LOCUS       NM_001320537            3712 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 37 member 1 (SLC37A1),
            transcript variant 1, mRNA.
ACCESSION   NM_001320537 XM_005261141
VERSION     NM_001320537.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3712)
  AUTHORS   Pan,C.J., Chen,S.Y., Jun,H.S., Lin,S.R., Mansfield,B.C. and
            Chou,J.Y.
  TITLE     SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate
            antiporters
  JOURNAL   PLoS One 6 (9), e23157 (2011)
   PUBMED   21949678
  REMARK    GeneRIF: Data show that SLC37A1 and SLC37A2 are endoplasmic
            reticulum associated, P(i)-linked antiporters, that can transport
            glucose-6-phosphate.
REFERENCE   2  (bases 1 to 3712)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 3712)
  AUTHORS   Pope,S.N. and Lee,I.R.
  TITLE     Yeast two-hybrid identification of prostatic proteins interacting
            with human sex hormone-binding globulin
  JOURNAL   J Steroid Biochem Mol Biol 94 (1-3), 203-208 (2005)
   PUBMED   15862967
REFERENCE   4  (bases 1 to 3712)
  AUTHORS   Bartoloni,L., Wattenhofer,M., Kudoh,J., Berry,A., Shibuya,K.,
            Kawasaki,K., Wang,J., Asakawa,S., Talior,I., Bonne-Tamir,B.,
            Rossier,C., Michaud,J., McCabe,E.R., Minoshima,S., Shimizu,N.,
            Scott,H.S. and Antonarakis,S.E.
  TITLE     Cloning and characterization of a putative human glycerol
            3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation
            analysis in two candidate phenotypes, DFNB10 and a glycerol kinase
            deficiency
  JOURNAL   Genomics 70 (2), 190-200 (2000)
   PUBMED   11112347
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001625.1, DA755019.1,
            AF311320.1, BM550728.1 and BI912541.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001320537.1.
            
            Summary: The protein encoded by this gene localizes to the
            endoplasmic reticulum (ER) membrane. This protein translocates
            glucose-6-phosphate from the cytoplasm into the lumen of the ER for
            hydrolysis into glucose by another ER membrane protein. This gene
            is a member of the solute carrier 37 gene family. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is inferred to be translated from a downstream start
            codon via ribosomal leaky scanning. Variants 1 and 2 encode the
            same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF311320.1, SRR1803612.235414.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352133.3/ ENSP00000344648.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AP001625.1         32557-32557
            2-73                DA755019.1         1-72
            74-723              AP001625.1         32630-33279
            724-1712            AF311320.1         662-1650
            1713-2283           BM550728.1         113-683
            2284-2284           BI912541.1         595-595
            2285-3076           AF311320.1         2223-3014
            3077-3712           AP001625.1         99496-100131
FEATURES             Location/Qualifiers
     source          1..3712
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..3712
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /note="solute carrier family 37 member 1"
                     /db_xref="GeneID:54020"
                     /db_xref="HGNC:HGNC:11024"
                     /db_xref="MIM:608094"
     exon            1..866
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1100
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1045..2646
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /note="glycerol-3-phosphate permease; glycerol-3-phosphate
