LOCUS       NM_030674               8097 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens solute carrier family 38 member 1 (SLC38A1),
            transcript variant 1, mRNA.
ACCESSION   NM_030674
VERSION     NM_030674.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8097)
  AUTHORS   Li,S., Zhang,Z., Li,Z., Yang,L., Liu,J., Liu,Y., Liu,Y., Hou,Y.,
            Mei,M. and Huang,Y.
  TITLE     CENPA promotes glutamine metabolism and tumor progression by
            up-regulating SLC38A1 in endometrial cancer
  JOURNAL   Cell Signal 117, 111110 (2024)
   PUBMED   38382691
  REMARK    GeneRIF: CENPA promotes glutamine metabolism and tumor progression
            by up-regulating SLC38A1 in endometrial cancer.
REFERENCE   2  (bases 1 to 8097)
  AUTHORS   Liu,H.T., Zhao,Y., Wang,H.C. and Liu,Q.L.
  TITLE     METTL3-mediated m6A methylation of SLC38A1 stimulates cervical
            cancer growth
  JOURNAL   Biochem Biophys Res Commun 716, 150039 (2024)
   PUBMED   38701556
  REMARK    GeneRIF: METTL3-mediated m[6]A methylation of SLC38A1 stimulates
            cervical cancer growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8097)
  AUTHORS   Yang,Y., Jia,S., Zhu,N., Xiao,X., Ma,Y., Tu,K., Guo,Y. and Xu,Q.
  TITLE     OTUD5 promotes the growth of hepatocellular carcinoma by
            deubiquitinating and stabilizing SLC38A1
  JOURNAL   Biol Direct 19 (1), 31 (2024)
   PUBMED   38658981
  REMARK    GeneRIF: OTUD5 promotes the growth of hepatocellular carcinoma by
            deubiquitinating and stabilizing SLC38A1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8097)
  AUTHORS   Cai,C., Lin,J., Li,J., Wang,X.D., Xu,L.M., Chen,D.Z. and Chen,Y.P.
  TITLE     miRNA-432 and SLC38A1 as Predictors of Hepatocellular Carcinoma
            Complicated with Alcoholic Steatohepatitis
  JOURNAL   Oxid Med Cell Longev 2022, 4832611 (2022)
   PUBMED   35663198
  REMARK    GeneRIF: miRNA-432 and SLC38A1 as Predictors of Hepatocellular
            Carcinoma Complicated with Alcoholic Steatohepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8097)
  AUTHORS   Yu,J., Chen,X., Li,J. and Wang,F.
  TITLE     CircRUNX1 functions as an oncogene in colorectal cancer by
            regulating circRUNX1/miR-485-5p/SLC38A1 axis
  JOURNAL   Eur J Clin Invest 51 (7), e13540 (2021)
   PUBMED   33769559
  REMARK    GeneRIF: CircRUNX1 functions as an oncogene in colorectal cancer by
            regulating circRUNX1/miR-485-5p/SLC38A1 axis.
REFERENCE   6  (bases 1 to 8097)
  AUTHORS   Gegelashvili,M., Rodriguez-Kern,A., Pirozhkova,I., Zhang,J.,
            Sung,L. and Gegelashvili,G.
  TITLE     High-affinity glutamate transporter GLAST/EAAT1 regulates cell
            surface expression of glutamine/neutral amino acid transporter
            ASCT2 in human fetal astrocytes
  JOURNAL   Neurochem Int 48 (6-7), 611-615 (2006)
   PUBMED   16516348
REFERENCE   7  (bases 1 to 8097)
  AUTHORS   Melone,M., Quagliano,F., Barbaresi,P., Varoqui,H., Erickson,J.D.
            and Conti,F.
  TITLE     Localization of the glutamine transporter SNAT1 in rat cerebral
            cortex and neighboring structures, with a note on its localization
            in human cortex
  JOURNAL   Cereb Cortex 14 (5), 562-574 (2004)
   PUBMED   15054072
REFERENCE   8  (bases 1 to 8097)
  AUTHORS   Gu,S., Roderick,H.L., Camacho,P. and Jiang,J.X.
  TITLE     Characterization of an N-system amino acid transporter expressed in
            retina and its involvement in glutamine transport
  JOURNAL   J Biol Chem 276 (26), 24137-24144 (2001)
   PUBMED   11325958
REFERENCE   9  (bases 1 to 8097)
  AUTHORS   Wang,H., Huang,W., Sugawara,M., Devoe,L.D., Leibach,F.H.,
            Prasad,P.D. and Ganapathy,V.
