LOCUS       NM_173508               3143 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 35 member F3 (SLC35F3),
            transcript variant 1, mRNA.
ACCESSION   NM_173508 XM_939358
VERSION     NM_173508.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3143)
  AUTHORS   Zhang,K., Huentelman,M.J., Rao,F., Sun,E.I., Corneveaux,J.J.,
            Schork,A.J., Wei,Z., Waalen,J., Miramontes-Gonzalez,J.P.,
            Hightower,C.M., Maihofer,A.X., Mahata,M., Pastinen,T., Ehret,G.B.,
            Schork,N.J., Eskin,E., Nievergelt,C.M., Saier,M.H. Jr. and
            O'Connor,D.T.
  CONSRTM   International Consortium for Blood Pressure Genome-Wide Association
            Studies
  TITLE     Genetic implication of a novel thiamine transporter in human
            hypertension
  JOURNAL   J Am Coll Cardiol 63 (15), 1542-1555 (2014)
   PUBMED   24509276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL713868.12 and AK095031.1.
            
            On Nov 22, 2018 this sequence version replaced NM_173508.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.165667.1, AK095031.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366618.8/ ENSP00000355577.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-257               AL713868.12        25539-25795
            258-3143            AK095031.1         3-2888
FEATURES             Location/Qualifiers
     source          1..3143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..3143
                     /gene="SLC35F3"
                     /note="solute carrier family 35 member F3"
                     /db_xref="GeneID:148641"
                     /db_xref="HGNC:HGNC:23616"
     exon            1..455
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..1875
                     /gene="SLC35F3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative thiamine transporter SLC35F3"
                     /codon_start=1
                     /product="solute carrier family 35 member F3 isoform 1"
                     /protein_id="NP_775779.1"
                     /db_xref="CCDS:CCDS1600.1"
                     /db_xref="GeneID:148641"
                     /db_xref="HGNC:HGNC:23616"
                     /translation="MGIREFPSGAPRGKSIAVGMRRSPDVSPRRLSDISPQLRQLKYL
                     VVDEAIKEDLKWSRSVEDLTSGPVGLTSIEERILRITGYYGYQPWAASCKREERPRDS
                     PGPAEAQAPAGVEAGGRASRRCWTCSRAQLKKIFWGVAVVLCVCSSWAGSTQLAKLTF
                     RKFDAPFTLTWFATNWNFLFFPLYYVGHVCKSTEKQSVKQRYRECCRFFGDNGLTLKV
                     FFTKAAPFGVLWTLTNYLYLHAIKKINTTDVSVLFCCNKAFVFLLSWIVLRDRFMGVR
                     IVAAILAIAGIVMMTYADGFHSHSVIGIALVVASASMSALYKVLFKLLLGSAKFGEAA
                     LFLSILGVFNILFITCIPIILYFTKVEYWSSFDDIPWGNLCGFSVLLLTFNIVLNFGI
                     AVTYPTLMSLGIVLSIPVNAVIDHYTSQIVFNGVRVIAIIIIGLGFLLLLLPEEWDVW
                     LIKLLTRLKVRKKEEPAEGAADLSSGPQSKNRRARPSFAR"
     exon            456..685
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1010
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1230
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1356
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1549
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1639
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..3143
                     /gene="SLC35F3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3123..3128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35F3"
                     /note="hexamer: AATAAA"
     polyA_site      3143
                     /gene="SLC35F3"
                     /note="major polyA site"
ORIGIN      
        1 gacccgacgc ctccccgccc gaccaggtgc ctcgagagcg cacagctggg agggctctcc
       61 cggtcgcggc gagactcacg cctgcggtgt gctagggcgg cggcgacggt gacgggcgtg
      121 gggcgcggcg ctgcctcggc tgccgggtcg ttgcggcgag cgcgcgggcc ggcctggagt
