LOCUS       NM_006841               2953 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens solute carrier family 38 member 3 (SLC38A3), mRNA.
ACCESSION   NM_006841
VERSION     NM_006841.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2953)
  AUTHORS   Tan,Z., Boyapati,K., Tressler,C.M., Jenkinson,N.M. and Glunde,K.
  TITLE     Glutamine transporter SLC38A3 promotes breast cancer metastasis via
            Gsk3beta/beta-catenin/EMT pathway
  JOURNAL   Cancer Lett 586, 216653 (2024)
   PUBMED   38309615
  REMARK    GeneRIF: Glutamine transporter SLC38A3 promotes breast cancer
            metastasis via Gsk3beta/beta-catenin/EMT pathway.
REFERENCE   2  (bases 1 to 2953)
  AUTHORS   Marafi,D., Fatih,J.M., Kaiyrzhanov,R., Ferla,M.P., Gijavanekar,C.,
            Al-Maraghi,A., Liu,N., Sites,E., Alsaif,H.S., Al-Owain,M.,
            Zakkariah,M., El-Anany,E., Guliyeva,U., Guliyeva,S., Gaba,C.,
            Haseeb,A., Alhashem,A.M., Danish,E., Karageorgou,V., Beetz,C.,
            Subhi,A.A., Mullegama,S.V., Torti,E., Sebastin,M., Breilyn,M.S.,
            Duberstein,S., Abdel-Hamid,M.S., Mitani,T., Du,H., Rosenfeld,J.A.,
            Jhangiani,S.N., Coban Akdemir,Z., Gibbs,R.A., Taylor,J.C.,
            Fakhro,K.A., Hunter,J.V., Pehlivan,D., Zaki,M.S., Gleeson,J.G.,
            Maroofian,R., Houlden,H., Posey,J.E., Sutton,V.R., Alkuraya,F.S.,
            Elsea,S.H. and Lupski,J.R.
  TITLE     Biallelic variants in SLC38A3 encoding a glutamine transporter
            cause epileptic encephalopathy
  JOURNAL   Brain 145 (3), 909-924 (2022)
   PUBMED   34605855
  REMARK    GeneRIF: Biallelic variants in SLC38A3 encoding a glutamine
            transporter cause epileptic encephalopathy.
REFERENCE   3  (bases 1 to 2953)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   4  (bases 1 to 2953)
  AUTHORS   Wang,Y., Fu,L., Cui,M., Wang,Y., Xu,Y., Li,M. and Mi,J.
  TITLE     Amino acid transporter SLC38A3 promotes metastasis of non-small
            cell lung cancer cells by activating PDK1
  JOURNAL   Cancer Lett 393, 8-15 (2017)
   PUBMED   28202352
  REMARK    GeneRIF: SLC38A3 activated PDK1/AKT signaling and promoted
            metastasis of non-small cell lung cancer cells through regulating
            glutamine and histidine transport.
REFERENCE   5  (bases 1 to 2953)
  AUTHORS   Zhao,Z., Nelson,A.R., Betsholtz,C. and Zlokovic,B.V.
  TITLE     Establishment and Dysfunction of the Blood-Brain Barrier
  JOURNAL   Cell 163 (5), 1064-1078 (2015)
   PUBMED   26590417
  REMARK    Review article
REFERENCE   6  (bases 1 to 2953)
  AUTHORS   Boehmer,C., Okur,F., Setiawan,I., Broer,S. and Lang,F.
  TITLE     Properties and regulation of glutamine transporter SN1 by protein
            kinases SGK and PKB
  JOURNAL   Biochem Biophys Res Commun 306 (1), 156-162 (2003)
   PUBMED   12788082
  REMARK    GeneRIF: SN1 is a target for the ubiquitin ligase Nedd4-2, which is
            inactivated by the serum and glucocorticoid inducible kinase SGK1,
            its isoform SGK3, and protein kinase B.
REFERENCE   7  (bases 1 to 2953)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   8  (bases 1 to 2953)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   9  (bases 1 to 2953)
  AUTHORS   Fei,Y.J., Sugawara,M., Nakanishi,T., Huang,W., Wang,H.,
            Prasad,P.D., Leibach,F.H. and Ganapathy,V.