  TITLE     Cloning and functional expression of ATA1, a subtype of amino acid
            transporter A, from human placenta
  JOURNAL   Biochem Biophys Res Commun 273 (3), 1175-1179 (2000)
   PUBMED   10891391
REFERENCE   10 (bases 1 to 8097)
  AUTHORS   Salesiotis,A.N., Wang,C.K., Wang,C.D., Burger,A., Li,H. and Seth,A.
  TITLE     Identification of novel genes from stomach cancer cell lines by
            differential display
  JOURNAL   Cancer Lett 91 (1), 47-54 (1995)
   PUBMED   7750094
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB229647.1, BX648495.1, BC010620.1, AK056670.1 and AC016254.14.
            
            On May 17, 2019 this sequence version replaced NM_030674.3.
            
            Summary: Amino acid transporters play essential roles in the uptake
            of nutrients, production of energy, chemical metabolism,
            detoxification, and neurotransmitter cycling. SLC38A1 is an
            important transporter of glutamine, an intermediate in the
            detoxification of ammonia and the production of urea. Glutamine
            serves as a precursor for the synaptic transmitter, glutamate (Gu
            et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) lacks an exon in the 5' UTR,
            compared to variant 3. Variants 1, 2, 3, 4 and 5 encode the same
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.151155.1,
                                           SRR1803611.29977.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398637.10/ ENSP00000381634.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB229647.1         395-425
            32-3358             BX648495.1         2-3328
            3359-3375           BC010620.1         2948-2964
            3376-3378           BX648495.1         3346-3348
            3379-6240           AK056670.1         54-2915
            6241-8097           AC016254.14        38861-40717
FEATURES             Location/Qualifiers
     source          1..8097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.11"
     gene            1..8097
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /note="solute carrier family 38 member 1"
                     /db_xref="GeneID:81539"
                     /db_xref="HGNC:HGNC:13447"
                     /db_xref="MIM:608490"
     exon            1..518
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..633
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..848
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             727..2190
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /note="isoform 1 is encoded by transcript variant 1; amino
                     acid transporter system A1; sodium-coupled neutral amino
                     acid transporter 1; amino acid transporter A1; N-system
                     amino acid transporter 2; system A amino acid transporter
                     1; system N amino acid transporter 1; sodium-coupled
                     neutral amino acid symporter 1"
                     /codon_start=1
                     /product="sodium-coupled neutral amino acid symporter 1
                     isoform 1"
                     /protein_id="NP_109599.3"
                     /db_xref="CCDS:CCDS41774.1"
                     /db_xref="GeneID:81539"
                     /db_xref="HGNC:HGNC:13447"
                     /db_xref="MIM:608490"
                     /translation="MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFI
                     SDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGIL
                     LFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTG
                     AMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYL
                     GYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTV
                     YALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFY
