LOCUS       NM_001145290            3951 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens solute carrier family 37 member 2 (SLC37A2),
            transcript variant 2, mRNA.
ACCESSION   NM_001145290
VERSION     NM_001145290.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3951)
  AUTHORS   Villani,A., Benjaminsen,J., Moritz,C., Henke,K., Hartmann,J.,
            Norlin,N., Richter,K., Schieber,N.L., Franke,T., Schwab,Y. and
            Peri,F.
  TITLE     Clearance by Microglia Depends on Packaging of Phagosomes into a
            Unique Cellular Compartment
  JOURNAL   Dev Cell 49 (1), 77-88 (2019)
   PUBMED   30880002
  REMARK    GeneRIF: Using both living fish embryos and mammalian macrophages,
            we show that processing depends on the shrinkage and packaging of
            phagosomes into a unique cellular compartment, the gastrosome, with
            distinct molecular and ultra-structural characteristics. Loss of
            the transporter Slc37a2 blocks phagosomal shrinkage, resulting in
            the expansion of the gastrosome and the dramatic bloating of the
            cell.
REFERENCE   2  (bases 1 to 3951)
  AUTHORS   Pan,C.J., Chen,S.Y., Jun,H.S., Lin,S.R., Mansfield,B.C. and
            Chou,J.Y.
  TITLE     SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate
            antiporters
  JOURNAL   PLoS One 6 (9), e23157 (2011)
   PUBMED   21949678
  REMARK    GeneRIF: Data show that SLC37A1 and SLC37A2 are endoplasmic
            reticulum associated, P(i)-linked antiporters, that can transport
            glucose-6-phosphate.
REFERENCE   3  (bases 1 to 3951)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 3951)
  AUTHORS   Bartoloni,L. and Antonarakis,S.E.
  TITLE     The human sugar-phosphate/phosphate exchanger family SLC37
  JOURNAL   Pflugers Arch 447 (5), 780-783 (2004)
   PUBMED   12811562
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290314.1 and AP001007.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001145290.1.
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region that causes a frameshift. The resulting isoform (2) has a
            distinct C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290314.1, SRR1660805.141354.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403796.7/ ENSP00000384407.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1660              AK290314.1         1-1660
            1661-3951           AP001007.5         5785-8075
FEATURES             Location/Qualifiers
     source          1..3951
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..3951
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /note="solute carrier family 37 member 2"
                     /db_xref="GeneID:219855"
                     /db_xref="HGNC:HGNC:20644"
                     /db_xref="MIM:619136"
     exon            1..122
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1569
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /note="isoform 2 is encoded by transcript variant 2; sugar
                     phosphate exchanger 2; solute carrier family 37
                     (glycerol-3-phosphate transporter), member 2; solute
                     carrier family 37 (glucose-6-phosphate transporter),
                     member 2; glucose-6-phosphate exchanger SLC37A2;
                     sugar-phosphate exchange protein 2"
                     /codon_start=1
                     /product="glucose-6-phosphate exchanger SLC37A2 isoform 2"
                     /protein_id="NP_001138762.1"
                     /db_xref="CCDS:CCDS44757.1"
                     /db_xref="GeneID:219855"
