LOCUS       NM_207113               3330 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens solute carrier family 37 member 3 (SLC37A3),
            transcript variant 1, mRNA.
ACCESSION   NM_207113
VERSION     NM_207113.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3330)
  AUTHORS   Yu,Z., Surface,L.E., Park,C.Y., Horlbeck,M.A., Wyant,G.A.,
            Abu-Remaileh,M., Peterson,T.R., Sabatini,D.M., Weissman,J.S. and
            O'Shea,E.K.
  TITLE     Identification of a transporter complex responsible for the
            cytosolic entry of nitrogen-containing bisphosphonates
  JOURNAL   Elife 7, e36620 (2018)
   PUBMED   29745899
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3330)
  AUTHORS   Palmieri,M., Impey,S., Kang,H., di Ronza,A., Pelz,C., Sardiello,M.
            and Ballabio,A.
  TITLE     Characterization of the CLEAR network reveals an integrated control
            of cellular clearance pathways
  JOURNAL   Hum Mol Genet 20 (19), 3852-3866 (2011)
   PUBMED   21752829
  REMARK    GeneRIF: SLC37A3 protein localizes in lysosomes in HeLa cells
REFERENCE   3  (bases 1 to 3330)
  AUTHORS   Pan,C.J., Chen,S.Y., Jun,H.S., Lin,S.R., Mansfield,B.C. and
            Chou,J.Y.
  TITLE     SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate
            antiporters
  JOURNAL   PLoS One 6 (9), e23157 (2011)
   PUBMED   21949678
REFERENCE   4  (bases 1 to 3330)
  AUTHORS   Bartoloni,L. and Antonarakis,S.E.
  TITLE     The human sugar-phosphate/phosphate exchanger family SLC37
  JOURNAL   Pflugers Arch 447 (5), 780-783 (2004)
   PUBMED   12811562
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB481623.1, AK074823.1, BC028380.1, AL136583.1 and BM669953.1.
            
            On Nov 23, 2018 this sequence version replaced NM_207113.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074823.1, BC028380.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326232.14/ ENSP00000321498.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DB481623.1         21-39
            20-148              AK074823.1         1-129
            149-378             BC028380.1         119-348
            379-1027            AK074823.1         360-1008
            1028-1049           AL136583.1         955-976
            1050-3328           AK074823.1         1031-3309
            3329-3330           BM669953.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..3330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3330
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /note="solute carrier family 37 member 3"
                     /db_xref="GeneID:84255"
                     /db_xref="HGNC:HGNC:20651"
                     /db_xref="MIM:619137"
     exon            1..115
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            116..274
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1670
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /note="isoform 1 is encoded by transcript variant 1; sugar
                     phosphate exchanger 3; solute carrier family 37
                     (glycerol-3-phosphate transporter), member 3;
                     sugar-phosphate exchange protein 3"
                     /codon_start=1
                     /product="sugar phosphate exchanger 3 isoform 1"
                     /protein_id="NP_996996.1"
                     /db_xref="CCDS:CCDS5859.1"
                     /db_xref="GeneID:84255"
                     /db_xref="HGNC:HGNC:20651"
                     /db_xref="MIM:619137"
                     /translation="MAWPNVFQRGSLLSQFSHHHVVVFLLTFFSYSLLHASRKTFSNV
                     KVSISEQWTPSAFNTSVELPVEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFIS
                     GIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWP
                     CVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFA
                     GGIVIFFGLLVSPEEIGLSGIEAEENFEEDSHRPLINGGENEDEYEPNYSIQDDSSVA
                     QVKAISFYQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIW
                     YDVGGIIGGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTG
                     FFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQYLVSLIRD
                     KLGWMWVFYFFILMTSCTIVFISPLIVREIFSLVLRRQAHILRE"
     exon            275..383
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            384..476
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..560
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            561..706
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            707..803
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            804..888
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1067
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1209
