LOCUS       NM_001037984            4491 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 38 member 10 (SLC38A10),
            transcript variant 1, mRNA.
ACCESSION   NM_001037984
VERSION     NM_001037984.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4491)
  AUTHORS   Hashimoto,M., Yamazaki,A., Ohno,A., Kimura,T., Winblad,B. and
            Tjernberg,L.O.
  TITLE     A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's
            Disease
  JOURNAL   J Alzheimers Dis 71 (4), 1163-1174 (2019)
   PUBMED   31524172
  REMARK    GeneRIF: A Fragment of S38AA is a Novel Plasma Biomarker of
            Alzheimer's Disease.
REFERENCE   2  (bases 1 to 4491)
  AUTHORS   Hellsten,S.V., Hagglund,M.G., Eriksson,M.M. and Fredriksson,R.
  TITLE     The neuronal and astrocytic protein SLC38A10 transports glutamine,
            glutamate, and aspartate, suggesting a role in neurotransmission
  JOURNAL   FEBS Open Bio 7 (6), 730-746 (2017)
   PUBMED   28593130
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4491)
  AUTHORS   Schioth,H.B., Roshanbin,S., Hagglund,M.G. and Fredriksson,R.
  TITLE     Evolutionary origin of amino acid transporter families SLC32, SLC36
            and SLC38 and physiological, pathological and therapeutic aspects
  JOURNAL   Mol Aspects Med 34 (2-3), 571-585 (2013)
   PUBMED   23506890
  REMARK    Review article
REFERENCE   4  (bases 1 to 4491)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   5  (bases 1 to 4491)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
REFERENCE   6  (bases 1 to 4491)
  AUTHORS   Sundberg,B.E., Waag,E., Jacobsson,J.A., Stephansson,O., Rumaks,J.,
            Svirskis,S., Alsio,J., Roman,E., Ebendal,T., Klusa,V. and
            Fredriksson,R.
  TITLE     The evolutionary history and tissue mapping of amino acid
            transporters belonging to solute carrier families SLC32, SLC36, and
            SLC38
  JOURNAL   J Mol Neurosci 35 (2), 179-193 (2008)
   PUBMED   18418736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY036951.1, BQ642219.1, BC014642.1, AK128330.1, BU552914.1,
            BI194553.1, BM129331.1 and CA447446.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001037984.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2090179.1,
                                           DRR138512.182977.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374759.8/ ENSP00000363891.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                HY036951.1         34-44
            12-742              BQ642219.1         11-741
            743-2331            BC014642.1         702-2290
            2332-2687           AK128330.1         2548-2903
            2688-3274           BU552914.1         57-643
            3275-4015           BI194553.1         68-808
            4016-4486           BM129331.1         8-478               c
            4487-4491           CA447446.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..4491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..4491
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /note="solute carrier family 38 member 10"
                     /db_xref="GeneID:124565"
                     /db_xref="HGNC:HGNC:28237"
                     /db_xref="MIM:616525"
     exon            1..485
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..3746
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /note="isoform a is encoded by transcript variant 1;
                     putative sodium-coupled neutral amino acid transporter 10;
                     Sodium-coupled neutral amino acid transporter 10; amino
                     acid transporter SLC38A10"
                     /codon_start=1
                     /product="solute carrier family 38 member 10 isoform a"
                     /protein_id="NP_001033073.1"
                     /db_xref="CCDS:CCDS42397.1"
                     /db_xref="GeneID:124565"
                     /db_xref="HGNC:HGNC:28237"
                     /db_xref="MIM:616525"
                     /translation="MTAAAASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLGALLLV
                     FCSWMTHQSCMFLVKSASLSKRRTYAGLAFHAYGKAGKMLVETSMIGLMLGTCIAFYV
                     VIGDLGSNFFARLFGFQVGGTFRMFLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLF
