LOCUS       NM_018976               4795 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens solute carrier family 38 member 2 (SLC38A2),
            transcript variant 1, mRNA.
ACCESSION   NM_018976 NM_018573
VERSION     NM_018976.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4795)
  AUTHORS   Li,W., Chen,C., Zheng,H., Lin,Y., An,M., Liu,D., Zhang,Y., Gao,M.,
            Lan,T. and He,W.
  TITLE     UBE2C-induced crosstalk between mono- and polyubiquitination of
            SNAT2 promotes lymphatic metastasis in bladder cancer
  JOURNAL   J Clin Invest 134 (13), e179122 (2024)
   PUBMED   38949026
  REMARK    GeneRIF: UBE2C-induced crosstalk between mono- and
            polyubiquitination of SNAT2 promotes lymphatic metastasis in
            bladder cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4795)
  AUTHORS   Barroso,E., Diaz,M., Reguera,A.C., Peyman,M., Balsinde,J.,
            Jurado-Aguilar,J., Zhang,M., Rostami,A., Palomer,X., Ibanez,L. and
            Vazquez-Carrera,M.
  TITLE     CHOP upregulation and dysregulation of the mature form of the SNAT2
            amino acid transporter in the placentas from small for gestational
            age newborns
  JOURNAL   Cell Commun Signal 21 (1), 326 (2023)
   PUBMED   37957724
  REMARK    GeneRIF: CHOP upregulation and dysregulation of the mature form of
            the SNAT2 amino acid transporter in the placentas from small for
            gestational age newborns.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4795)
  AUTHORS   Wan,Y., Chen,M., Li,X., Han,X., Zhong,L., Xiao,F., Liu,J.,
            Xiang,J., Jiang,J., Chen,X., Liu,J., Li,H., Li,B., Huang,H. and
            Hou,J.
  TITLE     Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic
            regulator in cytotoxic T lymphocytes in multiple myeloma
  JOURNAL   Cancer Lett 562, 216171 (2023)
   PUBMED   37054944
  REMARK    GeneRIF: Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a
            metabolic regulator in cytotoxic T lymphocytes in multiple myeloma.
REFERENCE   4  (bases 1 to 4795)
  AUTHORS   Zhu,L., Wang,Z., Han,W. and Xu,A.
  TITLE     Comprehensive analysis of the biological function and immune
            infiltration of SLC38A2 in gastric cancer
  JOURNAL   BMC Gastroenterol 23 (1), 74 (2023)
   PUBMED   36918802
  REMARK    GeneRIF: Comprehensive analysis of the biological function and
            immune infiltration of SLC38A2 in gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4795)
  AUTHORS   Li,L., Wang,N., Wang,J. and Li,J.
  TITLE     Hsa_circRNA_001859 regulates pancreatic cancer progression and
            epithelial-mesenchymal transition through the miR-21-5p/SLC38A2
            pathway
  JOURNAL   Cancer Biomark 37 (1), 39-52 (2023)
   PUBMED   37005877
  REMARK    GeneRIF: Hsa_circRNA_001859 regulates pancreatic cancer progression
            and epithelial-mesenchymal transition through the miR-21-5p/SLC38A2
            pathway.
REFERENCE   6  (bases 1 to 4795)
  AUTHORS   Franchi-Gazzola,R., Gaccioli,F., Bevilacqua,E., Visigalli,R.,
            Dall'Asta,V., Sala,R., Varoqui,H., Erickson,J.D., Gazzola,G.C. and
            Bussolati,O.
  TITLE     The synthesis of SNAT2 transporters is required for the hypertonic
            stimulation of system A transport activity
  JOURNAL   Biochim Biophys Acta 1667 (2), 157-166 (2004)
   PUBMED   15581851
  REMARK    GeneRIF: The synthesis of SNAT2 is required for the hypertonic
            stimulation of system A transport activity.
REFERENCE   7  (bases 1 to 4795)
  AUTHORS   Palii,S.S., Chen,H. and Kilberg,M.S.
  TITLE     Transcriptional control of the human sodium-coupled neutral amino
            acid transporter system A gene by amino acid availability is
            mediated by an intronic element
  JOURNAL   J Biol Chem 279 (5), 3463-3471 (2004)
   PUBMED   14623874
  REMARK    GeneRIF: SNAT2 amino acid response element, along with a nearby
            conserved CAAT box, has enhancer activity and it confers regulated
            transcription to a heterologous promoter
REFERENCE   8  (bases 1 to 4795)
  AUTHORS   Freeman,T.L., Thiele,G.M., Tuma,D.J., Machu,T.K. and Mailliard,M.E.
