LOCUS       NM_018018               3983 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens solute carrier family 38 member 4 (SLC38A4),
            transcript variant 1, mRNA.
ACCESSION   NM_018018 XM_005268996
VERSION     NM_018018.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Kashiwagi,H., Sato,Y., Nashimoto,S., Imai,S., Takekuma,Y. and
            Sugawara,M.
  TITLE     Platelets Affect the Activity of Amino Acid Transporter SNAT4 in
            HuH-7 Human Hepatoma Cells
  JOURNAL   Biol Pharm Bull 47 (3), 652-659 (2024)
   PUBMED   38508745
  REMARK    GeneRIF: Platelets Affect the Activity of Amino Acid Transporter
            SNAT4 in HuH-7 Human Hepatoma Cells.
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Kadife,E., Harper,A., De Alwis,N., Chien,K., Hannan,N. and
            Brownfoot,F.C.
  TITLE     SLC38A4 Amino Acid Transporter Expression Is Significantly Lower in
            Early Preterm Intrauterine Growth Restriction Complicated Placentas
  JOURNAL   Int J Mol Sci 24 (1), 403 (2022)
   PUBMED   36613847
  REMARK    GeneRIF: SLC38A4 Amino Acid Transporter Expression Is Significantly
            Lower in Early Preterm Intrauterine Growth Restriction Complicated
            Placentas.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Li,J., Li,M.H., Wang,T.T., Liu,X.N., Zhu,X.T., Dai,Y.Z., Zhai,K.C.,
            Liu,Y.D., Lin,J.L., Ge,R.L., Sun,S.H., Wang,F. and Yuan,J.H.
  TITLE     SLC38A4 functions as a tumour suppressor in hepatocellular
            carcinoma through modulating Wnt/beta-catenin/MYC/HMGCS2 axis
  JOURNAL   Br J Cancer 125 (6), 865-876 (2021)
   PUBMED   34274945
  REMARK    GeneRIF: SLC38A4 functions as a tumour suppressor in hepatocellular
            carcinoma through modulating Wnt/beta-catenin/MYC/HMGCS2 axis.
REFERENCE   4  (bases 1 to 3983)
  AUTHORS   Fairweather,S.J., Okada,S., Gauthier-Coles,G., Javed,K., Broer,A.
            and Broer,S.
  TITLE     A GC-MS/Single-Cell Method to Evaluate Membrane Transporter
            Substrate Specificity and Signaling
  JOURNAL   Front Mol Biosci 8, 646574 (2021)
   PUBMED   33928121
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3983)
  AUTHORS   Broer,S.
  TITLE     Amino acid transport across mammalian intestinal and renal
            epithelia
  JOURNAL   Physiol Rev 88 (1), 249-286 (2008)
   PUBMED   18195088
  REMARK    Review article
REFERENCE   6  (bases 1 to 3983)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   7  (bases 1 to 3983)
  AUTHORS   Desforges,M., Lacey,H.A., Glazier,J.D., Greenwood,S.L.,
            Mynett,K.J., Speake,P.F. and Sibley,C.P.
  TITLE     SNAT4 isoform of system A amino acid transporter is expressed in
            human placenta
  JOURNAL   Am J Physiol Cell Physiol 290 (1), C305-C312 (2006)
   PUBMED   16148032
  REMARK    GeneRIF: evidence of SNAT4 mRNA and protein expression in the human
            placenta, both at the first trimester and at full term
REFERENCE   8  (bases 1 to 3983)
  AUTHORS   Mackenzie,B. and Erickson,J.D.
  TITLE     Sodium-coupled neutral amino acid (System N/A) transporters of the
            SLC38 gene family
  JOURNAL   Pflugers Arch 447 (5), 784-795 (2004)
   PUBMED   12845534
  REMARK    Review article
REFERENCE   9  (bases 1 to 3983)
  AUTHORS   Gu,S., Adan-Rice,D., Leach,R.J. and Jiang,J.X.
  TITLE     A novel human amino acid transporter, hNAT3: cDNA cloning,
            chromosomal mapping, genomic structure, expression, and functional
            characterization
  JOURNAL   Genomics 74 (3), 262-272 (2001)
   PUBMED   11414754
REFERENCE   10 (bases 1 to 3983)
  AUTHORS   Hatanaka,T., Huang,W., Ling,R., Prasad,P.D., Sugawara,M.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Evidence for the transport of neutral as well as cationic amino
            acids by ATA3, a novel and liver-specific subtype of amino acid
            transport system A
  JOURNAL   Biochim Biophys Acta 1510 (1-2), 10-17 (2001)
   PUBMED   11342143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080136.24, AC008014.5 and KF459548.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018018.4.
