LOCUS       NM_078483               5772 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 36 member 1 (SLC36A1),
            transcript variant 1, mRNA.
ACCESSION   NM_078483
VERSION     NM_078483.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5772)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5772)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5772)
  AUTHORS   Yoshida,A., Bu,Y., Qie,S., Wrangle,J., Camp,E.R., Hazard,E.S.,
            Hardiman,G., de Leeuw,R., Knudsen,K.E. and Diehl,J.A.
  TITLE     SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6
            inhibitors
  JOURNAL   Sci Adv 5 (9), eaax6352 (2019)
   PUBMED   31555743
  REMARK    GeneRIF: SLC36A1-mTORC1 signaling drives acquired resistance to
            CDK4/6 inhibitors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5772)
  AUTHORS   Zhao,L., Zhang,X., Ji,X., Jin,Y. and Liu,W.
  TITLE     The amino acid transporter PAT1 regulates mTORC1 in a
            nutrient-sensitive manner that requires its transport activity
  JOURNAL   Cell Signal 53, 59-67 (2019)
   PUBMED   30253187
  REMARK    GeneRIF: Increasing the PAT1 level does not readily increase the
            mTORC1 activity. The lysosomal PAT1 was increased by starvation and
            decreased by nutrient replenishment. The lysosomal PAT1 plays a
            negative role on the mTORC1 activity.
REFERENCE   5  (bases 1 to 5772)
  AUTHORS   Bermingham,J.R. Jr. and Pennington,J.
  TITLE     Organization and expression of the SLC36 cluster of amino acid
            transporter genes
  JOURNAL   Mamm Genome 15 (2), 114-125 (2004)
   PUBMED   15058382
REFERENCE   6  (bases 1 to 5772)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I. and Daniel,H.
  TITLE     A cluster of proton/amino acid transporter genes in the human and
            mouse genomes
  JOURNAL   Genomics 82 (1), 47-56 (2003)
   PUBMED   12809675
REFERENCE   7  (bases 1 to 5772)
  AUTHORS   Chen,Z., Fei,Y.J., Anderson,C.M., Wake,K.A., Miyauchi,S., Huang,W.,
            Thwaites,D.T. and Ganapathy,V.
  TITLE     Structure, function and immunolocalization of a proton-coupled
            amino acid transporter (hPAT1) in the human intestinal cell line
            Caco-2
  JOURNAL   J Physiol 546 (Pt 2), 349-361 (2003)
   PUBMED   12527723
  REMARK    GeneRIF: PAT1 expressed exclusively in apical membrane of Caco-2
            cells. hPAT1 may be responsible for H(+)-coupled amino acid
            transport expressed in apical membrane of Caco-2 cells.
REFERENCE   8  (bases 1 to 5772)
  AUTHORS   Boll,M., Foltz,M., Rubio-Aliaga,I., Kottra,G. and Daniel,H.
  TITLE     Functional characterization of two novel mammalian electrogenic
            proton-dependent amino acid cotransporters
  JOURNAL   J Biol Chem 277 (25), 22966-22973 (2002)
   PUBMED   11959859
REFERENCE   9  (bases 1 to 5772)
  AUTHORS   Sagne,C., Agulhon,C., Ravassard,P., Darmon,M., Hamon,M., El
            Mestikawy,S., Gasnier,B. and Giros,B.
  TITLE     Identification and characterization of a lysosomal transporter for
            small neutral amino acids
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7206-7211 (2001)
   PUBMED   11390972
REFERENCE   10 (bases 1 to 5772)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM787446.1, AY162213.1,
            BC136438.1 and AL833703.1.
            
            On Nov 22, 2018 this sequence version replaced NM_078483.3.
