LOCUS       NM_025246               1949 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 35 member G2 (SLC35G2),
            transcript variant 1, mRNA.
ACCESSION   NM_025246
VERSION     NM_025246.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1949)
  AUTHORS   Qian,C., Wu,Z., Sun,R., Yu,H., Zeng,J., Rao,Y. and Li,Y.
  TITLE     Localization, proteomics, and metabolite profiling reveal a
            putative vesicular transporter for UDP-glucose
  JOURNAL   Elife 10, e65417 (2021)
   PUBMED   34269178
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1949)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1949)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1949)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1949)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1949)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1949)
  AUTHORS   Dobashi,S., Katagiri,T., Hirota,E., Ashida,S., Daigo,Y., Shuin,T.,
            Fujioka,T., Miki,T. and Nakamura,Y.
  TITLE     Involvement of TMEM22 overexpression in the growth of renal cell
            carcinoma cells
  JOURNAL   Oncol Rep 21 (2), 305-312 (2009)
   PUBMED   19148500
  REMARK    GeneRIF: the TMEM22/RAB37 complex is likely to play a crucial role
            in growth of renal cell carcinoma
REFERENCE   8  (bases 1 to 1949)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 1949)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050423.1 and CB123281.1.
            
            On Nov 22, 2018 this sequence version replaced NM_025246.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136661.1, SRR1803612.187929.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446465.3/ ENSP00000400839.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1945              BC050423.1         108-2052
            1946-1949           CB123281.1         36-39               c
FEATURES             Location/Qualifiers
     source          1..1949
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..1949
                     /gene="SLC35G2"
                     /gene_synonym="TMEM22"
                     /note="solute carrier family 35 member G2"
                     /db_xref="GeneID:80723"
                     /db_xref="HGNC:HGNC:28480"
                     /db_xref="MIM:617812"
     exon            1..503
                     /gene="SLC35G2"
                     /gene_synonym="TMEM22"
                     /inference="alignment:Splign:2.1.0"
     exon            504..1949
                     /gene="SLC35G2"
                     /gene_synonym="TMEM22"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..1760
                     /gene="SLC35G2"
                     /gene_synonym="TMEM22"
                     /note="transmembrane protein 22"
                     /codon_start=1
                     /product="solute carrier family 35 member G2"
                     /protein_id="NP_079522.2"
                     /db_xref="CCDS:CCDS3091.1"
                     /db_xref="GeneID:80723"
                     /db_xref="HGNC:HGNC:28480"
                     /db_xref="MIM:617812"
                     /translation="MDTSPSRKYPVKKRVKIHPNTVMVKYTSHYPQPGDDGYEEINEG
                     YGNFMEENPKKGLLSEMKKKGRAFFGTMDTLPPPTEDPMINEIGQFQSFAEKNIFQSR
                     KMWIVLFGSALAHGCVALITRLVSDRSKVPSLELIFIRSVFQVLSVLVVCYYQEAPFG
                     PSGYRLRLFFYGVCNVISITCAYTSFSIVPPSNGTTMWRATTTVFSAILAFLLVDEKM
                     AYVDMATVVCSILGVCLVMIPNIVDEDNSLLNAWKEAFGYTMTVMAGLTTALSMIVYR
                     SIKEKISMWTALFTFGWTGTIWGISTMFILQEPIIPLDGETWSYLIAICVCSTAAFLG
                     VYYALDKFHPALVSTVQHLEIVVAMVLQLLVLHIFPSIYDVFGGVIIMISVFVLAGYK
                     LYWRNLRKQDYQEILDSPIK"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35G2"
                     /gene_synonym="TMEM22"
                     /note="hexamer: ATTAAA"
     polyA_site      1949
                     /gene="SLC35G2"
                     /gene_synonym="TMEM22"
                     /note="major polyA site"
ORIGIN      
        1 actccgggca gcgcccgcct cgattttccc aggcgagggc acgcccgcgt cagtcgcctc
       61 cggggcacct tcctcgccac gacacgcagg taaccgggcc ccgggagccg gtcggcggcg
      121 gcggactggg accttgatcc tgcctgcccg gccgcccgac aagggaatga gagcggaccc
      181 cgaactccac acacccgcgt ttagccgcca cacctaaggg gcacaacagt ctttttgggt
      241 aagggccggg ctgggggcga cgcgccccgc ccgctttgca gacttcgggg tgctctgcac
      301 gacgcctgaa aggccgcggg gcccgcattt ctctgtgctg ccctcctgga gaaccgggac
      361 acggggacgg gagggccagc atcggctacg gcccggtttc ccgtttcttt ccgctgtcgc
      421 gtgtctgggc cctcctgcag cgtccatgat gaaggccagg ggctgttgct ttcctctcgc
      481 ccagtagcca acccaagcaa gggaattgat tatctgaaga aatggatact tctccctcca
      541 gaaaatatcc agttaaaaaa cgggtgaaaa tacatcccaa cacagtgatg gtgaaatata
      601 cttctcatta tccccagcct ggcgatgatg gatatgaaga aatcaatgaa ggctatggaa
      661 attttatgga ggaaaatcca aagaaaggtc tgctgagtga aatgaaaaaa aaagggagag
      721 ctttctttgg aaccatggat accctacctc caccaacaga agacccaatg atcaatgaga
      781 ttggacaatt ccagagcttt gcagaaaaaa acatttttca atcccgaaaa atgtggatag
      841 tgctgtttgg atctgctttg gctcatggat gtgtagctct tatcactagg cttgtttctg
      901 atcggtctaa agttccatct ctagaactga tttttatccg ttctgttttt caggtcttat
      961 ctgtgttagt tgtgtgttac tatcaggagg ccccctttgg acccagtgga tacagattac
     1021 gactcttctt ttatggtgta tgcaatgtca tttctatcac ttgtgcttat acatcatttt
     1081 caatagttcc tcccagcaat gggaccacta tgtggagagc cacaactaca gtcttcagtg
     1141 ccattttggc ttttttactc gtagatgaga aaatggctta tgttgacatg gctacagttg
     1201 tttgcagcat cttaggtgtt tgtcttgtca tgatcccaaa cattgttgat gaagacaatt
     1261 ctttgttaaa tgcctggaaa gaagcctttg ggtacaccat gactgtgatg gctggactga
     1321 ccactgctct ctcaatgata gtatacagat ccatcaagga gaagatcagc atgtggactg
     1381 cactgtttac ttttggttgg actgggacaa tttggggaat atctactatg tttattcttc
     1441 aagaacccat catcccatta gatggagaaa cctggagtta tctcattgct atatgtgtct
     1501 gttctactgc agcattctta ggagtttatt atgccttgga caaattccat ccagctttgg
     1561 ttagcacagt acaacatttg gagattgtgg tagctatggt cttgcagctt ctcgtgctgc
     1621 acatatttcc tagcatctat gatgtttttg gaggggtaat cattatgatt agtgtttttg
     1681 tccttgctgg ctataaactt tactggagga atttaagaaa gcaggactac caggaaatac
     1741 tagactctcc cattaaatga atacctgatt attattgtct cattaatgtt cagttattat
     1801 gtatactgcc attttaatgt ttacctatga atgtcttttg tgttatataa ctgacagagt
     1861 gctataaaat atataatata tacaaatgca gaaaatttat tctagtctaa tatattcaaa
     1921 tacaaatatt aaatatatga aatacgtta
//