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1311
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1359
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1511
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1577
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..3330
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /note="hexamer: AATAAA"
     polyA_site      3330
                     /gene="SLC37A3"
                     /gene_synonym="SPX3"
                     /note="major polyA site"
ORIGIN      
        1 aaaccctggt cgcaccgcca ggggtgagct ggcggcgggg gaggcgggca gcggagccaa
       61 gctgacccgg cgagcggagc cggggctgga gagcggcgac cactgcggat ctcggaagga
      121 agaaatgatg taaatcactc atccaaacct taaggtcaaa ggtgagaagg aaggtcagga
      181 agaacatggc ctggccaaat gtttttcaaa gagggtctct gctgtcccag ttcagccatc
      241 atcatgttgt agtgttcctg ctcactttct tcagttattc gttgctccat gcttcacgaa
      301 aaacatttag caatgtcaaa gtcagtatct ctgagcagtg gaccccaagt gcttttaaca
      361 cgtcagttga gctgcctgtg gagatctgga gcagcaacca tttgttcccc agtgcagaga
      421 aagcgactct tttcctcggc acactggata ccattttcct cttctcctat gctgtgggcc
      481 tattcatcag tggcatcgtt ggggatcggt tgaatttgcg atgggttctg tcttttggca
      541 tgtgctcttc tgcattagtg gtgtttgtct ttggtgcgct cacagaatgg ctgcgtttct
      601 acaacaaatg gctgtactgc tgcctgtgga ttgtgaacgg cctgctgcag tccactggtt
      661 ggccctgtgt ggttgctgtt atgggcaact ggtttgggaa agccggacga ggagttgttt
      721 ttggtctctg gagtgcctgt gcttcggtgg gcaacatttt gggagcgtgc ctagcttctt
      781 ctgttcttca gtatggttat gagtatgcct ttctggtgac ggcgtctgtg cagtttgctg
      841 gtgggatcgt tatcttcttt ggactcctgg tgtcaccaga agaaattggt ctctcgggta
      901 ttgaggcaga agaaaacttt gaagaagact cacacaggcc attaattaat ggtggtgaaa
      961 atgaagacga atatgagccg aattattcaa tccaagatga tagttctgtt gcccaagtca
     1021 aggcgataag cttctaccag gcatgttgcc ttcctggagt cataccgtac tcactggcct
     1081 acgcctgctt gaagttagtg aattactcct tcttcttctg gctccccttt tatctgagta
     1141 acaacttcgg ctggaaggag gcggaagccg acaagctgtc catttggtac gacgttggag
     1201 ggatcatagg tggaactttg caaggcttca tctctgatgt actacagaag agagcgccgg
     1261 ttcttgccct gagtctgctt ctggcagttg ggtccctcat cgggtatagt cgttctccaa
     1321 atgataagtc catcaatgcc cttctgatga ctgttacagg attttttatt ggtggacctt
     1381 ctaatatgat tagttctgct atttctgcgg acttgggtcg ccaggagctc atccaaagga
     1441 gcagtgaagc tttggccact gtcacaggaa ttgtggatgg ttcggggagc attggagctg
     1501 cagtgggcca gtatttagtg tctctgatcc gggacaagct aggatggatg tgggttttct
     1561 actttttcat tctcatgaca agttgtacaa ttgtgtttat ctcgccatta atagtgaggg
     1621 aaatattctc tctcgtgcta aggagacagg ctcacatatt gagggagtga ccggtgcccg
     1681 cgagacagaa agaacaatgt cagccacatc aggaccgctg gggcttcgag tctgccctaa
     1741 tttgggtttg tctaggagct ccagcctgat cttggattgt caggcgtctc tcaacactgc
     1801 cagccacctg agatgctgac cagcagtgaa ggctgcacta gttttctaca ctacaggaat
     1861 tactgttgat gatttttgct gttgtttcat gaatgtgccg agtgacttct gactctgcca
     1921 gcatctttga cctctgactc tgcccgcgtc tttgtttggc ctattgaggt ttagcgtttt
     1981 aaccttaact gttgttttgg acttgaactt tctctagcct tgaaaatgga gtgaacagga
     2041 ggcaaagcca cgcgtggttt gtgttggtgg tatgttccac aaatggaaga gatcattgca
     2101 ttttgctttg gtaatgagtt tacagagagt gggtcatctt tgaagcatca aatcctgatc
     2161 aaatgctcaa gctggaccga gctgcaagcc tgccttggac aaagaatccc tctgttcact
     2221 gtggtgggaa agatcacact acatgcctgt tgattggctc agtcactctg tgtctgatct
     2281 aaacgtcatt cagccctaga agcatgaatt gcttcaaatt attgtcaact tgttctcttc
     2341 cattttcatt caaattaact ttgactcctg gaagtattga gtcttccttt caaggaccat
     2401 aaggtacatc agttatcttg aacattctga cgtgtaaagg accataaggt acatcattta
     2461 tcttgaacat tccgacgtgt aactcacagc cgaagcactc catcccagat ttgttgtctg
     2521 ggaacttagg atcctctagg aagctaatct gcttagtcta tttttagagg attgatctct
     2581 ggcacaagca gcttcctgga gttacctcag cagaagacta gaattagaga aaagggaaag
     2641 accttttctt ctagtaagtg tcaagtacag atgctctttg acttatgatg gggttatgtc
     2701 ccagtaaacc cattggaagt caaatgcatt taatacccct gactggacac cacagcttag
     2761 cctcgtccac cctaaatgta ctcagaacac ttagaattgc ccacagttgg gcagaatcat
     2821 ctaacacaaa ctctatttta taatcgagtg ttgaatatat catgtaattt attgaatatt
     2881 gtacattatg ttgaaattgc aaccatttca caccattgta aagtccaaaa atcagaagct
     2941 gaggactgtc tgtacatgac attgaatcac atgaatggat tactagggcc tgaggggtgt
     3001 ccgttcttta gaaaaatgta gagtatatat atcttcaggg ctgtgaattc catactagtt
     3061 atcaatattt taagatcatt ctgtatatac atattttaaa ttatgcaagc aaactaggag
     3121 gagaatgtgc aattttgagg gatacctaat ttgcattcgg ttaggggata tttttcaacc
     3181 tcttgcttta tactctgata tggggtgtgt ttatgaactt gttaatgtta tttaatcatg
     3241 cagatttcca atcagtgtat tgctcattta ctgacaaaaa gggaaaatac gaaacacaga
     3301 aagggaaaat aaactgactt ttataatgaa
//
