LOCUS       NM_033518               1990 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 38 member 5 (SLC38A5), mRNA.
ACCESSION   NM_033518
VERSION     NM_033518.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1990)
  AUTHORS   Kim,M.J., Kim,H.S., Kang,H.W., Lee,D.E., Hong,W.C., Kim,J.H.,
            Kim,M., Cheong,J.H., Kim,H.J. and Park,J.S.
  TITLE     SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine Resistance in
            Pancreatic Cancer
  JOURNAL   Cells 12 (20), 2509 (2023)
   PUBMED   37887353
  REMARK    GeneRIF: SLC38A5 Modulates Ferroptosis to Overcome Gemcitabine
            Resistance in Pancreatic Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1990)
  AUTHORS   Sniegowski,T., Rajasekaran,D., Sennoune,S.R., Sunitha,S., Chen,F.,
            Fokar,M., Kshirsagar,S., Reddy,P.H., Korac,K., Mahmud Syed,M.,
            Sharker,T., Ganapathy,V. and Bhutia,Y.D.
  TITLE     Amino acid transporter SLC38A5 is a tumor promoter and a novel
            therapeutic target for pancreatic cancer
  JOURNAL   Sci Rep 13 (1), 16863 (2023)
   PUBMED   37803043
  REMARK    GeneRIF: Amino acid transporter SLC38A5 is a tumor promoter and a
            novel therapeutic target for pancreatic cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1990)
  AUTHORS   Zhu,L., Xia,X., Li,G., Zhu,C., Li,Q., Wang,B., Shi,N.X., Lei,Z.,
            Yang,S., Zhang,Z., Li,H., Tan,J., Liu,Z., Wen,Q., Zhong,H.,
            Lin,X.J., Sun,G., Bao,X., Wang,Q., Deng,L., Bin,L., Cao,G. and
            Yin,Z.
  TITLE     SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via
            potentiating lysosomal acidification
  JOURNAL   Cell Rep 42 (8), 112910 (2023)
   PUBMED   37531255
  REMARK    GeneRIF: SLC38A5 aggravates DC-mediated psoriasiform skin
            inflammation via potentiating lysosomal acidification.
REFERENCE   4  (bases 1 to 1990)
  AUTHORS   Taurino,G., Chiu,M., Bianchi,M.G., Griffini,E. and Bussolati,O.
  TITLE     The SLC38A5/SNAT5 amino acid transporter: from pathophysiology to
            pro-cancer roles in the tumor microenvironment
  JOURNAL   Am J Physiol Cell Physiol 325 (2), C550-C562 (2023)
   PUBMED   37458433
  REMARK    GeneRIF: The SLC38A5/SNAT5 amino acid transporter: from
            pathophysiology to pro-cancer roles in the tumor microenvironment.
            Review article
REFERENCE   5  (bases 1 to 1990)
  AUTHORS   Wang,Z., Yemanyi,F., Blomfield,A.K., Bora,K., Huang,S., Liu,C.H.,
            Britton,W.R., Cho,S.S., Tomita,Y., Fu,Z., Ma,J.X., Li,W.H. and
            Chen,J.
  TITLE     Amino acid transporter SLC38A5 regulates developmental and
            pathological retinal angiogenesis
  JOURNAL   Elife 11, e73105 (2022)
   PUBMED   36454214
  REMARK    GeneRIF: Amino acid transporter SLC38A5 regulates developmental and
            pathological retinal angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1990)
  AUTHORS   Desjardins,P., Du,T., Jiang,W., Peng,L. and Butterworth,R.F.
  TITLE     Pathogenesis of hepatic encephalopathy and brain edema in acute
            liver failure: role of glutamine redefined
  JOURNAL   Neurochem Int 60 (7), 690-696 (2012)
   PUBMED   22382077
  REMARK    Review article
REFERENCE   7  (bases 1 to 1990)
  AUTHORS   Sundberg,B.E., Waag,E., Jacobsson,J.A., Stephansson,O., Rumaks,J.,
            Svirskis,S., Alsio,J., Roman,E., Ebendal,T., Klusa,V. and
            Fredriksson,R.
