LOCUS       NM_017515               2769 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 35 member F2 (SLC35F2), mRNA.
ACCESSION   NM_017515
VERSION     NM_017515.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2769)
  AUTHORS   Colaco,J.C., Chandrasekaran,A.P., Karapurkar,J.K., Birappa,G.,
            Rajkumar,S., Gowda,D.A.A., Suresh,B., Lee,J., Singh,V., Hong,S.H.,
            Kim,K.S. and Ramakrishna,S.
  TITLE     betaTrCP1 promotes SLC35F2 protein ubiquitination and inhibits
            cancer progression in HeLa cells
  JOURNAL   Biochem Biophys Res Commun 682, 27-38 (2023)
   PUBMED   37801987
  REMARK    GeneRIF: betaTrCP1 promotes SLC35F2 protein ubiquitination and
            inhibits cancer progression in HeLa cells.
REFERENCE   2  (bases 1 to 2769)
  AUTHORS   Che,B., Du,Y., Yuan,R., Xiao,H., Zhang,W., Shao,J., Lu,H., Yu,Y.,
            Xiang,M., Hao,L., Zhang,S., Du,X., Liu,X., Zhou,W., Wang,K. and
            Chen,L.
  TITLE     SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis of
            pancreatic cancer cells by inhibiting endogenous p53
  JOURNAL   Oncogene 42 (44), 3260-3273 (2023)
   PUBMED   37740007
  REMARK    GeneRIF: SLC35F2-SYVN1-TRIM59 axis critically regulates ferroptosis
            of pancreatic cancer cells by inhibiting endogenous p53.
REFERENCE   3  (bases 1 to 2769)
  AUTHORS   Chandrasekaran,A.P., Kaushal,K., Park,C.H., Kim,K.S. and
            Ramakrishna,S.
  TITLE     USP32 confers cancer cell resistance to YM155 via promoting
            ER-associated degradation of solute carrier protein SLC35F2
  JOURNAL   Theranostics 11 (20), 9752-9771 (2021)
   PUBMED   34815782
  REMARK    GeneRIF: USP32 confers cancer cell resistance to YM155 via
            promoting ER-associated degradation of solute carrier protein
            SLC35F2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2769)
  AUTHORS   Kotolloshi,R., Holzer,M., Gajda,M., Grimm,M.O. and Steinbach,D.
  TITLE     SLC35F2, a Transporter Sporadically Mutated in the Untranslated
            Region, Promotes Growth, Migration, and Invasion of Bladder Cancer
            Cells
  JOURNAL   Cells 10 (1), 80 (2021)
   PUBMED   33418944
  REMARK    GeneRIF: SLC35F2, a Transporter Sporadically Mutated in the
            Untranslated Region, Promotes Growth, Migration, and Invasion of
            Bladder Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2769)
  AUTHORS   He,J., Jin,Y., Zhou,M., Li,X., Chen,W., Wang,Y., Gu,S., Cao,Y.,
            Chu,C., Liu,X. and Zou,Q.
  TITLE     Solute carrier family 35 member F2 is indispensable for papillary
            thyroid carcinoma progression through activation of transforming
            growth factor-beta type I receptor/apoptosis signal-regulating
            kinase 1/mitogen-activated protein kinase signaling axis
  JOURNAL   Cancer Sci 109 (3), 642-655 (2018)
   PUBMED   29274137
  REMARK    GeneRIF: Study showed that SLC35F2 was prominently upregulated in
            papillary thyroid carcinoma (PTC) tissues at both protein and mRNA
            expression level and significantly associated with lymph node
            metastasis. These findings suggest that SLC35F2 exerts its
            oncogenic effect on PTC progression through the mitogen-activated
            protein kinase pathway, with dependence on activation of TGFBR-1
            and apoptosis signal-regulating kinase 1.
REFERENCE   6  (bases 1 to 2769)
  CONSRTM   Cross-Disorder Group of the Psychiatric Genomics Consortium
  TITLE     Identification of risk loci with shared effects on five major
            psychiatric disorders: a genome-wide analysis
  JOURNAL   Lancet 381 (9875), 1371-1379 (2013)
   PUBMED   23453885
  REMARK    Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE   7  (bases 1 to 2769)
  AUTHORS   Bu,L., Jiang,G., Yang,F., Liu,J. and Wang,J.