                     /db_xref="HGNC:HGNC:20644"
                     /db_xref="MIM:619136"
                     /translation="MRSSLAPGVWFFRAFSRDSWFRGLILLLTFLIYACYHMSRKPIS
                     IVKSRLHQNCSEQIKPINDTHSLNDTMWCSWAPFDKDNYKELLGGVDNAFLIAYAIGM
                     FISGVFGERLPLRYYLSAGMLLSGLFTSLFGLGYFWNIHELWYFVVIQVCNGLVQTTG
                     WPSVVTCVGNWFGKGKRGFIMGIWNSHTSVGNILGSLIAGIWVNGQWGLSFIVPGIIT
                     AVMGVITFLFLIEHPEDVDCAPPQHHGEPAENQDNPEDPGNSPCSIRESGLETVAKCS
                     KGPCEEPAAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPLYIANVAHFSAKEAG
                     DLSTLFDVGGIIGGIVAGLVSDYTNGRATTCCVMLILAAPMMFLYNYIGQDGIASSIV
                     MLIICGGLVNGPYALITTAVSADLGTHKSLKGNAKALSTVTAIIDGTGSIGAALGPLL
                     AGLISPTGWNNVFYMLISADVLACLLLCRLVYKEILAWKVSLSRGSGYKEI"
     exon            123..204
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            205..298
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            299..377
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..513
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            514..590
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            591..757
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..795
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            796..948
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1039
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1102
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1188
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1237
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1311
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1390
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1488
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1553
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..3951
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /note="hexamer: AATAGA"
     polyA_site      2670
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
     regulatory      3931..3936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /note="hexamer: AATAAA"
     polyA_site      3951
                     /gene="SLC37A2"
                     /gene_synonym="pp11662; SPX2"
                     /note="major polyA site"
ORIGIN      
        1 gggacacgcg cccagctctg tagcctcctc cgtcgactca gccttaggta ccggtcaggc
       61 aaaatgcggt cctccctggc tccgggagtc tggttcttcc gggccttctc cagggacagc
      121 tggttccgag gcctcatcct gctgctgacc ttcctaattt acgcctgcta tcacatgtcc
      181 aggaagccta tcagtatcgt caagagccgt ctgcaccaga actgctcgga gcagatcaaa
      241 cccatcaatg atactcacag tctcaatgac accatgtggt gcagctgggc cccatttgac
      301 aaggacaact ataaggagtt actagggggc gtggacaacg ccttcctcat cgcctatgcc
      361 atcggcatgt tcatcagtgg ggtttttggg gagcggcttc cgctccgtta ctacctctca
      421 gctggaatgc tgctcagtgg ccttttcacc tcgctctttg gcctgggata tttctggaac
      481 atccacgagc tctggtactt tgtggtcatc caggtctgta atggactcgt ccagaccaca
      541 ggctggccct ctgtggtgac ctgtgttggc aactggttcg ggaaggggaa gcgggggttc
      601 atcatgggca tctggaattc ccacacatct gtgggcaaca tcctgggctc cctgatcgcc
      661 ggcatctggg tgaacgggca gtggggcctg tcgttcatcg tgcctggcat cattactgcc
      721 gtcatgggcg tcatcacctt cctcttcctc atcgaacacc cagaagatgt ggactgcgcc
      781 cctcctcagc accacggtga gccagctgag aaccaggaca accctgagga ccctgggaac
      841 agtccctgct ctatcaggga gagcggcctt gagactgtgg ccaaatgctc caaggggcca
      901 tgcgaagagc ctgctgccat cagcttcttt ggggcgctcc ggatcccagg cgtggtcgag
      961 ttctctctgt gtctgctgtt tgccaagctg gtcagttaca ccttcctcta ctggctgccc
     1021 ctctacatcg ccaatgtggc tcactttagt gccaaggagg ctggggacct gtctacactc