                     YTVFMFVIVLSSLKHGLFSGQWLRRVSYVRWEGVFRCIPIFGMSFACQSQVLPTYDSL
                     DEPSVKTMSSIFASSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFPSNLVTEMLRVG
                     FMMSVAVGFPMMILPCRQALSTLLCEQQQKDGTFAAGGYMPPLRFKALTLSVVFGTMV
                     GGILIPNVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLWVGLGVLVVSTV
                     TTLSVSEEVPEDLAEEAPGGRLGEAEGLMKVEAARLSAQDPVVAVAEDGREKPKLPKE
                     REELEQAQIKGPVDVPGREDGKEAPEEAQLDRPGQGIAVPVGEAHRHEPPVPHDKVVV
                     DEGQDREVPEENKPPSRHAGGKAPGVQGQMAPPLPDSEREKQEPEQGEVGKRPGQAQA
                     LEEAGDLPEDPQKVPEADGQPAVQPAKEDLGPGDRGLHPRPQAVLSEQQNGLAVGGGE
                     KAKGGPPPGNAAGDTGQPAEDSDHGGKPPLPAEKPAPGPGLPPEPREQRDVERAGGNQ
                     AASQLEEAGRAEMLDHAVLLQVIKEQQVQQKRLLDQQEKLLAVIEEQHKEIHQQRQED
                     EEDKPRQVEVHQEPGAAVPRGQEAPEGKARETVENLPPLPLDPVLRAPGGRPAPSQDL
                     NQRSLEHSEGPVGRDPAGPPDGGPDTEPRAAQAKLRDGQKDAAPRAAGTVKELPKGPE
                     QVPVPDPAREAGGPEERLAEEFPGQSQDVTGGSQDRKKPGKEVAATGTSILKEANWLV
                     AGPGAETGDPRMKPKQVSRDLGLAADLPGGAEGAAAQPQAVLRQPELRVISDGEQGGQ
                     QGHRLDHGGHLEMRKARGGDHVPVSHEQPRGGEDAAVQEPRQRPEPELGLKRAVPGGQ
                     RPDNAKPNRDLKLQAGSDLRRRRRDLGPHAEGQLAPRDGVIIGLNPLPDVQVNDLRGA
                     LDAQLRQAAGGALQVVHSRQLRQAPGPPEES"
     exon            486..603
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            604..649
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            650..743
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            744..887
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1012
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1115
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1298
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1410
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1517
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1674
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1842
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2331
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2451
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2628
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..4491
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4279..4284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /note="hexamer: AATAAA"
     polyA_site      4302
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /note="major polyA site"
     regulatory      4466..4471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
                     /note="hexamer: AGTAAA"
     polyA_site      4491
                     /gene="SLC38A10"
                     /gene_synonym="PP1744; SNAT10"
ORIGIN      
        1 ggaagtgtga gcgccgcggc ggcagctgag ttgggctgag gtgtccctag ctggctctgc
       61 ggctcttccg ggtctgggct cggagattca caggcggccc gcgaggccga gcgagggacg
      121 catggccctg aggcggccgc agggcttggc ggggtccgga ggttgacctc gcccccgcag
      181 ccggccttcg aggctgcctc ctccaggcag cctctggggc ccgcgcccgc gcctgctcag
      241 gctcccgtgt tcaggctgcc catcccctcc ccaccggcgt cccggacgtt gggacctgtg
      301 accgtggcct cgggctgggc ttccaaagcc ggccgcagcc cggcgacccc cgaggcctct
      361 cgccccgggc ccctagacct ctcactatga ccgcggccgc cgcctccaac tgggggctga
      421 tcacgaacat cgtgaacagc atcgtagggg tcagtgtcct caccatgccc ttctgcttca
      481 aacagtgcgg catcgtcctg ggggcgctgc tcttggtctt ctgctcatgg atgacgcacc
      541 agtcgtgcat gttcttggtg aagtcggcca gcctgagcaa gcggaggacc tacgccggcc
      601 tggcattcca cgcctacggg aaggcaggca agatgctggt ggagaccagc atgatcgggc
      661 tgatgctggg cacctgcatc gccttctacg tcgtgatcgg cgacttgggg tccaacttct
      721 ttgcccggct gttcgggttt caggtgggcg gcaccttccg catgttcctg ctgttcgccg
      781 tgtcgctgtg catcgtgctc ccgctcagcc tgcagcggaa catgatggcc tccatccagt
      841 ccttcagcgc catggccctc ctcttctaca ccgtgttcat gttcgtgatc gtgctctcct
      901 ctctcaagca cggcctcttc agtgggcagt ggctgcggcg ggtcagctac gtccgctggg
      961 agggcgtctt ccgctgcatc cccatcttcg gcatgtcctt cgcctgccag tcccaggtgc
     1021 tgcccaccta cgacagcctg gatgagccgt cagtgaaaac catgagctcc atatttgctt
     1081 cctcccttaa tgtggtcacc accttctacg tcatggtggg gtttttcggc tacgtcagct
