LOCUS       NM_001134658            3488 bp    mRNA    linear   PRI 17-NOV-2024
DEFINITION  Homo sapiens solute carrier family 35 member G1 (SLC35G1),
            transcript variant 1, mRNA.
ACCESSION   NM_001134658
VERSION     NM_001134658.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3488)
  AUTHORS   Mimura,Y., Yasujima,T., Inoue,K., Akino,S., Namba,C., Kusuhara,H.,
            Sekiguchi,Y., Ohta,K., Yamashiro,T. and Yuasa,H.
  TITLE     SLC35G1 is a highly chloride-sensitive transporter responsible for
            the basolateral membrane transport in intestinal citrate absorption
  JOURNAL   Elife 13, 98853 (2024)
   PUBMED   39508819
  REMARK    GeneRIF: SLC35G1 is a highly chloride-sensitive transporter
            responsible for the basolateral membrane transport in intestinal
            citrate absorption.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3488)
  AUTHORS   Wang,J., Yu,J., Wang,M., Zhang,L., Yang,K., Du,X., Wu,J., Wang,X.,
            Li,F. and Qiu,Z.
  TITLE     Discovery and Validation of Novel Genes in a Large Chinese Autism
            Spectrum Disorder Cohort
  JOURNAL   Biol Psychiatry 94 (10), 792-803 (2023)
   PUBMED   37393044
  REMARK    GeneRIF: Discovery and Validation of Novel Genes in a Large Chinese
            Autism Spectrum Disorder Cohort.
REFERENCE   3  (bases 1 to 3488)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3488)
  AUTHORS   Hirayama,S., Sugihara,M., Morito,D., Iemura,S.I., Natsume,T.,
            Murata,S. and Nagata,K.
  TITLE     Nuclear export of ubiquitinated proteins via the UBIN-POST system
  JOURNAL   Proc Natl Acad Sci U S A 115 (18), E4199-E4208 (2018)
   PUBMED   29666234
  REMARK    GeneRIF: results suggest that ubiquitinated proteins are exported
            from the nucleus to the cytosol in the UBIN-POST complex-dependent
            manner for the maintenance of nuclear protein homeostasis.
REFERENCE   5  (bases 1 to 3488)
  AUTHORS   Sherva,R., Wang,Q., Kranzler,H., Zhao,H., Koesterer,R., Herman,A.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Genome-wide Association Study of Cannabis Dependence Severity,
            Novel Risk Variants, and Shared Genetic Risks
  JOURNAL   JAMA Psychiatry 73 (5), 472-480 (2016)
   PUBMED   27028160
REFERENCE   6  (bases 1 to 3488)
  AUTHORS   Hatzirodos,N., Hummitzsch,K., Irving-Rodgers,H.F. and Rodgers,R.J.
  TITLE     Transcriptome comparisons identify new cell markers for theca
            interna and granulosa cells from small and large antral ovarian
            follicles
  JOURNAL   PLoS One 10 (3), e0119800 (2015)
   PUBMED   25775029
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3488)
  AUTHORS   Krapivinsky,G., Krapivinsky,L., Stotz,S.C., Manasian,Y. and
            Clapham,D.E.
  TITLE     POST, partner of stromal interaction molecule 1 (STIM1), targets
            STIM1 to multiple transporters
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19234-19239 (2011)
   PUBMED   22084111
REFERENCE   8  (bases 1 to 3488)
  AUTHORS   Vastermark,A., Almen,M.S., Simmen,M.W., Fredriksson,R. and
            Schioth,H.B.
  TITLE     Functional specialization in nucleotide sugar transporters occurred
            through differentiation of the gene cluster EamA (DUF6) before the
            radiation of Viridiplantae
  JOURNAL   BMC Evol Biol 11, 123 (2011)
   PUBMED   21569384
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK091309.1, BC104814.1,
            BC041432.1 and AL138923.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001134658.2.