  TITLE     ATA2-mediated amino acid uptake following partial hepatectomy is
            regulated by redistribution to the plasma membrane
  JOURNAL   Arch Biochem Biophys 400 (2), 215-222 (2002)
   PUBMED   12054432
REFERENCE   9  (bases 1 to 4795)
  AUTHORS   Hatanaka,T., Huang,W., Wang,H., Sugawara,M., Prasad,P.D.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Primary structure, functional characteristics and tissue expression
            pattern of human ATA2, a subtype of amino acid transport system A
  JOURNAL   Biochim Biophys Acta 1467 (1), 1-6 (2000)
   PUBMED   10930503
REFERENCE   10 (bases 1 to 4795)
  AUTHORS   Sugawara,M., Nakanishi,T., Fei,Y.J., Huang,W., Ganapathy,M.E.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning of an amino acid transporter with functional
            characteristics and tissue expression pattern identical to that of
            system A
  JOURNAL   J Biol Chem 275 (22), 16473-16477 (2000)
   PUBMED   10747860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA725217.1, BC040342.1 and AC025031.30.
            
            On Nov 23, 2018 this sequence version replaced NM_018976.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF298897.1, SRR1660803.108319.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256689.10/ ENSP00000256689.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DA725217.1         90-98
            10-3891             BC040342.1         1-3882
            3892-3893           AC025031.30        61028-61029
            3894-4795           BC040342.1         3883-4784
FEATURES             Location/Qualifiers
     source          1..4795
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..4795
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /note="solute carrier family 38 member 2"
                     /db_xref="GeneID:54407"
                     /db_xref="HGNC:HGNC:13448"
                     /db_xref="MIM:605180"
     exon            1..265
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..467
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1872
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /note="isoform 1 is encoded by transcript variant 1; amino
                     acid transporter 2; sodium-coupled neutral amino acid
                     transporter 2; system A amino acid transporter 2; system N
                     amino acid transporter 2; protein 40-9-1; system A
                     transporter 1; amino acid transporter A2; sodium-coupled
                     neutral amino acid symporter 2"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid symporter 2
                     isoform 1"
                     /protein_id="NP_061849.2"
                     /db_xref="CCDS:CCDS8749.1"
                     /db_xref="GeneID:54407"
                     /db_xref="HGNC:HGNC:13448"
                     /db_xref="MIM:605180"
                     /translation="MKKAEMGRFSISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADV
                     DPENQNFLLESNLGKKKYETEFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIA
                     LFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGYKAFGLVGKLAASGSITMQNIG
                     AMSSYLFIVKYELPLVIQALTNIEDKTGLWYLNGNYLVLLVSLVVILPLSLFRNLGYL
                     GYTSGLSLLCMVFFLIVVICKKFQVPCPVEAALIINETINTTLTQPTALVPALSHNVT
                     ENDSCRPHYFIFNSQTVYAVPILIFSFVCHPAVLPIYEELKDRSRRRMMNVSKISFFA
                     MFLMYLLAALFGYLTFYEHVESELLHTYSSILGTDILLLIVRLAVLMAVTLTVPVVIF
                     PIRSSVTHLLCASKDFSWWRHSLITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLI
                     FILPSAFYIKLVKKEPMKSVQKIGALFFLLSGVLVMTGSMALIVLDWVHNAPGGGH"
     exon            468..549
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..665
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..739
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            740..832
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            833..914
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            915..997
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1056
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1224
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1304
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1405
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1530
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1675
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1773
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..4795
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4773..4778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /note="hexamer: AATAAA"
     polyA_site      4795
                     /gene="SLC38A2"
                     /gene_synonym="ATA2; PRO1068; SAT2; SNAT2"
                     /note="major polyA site"
ORIGIN      
        1 acagccgcgc gacgccgccg ccttagaacg cctttccagt actgctagca gcagcccgac
       61 cacgcgttac cgcacgctcg cgcctttccc ttgacacggc ggacgccgga ggattggggc
      121 ggcaatttgt cttttccttt tttattaaaa ttatttttcc tgcctgttgt tggatttggg
      181 gaaatttttt gtttgttttt tatgatttgt atttgactga gagaaaccca ctgaagacgt
      241 ctgcgtgaga atagagacca ccgaggccga ctcgcgggcc gctgcaccca ccgccaagga
      301 caaaaggagc ccagcgctac tagctgcacc cgattcctcc cagtgcttag catgaagaag
      361 gccgaaatgg gacgattcag tatttccccg gatgaagaca gcagcagcta cagttccaac
      421 agcgacttca actactccta ccccaccaag caagctgctc tgaaaagcca ttatgcagat
      481 gtagatcctg aaaaccagaa ctttttactt gaatcgaatt tggggaagaa gaagtatgaa
      541 acagaatttc atccaggtac tacttccttt ggaatgtcag tatttaatct gagcaatgcg
      601 attgtgggca gtggaatcct tgggctttct tatgccatgg ctaatactgg aattgctctt
      661 tttataattc tcttgacatt tgtgtcaata ttttccctgt attctgttca tctccttttg
      721 aagactgcca atgaaggagg gtctttatta tatgaacaat tgggatataa ggcatttgga
      781 ttagttggaa agcttgcagc atctggatca attacaatgc agaacattgg agctatgtca
      841 agctacctct tcatagtgaa atatgagttg cctttggtga tccaggcatt aacgaacatt
      901 gaagataaaa ctggattgtg gtatctgaac gggaactatt tggttctgtt ggtgtcattg
      961 gtggtcattc ttcctttgtc gctgtttaga aatttaggat atttgggata taccagtggc
     1021 ctttccttgt tgtgtatggt gttctttctg attgtggtca tttgcaagaa atttcaggtt
     1081 ccgtgtcctg tggaagctgc tttgataatt aacgaaacaa taaacaccac cttaacacag
     1141 ccaacagctc ttgtacctgc tttgtcacat aacgtgactg aaaatgactc ttgcagacct
     1201 cactatttta ttttcaactc acagactgtc tatgctgtgc caattctgat cttttcattt
     1261 gtctgtcatc ctgctgttct tcccatctat gaagaactga aagaccgcag ccgtagaaga
     1321 atgatgaatg tgtccaagat ttcatttttt gctatgtttc tcatgtatct gcttgccgcc
     1381 ctctttggat acctaacatt ttacgaacat gttgagtcag aattgcttca tacctactct
     1441 tctatcttgg gaactgatat tcttcttctc attgtccgtc tggctgtgtt aatggctgtg
     1501 accctgacag taccagtagt tattttccca atccggagtt ctgtaactca cttgttgtgt
     1561 gcatcaaaag atttcagttg gtggcgtcat agtctcatta cagtgtctat cttggcattt
     1621 accaatttac ttgtcatctt tgtcccaact attagggata tctttggttt tattggtgca
     1681 tctgcagctt ctatgttgat ttttattctt ccttctgcct tctatatcaa gttggtgaag
     1741 aaagaaccta tgaaatctgt acaaaagatt ggggctttgt tcttcctgtt aagtggtgta
     1801 ctggtgatga ccggaagcat ggccttgatt gttttggatt gggtacacaa tgcacctgga
     1861 ggtggccatt aattggcacc actcaaactc aaactcagtc catctgatgc cagtgttgag