            
            Summary: This gene encodes a member of the eukaryote-specific amino
            acid/auxin permease (AAAP) 1 transporter family. The encoded
            protein functions as a proton-dependent, small amino acid
            transporter. This gene is clustered with related family members on
            chromosome 5q33.1. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537963.1, SRR1803615.110778.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000243389.8/ ENSP00000243389.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               BM787446.1         8-144
            138-1798            AY162213.1         50-1710
            1799-3380           BC136438.1         1677-3258
            3381-5772           AL833703.1         653-3044
FEATURES             Location/Qualifiers
     source          1..5772
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.1"
     gene            1..5772
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /note="solute carrier family 36 member 1"
                     /db_xref="GeneID:206358"
                     /db_xref="HGNC:HGNC:18761"
                     /db_xref="MIM:606561"
     exon            1..211
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            212..359
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1647
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /note="isoform a is encoded by transcript variant 1;
                     lysosomal amino acid transporter 1; proton/amino acid
                     transporter 1; proton-coupled amino acid transporter 1;
                     solute carrier family 36 (proton/amino acid symporter),
                     member 1"
                     /codon_start=1
                     /product="proton-coupled amino acid transporter 1 isoform
                     a"
                     /protein_id="NP_510968.2"
                     /db_xref="CCDS:CCDS4316.1"
                     /db_xref="GeneID:206358"
                     /db_xref="HGNC:HGNC:18761"
                     /db_xref="MIM:606561"
                     /translation="MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQS
                     NSTTWFQTLIHLLKGNIGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCA
                     HHFCRRLNKSFVDYGDTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFV
                     FLADNFKQVIEAANGTTNNCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALS
                     IFSLLANITMLVSLVMIYQFIVQRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVL
                     PLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGANIQGSITLNLPNCWLYQS
                     VKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPEHCELVVDLFVRTVLVCLTCILAIL
                     IPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVV
                     GTYEALYELIQPSNAPIFINSTCAFI"
     exon            360..450
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            451..539
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            540..635
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            636..720
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..939
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1038
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1205
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1375
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..5772
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5745..5750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /note="hexamer: AATAAA"
     polyA_site      5772
                     /gene="SLC36A1"
                     /gene_synonym="Dct1; LYAAT1; PAT1; TRAMD3"