            
            Summary: This gene encodes a transmembrane protein which is a
            member of the drug/metabolite transporter protein superfamily. The
            encoded protein may play a role in the regulation of calcium levels
            inside the cell. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.278208.1,
                                           ERR279849.2066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000427197.2/ ENSP00000400932.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK091309.1         6-31
            27-1238             BC104814.1         3-1214
            1239-2398           BC041432.1         973-2132
            2399-3488           AL138923.9         71362-72451
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.33"
     gene            1..3488
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /note="solute carrier family 35 member G1"
                     /db_xref="GeneID:159371"
                     /db_xref="HGNC:HGNC:26607"
                     /db_xref="MIM:617167"
     exon            1..234
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1154
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transmembrane protein 20; partner of STIM1"
                     /codon_start=1
                     /product="solute carrier family 35 member G1 isoform 1"
                     /protein_id="NP_001128130.1"
                     /db_xref="CCDS:CCDS44459.1"
                     /db_xref="GeneID:159371"
                     /db_xref="HGNC:HGNC:26607"
                     /db_xref="MIM:617167"
                     /translation="MRPQDSTGVAELQEPGLPLTDDAPPGATEEPAAAEAAGAPDRGR
                     CWLCLSSPCCSRTEPEAKKKAPCPGLGLFYTLLSAFLFSVGSLFVKKVQDVHAVEISA
                     FRCVFQMLVVIPCLIYRKTGFIGPKGQRIFLILRGVLGSTAMMLIYYAYQTMSLADAT
                     VITFSSPVFTSIFAWICLKEKYSPWDALFTVFTITGVILIVRPPFLFGSDTSGMEESY
                     SGHLKGTFAAIGSAVFAASTLVILRKMGKSVDYFLSIWYYVVLGLVESVIILSVLGEW
                     SLPYCGLDRLFLIFIGLFGLGGQIFITKALQIEKAGPVAIMKTMDVVFAFIFQIIFFN
                     NVPTWWTVGGALCVVASNVGAAIRKWYQSSK"
     exon            235..415
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /inference="alignment:Splign:2.1.0"
     exon            416..3488
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2377..2382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /note="hexamer: AATAAA"
     polyA_site      2398
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /note="major polyA site"
     regulatory      3464..3469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
                     /note="hexamer: AATAAA"
     polyA_site      3484
                     /gene="SLC35G1"
                     /gene_synonym="C10orf60; POST; TMEM20"
ORIGIN      
        1 aggcgctgct gctggcgcca gacggcaccg gccgctggta gagcgcgtgc cgcgagatgc
       61 ggcctcagga cagcaccggg gtcgcggagc tccaggagcc cgggctgccg ctaacggacg
      121 atgcaccccc gggcgccact gaggagccgg cggccgccga ggcagctggg gcgccagacc
      181 gcggtaggtg ctggctctgc ctttcctcgc cgtgttgctc ccgcaccgag ccggaagcca
      241 agaagaaagc accctgtcct ggacttggct tgttttacac attattgtct gccttccttt
      301 tctcagtggg ctctttattt gttaaaaaag tgcaagacgt ccatgctgta gagattagtg
      361 cgtttcgatg tgtgttccaa atgctagttg ttatcccttg cttaatatac agaaaaactg
      421 ggtttatagg cccaaaaggt caacgaattt tcctcattct cagaggagtc cttggttcta
      481 ccgccatgat gcttatatac tatgcttacc agacaatgtc cctcgctgat gccacagtta
      541 tcacgtttag cagtccagtg tttacgtcca tatttgcttg gatatgtctc aaggaaaaat
      601 atagcccttg ggatgctctt ttcaccgtgt tcacaatcac tggagtgatc cttatcgtga
