LOCUS       NM_181774               2860 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens solute carrier family 36 member 3 (SLC36A3),
            transcript variant 2, mRNA.
ACCESSION   NM_181774
VERSION     NM_181774.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2860)
  AUTHORS   Schioth,H.B., Roshanbin,S., Hagglund,M.G. and Fredriksson,R.
  TITLE     Evolutionary origin of amino acid transporter families SLC32, SLC36
            and SLC38 and physiological, pathological and therapeutic aspects
  JOURNAL   Mol Aspects Med 34 (2-3), 571-585 (2013)
   PUBMED   23506890
  REMARK    Review article
REFERENCE   2  (bases 1 to 2860)
  AUTHORS   Singla,A., Dwivedi,A., Saksena,S., Gill,R.K., Alrefai,W.A.,
            Ramaswamy,K. and Dudeja,P.K.
  TITLE     Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of
            intestinal apical Cl-/OH- exchange
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 298 (2), G182-G189 (2010)
   PUBMED   19910524
  REMARK    GeneRIF: lysophosphatidic acid stimulates apical Cl(-)/OH(-)
            exchange activity and surface levels of SLC36A3 and SLC26A6 in
            intestinal epithelial cells
REFERENCE   3  (bases 1 to 2860)
  AUTHORS   Bermingham,J.R. Jr. and Pennington,J.
  TITLE     Organization and expression of the SLC36 cluster of amino acid
            transporter genes
  JOURNAL   Mamm Genome 15 (2), 114-125 (2004)
   PUBMED   15058382
REFERENCE   4  (bases 1 to 2860)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I. and Daniel,H.
  TITLE     A cluster of proton/amino acid transporter genes in the human and
            mouse genomes
  JOURNAL   Genomics 82 (1), 47-56 (2003)
   PUBMED   12809675
  REMARK    GeneRIF: PAT3 was isolated and identified, but its function is not
            yet known.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008385.7 and BC101095.2.
            
            On Jun 2, 2019 this sequence version replaced NM_181774.3.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            coding region compared to variant 1. The resulting protein (isoform
            2) is shorter and has the identical N- and C-termini compared to
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127978.1, AY162215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2161674 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335230.8/ ENSP00000334750.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC008385.7         55610-55882
            274-1867            BC101095.2         4-1597
            1868-2860           AC008385.7         82026-83018
FEATURES             Location/Qualifiers
     source          1..2860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..2860
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /note="solute carrier family 36 member 3"
                     /db_xref="GeneID:285641"
                     /db_xref="HGNC:HGNC:19659"
                     /db_xref="MIM:608332"
     exon            1..540
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1825
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proton-coupled amino acid transporter 3; tramdorin 2;
                     proton/amino acid transporter 3; solute carrier family 36
                     (proton/amino acid symporter), member 3"
                     /codon_start=1
                     /product="proton-coupled amino acid transporter 3 isoform
                     2"
                     /protein_id="NP_861439.3"
                     /db_xref="CCDS:CCDS4314.1"
                     /db_xref="GeneID:285641"
                     /db_xref="HGNC:HGNC:19659"
                     /db_xref="MIM:608332"
                     /translation="MSLLGRDYNSELNSLDNGPQSPSESSSSITSENVHPAGEAGLSM
                     MQTLIHLLKCNIGTGLLGLPLAIKNAGLLVGPVSLLAIGVLTVHCMVILLNCAQHLSQ
                     RLQKTFVNYGEATMYGLETCPNTWLRAHAVWGRYTVSFLLVITQLGFCSVYFMFMADN
                     LQQMVEKAHVTSNICQPREILTLTPILDIRFYMLIILPFLILLVFIQNLKVLSVFSTL
                     ANITTLGSMALIFEYIMEGIPYPSNLPLMANWKTFLLFFGTAIFTFEGVGMVLPLKNQ
                     MKHPQQFSFVLYLGMSIVIILYILLGTLGYMKFGSDTQASITLNLPNCWLYQSVKLMY
                     SIGIFFTYALQFHVPAEIIIPFAISQVSESWALFVDLSVRSALVCLTCVSAILIPRLD
                     LVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVTIAKDIMISIVGLLGCIFGTYQA
                     LYELPQPISHSMANSTGVHA"
     exon            541..631