                     /note="major polyA site"
ORIGIN      
        1 gaggtccgga agcggctgcc gggcagcaaa ggaggatggc gaggggctga tactgaaccc
       61 gggaagggtg ggctgtgctg aagccagagc cggagccgga gctggggcca gaacccgagc
      121 agtgagttcc tccactggct gccggctggc ggcgctcgcc gccttgggca ggacccacct
      181 cgccttcctc ccggcgtggc agatgctcca gctgccatgt ccacgcagag acttcggaat
      241 gaagactacc acgactacag ctccacggac gtgagccctg aggagagccc gtcggaaggc
      301 ctcaacaacc tctcctcccc gggctcctac cagcgctttg gtcaaagcaa tagcacaaca
      361 tggttccaga ccttgatcca cctgttaaaa ggcaacattg gcacaggact cctgggactc
      421 cctctggcgg tgaaaaatgc aggcatcgtg atgggtccca tcagcctgct gatcataggc
      481 atcgtggccg tgcactgcat gggtatcctg gtgaaatgtg ctcaccactt ctgccgcagg
      541 ctgaataaat cctttgtgga ttatggtgat actgtgatgt atggactaga atccagcccc
      601 tgctcctggc tccggaacca cgcacactgg ggaagacgtg ttgtggactt cttcctgatt
      661 gtcacccagc tgggattctg ctgtgtctat tttgtgtttc tggctgacaa ctttaaacag
      721 gtgatagaag cggccaatgg gaccaccaat aactgccaca acaatgagac ggtgattctg
      781 acgcctacca tggactcgcg actctacatg ctctccttcc tgcccttcct ggtgctgctg
      841 gttttcatca ggaacctccg agccctgtcc atcttctccc tgttggccaa catcaccatg
      901 ctggtcagct tggtcatgat ctaccagttc attgttcaga ggatcccaga ccccagccac
      961 ctccccttgg tggccccttg gaagacctac cctctcttct ttggcacagc gattttttca
     1021 tttgaaggca ttggaatggt tctgcccctg gaaaacaaaa tgaaggatcc tcggaagttc
     1081 ccactcatcc tgtacctggg catggtcatc gtcaccatcc tctacatcag cctggggtgt
     1141 ctggggtacc tgcaatttgg agctaatatc caaggcagca taaccctcaa cctgcccaac
     1201 tgctggttgt accagtcagt taagctgctg tactccatcg ggatcttttt cacctacgca
     1261 ctccagttct acgtcccggc tgagatcatc atccccttct ttgtgtcccg agcgcccgag
     1321 cactgtgagt tagtggtgga cctgtttgtg cgcacagtgc tggtctgcct gacatgcatc
     1381 ttggccatcc tcatcccccg cctggacctg gtcatctccc tggtgggctc cgtgagcagc
     1441 agcgccctgg ccctcatcat cccaccgctc ctggaggtca ccaccttcta ctcagagggc
     1501 atgagccccc tcaccatctt taaggacgcc ctgatcagca tcctgggctt cgtgggcttt
     1561 gtggtgggga cctatgaggc tctctatgag ctgatccagc caagcaatgc tcccatcttc
     1621 atcaattcca cctgtgcctt catataggga tctgggttcg tctctgcagc tgcctacccc
     1681 tgccccatgt gtcccccgtt acctgtcctc agagcctcag gtatggtcca ggctctgagg
     1741 aaagtcaggg ttgctgtgtg ggaacccctc tgcctggcac ctggataccc tgggccaggt
     1801 aacctgaggg caggggagag gtggggtggc agacacgcag aagtgctact agtgacaggg
     1861 ctgccatcgc tcacctgtac ctatttacac ccagaacttt ccagctcccc ctcatcatgc
     1921 ctcctccttc ctacctgcct cccctctgct ggtgcacctc gcccaactca ttcttactgc
     1981 acagttcact ttatttaaca attttcatgt cccccacctc atgttttcac cttttctggg
     2041 ccaggcatag attaagtaac tgggaacgcc ccctctttat aaagctgggc ttctttctca
     2101 tctctctccc aaatgttgta tctcagtatt cttcctattc gagtctccag ggggtggctg
     2161 gacctacctg gtcatttgaa acaggccccc aagctggagt ttttaatctg gactctctgg
     2221 cttgctgtga cccctaaggc aatgcttctc ttccctggat tccttagtgt gggtcacagt
     2281 actgtgttct tagttgcttt agctcttaaa acatacgaag tgttgcctaa actgaaaata
     2341 tttatctttt atttaaaatc agatttttgt ttttagactg tcttagatct ggggctatta
     2401 cgaatcactt cttcttcagt aaactttgac tcaacttctc ctgctgaaaa gaagctcgct
     2461 ccagatgtct gcatgggtcc tcggcactct tggctgagga ctcaaaggtt ttaatcagga
     2521 tcgtctaaaa atgtacctcg gtgaggaggc acagattttg cctcctgttg accagcctgg
     2581 tttcataccg aaaagacatt gaaggactgc agaaatgtat gggtgcaccg ggccgaggga
     2641 agggtggctg agtgagaggc gtataaaatg gggctgtgtg catgcaggcc catgtttcag
     2701 cctcagccca cgccaggtga aaggatcagc aatgctctgt tgccatcgtg ctgggacgac
     2761 accagctcta ttgccaccga tgagtagctg aggtcagtgt gcacagagtt tgaaattaag
     2821 ttaatagact ttacagcagc tggtctgaca ctacgcgcag tgctcggttg tttacaatca