      181 caccgggctg aaccgccgcg cctgcatcgt gccgcacgcc gcggaggcgc tcgggtacag
      241 accgcgcggg cgcgcacaaa gcggcccggg gcggccggcg cggcgcagac cctcggtggg
      301 cagcgcactc cagtcttccc aggctagcgg ctgcagggag ctccggcccg cggcccctcc
      361 gcctcaagtc tgggagctgc cggtcccact ctgtctttgc ctatggggat tcgagagttt
      421 cccagcggcg cacccagggg caagagcatt gccgttggca tgaggaggtc accggacgtc
      481 agcccccgga gactgtccga catcagcccc cagctccggc agctcaagta cttggtggtg
      541 gacgaggcga ttaaggagga tctgaaatgg tcgcgctccg tggaggatct caccagcggg
      601 ccggtggggc tcacgtccat cgaggagcgg atcctgcgca tcactggcta ctatggctac
      661 cagccctggg cagcgagctg caaaagggag gagcgccccc gggactcccc gggcccggcg
      721 gaggcccagg caccggccgg ggtggaggcc ggcgggagag cgagtcgccg ctgctggacg
      781 tgctcccggg cgcaactcaa gaagatcttc tggggcgtgg cggtcgtgct gtgcgtgtgc
      841 tcctcgtggg cgggctccac gcagctcgcc aagctgacct tcaggaagtt cgacgcgccc
      901 ttcaccctca cgtggtttgc caccaactgg aactttttat tcttcccgtt gtactacgtg
      961 gggcacgtct gcaagtccac agagaagcag tctgtgaagc agcgatacag ggaatgctgt
     1021 cgattttttg gagacaatgg cttgactttg aaggtgtttt ttaccaaggc agcacccttt
     1081 ggtgttcttt ggacactcac aaactacctg tacttacatg caataaagaa aataaacact
     1141 acggatgtct ccgtgttgtt ctgctgcaac aaagcttttg tgttcttgct ctcatggatc
     1201 gttctcaggg acagattcat gggagtgagg attgtggccg ccatcctcgc catcgctggc
     1261 attgtgatga tgacctacgc tgatggcttc cacagccact ccgtcatcgg catcgcactg
     1321 gtggtggcct cagcatcgat gtctgccctc tacaaggttt tgttcaagct cctcctgggc
     1381 agtgctaagt ttggagaagc cgccttattt ttgtccatct tgggtgtgtt taacatcctc
     1441 ttcatcacct gcattcctat tatcctctac tttaccaaag tggaatactg gagctctttt
     1501 gatgacattc catggggaaa cctttgtgga ttttcagttc ttttattgac attcaatatt
     1561 gtattaaatt ttggaattgc cgttacatat cccactctga tgtctcttgg aatcgtcctc
     1621 agcatacctg tgaatgcagt gattgatcac tacaccagtc agatcgtctt caatggggtc
     1681 cgggtcatcg ccatcatcat catcggcctg ggttttctcc tcctgctcct gccagaggag
     1741 tgggatgtct ggttgatcaa gctgctcacc cgactcaaag tgaggaagaa ggaggagcct
     1801 gcagagggcg ctgccgacct gagctcagga cctcagagca agaacagaag agcccgccct
     1861 tccttcgccc gctaacacca ctcctctaga actcggtggt aatgactggg aggtctattc
     1921 ctgccgggag gaacctcagt tgggtaaggt gtacatacct gtacagtttt ggtcatctgc
     1981 ggtaagttct atggtattta ttggcatgtc caatttgctt gcacttttcc acatcagacc
     2041 ttccacttaa gggtaccaat tcaatacaaa agagaaaaga agaacctctc agtgcttttc
     2101 caacgaatgt aaagtgggtt taaaagttcc ctgcgtagat cgttttggat ggctgacgtt
     2161 cttgacaagc cagccatcag ggcaagtgtt ttgaatctta gcaagtgttt tgaatcttag
     2221 caactgaaca tgacattgca cactgtgatt atttttcagc tatggtaggt catattttgt
     2281 tttataccag agctgtactc ttaattttaa ggaatttcaa tgaaccaaaa gataactgtc
     2341 aatttatttg gatggatgga tggagggatg gaaggaggga gggaaggatg tctgggatgt
     2401 gaagaggcaa ggcagaaatg gatgatgaac atcaaaaact gtcagaggac aggtctgtgc
     2461 caggtaccag gaaggacaag ataagtccaa gccccggctg gcctgctctc acgtgtctgt
     2521 gtaagatcat gcaagagaaa tcacagtgcc ttctacagaa ttttcgtctt tacctatgtg
     2581 aagcgaggtg acgtgatacg tcactggcgc cgtcttataa tttagatgta aaaatcttta
     2641 gaaacaaata aaactctcta tatatgtgta tgtctgtgta caaaaaaatg acagagctga
     2701 tggccagtgt atacagagcg tggcccgcgg tgtacaatac ccatataagg tacattgtgc
     2761 aggaggggaa ttgctggctg cttttacttc ctgaccaaga ctgaaaaatt atttactgaa
     2821 atctgtaaac ctttttatga aacttttaag caccaggctg tttacttaca caatttaggt
     2881 ctgccagaaa attctatctg tgatagatct gtaaagaggg tcaggggtta gagtttacta
     2941 tttttgaagt ttacattgtt acatatgaaa tggaaacatt attttgaaac gttgtcataa
     3001 cccaatggtg cattctgtaa ccatggagtc ttctgtttcc tgggggaaag gggcattcat
     3061 gacctgaact ttttagcaaa ttattattct cagtttccat tacctgtttg gccaaacaga
     3121 ttaataaaat atttgaaaaa gaa
//
