LOCUS       NM_001351537            5750 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens solute carrier family 38 member 11 (SLC38A11),
            transcript variant 3, mRNA.
ACCESSION   NM_001351537 XM_005246350
VERSION     NM_001351537.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5750)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5750)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   3  (bases 1 to 5750)
  AUTHORS   Schioth,H.B., Roshanbin,S., Hagglund,M.G. and Fredriksson,R.
  TITLE     Evolutionary origin of amino acid transporter families SLC32, SLC36
            and SLC38 and physiological, pathological and therapeutic aspects
  JOURNAL   Mol Aspects Med 34 (2-3), 571-585 (2013)
   PUBMED   23506890
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC019197.7.
            
            On Mar 30, 2021 this sequence version replaced NM_001351537.1.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.910344.1,
                                           SRR14372079.1682221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685975.1/ ENSP00000508649.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-317               AC019197.7         90509-90825         c
            318-432             AC019197.7         89931-90045         c
            433-507             AC019197.7         88007-88081         c
            508-642             AC019197.7         80893-81027         c
            643-708             AC019197.7         79869-79934         c
            709-815             AC019197.7         74750-74856         c
            816-895             AC019197.7         72650-72729         c
            896-966             AC019197.7         51203-51273         c
            967-1128            AC019197.7         50412-50573         c
            1129-1241           AC019197.7         46936-47048         c
            1242-1373           AC019197.7         43940-44071         c
            1374-5750           AC019197.7         29654-34030         c
FEATURES             Location/Qualifiers
     source          1..5750
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..5750
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="solute carrier family 38 member 11"
                     /db_xref="GeneID:151258"
                     /db_xref="HGNC:HGNC:26836"
                     /db_xref="MIM:616526"
     exon            1..317
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..1667
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     putative sodium-coupled neutral amino acid transporter 11"
                     /codon_start=1
                     /product="putative sodium-coupled neutral amino acid
                     transporter 11 isoform 3"
                     /protein_id="NP_001338466.1"
                     /db_xref="CCDS:CCDS92885.1"
                     /db_xref="GeneID:151258"
                     /db_xref="HGNC:HGNC:26836"
                     /db_xref="MIM:616526"
                     /translation="MGYQRQEPVIPPQRDLDDRETLVSEHEYKEKTCQSAALFNVVNS
                     IIGSGIIGLPYSMKQAGFPLGILLLFWVSYVTDFSLVLLIKGGALSGTDTYQSLVNKT
                     FGFPGYLLLSVLQFLYPFIAMISYNIIAGDTLSKVFQRIPGVDPENVFIGRHFIIGLS
                     TVTFTLPLSLYRNIAKLGKVSLISTGLTTLILGIVMARAISLGPHIPKTEDAWVFAKP
                     NAIQAVGVMSFAFICHHNSFLVYSSLEEPTVAKWSRLIHMSIVISVFICIFFATCGYL
                     TFTGFTQGDLFENYCRNDDLVTFGRFCYGVTVILTYPMECFVTREVIANVFFGGNLSS
                     VFHIVVTVMVITVATLVSLLIDCLGIVLELNGVLCATPLIFIIPSACYLKLSEEPRTH
                     SDKIMSCVMLPIGAVVMVFGFVMAITNTQDCTHGQEMFYCFPDNFSLTNTSESHVQQT
                     TQLSTLNISIFQ"
     exon            318..432
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            433..507
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..642
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..708
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..815
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..895
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..966
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1128
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1241
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1373