     2881 gtggggaaaa gggcagaacc agtgcccggc cccacactgc ctctgtggcc tggactttga
     2941 aaggaaccca ctgaacacta attatgagcc ctgtctttcc cccagaatgc ctccctgggt
     3001 ttcacaaaca gccttgaggt tggccctcct caaggtcagc cttcagattt gggagcaaac
     3061 ttcagagaag gcagaggaag atacattgcc ttgctgtggg ctgcctcttc tttcctcttg
     3121 gtgtgcgaag tatttcagaa ggccattgat gaattccccc tctttagctg tgtatttgtg
     3181 cacgtgtgtg tgtacgtgcg tgtgtgtgtg tgttcctgtg taagtaacag accagactcc
     3241 ttttctcttc tgtcccgtca ccaggctctt gcttcactgc agatacagtt cactctgaaa
     3301 gctggttgaa ggagagcagc aaaaatgtat caggggtttt gcttctgtgt ttcgccaaag
     3361 ctcataaggg ctgtgaccca cccatatggc cccagttttt tctgtctctt ctgttccaaa
     3421 gccaggagag ctgacttcca ggtgaaggga tgggaaaagt ggactctcat tgtagtgact
     3481 cccaacctac ctaataattt gttaacttag gaatatgcta tcattgttga cttgttcttc
     3541 cttaggagaa ggacgatttt cacccaccct ttctgttcta tggtggactc ttaacaggtg
     3601 ctatgtgacc aggaatctag ccgggagtag cagaggccct gtcttctgaa gtctcaggct
     3661 tagaagttac caaagtgggc tcagaaactg tcatctcctg gttccaagtt cgggctctgg
     3721 cagcccagcc gctatcttag ctgtctttcc cagcggtgct aagagtggtc tcagtgagaa
     3781 ggtagatgcc aactggaggg ccagacctgt gtcctgccca tgtcctcctt ggtggacgtt
     3841 tctgtttact cagagctgct agagaccatc ctgcccatcc gagttctgag attgggactg
     3901 tgatgttggg acctgaggac tggatggtag aatactgggg tcccccagct cttagcagga
     3961 tgcaggctat tgcttccaca cccctggccg tgagaacgtg gtatgtagga gagttggctg
     4021 tagctttagg atttctggaa gccaatttgg catggcctat ttgatctctg gcttgtgctc
     4081 ctgctacact gacagactga ttgcgtggct ctttcagaag acccaggaag ggcagctcca
     4141 gccagaggac cttcctggct atgcaggtgc acagctctta ggcatcaagc aaagggtcag
     4201 ccagtcagta gtagtgggag gaagcccttc ctcctcttat gcaagcagct cgcagccagc
     4261 ccagaatctc ttatgcagcc caaagggctt cttgaggtag agagccctcc ccagtgtctt
     4321 cccaggataa gtagaaatat gatcacagag caacggagca aaggctttcg ggagtgtgag
     4381 gctgcatctg ctggagcaaa gggaaaccgt gggcttttcc ggccagatac tcttgagctc
     4441 tgtgaccctg ctcctgtcac cccaatttct ccaagccaga ggtagctttc tcagagcccc
     4501 ttggtggttc tgtcctccaa atgctgctgt tgggagcggg cttccagctc tcagtgggca
     4561 gtgcacctcc tcctaaatgc aggcacttgc taggaagagt gtgagctggc gtcttctgtt
     4621 caccctgcct agcagttgtc accattcaca agtggcatta tttatgttgt gctgctgtcc
     4681 agctgctaag atcccttcat ctgcacaagc cctggctaga tatgtgtgaa tgtgtggcat
     4741 catttcactt cagccgccca attccatctc tcctctgcag ccagattcac tggctgatgc
     4801 tcactgctca ctgtctatcc ccacgaaatt tagttttatc agtagtctta aagtgttgat
     4861 ctcaaacaag tacattagaa aaatcatgtt tcttctctct catcttactt tttcttctca
     4921 gatttctccc ttcctagaac attctctctg tttagcacta atgttcacct cgtatttttt
     4981 ggaagtgcaa aaatctcaat ttgtgtctgt ttacagctct ctctcctcac tgctcacagc
     5041 aaggggttct gtatcagtgg atttcatttt gtagctgctg agatgttaag gcaagcctca
     5101 gcatctgccc ctgctgggtg cacaatgctg cttcctcgaa gagaagacac agagtccaag
     5161 tggcaggact tgaggttggc ttccactctg ccttagaagt taattttcca aagtacatta
     5221 caaatctctg aggccattag gggaaaagga aggggtgtgg tttgtctttg aaattacggt
     5281 taatactttt agacagtaag tccggctggt tgcagggcta tttgccccga cagcatcagc
     5341 ctgtaacatt tcttctcttt cctttgtgcc actgagtcgt tccctggcca gaggacataa
     5401 atggtgctgg taggaggtta tcagagtaag gaaggtagca gatataggtg cagggtgcct
     5461 gtcattcact gtgttatttg gtttaaatca aagtgattct gggggaagct atgctctttc
     5521 agtggataat aaaattggta actctattgt aaaacatgtc aatggtgtgt gaagaaaaat
     5581 caaccaatct gtaggtgttg ataactagac agtactgtgt atgttacgtg cctgtgtgga
     5641 tgtgcacttc cagcatggta tgtgtagcga tgtggatcat gccagagttc gtagatcctg
     5701 ttttggggtt tgcacatgga tcgtatgtta agctttttct tttcaataaa tgaattttat
     5761 ttttattttt ga
//