  TITLE     Highly expressed SLC35F2 in non-small cell lung cancer is
            associated with pathological staging
  JOURNAL   Mol Med Rep 4 (6), 1289-1293 (2011)
   PUBMED   21874247
  REMARK    GeneRIF: SLC35F2 was highly expressed in NSCLC tissues and the
            levels of expression, in particular the levels of the SLC35F2
            transcript, were associated with NSCLC pathological staging.
REFERENCE   8  (bases 1 to 2769)
  AUTHORS   Stankovic,T., Byrd,P.J., Cooper,P.R., McConville,C.M., Munroe,D.J.,
            Riley,J.H., Watts,G.D., Ambrose,H., McGuire,G., Smith,A.D.,
            Sutcliffe,A., Mills,T. and Taylor,A.M.
  TITLE     Construction of a transcription map around the gene for ataxia
            telangiectasia: identification of at least four novel genes
  JOURNAL   Genomics 40 (2), 267-276 (1997)
   PUBMED   9119394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC048302.1 and AP001024.6.
            
            On Nov 22, 2018 this sequence version replaced NM_017515.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039195.2, AK023080.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525815.6/ ENSP00000436785.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1598              BC048302.1         8-1605
            1599-1845           AP001024.6         40186-40432         c
            1846-2769           BC048302.1         1855-2778
FEATURES             Location/Qualifiers
     source          1..2769
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     gene            1..2769
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /note="solute carrier family 35 member F2"
                     /db_xref="GeneID:54733"
                     /db_xref="HGNC:HGNC:23615"
                     /db_xref="MIM:620350"
     exon            1..130
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1145
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /note="lung squamous cell cancer related protein LSCC-3"
                     /codon_start=1
                     /product="solute carrier family 35 member F2"
                     /protein_id="NP_059985.2"
                     /db_xref="CCDS:CCDS41709.1"
                     /db_xref="GeneID:54733"
                     /db_xref="HGNC:HGNC:23615"
                     /db_xref="MIM:620350"
                     /translation="MEADSPAGPGAPEPLAEGAAAEFSSLLRRIKGKLFTWNILKTIA
                     LGQMLSLCICGTAITSQYLAERYKVNTPMLQSFINYCLLFLIYTVMLAFRSGSDNLLV
                     ILKRKWWKYILLGLADVEANYVIVRAYQYTTLTSVQLLDCFGIPVLMALSWFILHARY
                     RVIHFIAVAVCLLGVGTMVGADILAGREDNSGSDVLIGDILVLLGASLYAISNVCEEY
                     IVKKLSRQEFLGMVGLFGTIISGIQLLIVEYKDIASIHWDWKIALLFVAFALCMFCLY
                     SFMPLVIKVTSATSVNLGILTADLYSLFVGLFLFGYKFSGLYILSFTVIMVGFILYCS
                     TPTRTAEPAESSVPPVTSIGIDNLGLKLEENLQETHSAVL"
     exon            131..306
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..434
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..594
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            595..751
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..804
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..959
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2769
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2740..2745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /note="hexamer: ATTAAA"