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..5750
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: TATAAA"
     polyA_site      1775
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="major polyA site"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: AATAAA"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: AAGAAA"
     polyA_site      3544
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="major polyA site"
     polyA_site      3561
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: AATAAA"
     polyA_site      3657
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
     regulatory      3794..3799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: AATAAA"
     polyA_site      3833
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
     regulatory      3900..3905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
     regulatory      5728..5733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
                     /note="hexamer: AATAAA"
     polyA_site      5750
                     /gene="SLC38A11"
                     /gene_synonym="AVT2"
ORIGIN      
        1 agaaacatcc tgcagcatct ccgtctccgg aggaaaaata catttgtctg ggcgaactcc
       61 ggtggaaaag cgccccaggc tgccacagcc tagagatctt ggggctgcag ccctcgcggc
      121 ctgccgaggg agcagggggc gcccgtggaa ctggctccct gcagctctgc ggctacacgc
      181 ggacctcggc tgtgtgcgag gtggcggagg aggctggccg ggtgcgaatc cgtacccagc
      241 cccagcatct tccacctgct gaggaccacc gctcagccat gggctaccag aggcaggagc
      301 ctgtcatccc gccgcagaga gatttagatg acagagaaac ccttgtttct gaacatgagt
      361 ataaagagaa aacctgtcag tctgctgctc tttttaatgt tgtcaactcg attataggat
      421 ctggtataat aggattgcct tattcaatga agcaagctgg gtttcctttg ggaatattgc
      481 ttttattctg ggtttcatat gttacagact tttcccttgt tttattgata aaaggagggg
      541 ccctctctgg aacagatacc taccagtctt tggtcaataa aactttcggc tttccagggt
      601 atctgctcct ctctgttctt cagtttttgt atccttttat agcaatgata agttacaata
      661 taatagctgg agatactttg agcaaagttt ttcaaagaat cccaggagtt gatcctgaaa
      721 acgtgtttat tggtcgccac ttcattattg gactttccac agttaccttt actctgcctt
      781 tatccttgta ccgaaatata gcaaagcttg gaaaggtctc cctcatctct acaggtttaa
      841 caactctgat tcttggaatt gtaatggcaa gggcaatttc actgggtcca cacataccaa
      901 aaacagaaga cgcttgggta tttgcaaagc ccaatgccat tcaagcggtc ggggttatgt
      961 cttttgcatt tatttgccac cataactcct tcttagttta cagttctcta gaagaaccca
     1021 cagtagctaa gtggtcccgc cttatccata tgtccatcgt gatttctgta tttatctgta
     1081 tattctttgc tacatgtgga tacttgacat ttactggctt cacccaaggg gacttatttg
     1141 aaaattactg cagaaatgat gacctggtaa catttggaag attttgttat ggtgtcactg
     1201 tcattttgac ataccctatg gaatgctttg tgacaagaga ggtaattgcc aatgtgtttt
     1261 ttggtgggaa tctttcatcg gttttccaca ttgttgtaac agtgatggtc atcactgtag
     1321 ccacgcttgt gtcattgctg attgattgcc tcgggatagt tctagaactc aatggtgtgc
     1381 tctgtgcaac tcccctcatt tttatcattc catcagcctg ttatctgaaa ctgtctgaag
     1441 aaccaaggac acactccgat aagattatgt cttgtgtcat gcttcccatt ggtgctgtgg
     1501 tgatggtttt tggattcgtc atggctatta caaatactca agactgcacc catgggcagg
     1561 aaatgttcta ctgctttcct gacaatttct ctctcacaaa tacctcagag tctcatgttc
     1621 agcagacaac acaactttct actttaaata ttagtatctt tcaatgagtt gactgcttta
     1681 aaaatatgta tgttttcata gactttaaaa cacataacat ttacgcttgc tttagtctgt
     1741 atttatgtta tataaaatta ttattttggc ttttatcaag acttggcttt tatgagtagt
     1801 gcaatataaa agataaagaa aagaaaaatt gaatgtattt cacctttaac tggaacaaaa
     1861 taagggtttt gttctaatga ctgcactaca ctaatgctaa ttgaagaagg gagagttaag
     1921 cctttagcat tttctgccat ccccctttta tttaatatgc aaaccagtat attgtgctcc
     1981 aaaataagta ggtgattgtg ggttggaatt ttgtgtagat gtcttttggt gggggggtgt
     2041 ggggggtggg cattttcttt gtccttaaaa gtctgtggaa ctgaagagaa gggaaaccca
     2101 aaacgattga aaagaagaca tatcccaaga acaaagagga gctctccgtt ataatttcag
     2161 cagcatcctt tgtttaaagg gaaatggatc cctggagaaa tgagcaaaga cctctccatg
     2221 tgaggaatcc tgaatcatag actggctgtg aggagcaagg tgtgtaaaga atcaaaatca
     2281 cctcccatct tctgatgctg tgggaataca atggtagcac cattctaaaa cagaaaaaca
     2341 aacaaacaaa caaaaaaaac aaaaacaaaa aacagttgtt ctgtggcaag aacctaagag