  TITLE     The evolutionary history and tissue mapping of amino acid
            transporters belonging to solute carrier families SLC32, SLC36, and
            SLC38
  JOURNAL   J Mol Neurosci 35 (2), 179-193 (2008)
   PUBMED   18418736
REFERENCE   8  (bases 1 to 1990)
  AUTHORS   Broer,S.
  TITLE     Amino acid transport across mammalian intestinal and renal
            epithelia
  JOURNAL   Physiol Rev 88 (1), 249-286 (2008)
   PUBMED   18195088
  REMARK    Review article
REFERENCE   9  (bases 1 to 1990)
  AUTHORS   Froyen,G., Bauters,M., Boyle,J., Van Esch,H., Govaerts,K., van
            Bokhoven,H., Ropers,H.H., Moraine,C., Chelly,J., Fryns,J.P.,
            Marynen,P., Gecz,J. and Turner,G.
  TITLE     Loss of SLC38A5 and FTSJ1 at Xp11.23 in three brothers with
            non-syndromic mental retardation due to a microdeletion in an
            unstable genomic region
  JOURNAL   Hum Genet 121 (5), 539-547 (2007)
   PUBMED   17333282
  REMARK    GeneRIF: A 50kb deletion at Xp11.23 including the two genes,
            SLC38A5 and FTSJ1 was found in 3 brothers with moderate to severe
            mental retardation.
REFERENCE   10 (bases 1 to 1990)
  AUTHORS   Nakanishi,T., Sugawara,M., Huang,W., Martindale,R.G., Leibach,F.H.,
            Ganapathy,M.E., Prasad,P.D. and Ganapathy,V.
  TITLE     Structure, function, and tissue expression pattern of human SN2, a
            subtype of the amino acid transport system N
  JOURNAL   Biochem Biophys Res Commun 281 (5), 1343-1348 (2001)
   PUBMED   11243884
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF196972.1, DA089769.1,
            AF276889.1, BC027721.2 and AW183216.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_033518.3.
            
            Summary: The protein encoded by this gene is a system N
            sodium-coupled amino acid transporter. The encoded protein
            transports glutamine, asparagine, histidine, serine, alanine, and
            glycine across the cell membrane, but does not transport charged
            amino acids, imino acids, or N-alkylated amino acids. Alternative
            splicing results in multiple transcript variants, but the
            full-length nature of some of these variants has not been
            determined. [provided by RefSeq, Aug 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.362348.1,
                                           SRR3476690.813167.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620913.5/ ENSP00000481291.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AF196972.1         63623-63626         c
            5-79                DA089769.1         1-75
            80-1499             AF276889.1         741-2160
            1500-1875           BC027721.2         1037-1412
            1876-1990           AW183216.1         10-124              c
FEATURES             Location/Qualifiers
     source          1..1990
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..1990
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /note="solute carrier family 38 member 5"
                     /db_xref="GeneID:92745"
                     /db_xref="HGNC:HGNC:18070"
                     /db_xref="MIM:300649"
     exon            1..79
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            80..181
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            182..235
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1601
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /note="system N transporter 2; solute carrier family 38
                     (amino acid transporter), member 5; transport system N,
                     protein 2"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 5"
                     /protein_id="NP_277053.2"
                     /db_xref="CCDS:CCDS14293.1"
                     /db_xref="GeneID:92745"
                     /db_xref="HGNC:HGNC:18070"
                     /db_xref="MIM:300649"
                     /translation="MELQDPKMNGALPSDAVGYRQEREGFLPSRGPAPGSKPVQFMDF
                     EGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTC
                     AGIAGIRAYEQLGQRAFGPAGKVVVATVICLHNVGAMSSYLFIIKSELPLVIGTFLYM
