LOCUS       NM_017877               3902 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens solute carrier family 35 member F6 (SLC35F6), mRNA.
ACCESSION   NM_017877
VERSION     NM_017877.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3902)
  AUTHORS   Van den Bossche,F., Tevel,V., Gilis,F., Gaussin,J.F., Boonen,M. and
            Jadot,M.
  TITLE     Residence of the Nucleotide Sugar Transporter Family Members
            SLC35F1 and SLC35F6 in the Endosomal/Lysosomal Pathway
  JOURNAL   Int J Mol Sci 25 (12), 6718 (2024)
   PUBMED   38928424
  REMARK    GeneRIF: Residence of the Nucleotide Sugar Transporter Family
            Members SLC35F1 and SLC35F6 in the Endosomal/Lysosomal Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3902)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3902)
  AUTHORS   Schroder,B.A., Wrocklage,C., Hasilik,A. and Saftig,P.
  TITLE     The proteome of lysosomes
  JOURNAL   Proteomics 10 (22), 4053-4076 (2010)
   PUBMED   20957757
  REMARK    Review article
REFERENCE   4  (bases 1 to 3902)
  AUTHORS   Kashiwaya,K., Hosokawa,M., Eguchi,H., Ohigashi,H., Ishikawa,O.,
            Shinomura,Y., Nakamura,Y. and Nakagawa,H.
  TITLE     Identification of C2orf18, termed ANT2BP (ANT2-binding protein), as
            one of the key molecules involved in pancreatic carcinogenesis
  JOURNAL   Cancer Sci 100 (3), 457-464 (2009)
   PUBMED   19154410
  REMARK    GeneRIF: C2orf18, termed ANT2-binding protein (ANT2BP), might serve
            as a candidate molecular target for pancreatic cancer therapy.
REFERENCE   5  (bases 1 to 3902)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3902)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   7  (bases 1 to 3902)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   8  (bases 1 to 3902)
  AUTHORS   Ashikov,A., Routier,F., Fuhlrott,J., Helmus,Y., Wild,M.,
            Gerardy-Schahn,R. and Bakker,H.
  TITLE     The human solute carrier gene SLC35B4 encodes a bifunctional
            nucleotide sugar transporter with specificity for UDP-xylose and
            UDP-N-acetylglucosamine
  JOURNAL   J Biol Chem 280 (29), 27230-27235 (2005)
   PUBMED   15911612
REFERENCE   9  (bases 1 to 3902)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011740.7 and AY358820.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017877.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.85744.1,
                                           SRR1803617.250719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344420.10/ ENSP00000345528.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC011740.7         19456-19469
            15-1520             AY358820.1         1-1506
            1521-3902           AC011740.7         34022-36403
FEATURES             Location/Qualifiers
     source          1..3902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3902
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /note="solute carrier family 35 member F6"
                     /db_xref="GeneID:54978"
                     /db_xref="HGNC:HGNC:26055"
                     /db_xref="MIM:619667"
     exon            1..143
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1182
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /note="transmembrane protein C2orf18; ANT2-binding
                     protein; transport and golgi organization 9 homolog"
                     /codon_start=1
                     /product="solute carrier family 35 member F6 precursor"