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..720
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            721..816
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..901
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1120
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1219
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1386
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1556
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..2860
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2823..2828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /note="hexamer: AATAAA"
     polyA_site      2860
                     /gene="SLC36A3"
                     /gene_synonym="PAT3; TRAMD2; tramdorin2"
                     /note="major polyA site"
ORIGIN      
        1 gagcctggcc ccacgtccag gcaccaggac ctccaatcca atggtgtctt cttcctccca
       61 gtcacactgt tcactttgcc ctacagcagc aagggctaaa ctaggagagg ccaaaagccc
      121 aggcaagtcc tggttgggca agcaattgcg agtgaaactg aggaccatcc tgactgagat
      181 gggtctttca taagtccccc aagagccagg tgaggcatca tcaacatcag cctctcctgc
      241 caccaccgct tccctgattc atgcacttca ggcttcagcc agcagcacgc atccttgggg
      301 ttaggagcca gcatctcagg tcagcagcca tggtttctct ggagaaagac ccatcagagg
      361 ctcattcaga gccttaaccc tgagcctctg ccacctaccc accgtgttga agatgtcatt
      421 gcttggaagg gactacaaca gtgagctgaa ctccttggac aacggacctc agtcaccctc
      481 agagagcagc agtagcatta cttcagagaa tgtccatcct gctggagaag ctggactatc
      541 gatgatgcaa actttgatcc acttgttgaa atgcaacatt ggcacagggc tcctggggct
      601 tcccctggcc ataaagaatg ccggcttgtt ggtcggtcct gtcagccttc tggccatcgg
      661 ggtcctcacc gtgcactgca tggtcatcct gttgaactgt gctcaacacc tcagccagag
      721 actgcagaag acttttgtga actatggaga ggccacgatg tacggccttg aaacctgccc
      781 gaacacctgg ctgagggccc atgcagtgtg gggaaggtac actgtcagct tcttattagt
      841 catcacccag ctgggcttct gcagtgttta ttttatgttt atggcagaca atttacaaca
      901 gatggtggaa aaagcccacg tgacctccaa catctgccag cccagggaga ttctgacgct
      961 gacccccatc ctggacattc gtttctacat gctgataatc ctgcccttcc tgatcctgtt
     1021 ggtgtttatc cagaacctca aggtgctgtc cgtcttctcg acattggcca acatcaccac
     1081 ccttgggagc atggctctga tctttgagta tatcatggag gggattccat atcccagcaa
     1141 cctacccttg atggcaaact ggaagacctt cttgctgttc tttggtacag ccatcttcac
     1201 atttgaaggc gtcggtatgg ttctgcctct caaaaaccag atgaagcatc cacagcagtt
     1261 ttcttttgtt ctgtacttgg ggatgtccat tgtcatcatc ctctatatct tactggggac
     1321 actgggctac atgaagtttg ggtcagacac ccaggccagc atcaccctca acttgcccaa
     1381 ttgctggttg taccagtcag tcaagctgat gtactctatc ggcatcttct tcacctatgc
     1441 cctccagttc cacgtcccag ctgagatcat catcccgttt gccatctccc aagtgtcaga
     1501 gagctgggca ctgtttgtag acctgtctgt ccgctcagcc ttggtctgtc taacctgtgt
     1561 ctcagccatc ctcatccccc gcctggactt ggtcatctcc ctggtaggct ccgtgagcag
     1621 cagcgccctg gctctcatca tcccagccct cctggagatc gtcatctttt actctgagga
     1681 catgagctgt gtcaccattg ccaaggacat catgattagc atcgtgggcc ttttagggtg
     1741 tatatttggg acataccaag ccctctatga gttgccccaa cccatcagcc attccatggc
     1801 caactccaca ggtgtccatg cataattatc tgtttttatt ctaatagctc tcccttcctc
     1861 ccatccccag tttgacttcc atgtggatgt tatatacctt catcaaatcc caacatctct
     1921 atattaatta gtggcgtctt tatctttcca agagaaatgc agatgagaaa agttagcact
     1981 gatgtctctc aggctacacc tcttttggtt ttatattttt tggatggcct tttgtacctc
     2041 tgaaccaaaa ttagattcaa ctattcatat tatcagcctc attttatgga aaagggatgc
     2101 cacttacccc aatagccctt gaaacagaga ccaagcataa atacaaaagt aactgttttc
     2161 tctacactgc agtagctgcc cttaaagcat cagatttaga aaagtgtatg ttgggcgaag
     2221 ggagttttct atttagatat tctaagtaga agagtcatag acagaacaaa aacagaactc
     2281 agcagtaatt ttgtccaacc actggctccg ccactgattt cctactggcc ctcaggcaag
     2341 ttcctcccca tctctcagtc tatgaagtga acagttggac taactgatta ttaaggactc
     2401 tgtcaactct gatattctga aagtgaataa aagaaattaa cttatccacc aaccacaaaa
     2461 actggccatg ctagtgttgg tgaggaggtg gagtaactga aactccatac cctgctatgt
     2521 ggatagaaag tagtacaatc agtttgataa acatcttgta gtttctttaa aacttaaaca
     2581 tatacctacc atatgatcca actattccac tccagaaaaa agaaatatat atccataaaa
     2641 agacttgtac aaaaatattc atggtaactt tacttataaa agcaaagaag ttggaaatac
     2701 tctaaatgtc tataaacaag agaatggata aataaattgt gatgtagcca tacaatggaa
     2761 tattcctcag caaggaacag aaacaaactg ttgaaataca caataaaatg tatgaatctt
     2821 aaaataaata tgctgaatga caaaatccag accaaaaaaa
//
