
                     /product="solute carrier family 38 member 6 isoform 2"
                     /protein_id="NP_722518.2"
                     /db_xref="CCDS:CCDS9751.1"
                     /db_xref="GeneID:145389"
                     /db_xref="HGNC:HGNC:19863"
                     /db_xref="MIM:616518"
                     /translation="MEASWGSFNAERGWYVSVQQPEEAEAEELSPLLSNELHRQRSPG
                     VSFGLSVFNLMNAIMGSGILGLAYVLANTGVFGFSFLLLTVALLASYSVHLLLSMCIQ
                     TAVTSYEDLGLFAFGLPGKLVVAGTIIIQNIGAMSSYLLIIKTELPAAIAEFLTGDYS
                     RYWYLDGQTLLIIICVGIVFPLALLPKIGFLGYTSSLSFFFMMFFALVVIIKKWSIPC
                     PLTLNYVEKGFQISNVTDDCKPKLFHFSKESAYALPTMAFSFLCHTSILPIYCELQSP
                     SKKRMQNVTNTAIALSFLIYFISALFGYLTFYDKVESELLKGYSKYLSHDVVVMTVKL
                     CILFAVLLTVPLIHFPARKAVTMMFFSNFPFSWIRHFLITLALNIIIVLLAIYVPDIR
                     NVFGVVGASTSTCLIFIFPGLFYLKLSREDFLSWKKLGAFVLLIFGILVGNFSLALII
                     FDWINK"
     exon            139..269
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            270..343
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            344..396
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            397..436
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            437..515
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            516..598
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            599..657
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            658..723
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            724..777
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            778..857
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            858..958
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1083
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1228
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1323
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1605
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="hexamer: AATAAA"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="hexamer: AAGAAA"
     polyA_site      1420
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="major polyA site"
     polyA_site      1440
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="major polyA site"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="hexamer: AATAAA"
     polyA_site      1520
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="major polyA site"
     regulatory      1583..1588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="hexamer: AACAAA"
     polyA_site      1605
                     /gene="SLC38A6"
                     /gene_synonym="NAT-1; SNAT6"
                     /note="major polyA site"
ORIGIN      
        1 gtagatggaa ctggtagtca gctggagagc agcatggagg cgtcctgggg gagcttcaac
       61 gctgagcggg gctggtatgt ctctgtccag cagcctgaag aagcggaggc cgaagagttg
      121 agtccgttgc taagcaacga acttcacaga cagcgatccc caggtgtttc atttggttta
      181 tcagtgttta atttgatgaa tgccatcatg ggaagtggca tccttggctt agcttatgtt
      241 ttggctaata ccggtgtctt tggatttagc ttcttgctgc tgacagttgc tctcctggct
      301 tcttactcag tccatcttct gcttagtatg tgtattcaga cagctgtaac atcttatgaa
      361 gatcttggac tctttgcatt tggattacct ggaaagttgg tggtggcagg caccataata
      421 attcagaata ttggagctat gtcatcttat cttttaatta ttaaaacaga gcttcctgct
      481 gctattgcag aatttttgac tggagactat agtagatatt ggtatcttga tggacaaaca
      541 ctactaataa tcatatgtgt tggcattgtg ttccctcttg cacttcttcc caaaataggc
      601 tttcttggct acacaagtag tttatcattt ttctttatga tgttctttgc tcttgtggta
      661 ataattaaaa aatggtccat cccttgtcct ctgacattaa attatgtaga gaaaggtttc
      721 cagatttcaa atgttacaga tgattgtaag ccaaagctct ttcatttctc caaagagagt
      781 gcttatgcct taccaaccat ggctttttca tttctctgcc atacctcaat attgcccata
      841 tactgtgaac ttcaaagtcc ttcaaagaaa agaatgcaga atgttaccaa tacagcaatt
      901 gctttaagtt ttctcattta ttttatatct gcactctttg ggtacctcac tttttatgac
      961 aaagtggagt cagaattact aaaaggttat agtaaatact tatcacatga tgttgttgtc
     1021 atgactgtga agttatgcat actatttgct gtgcttttga cagtccctct aatccacttc
     1081 cctgccagaa aagctgtaac aatgatgttt ttctccaatt ttccattctc atggattcgc
     1141 cattttttga tcactctagc actcaatatt atcatcgttt tacttgcaat atatgttcct
     1201 gacattagaa atgtatttgg tgtagttggt gccagtacat caacatgttt gatttttata
     1261 ttcccaggac tattttatct taaacttagc agagaggatt ttctgtcatg gaaaaagctt
     1321 ggggcattcg ttttgctcat ctttggaatt ttggttggga attttagttt agcactcatc
     1381 atttttgatt ggattaataa ataaaagaaa tattttccta cttcttacaa gaataatata
     1441 cccctagttg caagaatgaa ttattccgga agacaccctg gatgaaaaat aacattttaa
     1501 taaaaattat taacagaaaa gcagaacaaa atggcagtgg gtatggggaa gtaagagtgt
     1561 ggcagtttta atcaaaaaaa gaaacaaact cgaaatgctc ttaaa
//