                     /protein_id="NP_060347.2"
                     /db_xref="CCDS:CCDS1728.1"
                     /db_xref="GeneID:54978"
                     /db_xref="HGNC:HGNC:26055"
                     /db_xref="MIM:619667"
                     /translation="MAWTKYQLFLAGLMLVTGSINTLSAKWADNFMAEGCGGSKEHSF
                     QHPFLQAVGMFLGEFSCLAAFYLLRCRAAGQSDSSVDPQQPFNPLLFLPPALCDMTGT
                     SLMYVALNMTSASSFQMLRGAVIIFTGLFSVAFLGRRLVLSQWLGILATIAGLVVVGL
                     ADLLSKHDSQHKLSEVITGDLLIIMAQIIVAIQMVLEEKFVYKHNVHPLRAVGTEGLF
                     GFVILSLLLVPMYYIPAGSFSGNPRGTLEDALDAFCQVGQQPLIAVALLGNISSIAFF
                     NFAGISVTKELSATTRMVLDSLRTVVIWALSLALGWEAFHALQILGFLILLIGTALYN
                     GLHRPLLGRLSRGRPLAEESEQERLLGGTRTPINDAS"
     exon            144..216
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /inference="alignment:Splign:2.1.0"
     exon            217..388
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /inference="alignment:Splign:2.1.0"
     exon            389..601
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /inference="alignment:Splign:2.1.0"
     exon            602..712
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /inference="alignment:Splign:2.1.0"
     exon            713..3902
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3799..3804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /note="hexamer: AAGAAA"
     polyA_site      3818
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /note="major polyA site"
     polyA_site      3853
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
     regulatory      3878..3883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /note="hexamer: TATAAA"
     regulatory      3882..3887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
                     /note="hexamer: AAGAAA"
     polyA_site      3897
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
     polyA_site      3902
                     /gene="SLC35F6"
                     /gene_synonym="ANT2BP; C2orf18; TANGO9"
ORIGIN      
        1 gcgcaggaga ccccgggtga cggggcccgg cgccgctaac tggagcgaac cccagcgtcc
       61 gccgacatgg cctggaccaa gtaccagctg ttcctggccg ggctcatgct tgttaccggc
      121 tccatcaaca cgctctcggc aaaatgggcg gacaatttca tggccgaggg ctgtggaggg
      181 agcaaggagc acagcttcca gcatcccttc ctccaggcag tgggcatgtt cctgggagaa
      241 ttctcctgcc tggctgcctt ctacctcctc cgatgcagag ctgcagggca atcagactcc
      301 agcgtagacc cccagcagcc cttcaaccct cttcttttcc tgcccccagc gctctgtgac
      361 atgacaggga ccagcctcat gtatgtggct ctgaacatga ccagtgcctc cagcttccag
      421 atgctgcggg gtgcagtgat catattcact ggcctgttct cggtggcctt cctgggccgg
      481 aggctggtgc tgagccagtg gctgggcatc ctagccacca tcgcggggct ggtggtcgtg
      541 ggcctggctg acctcctgag caagcacgac agtcagcaca agctcagcga agtgatcaca
      601 ggggacctgt tgatcatcat ggcccagatc atcgttgcca tccagatggt gctagaggag
      661 aagttcgtct acaaacacaa tgtgcaccca ctgcgggcag ttggcactga gggcctcttt
      721 ggctttgtga tcctctccct gctgctggtg cccatgtact acatccccgc cggctccttc
      781 agcggaaacc ctcgtgggac actggaggat gcattggacg ccttctgcca ggtgggccag
      841 cagccgctca ttgccgtggc actgctgggc aacatcagca gcattgcctt cttcaacttc
      901 gcaggcatca gcgtcaccaa ggaactgagc gccaccaccc gcatggtgtt ggacagcttg
      961 cgcaccgttg tcatctgggc actgagcctg gcactgggct gggaggcctt ccatgcactg
     1021 cagatccttg gcttcctcat actccttata ggcactgccc tctacaatgg gctacaccgt
     1081 ccgctgctgg gccgcctgtc caggggccgg cccctggcag aggagagcga gcaggagaga