                     DNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCR
                     HTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGT
                     QRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH"
     exon            849..924
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1040
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1114
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1207
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1289
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1372
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1431
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1548
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1628
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1729
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1848
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1990
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2088
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..8097
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8074..8079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /note="hexamer: ATTAAA"
     polyA_site      8097
                     /gene="SLC38A1"
                     /gene_synonym="ATA1; NAT2; SAT1; SNAT1"
                     /note="major polyA site"
ORIGIN      
        1 actgacacgc agctttggtt aaagagcggg cgcacaggag gggaggagac cgcgcgcggg
       61 acggggagga atggcctgtc cgcgttaaac catcacaagc catggttgcg gaagggccac
      121 gcgtccccca gtaggagaat gactccgatt cgtgaccctc agcgccggtg catgtcgatg
      181 taagtgcgag gccggcgagc agagtgtgag tgggggttgg tggtgagggg agattctgat
      241 gcaatcggcc cggaaaggag gagagccagg cgagcgcgga ctggggcggc cacgccactc
      301 cgccagaagg tcgccaggag cctccgccct tcaccttcct ccgaaatccg ccaggccacg
      361 ccaagctccc tgcccaaccc ttactgacgg gggccacatt ttcccggcct ccgcagccag
      421 accttgacac aaaggacatc aaactgccga gggtaaaaac cccggaaggg cggacacctc
      481 cacatcgcct tttgccacct ttccctttat ttccggagat atttattgag tgtctactgt
      541 gtgccaggca ctatatctat gtgcatagaa aaaccctgga aggccataca acaatatata
      601 tagagtgatc gtctctgctt gctgagctaa caggggtgtc aagcttccat tttggtatct
      661 acttctaaat acactcagaa caggagaaat ttggactaat tttcaaacta cagacacttt
      721 ctaatcatga tgcatttcaa aagtggactc gaattaactg agttgcaaaa catgacagtg
      781 cccgaggatg ataacattag caatgactcc aatgatttca ccgaagtaga aaatggtcag
      841 ataaatagca agtttatttc tgatcgtgaa agtagaagaa gtctcacaaa cagccatttg
      901 gaaaaaaaga agtgtgatga gtatattcca ggtacaacct ccttaggcat gtctgttttt
      961 aacctaagca acgccattat gggcagtggg attttgggac tcgcctttgc cctggcaaac
     1021 actggaatcc tactttttct ggtacttttg acttcagtga cattgctgtc tatatattca
     1081 ataaacctcc tattgatctg ttcaaaagaa acaggctgca tggtgtatga aaagctgggg
     1141 gaacaagtct ttggcaccac agggaagttc gtaatctttg gagccacctc tctacagaac
     1201 actggagcaa tgctgagcta cctcttcatc gtaaaaaatg aactaccctc tgccataaag
     1261 tttctaatgg gaaaggaaga gacattttca gcctggtacg tggatggccg cgttctggtg
     1321 gtgatagtta cctttggcat aattctccct ctgtgtctct tgaagaactt agggtatctt
     1381 ggctatacta gtggattttc cttgagctgt atggtttttt tcctaattgt ggttatttac
     1441 aagaaatttc aaattccctg cattgttcca gagctaaatt caacaataag tgctaattca
     1501 acaaatgctg acacgtgtac gccaaaatat gttaccttca attcaaagac cgtgtatgct
     1561 ttacccacca ttgcatttgc atttgtttgc cacccgtcag tcctgccaat ttacagtgag
     1621 cttaaagacc gatcacagaa aaaaatgcag atggtttcaa acatctcctt tttcgccatg
     1681 tttgttatgt acttcttgac tgccattttt ggctacttga cattctatga caacgtgcag
     1741 tccgacctcc ttcacaaata tcagagtaaa gatgacattc tcatcctgac agtgcggctg
     1801 gctgtcattg ttgctgtgat cctcacagtg ccggtgttat ttttcacggt tcgttcatct
     1861 ttatttgaac tggctaagaa aacaaagttt aatttatgtc gtcataccgt ggttacctgc
     1921 atactcttgg ttgttatcaa cttgttggtg atcttcatac cctccatgaa ggatattttt
