LOCUS       NM_054028               1349 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens solute carrier family 35 member G5 (SLC35G5), mRNA.
ACCESSION   NM_054028
VERSION     NM_054028.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1349)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1349)
  AUTHORS   Park,M.H., Kim,N., Lee,J.Y. and Park,H.Y.
  TITLE     Genetic loci associated with lipid concentrations and
            cardiovascular risk factors in the Korean population
  JOURNAL   J Med Genet 48 (1), 10-15 (2011)
   PUBMED   20972250
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1349)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Sinsheimer,J.S.,
            Riba,L., Huertas-Vazquez,A., Ordonez-Sanchez,M.L.,
            Rodriguez-Guillen,R., Cantor,R.M., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Investigation of variants identified in caucasian genome-wide
            association studies for plasma high-density lipoprotein cholesterol
            and triglycerides levels in Mexican dyslipidemic study samples
  JOURNAL   Circ Cardiovasc Genet 3 (1), 31-38 (2010)
   PUBMED   20160193
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1349)
  AUTHORS   Kathiresan,S., Willer,C.J., Peloso,G.M., Demissie,S., Musunuru,K.,
            Schadt,E.E., Kaplan,L., Bennett,D., Li,Y., Tanaka,T., Voight,B.F.,
            Bonnycastle,L.L., Jackson,A.U., Crawford,G., Surti,A., Guiducci,C.,
            Burtt,N.P., Parish,S., Clarke,R., Zelenika,D., Kubalanza,K.A.,
            Morken,M.A., Scott,L.J., Stringham,H.M., Galan,P., Swift,A.J.,
            Kuusisto,J., Bergman,R.N., Sundvall,J., Laakso,M., Ferrucci,L.,
            Scheet,P., Sanna,S., Uda,M., Yang,Q., Lunetta,K.L., Dupuis,J., de
            Bakker,P.I., O'Donnell,C.J., Chambers,J.C., Kooner,J.S.,
            Hercberg,S., Meneton,P., Lakatta,E.G., Scuteri,A., Schlessinger,D.,
            Tuomilehto,J., Collins,F.S., Groop,L., Altshuler,D., Collins,R.,
            Lathrop,G.M., Melander,O., Salomaa,V., Peltonen,L.,
            Orho-Melander,M., Ordovas,J.M., Boehnke,M., Abecasis,G.R.,
            Mohlke,K.L. and Cupples,L.A.
  TITLE     Common variants at 30 loci contribute to polygenic dyslipidemia
  JOURNAL   Nat Genet 41 (1), 56-65 (2009)
   PUBMED   19060906
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   5  (bases 1 to 1349)
  AUTHORS   Xing,J., Wang,H., Belancio,V.P., Cordaux,R., Deininger,P.L. and
            Batzer,M.A.
  TITLE     Emergence of primate genes by retrotransposon-mediated sequence
            transduction
  JOURNAL   Proc Natl Acad Sci U S A 103 (47), 17608-17613 (2006)
   PUBMED   17101974
REFERENCE   6  (bases 1 to 1349)
  AUTHORS   Appel,S., Filter,M., Reis,A., Hennies,H.C., Bergheim,A.,
            Ogilvie,E., Arndt,S., Simmons,A., Lovett,M., Hide,W., Ramsay,M.,
            Reichwald,K., Zimmermann,W. and Rosenthal,A.
  TITLE     Physical and transcriptional map of the critical region for
            keratolytic winter erythema (KWE) on chromosome 8p22-p23 between
            D8S550 and D8S1759
  JOURNAL   Eur J Hum Genet 10 (1), 17-25 (2002)
   PUBMED   11896452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF131216.2.
            
            On Nov 26, 2019 this sequence version replaced NM_054028.1.