                     transporter; G-3-P permease; G-3-P transporter;
                     sugar-phosphate exchange protein 1; solute carrier family
                     37 (glycerol-3-phosphate transporter), member 1; solute
                     carrier family 37 (glucose-6-phosphate transporter),
                     member 1"
                     /codon_start=1
                     /product="glucose-6-phosphate exchanger SLC37A1"
                     /protein_id="NP_001307466.1"
                     /db_xref="CCDS:CCDS13689.1"
                     /db_xref="GeneID:54020"
                     /db_xref="HGNC:HGNC:11024"
                     /db_xref="MIM:608094"
                     /translation="MARLPAGIRFIISFSRDQWYRAFIFILTFLLYASFHLSRKPISI
                     VKGELHKYCTAWDEADVRFSSQNRKSGSAAPHQLPDNETDCGWAPFDKNNYQQLLGAL
                     DYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVV
                     TQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC
                     WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGYENGTNRLRLQKQILK
                     SEKNKPLDPEMQCLLLSDGKGSIHPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSL
                     CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK
                     RASTCGLMLLLAAPTLYIFSTVSKMGLEATIAMLLLSGALVSGPYTLITTAVSADLGT
                     HKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSGWSNVFYMLMFADACALLF
                     LIRLIHKELSCPGSATGDQVPFKEQ"
     exon            1101..1182
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1315
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1394
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1530
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1607
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1774
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1812
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1893
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2025
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2116
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2179
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2265
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2314
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2388
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2467
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2565
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2630
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..3712
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3689..3694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /note="hexamer: AATAAA"
     polyA_site      3712
                     /gene="SLC37A1"
                     /gene_synonym="G3PP; SPX1"
                     /note="major polyA site"
ORIGIN      
        1 gaagtcgcga gcaggaagcg cccgcggcgg ccgggccggg ctgggctgcg gagcgcgggc
       61 ctcggcggcg caggtgaggc gcggggccgg ggccggaccg ggaggcgggg accccccgcc
      121 cccccgcccg cacctgcggg gcagccggcg ctcaggcgcc gcagccgctc agcacctgcg
      181 gcgccctcag ggagccgggc gcggggccct gcgcactcgg agctcggctc ctctccttcc
      241 ttttcttttt tttcgggggg aggtgggggc tggtttggat gttttccgag agccggggac
      301 ggtctcaagc tattttcgcg gagggaagtc tttgaaatac gacatctaga agagtggccc
      361 tcggcgacaa tgccgggcgt tcccggaccg gggcaacgct gggattccgg ggaagtggag
      421 gcagagggag cgggcacggg gccggcagcc gctccacgga gtccccggca ggggcgagct
      481 tagctgtcca gccgggtccc ctgcccaccc cggcccgggc cgcggtgaca gctgagggtc
      541 cagagagccg gcaggagggg accctgcgca ttgtctgccg cgatggggac gtgggcgtgc
      601 ccgcggaatt cacctcctcc ggggaccagc cgcccaggga ggagccggca cagaacgctg
      661 gctcggagcg ccggcaccct gggcctttgc gttgtttgtc ggctgagcag ctggttcccg
      721 gagcccgtgg gcctcctggc caatgcgagt gacagcgacc ttctgggttt ataataaagg