     1981 ggagtcgtag gagttacatc tgctaacatg cttattttca ttcttccttc atctctttat
     2041 ttaaaaatca cagaccagga tggagataaa ggaactcaaa gaatttgggc tgcccttttc
     2101 ttgggcctgg gggtgttgtt ctccttggtc agcattccct tggtcatcta tgactgggcc
     2161 tgctcatcga gtagtgacga aggccactga aacccgccga gaaaaagaaa catccctgtt
     2221 gtctgctcag tcaagtcccc acacatcagc aatctctcac cacttctttt gcaagtttac
     2281 agaagcaaac agaaatgtac aggatactta aaatggaata actttttggt tgcaaaacag
     2341 agacatggtt ctataatgct tcatgtccct ccaagatttg agatcaattt agggattgtg
     2401 aaattttttt ttcaaatttc atacaatcat atttcccagt acttttcaca atcatttttt
     2461 acccatctaa ctctatgttt tgtggcttcc cggtctctta gaactttgaa aacatgatat
     2521 acaataatgt ttatttatta tacatccaga ttctgaaata attttcctac tgatgttcag
     2581 ctcacactat ctgtaccttt ttagaagaga aaagaatctt gaattgtata tatttatttt
     2641 gctttacaga aaaaaatggt ttcgtaaata atttgcctat tttggttaac atagcacatg
     2701 gagataatca tctgaaagtt atagggcact gccactgctg aatcagagca tgcccaatat
     2761 ttgaggtggc tctgatttcc tggcagctga actcgggtag tccagtggcc tagctggtac
     2821 cacatctatt cccatccaga gacattctct ggcaagtgtt ctcagctgaa aagtggttgg
     2881 ggatgattct taccttggta attaaatgaa gctacacatt tgggtaatct agcaaatgaa
     2941 gtattttttc cctcttggca acttgtgtca gagttactct ggtctgagtc aactttcgct
     3001 ggggaaaacc tatggaacct actgcaaaaa gattgtccaa aatgcctaag aaaatactcc
     3061 tctgatgcat ttagccttca accctacctg tcttgctgaa gggagaaaaa tgttttagta
     3121 cattataggc ccagcagctt ttattcatgt ccaccagcta gttgcacaga gaatcatgtg
     3181 tacctaacta aggatgatct aggataagta actcctgttt tatattgagt attttaggga
     3241 agtctttaaa agacttgttt tatatctata aatctaggtt attacaaata caagaatttt
     3301 gtaccttaaa taagcctcat ttctatttct tcttcattaa ttctccatct agtcttgtga
     3361 aaaaaaaaaa aaaaaaaccc tcagagatag tctttgtgaa gagcttctga cagaatcact
     3421 gagtaccttc cttcccccag atgaggaaga caagggggtc tcagtgtctg tgctgtctcc
     3481 tcttctcttc cccaaccaag gactgtgcca ttactgcccg tctcaactgt ccatgcagga
     3541 ggacagagtt gcctggtact cttacccttg tccctctcct aaagggagca caaggaaact
     3601 gaagagactg aaaaagaaga gagtttgtag ctgaaaaaga atagggatag caaggaaacc
     3661 cagaactgca ttcccctaag tggggccatc ccatgtgatt gaattgtcca tagcttgcct
     3721 atggtgagaa atgtgcatgc tccgtgagct ggtctcttga aacaggactt atgcttcctc
     3781 tatattctgg ttaaattttc caaacacata agttcactga gcacagattt cttatccaga
     3841 gacaagtaga atctaaccgc agactgttgg cagagtttcc aggcacttag ccatgttccc
     3901 ttcctgactc aaatccccaa aggccttcac tctcactgag aatcacacta ctgtcccata
     3961 gataaggcag gcattgaagc acctgtcgtg atcctctagg ggggagaatg aaaggttatt
     4021 tcctgcattg catcatcata gcttttaata taatgctaca gaatcatatc cacattaggt
     4081 tagagttcag atatttggat atgaatacct aacctagcca tatccatggc catctctgtt
     4141 cttttcagca atgttttcca tattatatta gcaatgacag aaacagaaca agccaagatc
     4201 cagtcagttc ttgggagctt gtctagagca ccaagtaatg aaatagccag gtagtgggat
     4261 gactgtacct ttaaaaatac ataatttagt ttgcaagcta tattatgcta ctttctattt
     4321 tccttgttac tttatagcaa ttcattttac cctcacaaag tcaatttaga accttatcat
     4381 taactgggat gtgtagtgat atttttgggc ctctgggttt catgtgtcaa tacaaggaat
     4441 atttatttaa aatagattta tttagaggag gcacagtgtt gttgatctgt gtgacaccac
     4501 ccatattttt aaaaaccttt gtatgtttct ctaaatttgt tgttgactga atataataga
     4561 ccctaccata attcgtcaaa tatcactgat tagttacatc ctttgtgtga gattagctgt
     4621 aaagtatact gctcttattc ttattcagaa tagttaattg gtagccaaaa atacatgtat
     4681 cacagatgtt aggtcgaatt taaacagcac agtcaagtgc tatggaagtt tttctgctaa
     4741 attagtagat taaagaatac tataccctag gcatggggag cagcacgttt tcctttggta
     4801 ggtaggatct ctatactagt gaacagtgcc agttccacac tttggactta gaactgttct
     4861 ctagttattg taacacagaa tactgtcaat ccctaattta cttaatgtta cttattggaa
     4921 gtggggctga tgaaatacgc acaggaggga aatctactgt gtttaggcac aggcagcccc
     4981 agtgtataag gagatcatat tccaaaaggt tgtcagttgg ttgtttgcaa cctggaatgt