  TITLE     Primary structure, genomic organization, and functional and
            electrogenic characteristics of human system N 1, a Na+- and
            H+-coupled glutamine transporter
  JOURNAL   J Biol Chem 275 (31), 23707-23717 (2000)
   PUBMED   10823827
REFERENCE   10 (bases 1 to 2953)
  AUTHORS   Chaudhry,F.A., Reimer,R.J., Krizaj,D., Barber,D.,
            Storm-Mathisen,J., Copenhagen,D.R. and Edwards,R.H.
  TITLE     Molecular analysis of system N suggests novel physiological roles
            in nitrogen metabolism and synaptic transmission
  JOURNAL   Cell 99 (7), 769-780 (1999)
   PUBMED   10619430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP362985.1, BX537382.1, BM662099.1 and AC002077.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006841.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.25344.1, BX537382.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614032.5/ ENSP00000481301.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BP362985.1         26-26
            2-2441              BX537382.1         1-2440
            2442-2446           BM662099.1         19-23               c
            2447-2953           AC002077.1         8667-9173           c
FEATURES             Location/Qualifiers
     source          1..2953
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2953
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /note="solute carrier family 38 member 3"
                     /db_xref="GeneID:10991"
                     /db_xref="HGNC:HGNC:18044"
                     /db_xref="MIM:604437"
     exon            1..78
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            79..230
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1644
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /note="system N1 Na+ and H+-coupled glutamine transporter;
                     N-system amino acid transporter 1; system N amino acid
                     transporter 1; Na(+)-coupled neutral amino acid
                     transporter 3"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid transporter 3"
                     /protein_id="NP_006832.1"
                     /db_xref="CCDS:CCDS74940.1"
                     /db_xref="GeneID:10991"
                     /db_xref="HGNC:HGNC:18044"
                     /db_xref="MIM:604437"
                     /translation="MEAPLQTEMVELVPNGKHSEGLLPVITPMAGNQRVEDPARSCME
                     GKSFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFL
                     LTAVALLSSYSIHLLLKSSGVVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSY
                     LYIIKSELPLVIQTFLNLEEKTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSG
                     FSLSCMVFFLIAVIYKKFHVPCPLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCT
                     PSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKKKMQHISNLSIAVMYIMYF
                     LAALFGYLTFYNGVESELLHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAI
                     QQMLFPNQEFSWLRHVLIAVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAI
                     FYFRIMPTEKEPARSTPKILALCFAMLGFLLMTMSLSFIIIDWASGTSRHGGNH"
     exon            231..312
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..428
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            429..502
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            503..595
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            596..677
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..760
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..819
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            820..984
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1064
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1165
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1290
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1435
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1539
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..2953
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2422..2427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /note="hexamer: TATAAA"