      661 gaccaccatt tttgtttggt tccgacactt cggggatgga agaaagctat tcaggccacc
      721 ttaagggaac attcgcagca attggaagtg ccgtatttgc tgcatcgact ctagttatcc
      781 taagaaaaat gggaaaatct gtggactact ttctgagcat ttggtattat gtagtacttg
      841 gcctcgttga aagtgtcatc atcctctctg tattaggaga gtggagtctg ccttactgtg
      901 ggttggacag gctatttctc atattcattg ggctctttgg tttggggggt cagatattta
      961 tcacaaaagc acttcaaata gaaaaagcag ggccagtagc aataatgaag acaatggatg
     1021 tggtctttgc ttttatcttt cagattattt tctttaataa tgtgccaacg tggtggacag
     1081 tgggtggtgc tctctgcgta gtagccagta atgttggagc ggccattcgt aaatggtacc
     1141 aaagttccaa atgaagcatc attgctgaaa tacatatttt tttcaagtac accatcacct
     1201 aattcacata cagcatacgc acacatctgg aaaatctgca ttttcttcat tggttgtatt
     1261 taataaattg cctaaagtac catttttgaa tatagtatgt ctttagttaa gaatagctag
     1321 tctgtttggt gtaacaattt tttggtagct ttggttttgg ttttggtttt ttttgttgtt
     1381 gttgttgggg tcaagttggt gagaggagag ctcattgttt gaagaaaaac caaaacattt
     1441 tatggctagt aatatttatg taatttttaa aatgtatttt tggtactgat gggatatggg
     1501 tggggaggct attttagata ttcttttagc agtgtagagc ctaagaaact tggttctact
     1561 accatgatct ttataaacta tgccttccag acaattgata atgctgctat aattagtatt
     1621 atgttgataa ttcatttgca accttattct atttaggagg atgaagttga agcttagaat
     1681 aggtgcctgc ttaatggtgt taataataca aatgaattgg ccttattttc aaggatttta
     1741 taaatgatta tcatacttgt aactcatatt tgtgcctttt cattttaatg ctggaatttt
     1801 tattatgtca cctctaaaac acttaaattg ccaaatttgg ctagtagttt tgtttcagtg
     1861 gcattagcaa ctgcagctag catactataa ttttaattgt cctcactttt ttttgaaact
     1921 gcactaaatt tttcttaaca ttccaagatt tcagatctct aaatcacaaa gagaaatctt
     1981 ggcatgacca gtgtgcacgt ttccatcctg aagtgttttc tcttcactag aaatgtgatt
     2041 ttctataaat tccccttgaa tttatagtgt gatgccaaat aaaattttct caggatctta
     2101 ttaggttgaa ccatatgtaa ttgccaagat tttactattt taacttagaa aaaccatcgt
     2161 ttcatatgat tcaccctaat agatacctcc attattctct aaatgaaata gaagactttg
     2221 gagtatatgt ttttaaagta attttttaaa atatggtaat gtattaaact tatttttata
     2281 gttatgaaat tatgtgtaat aatgctttat gttatacatt aaatgtaaag acttgtgaat
     2341 ccatgtttga ttgactttca tagtttcctg cattgaaata aaatcactat gaattctagt
     2401 ttatcagcat gatgttaaat gtcagtgcca taccatgatg cagcaccatg acactaacgc
     2461 catgaattca aacagcacgt tttacacctg gaacttcatc agaccaatac tttgcagtta
     2521 gagagaattt aatatctaga aaagcttggg aggttagtca ggacttaggg agtatacata
     2581 aatggttact tgttgtaatg agccctttat tggtgaggtt gcaatagctt ccagctctta
     2641 ctgtgtcaga tgaagcatct gtcattatct taagcctgca gagttgaaag gttataggct
     2701 ctttcctacc ctctcatcat aatttttcca aagcaaagag gaacttggct tctggggttc
     2761 gtgccttagt gagaaagaat cttttccaat agttccaatg ggggaatttt tggcttgctg
     2821 attttatcaa ttgccttgac acctgacaaa ccctaaatga agtctatgta ggtgagtcat
     2881 ctctgttcca cctgatttac agtattggaa tttagacttg caaaaacatc attctgcaaa
     2941 tatcttagat aattacagaa tcaggagcat ttgagaactc tagaggtctc agaaatcatc
     3001 acataggggc catgcttcgt agatagggat gatagagagg agacctgccc aagttgaatt
     3061 tccatggcct tcctcccttc cttagttcca tgataaagta tggacagtaa accactactt
     3121 gagctaccta aggtgaatta actctcaggg aaccctcttc cagttcttta ccttgcacag
     3181 tgaaagaatc agtggcacct agaaagttaa atccctttag gcccatacac tagagacatg
     3241 ttttgtttga acaatgtagt ttaagtactt gaatgtcaca ctatataact gaggttagag
     3301 aaaatgtttc ttctagccct tacagggtgt gattcttaaa cacaatgtcc aaggtgtata
     3361 caaggatatg tattgtaaca actatgggta tgtatatttt gcagagcgta gtttctatat
     3421 cttgaaaagg aaaatatttt cataaattgt ttttataagt actaataaaa taatatgaaa
     3481 gaaagcta
//