     5041 attttccttt agagaccagg ttatccatgg tggttaggcc cctagagcag ctggaaaaga
     5101 tgatcaaacc aataggttag ctgacatcga ataatgtaat aggtttgcta aagaatctaa
     5161 ccatcaaata taatattgtt tccagggagg gtgtttgttc agagttgcct gttagtagaa
     5221 tctggactgt ccatcccagc cacatcccac ctactggaca gtaggggtag agatgccacc
     5281 agactacagg tgaccagatt ggcctgaaac atggtgtcca gtaaaaacgg ggaggaataa
     5341 gtccatgact gctggagagc ttggtggtag gaggagggtg aaggagggtg agggggcctc
     5401 tcatgggtca gaaacctcca gggacatccc tcagctggta actctgctgt tgtccggagg
     5461 gttcaggctt ggtgtgcctt cttctgtttg tctgactttt ggctcctatg gttcatctcc
     5521 tgccctgccc accacagaaa aggatgctgc tgcatagctt ctccaatgta ccagtcattg
     5581 aggccagcgc gcagcacttt taatgttttt agtgctagta actgtgtttt aactctccag
     5641 gaataagctg ggaggttaga aaacaagaaa aaagggggaa aaaaaaacct ctccacccac
     5701 tttccttttt tacagttaca gaccctgttg agaaaaagaa gcacccagat gggtgatggt
     5761 gatagggctt gtggtggaca cagggttgtg gtaagattcc tcagtgcttc ggcgagcacc
     5821 taagactatt accctggaac tgactgcttt ctagagcttg attcatgcct ctaagccagt
     5881 ggttctcaaa gtgtggcccc tagaccagta gcatcagcat catcggggac ctcattagaa
     5941 tgcagattct cagccccctc ccagacatgg tgaagtcaga agctctcagg gagggactca
     6001 gcaaatgatt ctaaagcgca tcaagtttga gaaccaccct aagccaatga gtctcccttt
     6061 tacttcccat tagtcctccc tcaccagatg attcctagga ctcatggtgc aacatacagg
     6121 agccaggctt tagggagggg aggaaaggag cctggcggca ggggtctctg caatggcaag
     6181 aaagtgagtg aatccagcgc tgccacctgg ttatcccctt ctcgttgaaa atagcagcgc
     6241 aggtgcaaat tcctaaacac aggctgcctg cactcggtgt tacctcgggc tgaggcatga
     6301 taatatttta ttttttaaag ctgtgaggaa atgaaagtga ggctttggtt ggggcgaggc
     6361 agttgtgaaa gaaattaaaa taaaagaccc tttgtaaatg cagacttaga agaaatactg
     6421 aatttgtgtc agaagttctc cagtgtttgt gttaatcgtg tggtgataat cctgtcctcc
     6481 ttttaaagcg aattctctac tgaaaggtct gctctgctta aggagctaca aactgctctc
     6541 aaaagaatga aatactgagt tccaattcag tgaggcacag tgttggacta tggcacattt
     6601 agttggagtc ggggggaggt caggaatatg atcagataat ggattttata ccttagagca
     6661 aaatctatta gtctctctca gtttatcaat ttaaatggct ttaggcttat agggggtgta
     6721 aactttaaga atataattct cccattcaag tttacagcaa acatctagcc accttcaaaa
     6781 caaagaatat acagaccatc atttagcaat actaatacat gattttcctt ggggatggca
     6841 ggtttgagaa tcctttagca acaggacata cttcccctaa attacagtga attatttata
     6901 acgagataaa gctttcaggt acaagctgaa ggtggggtgt ctaacaacta aaaactatca
     6961 ctaaatctca aagagaaagt tcttgcaaaa tatgtaaagt tcacaaggtg cagacatttt
     7021 ccttctttag gcttttatct aaggaagggc tatgaaactg ggcccatctg tatacaggct
     7081 caaatttacg tttttaaagg aagaatctat gcagctgagg cttattgcag gaaatacttc
     7141 atttgtatgt aaatattatt gtaaataaat aggaggctgt atatttttga agttgttgat
     7201 ctgcactgaa atagaagtct ctaggatctg catataaaca ataaatgttt cctagaaatt
     7261 agtggttttg tttgggaatt agaaaaattt acattctctc ccaggtaaca tagttctctc
     7321 aatgtaaact tggaacctga aaccctactt aatttagaga aagaaatgtc tgagaaatag
     7381 ttcccttgat ttcttatgct ggcattaaga tcaattattt aacagatagt cctctgagat
     7441 acaagtaagg aatatttaga cacaaatcct tgtcctatag aaacagatat acccaaatga
     7501 caaattgttt cttcataatg atcttccatt tttaacactg ataccactac acagtacata
     7561 tgaaaacaga agctggggag aagaatgttt ttttcacaat tgaattgctg catttctcaa
     7621 actttgggat ctatgaaagc ggggagaggg aacctgaata ttaattatga gcacaaattt
     7681 gaaggaaaga aaacaaagaa ccattatcta atcaagcttt gaaagtcctg catgtttgcc
     7741 ttttatttta gtgttgacgc caacatagac tgtctaaggt atttttttcc ccaaacactt
     7801 gaatcttggt cgttggtatg taatccactc tctagagtcc agtgtacttt agacttcatc
     7861 tgagtccaat acatgtacca cactactgtt ttattaatgt aaaaaccttg taaatgaatt
     7921 tcagatgggt gatttaagtg agtcacaagt cacaaaactt tgctattcat agttaatcaa
     7981 atagaactgg gttttttttt tcagagtgtg gtgtaaataa agaaatataa gaagttctgt
     8041 tctataactg ctctgttaac atagttttta aacattaaaa aatgtgaact aaaagta
//