            
            Summary: This gene is intronless and probably arose from
            retrotransposition of a similar gene. It has high sequence
            similarity to the gene encoding acyl-malonyl condensing enzyme on
            chromosome 17. [provided by RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AJ291677.1, BC131696.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382435.5/ ENSP00000371872.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1349              AF131216.2         121971-123319
FEATURES             Location/Qualifiers
     source          1..1349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.1"
     gene            1..1349
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
                     /note="solute carrier family 35 member G5"
                     /db_xref="GeneID:83650"
                     /db_xref="HGNC:HGNC:15546"
                     /db_xref="MIM:615199"
     exon            1..1349
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1112
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
                     /note="protein AMAC1L2; acyl-malonyl-condensing enzyme
                     1-like protein 2; acyl-malonyl condensing enzyme 1-like 2"
                     /codon_start=1
                     /product="solute carrier family 35 member G5"
                     /protein_id="NP_473369.1"
                     /db_xref="CCDS:CCDS5980.1"
                     /db_xref="GeneID:83650"
                     /db_xref="HGNC:HGNC:15546"
                     /db_xref="MIM:615199"
                     /translation="MAGSHPYFNLPDSTHPSPPSAPPSLRWHQRCQPSGATNGLLVAL
                     LGGGLPAGFVGPLSRMAYQGSNLPSLELLICRCLFHLPIALLLKLRGDPLLGPPDIRG
                     WACFCALLNVLSIGCAYSAVQVVPAGNAATVRKGSSTVCSAVLTLCLESQGLGGYEWC
                     GLLGSILGLIIILGPGLWTLQEGTTGVYTTLGYVQAFLGGLALSLGLLVYRSLHFPSC
                     LPTVAFLSGLVGLLGCVPGLFVLQTPVLPSDLLSWSCVGAEGILALVSFTCVGYAVTK
                     AHPALVCAVLHSEVVVALILQYYMLHETVALSDIMGAGVVLGSIAIITARNLSCERTG
                     KVEE"
     regulatory      1275..1280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
                     /note="hexamer: AATAAA"
     polyA_site      1300
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
                     /note="major polyA site"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
                     /note="hexamer: AATAAA"
     polyA_site      1349
                     /gene="SLC35G5"
                     /gene_synonym="AMAC; AMAC1L2"
ORIGIN      
        1 gaaccccacc cgcactccaa tgaggtcaca atggctggag ctctgagggg cccaggctcc
       61 ctgagccagg aggagaggag aaagtccaag gaaagatggc tggcagtcac ccctacttca
      121 acctgcctga ctccacacac ccatcgccgc cctccgctcc acccagcctc cgctggcacc
      181 agcgctgcca gccctctggt gccaccaatg gcctgctggt ggccctgctg ggtgggggcc
      241 tgcctgctgg cttcgtgggc cccctttctc gtatggctta ccagggttcc aacctgccct
      301 cgctggagct gctcatctgt cgatgcctct tccacctccc tattgccctg ctacttaaac
      361 tgcgtggcga cccccttctg ggacctcctg acatccgagg ctgggcctgc ttctgtgccc
      421 tgctcaacgt cctcagcatt ggatgtgcct acagtgcagt tcaggtggtg cccgctggca
      481 acgctgccac tgttcgcaaa ggttcttcca ccgtatgctc cgctgtcctc accctctgcc
      541 ttgagagcca gggtctcggt ggctacgagt ggtgtggact gttgggcagc atcctaggac
      601 taatcatcat tctgggacct ggactctgga cactacagga ggggaccaca ggtgtctaca
      661 ccaccctggg ctatgtgcag gctttcctgg gaggcctggc gctgtccctg gggcttctgg
      721 tctatcgttc tctgcacttt ccctcctgcc tcccaacagt ggccttccta tctggcttgg
      781 tggggctgct gggctgtgtg ccaggcctct ttgtgctgca gacccccgtg ttgcccagtg
      841 acctcctgag ttggagttgt gtgggggcag aggggatcct cgccttggtc tccttcacat
      901 gtgtgggcta tgcggtcacc aaggcccacc ctgccctggt gtgcgctgtc ctgcattccg
      961 aggtggttgt ggcccttata ctgcagtatt atatgctcca tgagactgtg gcactttctg
     1021 acatcatggg ggcaggggtt gtgctgggca gcattgccat cattacagcc cggaacctca
     1081 gctgtgagag gacagggaag gtggaggagt gagatagaac ttgggagccc gggggttggg
     1141 agggacaggg ataaataaag acaaagactg aagacaaaaa aaaaataaaa gaaaaaaaat
     1201 aattataata aatcctagga aagagtgaaa gtctaacttc catagcacat tataatattg
     1261 agatgttcag ttataataaa aatatcacaa agcatgcaaa caaatgagaa atctggctta
     1321 tttacaggaa taaaattaat tgaactatc
//