     2401 attggtgata tggacctgtt ggatttttag tgctgtcagg aatgtacaac tggaagctga
     2461 actttgaaac tagaaacgtg taagaagaat cagggctaca gaagaagctt tctcagtcca
     2521 ctgggggttc ctcagagaga tttctgggag ctcttgttga ctgggtcttt gggagcagat
     2581 agtgagatgg agtttatcat aactaatggg agagagggga aagcaggatt gttagggaga
     2641 ggtagaactg cagtgcaggc tgacctcagc caaatccaca gggaagctgg tgcatacatg
     2701 acccatcaga gttgtccctg ttcaagggta atagcccagt tttgatactg ctgcctccat
     2761 cagtcattta atgtgagcat ctggagaagg atgagttctt gggctaggca gctctttgca
     2821 gcagagcaaa ccctaaagga actgagagct cgaggtggtc tactgatagc tttgtcacca
     2881 catgcttcct tacaggggta tctgggagac acagctgtgc ccaccacaga tgccctcggt
     2941 ttactgagga tttttaaatg attttttaat gaggactttg tgtctttgta tgtatgacaa
     3001 tcttcaaaaa gtaacatgaa aatctggggc catctggatg gcttccttat atcaagtatc
     3061 acctaagatt ttcatttcat ttgtattcca atcaggttgt ccatctgtgg cactatatta
     3121 attgttgcca aataacgaga aactatcaca agcagagtta atacatatat gatgagtttg
     3181 tacaaatcaa atgcaaaaag aaatcctaca ggaagtgtat aaagggtagg ttcacagtag
     3241 tttgaataaa gtggcaagag ctgagtcact gtgtgactca tagtgagaaa ggcctattga
     3301 acataaagga agatgcattt tagcaggtag aaccatgctc agggttttag tggtgattta
     3361 ttttttcaat aaaatattat ccttaccatt aaattaattt aaattctgtt gggtaacttt
     3421 tctgtattta acttataaat ttgttttttt atagttaagg gtcataggct aagcagtttg
     3481 tgcctgtttt tagattggta catgtttagg taaaatataa taaaaatgct ttcattccat
     3541 gtaagaaatg aggaaatgta agaaattttt gccacagtct gtcattacat tgctcaagac
     3601 tgagaaacac tgacctacat aattattaaa taaagtcatg agggatgaga tctctaagca
     3661 tgtacaaaga aaagtatgtc aaggataaca taatttagca cgtaaccatc tcttatcttg
     3721 tactttggtg ttgcttcata ctcttcaagt agatgaaagc tcctggtagg aactgagcgc
     3781 agcattagtg cctaataaac atgtattggt ttatttattt ttaatcagct gtagaacaag
     3841 actgcttatg acccagttat tagctgcacg gattaccgac atctttcaaa ttataattta
     3901 ataaatctta ggaactcaca tttattttgc aagaatactt gtatgcttat tttgccacca
     3961 tgcataactg caagaacccc acccctcaat ctattttctg cctcagttca ataagagatt
     4021 cccctgaaaa tctttccatc cctgccactt gttgccccta acaaagcaac ttgaaggttt
     4081 taaaccagtt tttgaagctg tcaatacact taaatgtata aagcacttct taactttaaa
     4141 aaggtggtgg taggcaagaa tcacatcttt acacacaaat gagaacatct agcaatacac
     4201 ttcctttaag gatataagtt ggatagcatc tgtgtaattt agaaattgag tcattgttca
     4261 cttattatag aatctttatt atcaaaacta acttgaacca tcttcaaaca tcagaatggg
     4321 taaactgtct atgaccatac cttcctgaac gcaccagatc tcatctgatc ttggaagcta
     4381 agtatggtct ggccttgtta gtacttggat gggagaagaa gtaaactgcc ttgcctggac
     4441 tatttccaat gatgccaaac aataattgtt gccccttgtc tttcttaaaa ggagactgca
     4501 tccatttaac caaactaaga aattttcaat tagtcctctg ctgaagtcat actatacaca
     4561 tctacttaat taaagataca tttattgaag agaacaggtc tcctcctggt ttatctgcta
     4621 tagccttgct taggaaagga ataatagtct gtcttttaat taggtgtggc tattgattgg
     4681 agcaaatgtt gtcaggtggc ccaagcatga atcaatgagt gaccatgagg tcacccatca
     4741 gtgagggtac ccatgaatgc tttactaact gtggcaagga taataatttg ctacctcaat
     4801 agaataagcg cttttaagaa tgtatgctta ttctaaaaaa tgtgtaaaga atttgccaag
     4861 atagcagagc aaatatgtag agtggaccag agatgctgtg acctagagaa cacatagacc
     4921 aggagagaaa gaaaagagcc cagtctttgt ctagggtagt ggcttttaaa cttggacatg
     4981 tgtcagaatc acctggaggc cttgttgaaa cacagattgc tgggcttcac ccccacagtt
     5041 tctgattcag tacttggagt ggggcctcag aatttctatt tctgaaaagt tcccaggtga
     5101 tgctgctgct gctggttcag ggaccacgtt tgaaaaaggc tggaagttgg acataagaaa
     5161 gtgccagatg gagccatctg tttagaggct gggacacaat acaagcaaga tgtaggaata
     5221 ccatgctaga tctcagggaa gaaaatgagg ctggagatgt aggagggaga gcaattggta
     5281 catattaaat gtgttatcct ttgcctcttt gaaaaatcat ctagagacac agtgagaaga
     5341 ggagaaacca cgacaataat attagtgaag agcaatgaca aaggacatgg gaggagaatt
     5401 aacaagggag aaaatagaga ttacaacccc aaatcaacac agttatgctg gttaagctgc
     5461 aggcctggtt ctgagcctgc cagcactcag ggaaggttac ctgagtttca tggctgccat
     5521 tgtgagaatg aagaaaatat atcagtttct caaaagaaca ccaagttttc caaggactaa
     5581 actctcagca gaatggctta cttggaaaat tacataggga acatgagtaa aactgggtta
     5641 tgaatgataa tgtcattcag ataaagaatt tacatggttg tcttttgtta agacactttt
     5701 tcattccatt aatgtttgct cattgataat aaagattatc aatacattta
//