     1081 ttcgatgttg gtggcatcat aggcggcatc gtggcagggc tcgtctctga ctacaccaat
     1141 ggcagggcca ccacttgctg tgtcatgctc atcttggctg cccccatgat gttcctgtac
     1201 aactacattg gccaggacgg gattgccagc tccatagtga tgctgatcat ctgtgggggc
     1261 ctggtcaatg gcccatacgc gctcatcacc actgctgtct ctgctgatct ggggactcac
     1321 aagagcctga agggcaacgc caaagccctg tccacggtca cggccatcat tgacggcacc
     1381 ggctccatag gtgcggctct ggggcctctg ctggctgggc tcatctcccc cacgggctgg
     1441 aacaatgtct tctacatgct catctctgcc gacgtcctag cctgcttgct cctttgccgg
     1501 ttagtataca aagagatctt ggcctggaag gtgtccctga gcagaggcag cgggtataaa
     1561 gaaatatgag gccccaattg gaacagcagc atggagggtc ccagttgggt ccccaacgtg
     1621 ctccccatgg gcaagacaat ggaaacttcc acaagcaggg aaggcaaacc ctctttattg
     1681 aacattagcc agcccagccc agaccccagg gctgcctaag gacacagaga ttctccatgg
     1741 gaaggggact gccaagcatg aggaaataga agattcaggg gcctgagctc tggaagctgc
     1801 aagcaaaagg gatgggacta gggctgagtt gtgtctccat tttgataagg aaaggatatg
     1861 ctcagactct tgcttgttca gattccaaga cagaaggctt cacaaggcca acgcctggaa
     1921 aatgggcatc tctccttccc atgttaagct ttaacctctg taatctgcct gtatctatag
     1981 gtgggcatct cactccacca aaggagccca gcctctcttt gtccctctat ccatgcaaca
     2041 gtcttctctg tgcatttccc caagctgggc cctcttctac tctccattta ggcctgttga
     2101 taactccatt acccgcccat cactgctgtt cctccagggc cagcactcgg gcgaggcagg
     2161 ggagctgcct tcggtacata atttgaaggg gcactccctc ttgggcacat gccggccctg
     2221 agtgcctccc ttgcctcact ctgatcctgg ccccataatg tcctcagtgg aaggtgatgg
     2281 gggccggtgc tgtggggaga gtagaaagag gggttggcat gactaaaaat accagtatgt
     2341 gtattaagta ttttgagaat gaaatgccaa ggagtgccta ctatatgcca gctctaggaa
     2401 tggagtagac agtggacaca agaaggactt acgccctgag cacaggtgcc aatggtgaca
     2461 agactggcaa gacgtgaggg catgaatggt tcattcaggc agctgctgca gatgtggtca
     2521 cctggtgcca tctgctgctc ccttttccac ttttctatgt cctccttcca ccccaagtcc
     2581 cggatcactc gctgttttct ggctagctct tggcatctcc atctgagcct aaagttgccc
     2641 actggcacca atagattctg tttgacctgc tgtgcccatg ctcatctttg tcggggcttg
     2701 gcttggcagc gagcgaggct ggcatggggt gctgaagtgg ggtctcagtg aggggtgaca
     2761 gcgtgctggc agtcctcaca gccctcgctc gctctcggcg cctcctctgc ctgggctccc
     2821 actttggcgg cacttgagga gcccttcagc ccaccgctgc actgtgggga gcccctttct
     2881 gggctggcca aggccagagc aggctccctc agcttgcagg gaggtgtgga gcgagaggcg
     2941 cgagcgggaa ccggggctgc atgcagcgct tgcgggccag ctggagttcc gggtgggcat
     3001 gggcttggcg ggcctgcact cggagcagcc ggccggccct tccggccccg ggcagtgagg
     3061 gacttggcac ccgggccagc ggctgcagag ggtgtactgg gtcccccagc agtgccggcc
     3121 cacctgcgct gtgcttgatt tctcgctggg ccttagctgc cttcccgcgg ggcagggctc
     3181 gggacctgca gcccgcggtg cctgagcctc ccacccgctc catgggctcc tgtggggccc
     3241 gagcctcccc gacgagtacc accccctgct ccagggcgcc cagtcccatc gaccacccaa
     3301 gggctgagga gtgcgagcgc acggcgcggg actggcaggc agctccacct gcagccccgg
     3361 tgcgggatcc actaggtgaa gccagctggg ctcctgagtc tgatggggac gtggagagtc
     3421 cttatgtcct gctcagggat tgtaaacaca ccaatcagca ccctgtgttt agctcaaggt
     3481 ttgtgagtgc accagtcgac actctgtatc tagctgctct ggtggggcct cggagaacct
     3541 ttatatctag ctcagggatt gtaaatacac ccatcggcac tgtgtatcta gctcaaggtt
     3601 tataaacaca ccaatcaaca ccctgtgtct agctcagggt ttgtgagtgc accaatcaac
     3661 actctgtatc tagctgctct ggtggggcct tggagaacct gtgtgtcgaa actctgtatc
     3721 taactaatct gatggggacg tggagaacct ttgtatctag ctcagggatt gtaaacgcac
     3781 caatcaacga cctgtcaaaa caggccactc ggctctacca ataagcagga tgtgggtggg
     3841 gccagataag agaataaaag caggctgccc gagccagcat tggcaactcg ctcgggtccc
     3901 cttccacgct gtgggagctt tgttctttgc aataaatctt gctactgctc a
//