      781 gcttgacgcg ccggaaagtc ccctcgccgc tggccaccag ccttccagcc cttacggccc
      841 acgccgtaat cctggtgacc gagaagagag cagagccact gccagaagga aggggacaag
      901 acccagcagg acaccttctt tccacgcttt ccagcctgtg ggagcggcag gggcaacaga
      961 gagaggatct ggagccagga ttaatgactc atttatgaag catcttattc tgcgaccgag
     1021 gctcagtggt cagtggcgac gtaaatggct cgactccccg ctggcattcg cttcatcatc
     1081 tcattctcca gggatcagtg gtacagagcc ttcattttta ttttgacatt tctgctgtat
     1141 gcaagttttc acttatctcg aaagcctatc agcatagtta agggtgagct ccacaagtac
     1201 tgcactgctt gggatgaagc tgacgtcagg ttcagcagcc agaacaggaa gtctgggtcc
     1261 gctgcccccc accagctccc tgacaatgag accgactgtg gctgggcacc gtttgataag
     1321 aacaactatc agcagctgct tggggccctg gactactcct tcctgtgcgc ctatgccgtg
     1381 gggatgtacc tcagtggcat cattggggag cgcctgccga ttaggtatta cctaactttc
     1441 gggatgctcg ccagcggagc cttcaccgcc ctgttcggct tagggtattt ctacaacatc
     1501 cacagtttcg gattctacgt ggtaactcag gtcatcaacg ggctggtgca gaccaccggc
     1561 tggcccagcg tcgtcacctg cctcggcaac tggtttggaa aaggaaggag aggtttgatt
     1621 atgggggtct ggaactccca cacctccgtg ggcaacatct tggggtcatt gatcgctggc
     1681 tactgggtgt ccacatgctg gggcctgtcc ttcgtcgtgc ctggagccat cgtggcagcc
     1741 atggggatag tgtgctttct cttcctcatt gaacatccga acgacgtcag gtgctcctcc
     1801 accctggtga cgcactcaaa aggctatgag aatggtacaa acagattgag actccagaag
     1861 caaatcttga agagcgaaaa gaacaagcct ctggacccag agatgcagtg cctgctgctc
     1921 tcagatggga agggctccat ccacccgaac cacgtcgtca ttctccccgg ggacggtggg
     1981 agtggcacgg ccgccatcag cttcacaggg gccttgaaaa ttccaggcgt gatagagttc
     2041 tcactgtgtc tgctgtttgc caagctggtc agctatactt tcctcttctg gctgcccctg
     2101 tacatcacga atgtggatca ccttgatgcc aaaaaggcgg gggagctctc caccctgttt
     2161 gacgtgggcg gaatctttgg tgggatcctg gcaggtgtga tctcagaccg actggagaaa
     2221 agggcctcca cctgcggcct gatgctgctg ctcgcggccc ccacgctcta catcttctcc
     2281 accgtcagca agatggggct tgaggccacc atcgccatgc tgctgctcag cggagccctg
     2341 gtcagtgggc cctacacact catcaccacc gccgtctccg ccgacctggg gactcataaa
     2401 agtctgaaag gcaacgcgca cgccctctcc accgtgacgg ccatcattga cgggacgggc
     2461 tctgtaggag cagccctggg ccccctgctg gctgggctcc tctccccgtc cggctggagc
     2521 aatgtgtttt acatgctgat gtttgcagat gcctgtgcct tactgttcct gatccgcctc
     2581 atacacaagg agctgagctg cccagggtca gctacggggg accaagttcc atttaaggaa
     2641 cagtgacacc ccaccccagt cccgtggagg gggtctgggc ccacccttca caactgcctt
     2701 tcaaggacag ttcagacaaa gggccctgca tggaaagagt gacctccctt tgccttttgc
     2761 acacgcacct ggaaaagaca cagaagccaa cctgagaacc cctggtgcta ttttaaagga
     2821 gacatattgc tgaacagcag tgagaaaagt ctgcaggaac tgctgcctga gccaagccag
     2881 agaaccgaag acccggccgg ccctggcctc acaggcgtgt gcccatgcag ccacccaaat
     2941 gcacgcgtga caacaaggcc gggagggtgg ggggggtgca caggtagccc cgaccctctc
     3001 aggcattcca gccacagaac atcaaagtga gcgagtactg cgctggctgt ggcttcagag
     3061 aacctgtatg tgccacatgg aaaaacagga caccagagcc caccagacag tgccggccag
     3121 cagagaagca gagagccagc gccacacaac atcaagaagg ccgacaacca ggttggaaac
     3181 caagacggag ctcagaccca ccacatcgcc ccagaggctt ttccagcacc catgatgttt
     3241 cggactgacc taaaaactaa ttgtcgagaa gccaagggtg aggaggcagg aagcacctcc
     3301 ggttggaggc acccaggctt gccagccaca gagcgcccca aagtcaccgt catcccagcc
     3361 cctggccttc ctgctgccct ccggggccat ggcactgctg ttcagctcag gcacaggggc
     3421 acagcagagg tttgggaagc ggtctcccca ccggcactgg gattggcggg tccaagccca
     3481 gcaaccggct tcgctccaca acacacacca cacctgggac tgtttttaat acatagcaac
     3541 agactgggtt atttatttaa gatgtgtatt gtgtcatatg aagtttaaga gacataaatg
     3601 gcattttgtt atttattaag acaaactcca attgttctct ggctgttttt ttcagttgtg
     3661 tctagcaaaa tacttatctg ccctttgaaa taaaatgttt ttgtttaaaa aa
//