                     DPEGDWFLKGNLLIIIVSVLIILPLALMKHLGYLGYTSGLSLTCMLFFLVSVIYKKFQ
                     LGCAIGHNETAMESEALVGLPSQGLNSSCEAQMFTVDSQMSYTVPIMAFAFVCHPEVL
                     PIYTELCRPSKRRMQAVANVSIGAMFCMYGLTATFGYLTFYSSVKAEMLHMYSQKDPL
                     ILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPGKAFSWPRHVAIALILLVLVNVLVI
                     CVPTIRDIFGVIGSTSAPSLIFILPSIFYLRIVPSEVEPFLSWPKIQALCFGVLGVLF
                     MAVSLGFMFANWATGQSRMSGH"
     exon            236..311
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            312..427
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            428..501
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            502..594
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            595..673
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            674..756
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            757..815
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            816..953
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1033
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1134
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1250
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1395
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1499
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1990
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /note="hexamer: AATAAA"
     polyA_site      1990
                     /gene="SLC38A5"
                     /gene_synonym="JM24; pp7194; SN2; SNAT5"
                     /note="major polyA site"
ORIGIN      
        1 agccacaaat gccctccctg cctccctctg ggggccccca agatctaggg tcctctcgtg
       61 cctaggctgt ctgcctgagg aaaaaaaaaa aagtaccgct ccagagcagg agcctaggca
      121 gccgagaggg tgcccgaacc tgagtctgag ttgcggccac ttcaggagct gagaggagca
      181 ggatggaact gcaggatcca aagatgaatg gagccctccc ttcggatgct gtgggctaca
      241 ggcaagaacg tgagggcttc ctgcccagtc gtggtcctgc tcctgggagc aagccggtcc
      301 agttcatgga tttcgagggg aagacatcgt ttggaatgtc agtgttcaac ctcagcaacg
      361 ccatcatggg cagcggcatc ctggggctgg cctatgccat ggcccacacg ggggtcatct
      421 tcttcctggc cctgctgctg tgcattgcgc ttctgtcgtc ctactccatc cacctcctgc
      481 tgacctgtgc tggtattgca ggcatccgag cctatgagca gctgggacag agggcattcg
      541 ggcctgcggg gaaggtagtg gtggccacag tcatctgtct gcacaatgtt ggggccatgt
      601 ccagttacct gttcatcatc aaatctgagc tccccctggt tatcggcacc ttcctgtaca
      661 tggaccccga gggggactgg ttcttgaagg gaaacctcct catcatcatc gtcagtgtgt
      721 taatcatcct gcccctcgcc ctcatgaaac acttgggcta cctggggtac accagtggtc
      781 tctctctgac ctgcatgctg tttttccttg tttcggtcat ctacaagaag ttccaacttg
      841 gctgtgctat aggccacaat gaaacagcaa tggagagtga agctctcgtg ggactcccca
      901 gccaaggact caacagcagc tgtgaggccc agatgttcac agttgactca cagatgtcct
      961 acacagtgcc cattatggct tttgcttttg tctgccaccc tgaggtgctg cccatctata
     1021 cggagctctg ccggccctcc aagcgcagga tgcaggccgt ggccaacgtg tccattgggg
     1081 ccatgttctg catgtatggg ctcacagcaa cctttggata cctcaccttc tacagcagtg
     1141 tgaaggcgga gatgctgcac atgtacagcc agaaggaccc gctcatcctc tgtgtgcgcc
     1201 tggccgtgct gctcgcggtg accctcactg tgccagtcgt gctgttccct atccgccggg
     1261 ccctgcagca gctgcttttc ccaggcaagg ccttcagctg gccacgacat gtggccatag
     1321 ctctgatcct gcttgttttg gtcaatgtcc ttgtcatctg tgtgccaacc atccgggata
     1381 tctttggagt tatcgggtcc acctcagccc ccagcctcat cttcatcctc cccagcatct
     1441 tctacctccg cattgtaccc tctgaggtgg agcctttctt atcctggccc aagatccagg
     1501 ccctgtgctt tggagtcctg ggagtcctct tcatggccgt cagtctaggc tttatgtttg
     1561 ccaactgggc cacaggccag agccgcatgt ctggacactg atcaggccct gctggcccag
     1621 gtccctgtgc gcatgcacat ggaggggtca gggccgctcc ctagggtccc tcctgcccaa
     1681 catgtggagg tggctggttc ccatgaacgt ggttgtcaga ggcgggggac agcagaggct
     1741 gcagactggc ccacttccct cctccccagg gatgccaagc ttggatcatg gccctaatcc
     1801 caaccccaac cccatgggag gaggaggagg aggaagaaga ggaggaggag gaggaggagg
     1861 aggaggagga ggaggccagg tcctggtgga gcctttgccc agcccagtcc tctctgcctc
     1921 ctcctggctg aagctgtttg tcaggattac cctcgggcta aagaggaaaa ataaagatgt
     1981 tgagctacca
//