     1921 taaactcaac tactatgaaa tttcacctaa tgttttcagt ttcacttcct tttgaagtgc
     1981 agattcctcg ctggttcttc tgagtgcaga ataagtgaac ttttttgttt tgttttgttt
     2041 ttttaagaaa cttatctgta tgttagaaat ggatatgaac aacaaaacca cgagtctcgg
     2101 gttaagggaa gtgacaattt tattccattc cagagaatgg acaaactctt aacttttatc
     2161 aagccacatg cttggctgtg tcattgttta acttggatat tttatgattt tacttgaatg
     2221 tgcctaatgg aaccatttga tgtgagaaac aattcttttt aatttacagc aaaatattga
     2281 ataaccattg acaaaaacac tattattttt tgtaccaaaa atacttaaag acctcagaag
     2341 cactctttta cttttaagaa attgcttttt tgaactttat tcagaagcag ttatcaataa
     2401 attccataaa ataatgtcat tggtatttaa aaatgaatat taatataatg aaatggtttg
     2461 cctttttgta ggcataataa gccaaatact tttttaccca aaataatttt tagagaaaat
     2521 gatgtaatga aaaattgtac catgaattag gagcatagtt ttttccattt aaacgtcacc
     2581 attacttaaa agatgattga ttattgctat accaaatcag atgaactctg ttcatcactt
     2641 ttcttctctg tccccaaaca atttggttca ttcagactga aatgtttgtg tcttcaactt
     2701 attagaatgg aagataatgc agatatttct gtgggaaata aaataactaa ttttgaggta
     2761 ccaaatagtg caattgggta aaacagggtt tattcagttg catctgtctc cagtgttgta
     2821 ttgacagctc tgggtctttt tttgggccag cccttttttg acattgcttc cagcagtgga
     2881 aaatgggcat ttgatggcaa taggccaaaa ttattgtgtc cagagagtac actttttcaa
     2941 aatgctcacc tactggaagt gtgaattact tgacaatgta tggcttagtt gtgttcatgt
     3001 tttgtctaca gtagaggtct aatccacagg ttacacctat gtttgatatg atataagttc
     3061 tctttgcgta ggccactggg tttctcatgc agtaagcttt ataaaaactc atttgcactg
     3121 gactgtcatc tcattcttgt acaacgtaga attacttgtt tacatccaac aaatggttag
     3181 ctagggaaaa cagtgcaaac tgagtgttag tagtcatttt ggtccaactg catgtcaacc
     3241 cttccatttc aatcccagtt agaaatgaaa ataattactt tgaaacttgg ctttaagagc
     3301 acatttatcg tacgtcacag tgtatggtga atatattatt aaataatgtg gtacttcgct
     3361 catcaggcat aatgtctaaa atctaatata cataattcca ttaagtggtt gaaggaagca
     3421 aataatggaa ttgtcaattg gtcatctggc tgtaaggttt gcccttgaac taaaaatgtt
     3481 gtttggggca agggccagaa atgtggagac atggtttttg ttacgcattc ttgtattata
     3541 tgtgactaaa tttacaaaca agatacatgt gtaattaaag acccttatgg aactggaaga
     3601 cgtcttgtag tgctacattg ggtgaaaccg ttggtccatt tttgtctgtt tctatgaaga
     3661 taaaataatt gggggccatc tagaaataga aaggcagtgg gaagacagat tctacggcac
     3721 tgctttcatt taattgggct ttaggcactc cattcgaatg cagaacctca cctctagttg
     3781 agaccaagaa ttggcaaatt tgcatgagct cctggaaaga gttgctgact ttgtatctaa
     3841 gacctgccag ggaataccaa gagttgtttc tacagacttt tttttttttt tttgtatggg
     3901 agaagatact gtggcaacca ggaaggaatg gaaaaaaaat tcttttctct acagcaaatt
     3961 aatgtgagga agctcctcca atcctctggc tatttaaggt tcaaaatcaa gtgcctaggg
     4021 aaaattccaa tggatgattt tctgggagct atcttgtcta ccttgaggtt cctgaacaat
     4081 gaattcccat taatgagcag tcttcagtat taaaaccact gtcttgtcac ctcattttgc
     4141 attactgtct tccgtggatg tttcagttac aactgtaatg ttatttatag aacaacatta
     4201 atccattaaa gctaacctat ttttcaatat ttatgataat ctatgtacat atattgtctg
     4261 tccatatgta tttgtaaata ggttgtatat aatgtcaggt ttgggtcttg ggttcaagtg
     4321 tatatattcc tgtaagtttc ttaactgcat tttgatgaat tcacattatg taactataag
     4381 aattgtccca aaagtacctg tacagaaaat tgaatattga aaaattgaca aattgtgtac
     4441 aaacactaaa aaaaacttgt ttaaattgta tttgcaataa acaacatcaa attttttcat
     4501 gaaatcttgg tacaaattca gatctcttat ttaaaattta aataaggaat acattttcaa
     4561 aatgcagtaa tcaaaatgtg atctagtgta atgaaataaa atgtgatcta gtgtaatgga
     4621 agacctttga gaacctgggt gtattaactt tgtgtatata gtgtaaatat ccccactgta
     4681 ctgttagagg ccaacaattc tagtatggct tgttggcaaa gagtgctaca ccgtttcaat
     4741 gaaacaatgt atgtttgttt taactgaact aaaataaata catgcttaat cctga
//