     polyA_site      2441
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /note="major polyA site"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
                     /note="hexamer: AGTAAA"
     polyA_site      2953
                     /gene="SLC38A3"
                     /gene_synonym="DEE102; G17; NAT1; SN1; SNAT3"
ORIGIN      
        1 gcagccgagt tcagccggga gcagagcgaa ccgcaccggc ccgagcggag cgccgcacgt
       61 tcccaaccgc gaggccagac atctgactgt tggtgtgaga ccagtgctcc tggtggtgtg
      121 ccctgagcca tggaggcgcc tttgcagaca gagatggtgg agctggtgcc caatggcaaa
      181 cactcagagg ggctgctccc ggtcatcacc cccatggcag gcaaccagag ggtcgaggac
      241 cctgcacgga gctgtatgga gggcaagagc ttcctacaga aaagtcccag caaggagcca
      301 cacttcactg acttcgaggg gaagacatca ttcgggatgt cagtgttcaa cctcagcaat
      361 gccatcatgg gcagcggcat cctgggactc gcctatgcca tggccaatac gggcattatc
      421 cttttcctgt tcctgttgac agctgtcgcc ttgctctcca gctactccat ccacctgcta
      481 ctcaagtcct caggggtcgt gggcatccgt gcctatgagc agctgggcta ccgtgccttt
      541 gggaccccag gaaagctggc agcagccctg gccatcacgc tccagaacat cggagccatg
      601 tccagctacc tgtacatcat caagtctgag ctgccacttg tcatacagac cttcctgaac
      661 ctggaggaga aaacctcgga ctggtacatg aacgggaact acctggtaat ccttgtctct
      721 gtcaccatca ttctgcccct ggcactgatg cggcagcttg gctacctggg ctactccagc
      781 ggcttctctc ttagctgcat ggtgttcttc ctaattgcag tcatctacaa aaagttccac
      841 gtgccctgcc cactgccccc caacttcaac aacaccacag gcaacttcag ccacgtggag
      901 atcgtgaagg agaaggtgca gctgcaggtc gagcctgagg cttcagcctt ctgcactccc
      961 agctacttca cgctcaactc acagacagca tacaccatcc ccatcatggc cttcgccttc
     1021 gtctgccacc ccgaggtgct gcccatctat actgagctca aggacccctc caagaagaag
     1081 atgcagcaca tctccaacct gtccatcgct gtcatgtaca tcatgtactt cctggctgcc
     1141 ctcttcggct acctcacctt ctacaacggg gtggagtcgg agctgctgca cacctacagc
     1201 aaggtggacc cgtttgacgt cctgatcctg tgtgtgcgcg tggccgtgct gacagcagtc
     1261 acgctcacag tgcccatcgt tctgttcccg gtgcgccgcg ccatccagca gatgctgttt
     1321 ccaaaccagg agttcagctg gctgcggcat gtgcttattg ccgttggcct gctcacttgt
     1381 atcaacctgc tggtcatctt tgcccccaac atcctgggca tctttggggt catcggtgcc
     1441 acatctgccc cattcctcat cttcatcttc cctgccatct tctacttccg aatcatgccc
     1501 acggagaagg agcctgcaag atccaccccc aaaatcctgg ccctgtgttt tgctatgctt
     1561 ggcttcttgc tgatgaccat gagcttgagc ttcatcatca ttgactgggc ctcagggacc
     1621 agccggcatg gaggaaacca ctagggtgac cctcatcctg ttctgtctac tcaccctagc
     1681 agccctgccc agactcttca gcccctgctc ccatccagtg gccagtcggg ggaggagaaa
     1741 gacgcgatta acactgtggc attcagccag gccccatgtc ctctctgtgg aaggtttttg
     1801 ttcaagagcc aggaccaagg cccttgggcc actaccctgc taggctctgg agctgtagag
     1861 gcttcctgaa ctgggagcag ggtagggctg tcgccttaga tcccgcccaa gcccctcatt
     1921 ccctccttgc acagatgcat acactggggc ccagcagctg cctcctgagg tgacacagcc
     1981 tgtaggaaca tacacagctg ggatcagcct gcagccatcc cccgaccctg ctgctaggcc
     2041 acggtctgcg ccctggggcc tcatctcccc cagcccactt gttttccccc cttttattcc
     2101 ctaggccctt ttcagactcc tgggcccttg gatactcttc tcccatctcc cttcacagga
     2161 tgacaccctc ccatacccca tagctggggc cagcaggttc tgctgagggt ggggctggtg
     2221 tagggacccc caagagaccc ctgtcctgtc ccttcaccag tcctggggag gctgggactc
     2281 cccctgccac aagcctgggc cacagctcac attccactgc tgggagaaga aacaggccga
     2341 ggcccagagt ggcctgcccc cgggagccaa agaccccagt ggccacactg ggatagggtg
     2401 gggaggctgg cagccctctt ttataaatat tatacataag accagctgtg ttttctattc
     2461 ttggtctcca tggtccctgg attcctggaa agtgaggtac gggccagaac atggatggtg
     2521 atggagggcc cccgtctcct tgtctgggat gagggtgggg acagggcaag tcccccaccc
     2581 accccacccc ctgcctccca aactaaccag tggcacactc agacccagct ctgggcctgg
     2641 gccaggctca gcacagacct gctttctcac gggttgaggt ggggaggaat taatgaggcc
     2701 ccaggaagtg ggacagagag aggcctccgg aaggaggcaa cgtgaggtgc atccccagca
     2761 gcttcaggga gggtctgagc tgggggcagc tgagccctga gggagcccca ggaagggccc
     2821 cctgccctcc cctagctccc aggctgccat gtcaactctc tgtcaatgcc ctgagtctgg
     2881 ggacaaaagt ccaggaatcc tgtgccctgt tgggctgatc tttttatcaa cagtaaaatc
     2941 cactacgaat aaa
//