            
            Summary: SLC38A4 is found predominantly in liver and transports
            both cationic and neutral amino acids. The transport of cationic
            amino acids by SLC38A4 is Na(+) and pH independent, while the
            transport of neutral amino acids is Na(+) and pH dependent
            (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF305814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266579.9/ ENSP00000266579.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC080136.24        30901-30995         c
            96-287              AC080136.24        8601-8792           c
            288-518             AC008014.5         163884-164114       c
            519-609             AC008014.5         159459-159549       c
            610-725             AC008014.5         158847-158962       c
            726-799             AC008014.5         156035-156108       c
            800-892             AC008014.5         155473-155565       c
            893-974             AC008014.5         150880-150961       c
            975-1057            AC008014.5         150711-150793       c
            1058-1116           AC008014.5         150542-150600       c
            1117-1392           AC008014.5         149432-149707       c
            1393-1472           AC008014.5         149220-149299       c
            1473-1573           AC008014.5         147835-147935       c
            1574-1698           KF459548.1         106-230             c
            1699-1843           AC008014.5         140215-140359       c
            1844-1941           AC008014.5         139241-139338       c
            1942-3983           AC008014.5         135692-137733       c
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..3983
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /note="solute carrier family 38 member 4"
                     /db_xref="GeneID:55089"
                     /db_xref="HGNC:HGNC:14679"
                     /db_xref="MIM:608065"
     exon            1..95
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            96..287
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            288..518
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..2043
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /note="N amino acid transporter 3; amino acid transporter
                     system A3; amino acid transporter A3; system A amino acid
                     transporter 3; system N amino acid transporter 3;
                     Na(+)-coupled neutral amino acid transporter 4"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 4"
                     /protein_id="NP_060488.2"
                     /db_xref="CCDS:CCDS8750.1"
                     /db_xref="GeneID:55089"
                     /db_xref="HGNC:HGNC:14679"
                     /db_xref="MIM:608065"
                     /translation="MDPMELRNVNIEPDDESSSGESAPDSYIGIGNSEKAAMSSQFAN
                     EDTESQKFLTNGFLGKKKLADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMAN
                     TGIILFIIMLLAVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFVSITM
                     QNIGAMSSYLFIIKYELPEVIRAFMGLEENTGEWYLNGNYLIIFVSVGIILPLSLLKN
                     LGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPN
                     NSESSDVNFMMDYTHRNPAGLDENQAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAY
                     AIPILVFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYLTFYG
                     EVEDELLHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRPFSW
                     IRHFLIAAVLIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFR
                     SPQKVGALIFLVVGIFFMIGSMALIIIDWIYDPPNSKHH"
     exon            519..609
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            610..725
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..799
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            800..892
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            893..974
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1057
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1116
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1392
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1472
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1573
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1698
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1843
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1941
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..3983
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3961..3966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /note="hexamer: AATAAA"
     polyA_site      3983
                     /gene="SLC38A4"
                     /gene_synonym="ATA3; NAT3; PAAT; SNAT4"
                     /note="major polyA site"
ORIGIN      
        1 actggggtgt gcgcagcgcc tggagcatga gccgggtggt ggcgtgcacg gaggatcgcg