     1141 tcaccgaggc cacggccggc aacgtgctca tgcactttcc ctccaacctg gtgacggaga
     1201 tgctccgtgt gggcttcatg atgtcagtgg ctgtgggctt ccccatgatg atcctgccat
     1261 gcaggcaggc cctgagcacg ctgctgtgtg agcagcagca aaaagatggc acctttgcag
     1321 cagggggcta catgccccct ctccggttta aagcacttac cctctctgtg gtgtttggaa
     1381 ccatggttgg tggcatcctt atccccaacg tggagaccat cctgggcctc acaggagcga
     1441 ccatgggaag cctcatctgc ttcatctgcc cggcgctgat ctacaagaaa atccacaaga
     1501 acgcactttc ctcccaggtg gtgctgtggg tcggcctggg cgtcctggtg gtgagcactg
     1561 tcaccacact gtctgtgagc gaggaggtcc ccgaggactt ggcagaggaa gcccctggcg
     1621 gccggcttgg agaggccgag ggtttgatga aggtggaggc agcgcggctc tcagcccagg
     1681 atccggttgt ggccgtggct gaggatggcc gggagaagcc gaagctgccg aaggagagag
     1741 aggagctgga gcaggcccag atcaaggggc ccgtggatgt gcctggacgg gaagatggca
     1801 aggaggcacc ggaggaggca cagctcgatc gccctgggca agggattgct gtgcctgtgg
     1861 gcgaggccca ccgccacgag cctcctgttc ctcacgacaa ggtggtggta gatgaaggcc
     1921 aagaccgaga ggtgccagaa gagaacaaac ctccatccag acacgcgggc ggaaaggctc
     1981 caggggtcca gggccagatg gcgccgcctc tgcccgactc agaaagagag aaacaagagc
     2041 cggagcaggg agaggttggg aagaggcctg gacaggccca ggccttggag gaggcgggtg
     2101 atcttcctga agatccccag aaagttccag aagcagatgg tcagccagct gtccagcctg
     2161 caaaggagga cctggggcca ggagacaggg gcctgcatcc tcggccccag gcagtgctgt
     2221 ctgagcagca gaacggcctg gcggtgggtg gaggggaaaa ggccaagggg ggaccgccgc
     2281 caggcaacgc cgccggggac acagggcagc ccgcagagga cagcgaccac ggtgggaagc
     2341 ctcccctccc agcggagaag ccggctccag ggcctgggct gccgcccgag cctcgcgagc
     2401 agagggacgt ggagcgagcg ggtggaaacc aggcggccag ccagctggag gaagctggca
     2461 gggcggagat gctggaccac gccgtcctgc ttcaggtgat caaagaacag caggtgcagc
     2521 aaaagcgctt gctggaccag caggagaagc tgctggcggt gatcgaggag cagcacaagg
     2581 agatccacca gcagaggcag gaggacgagg aggataaacc caggcaggtg gaggtgcatc
     2641 aagagcccgg ggcagcggtg cccagaggcc aggaggcccc tgaaggcaag gccagggaga
     2701 cggtggagaa tctgcctccc ctgcctttgg accctgtcct cagagctcct gggggccgcc
     2761 ctgctccatc ccaggacctt aaccagcgct ccctggagca ctctgagggg cctgtgggca
     2821 gagaccctgc tggccctcct gacggcggcc ctgacacaga gcctcgggca gcccaggcca
     2881 agctgagaga tggccagaag gatgccgccc ccagggcagc tggcactgtg aaggagctcc
     2941 ccaagggccc ggagcaggtg cccgtgccag accccgccag ggaagccggg ggcccagagg
     3001 agcgcctcgc agaggaattc cctgggcaaa gtcaggacgt tactggcggt tcccaagaca
     3061 ggaaaaaacc tgggaaggag gtggcagcca ctggcaccag cattctgaag gaagccaact
     3121 ggctcgtggc agggccagga gcagagacgg gggaccctcg catgaagccc aagcaagtga
     3181 gccgagacct gggccttgca gcggacctgc ccggtggggc ggaaggagca gctgcacagc
     3241 cccaggctgt gttacgccag ccggaactgc gggtcatctc tgatggcgag cagggtggac
     3301 agcagggcca ccggctggac catggcggtc acctggagat gagaaaggcc cgcggggggg
     3361 accatgtgcc tgtgtcccac gagcagccga gaggcgggga ggacgctgct gtccaggagc
     3421 ccaggcagag gccagagcca gagctggggc tcaaacgagc tgtcccgggg ggccagaggc
     3481 cggacaatgc caagcccaac cgggacctga aactgcaggc tggctccgac ctccggaggc
     3541 gacggcggga ccttggccct catgcagagg gtcagctggc cccgagggat ggggtcatca
     3601 ttggccttaa ccccctgcct gatgtccagg tgaacgacct ccgtggcgcc ctggatgccc
     3661 agctccgcca ggctgcgggg ggagctctgc aggtggtcca cagccggcag cttagacagg
     3721 cgcctgggcc tccagaggag tcctagcacc tgctggccat gagggccacg ccagccactg
     3781 ccctcctcgg ccagcagcag gtctgtctca gccgcatccc agccaaactc tggaggtcac
     3841 actcgcctct ccccagggtt tcatgtctga ggccctcacc aagtgtgagt gacagtataa
     3901 aagattcact gtggcatcgt ttccagaatg ttcttgctgt cgttctgttg cagctcttag
     3961 tctgaggtcc tctgacctct agactctgag ctcactccag cctgtgagga gaaacggcct
     4021 ccgctgcgag ctggctggtg cactcccagg ctcaggctgg ggagctgctg cgtctgtggt
     4081 caggcctcct gctcctgcca gggagcacgc gtggtcttcg ggttgagctc ggccgtgcgt
     4141 ggaggtgcgc atggctgctc atggtcccaa cacaggctac tgtgagagcc agcatccaac
     4201 cccacgcttg cagtgactca gaatgataat tattatgact gtttatcgat gcttcccaca
     4261 gtgtggtaga aagtcttgaa taaacacttt tgccttcacc cagcctcggt ggatgctgtt
     4321 tggtgtccag gaagcacagg gagcaggggc cagacaagcc gggtgtccag gggcactggc
     4381 cggtgccgcc ctttgcactc ctcatggttg gcccagccct ccattgtctg tgtttttcaa
     4441 aatccaattg tggctttttt taaaaagtaa aaaacaccac tgataacctg a
//