     1141 ctgctgggtg gcacccgcac tcccatcaat gatgccagct gaggttccct ggaggcttct
     1201 actgccaccc gggtgctcct tctccctgag actgaggcca cacaggctgg tgggccccga
     1261 atgccctatc cccaaggcct caccctgtcc cctccctgca gaacccccag ggcagctgct
     1321 gccacagaag ataacaacac ccaagtcctc tttttctcac taccacctgc agggtggtgt
     1381 tacccagccc ccacaagcct gagtgcagtg gcagacctca gctctctgga cccctcctac
     1441 agcactagag ctaaatcatg aagttgaatt gtaggaattt accaccgtag tgtatctgaa
     1501 tcataaacta gattatcata gttatctagt ttatgagtca taagctagat ttgattcttc
     1561 aaagaagaaa agtcagtgag caaatttaaa ccagaactaa gcattatatt ttcttttttt
     1621 ttttttgaga cagagtctcg ctctgtcgcc caggctggag tgcagtggca cgatctcggc
     1681 ggctcactac aacctctgcc tcccaggttc aaatgattct cctgcctcag cctcccgagt
     1741 agctgggatt acaggtgcat aacacacctg ggtaactttt atagagatgg ggtttcacca
     1801 tgttggccag gctggtctca aactcctgac ctcaggtgat ctgcctgcct cggcctccca
     1861 aagtgctggg attacaggcg tgagacacca cacccagcca taactaagca ttatgttttc
     1921 taaaacttct aagatcctcc ctaaacccgt ctggagacat gggttttagc ccagactctg
     1981 cctcaaactc attgtagctc ccagcacatt acccagttgc tctgggcctt ggtgttatgc
     2041 tctgggaagt agatgttgat gctgtggcct tagtgccttc tggccccagc attccatggg
     2101 cctgtgatct tgaccaacct gagaaaacag taacagccca tccactggaa atacccctct
     2161 gcccacagca ccacccttct gtgctgtttt ttttgttgtt tgtttgtttc ttctttttga
     2221 gacagagtct tgctctgttg ccacgctgga gtgcagtggt gtgatctcgg ctcactgcaa
     2281 cctcccgctc ccaggttcaa gcaagtcccc tgagtagctg ggactacagg cgtgtgccac
     2341 cacatccggc taattttttg cattctttaa tagagacggg gttttgccat gttggccagg
     2401 atggtctcaa tctcctgacc tcatgatcca cctgcctcag cctcccaaag tgctggggtt
     2461 acaggcatga gccaccacgc ccagcctttt tttttttttt ttttttttct tgagagacag
     2521 ggtcttgctc tgtcacccag gcacagctta ctgcagcctt gaactcctgg gatcaatcag
     2581 tcctcctgcc tcagcctccc gagtagctaa gactaacagg tatgtaccac catgcctggt
     2641 ttattgtttt atttttttgg cagagatggg tctcactgtg ttgcccaggc tgatctcaaa
     2701 ctcctggcct caagcgatcc tcccatctca gcctcccaaa gtgctgggat tacagacctg
     2761 agccaccaca cctgggcaac agagtgaaac ctgtccctgt tttcctgctc ttactctcac
     2821 ctctgaggcc tcctctgcct ggaagagatt acagggaaat tccaggcagc ccttgtcaat
     2881 tgtttttatg aattctttac ctgttccttt taaagacaag gaaactgagg cccaaagttc
     2941 taagttgttt ggcaaatgga gtctcctacc ctcagctcct gcaaggacct gggggacccc
     3001 caggtccagc agccacatga ttctgcagca gacagggacc tagagcacat ctggatctca
     3061 gccccacccc tggcaacctg cctgcctaga gaactcccaa gatgacagac taagtaggat
     3121 tctgccattt agaataattc tggtatcctg ggcgttgcgt taagttgctt aactttcatt
     3181 ctgtcttacg atagtcttca gaggtgggaa cagatgaaga aaccatgccc cagagaaggt
     3241 taagtgactt cctctttatg gagccagtgt tccaacctag gtttgcctga taccagacct
     3301 gtggccccac ctcccatgca ggtctctgtg gggtctttgg gatggatctc ctagggctgg
     3361 gctggaagcc tcatgtactg ttgtcttcta ggtaaccacc ctgaagagaa ggggtggcat
     3421 caggaaccgc agggaaccaa gcagcctttg gtccagtgct gctccttgga acagttgagt
     3481 gtggcctcaa accattctcc tgggtagctc agtcataaaa caccgaatgc ctgcctcaaa
     3541 atagcctctg agggaaggga gctgttgaca agtgaagccc tcaggttgtg tgggattcca
     3601 gcaggttatt acagcttgtg gggggaggga gggtccattc caccagcttt gaatcccagg
     3661 gtcccctcag cttcactggg ccacagtgtc tgtcccagga agaagcaaat ggacagtgag
     3721 gatgatggag agactacagc tgccttgtct aaaacctggg atcttaaaag tgttattttg
     3781 gcttttattt tttaaaaaaa gaaaaggaaa attggcaatt gtattaatcc attctcgaat
     3841 tgctgtaaag aaatacctga gactgggtaa tttaatttat aaagaaaaga ggtttaattg
     3901 gc
//