       61 ggaggctgcc gcctcgggac accccactca cacagagctg acgcaagttg gacagaagga
      121 ggtgttgggg tgaggtggtg gtgttgattg gcttgtctcg ttcactccca ctggtcttta
      181 aatcaatgtc tagatctcta aagtttcata taaatcaaag ctgttacacg ggtctgccat
      241 tccaaacaag tcaggaaagc ctgcacagga ctggataaat aattaagaac agagtgttct
      301 gaacatcaac acaaagtgga agaaccttaa gctgaaggta cagtatatta tttacactga
      361 aggggcttgt gtgtggacaa gaaagcgctg acagctcaaa tggatcccat ggaactgaga
      421 aatgtcaaca tcgaaccaga tgatgagagc agcagtggag aaagtgctcc agatagctac
      481 atcgggatag gaaattcaga aaaggcagca atgagcagtc aatttgctaa tgaagacact
      541 gaaagtcaga aattcctgac aaatggattt ttggggaaaa agaagctggc agattatgct
      601 gatgaacacc atcccggaac cacttccttt ggaatgtctt catttaacct gagtaatgcc
      661 atcatgggca gtgggatcct gggcttgtcc tatgccatgg ccaacacagg gatcatactt
      721 tttataatca tgctgcttgc tgtggcaata ttatcactgt attcagttca ccttttatta
      781 aaaacagcca aggaaggagg gtctttgatt tatgaaaaat taggagaaaa ggcatttgga
      841 tggccgggaa aaattggagc ttttgtttcc attacaatgc agaacattgg agcaatgtca
      901 agctacctct ttatcattaa atatgaacta cctgaagtaa tcagagcatt catgggactt
      961 gaagaaaata ctggagaatg gtacctcaat ggcaactacc tcatcatatt tgtgtctgtt
     1021 ggaattattc ttccactttc gctccttaaa aatttaggtt atcttggcta taccagtgga
     1081 ttttctctta cctgcatggt gttttttgtt agtgtggtga tttacaagaa attccaaata
     1141 ccctgccctc tacctgtttt ggatcacagt gttggaaatc tgtcattcaa caacacgctt
     1201 ccaatgcatg tggtaatgtt acccaacaac tctgagagtt ctgatgtgaa cttcatgatg
     1261 gattacaccc accgcaatcc tgcagggctg gatgagaacc aggccaaggg ctctcttcat
     1321 gacagtggag tagaatatga agctcatagt gatgacaagt gtgaacccaa atactttgta
     1381 ttcaactccc ggacggccta tgcaattcct atcctagtat ttgcttttgt atgccaccct
     1441 gaggtccttc ccatctacag tgaacttaaa gatcggtccc ggagaaaaat gcaaacggtg
     1501 tcaaatattt ccatcacggg gatgcttgtc atgtacctgc ttgccgccct ctttggttac
     1561 ctaaccttct atggagaagt tgaagatgaa ttacttcatg cctacagcaa agtgtataca
     1621 ttagacatcc ctcttctcat ggttcgcctg gcagtccttg tggcagtaac actaactgtg
     1681 cccattgtcc tcttcccaat tcgtacatca gtgatcacac tgttatttcc caaacgaccc
     1741 ttcagctgga tacgacattt cctgattgca gctgtgctta ttgcacttaa taatgttctg
     1801 gtcatccttg tgccaactat aaaatacatc ttcggattca taggggcttc ttctgccact
     1861 atgctgattt ttattcttcc agcagttttt tatcttaaac ttgtcaagaa agaaactttt
     1921 aggtcacccc aaaaggtcgg ggctttaatt ttccttgtgg ttggaatatt cttcatgatt
     1981 ggaagcatgg cactcattat aattgactgg atttatgatc ctccaaattc caagcatcac
     2041 taacacaagg aaaaatactt tctttttcta ttggaaatgg ttacaagtta tactccaaaa
     2101 gatatttgaa ttatcttgat tggaatgtta ttcataggaa ataacaggaa gattccaaag
     2161 acgtttacca gtaatatcac caggcacctg cagaagagga aaatcactgt ttttgtcaag
     2221 gatggttgtg tatgtgttta aaataaaacc tgtggtgcac atttctaccc aggttttgct
     2281 agagcagtgt gagatgatga aggtgtattt ttgctgcttt acgagcagaa taagggtaac
     2341 tgcatgtaac aatcatcaga tagtactctt tcccctgccg tctcctcatc ctgcaccccc
     2401 taaaaaagta ccaaacattt gcattctcag aacatcaaac aaaaatgccc tggtggcaaa
     2461 gctatcacca tttaatgtct tctctcagtc ttgcaccaaa gtctctggtc tgtttactaa
     2521 cagaggcaaa aggcatgtct taggaactgt ttctgtttct gtaaggtaca tgaatggtca
     2581 aacaccagtc tagagcatct tattgtcaac agcaaaataa tattttgccc accctgtttg
     2641 tgacattgag ttgtgacttc tatattcaat agatttttgt aaatgttaaa acatctatat
     2701 ttaaatgtta aaacactaaa tatagagagg ggctttattt caatcataga gcaacaacaa
     2761 aaataatgct tatagctaaa ctgcctgttc tagaaagcat ctgctttttc atgttattcc
     2821 taaatcctct tgtcatactt ttgtcattga acaatgctct ccctctcgtc ttccatcctc
     2881 attcagaatt tttagaagac cacaatcgtg gagatacact acccagtatt gtttgataca
     2941 tttttatttg ataaacattc agtgcaggaa actgtgattt gctatatgtt tatgtatata
     3001 atcttattct gtagtcatca gaatgttaat gtaaggtaca tttgattttt attttttaca
     3061 tgtgtagttt tctttcttca cagtcaaagc atttatatta ttgggggtgg gggcagggaa
     3121 ttaagttggt gggctcgaaa atccattcat atgtatctgt ctacaaatgt ctggggataa
     3181 tttaaatttg aaacctaagt tatatatagt ttggcaatgc tcttcttcaa tatttacaat
     3241 aataggatga tctacaagaa aataagtttc tttttgcaaa tttttatcat actaaagttg
     3301 ttcttttaat ttagcatatc taaaatagga tttagttcag tttagctcac acaggtgttt
     3361 gctgacattc attggccatt taatacagtg ttgagtggtt ctctgtaaaa gtataagtgc
     3421 taacactacg aagaaatgca cacgatcatt cttgctcact tctataacaa acttacataa
     3481 aatggattta aaaattccta ctcacagcct aaaacttctg gagttcacta cctttttttc
     3541 aaatcatagt aagatcactt gtgtatttta tattttagta aagccaatta tgaagtacaa
     3601 gtatcataca cgtacttttg agctactatt atttgaaaaa aatctgccaa atagcatctt
     3661 taggatatat ttacattttc actcatctaa aaagtataca aaaataaaaa gtggaaaaag
     3721 gtatcttctg aatgttcaag agcatcctat agtgccaaat aataaagcac catttttttc
     3781 ttcataacca ggattaaaat tcatatatac tgcagggcag acatacatat gatagcttgt
     3841 gctgattaat ttaaccccat ttgtaaacag atgaaaattt tattttctta tttcatttat
     3901 aagatggctc aatgtattgg gaggcttctt ttttattaca gaaagtgtat attggtatat
     3961 aataaatgaa cttttcaaat gac
//