     polyA_site      2769
                     /gene="SLC35F2"
                     /gene_synonym="HSNOV1"
                     /note="major polyA site"
ORIGIN      
        1 ggagacgcgc aagggcgccg atggaggcag actcgccagc gggccccggc gccccagagc
       61 ccctcgcgga gggagcggcg gccgagttct ccagcctgct gcgcaggata aaaggcaaac
      121 tcttcacctg gaatattttg aaaacaattg ccctgggtca gatgttgtcc ttgtgtatat
      181 gtgggacagc catcaccagc cagtatttgg cagaaagata caaagtgaac acccccatgc
      241 ttcagagctt tatcaattat tgcttgctgt tcctaattta tacagtgatg ctggcatttc
      301 gatcaggcag tgataacctt ttagtaatct tgaaaagaaa atggtggaag tacatcctgc
      361 tgggactagc agatgtggaa gctaattatg tgatcgtcag agcctaccag tacacaactc
      421 taaccagtgt ccagcttttg gattgctttg ggattcctgt gttgatggct ctgtcatggt
      481 ttattcttca tgcaagatac agagtgatcc acttcatcgc cgtggctgtc tgtctgttgg
      541 gtgtaggaac catggttggt gcagacatac tagcagggag ggaagacaat tcagggagtg
      601 atgtattgat tggtgacatc ttggtccttc ttggggcttc cctctatgcc atttcaaatg
      661 tttgtgagga atacatcgtg aagaagctga gcagacagga gtttttagga atggtgggcc
      721 tgtttggaac aattatcagt ggtatacagc tattgattgt ggaatataag gatattgcca
      781 gcattcattg ggactggaaa attgccctgc tgttcgtggc atttgccctg tgtatgtttt
      841 gcctgtacag cttcatgcca ttggtgatta aagtcactag tgccacttcc gtcaacctgg
      901 gcatcctgac agcggacctc tacagccttt ttgttggact ctttctgttt ggctataagt
      961 tttcaggact ctacatcctg tccttcactg tcatcatggt ggggtttatc ctgtactgct
     1021 ccacccctac tcgcacggcc gagccggctg aaagcagcgt gcctccagtc accagcattg
     1081 ggattgacaa cctggggctg aagctggagg agaacctcca ggagacccac tctgctgtct
     1141 tgtagctgga gaagatggcg cacccatccc ccaccaggat aaagcagagc ctgctgcctg
     1201 ctgaggggac acttggggaa atagcagact cagaatggac actctacaac cctgggttgg
     1261 atccagtggt taggttttag aaaggaacac tgaacaaagt tcaaaagtag aaataccaaa
     1321 atagagcaga aaccaagcta agagtgtgtt tctgtgtttg aggaccaata tctgttcgtg
     1381 ttgaggagat gaggtgcaga ctccacactg gggtcttaga ggcaccagtg ggaaagcagg
     1441 actggggaga gatccaggac tgagccagcc tcaggccagg gcgggaaagc aggctgtcca
     1501 ggctgggctt ggtggtcagg aacaggggca gctcacggtg gctctggagt acgtttcctc
     1561 tgtcagatgc ttcaaggttt tttttttttt ttttttttgc tgaggcagtt attgtccaca
     1621 ggcctttggg tacagatgag gccttggggc tgactgcatg tggcagaaaa cgggtgggtc
     1681 agcccttgaa aagtcttgag atataagtgt gagtactata caagcattaa actggagtgc
     1741 agtaaaccta ggaaccttcc cacaattgtt tttttgtttg tttgagatgc agagtctaga
     1801 gtgcagtggt gcaagctcag cttactgtaa cctctgcctc ctggattcaa gtgttagtag
     1861 ctgggattac aaaagcatgt ggccccacgc ccagctaagt tttgtatttt tagtagacat
     1921 ggggtttcac catgttgccc aggctggtct tgacctcccg acctcaagtg atctgcctgc
     1981 cccgacctcc caaagtgctg ggattacagg cttgagccac cgtgccaggc ctgttttgtt
     2041 tgtttttgta gagagatggg gtttcgccat gttgcccagg ctaatctcaa attcctgagc
     2101 taaagcgatc tgcccacctc ggcctccgaa agtgctagga ttacagatgt gaaccactgt
     2161 gcctggcctg tttgtttgtt tgtttaaaac atttctccat cactcattcc aggtcccaga
     2221 gcaaactctc tctgctctcg gagcctgtga cactggctat gtgctccaca gtttcagtcc
     2281 caggtcatac tctccaacag ttttcagagc tccatatata tgtagatgcc atcctttcta
     2341 aaaacttctc acgacctcct ggaatattcc tattgatctc attttattta gcatcagctc
     2401 aagaaactaa gtcttagtgc acagtatcac aacaaagaaa aagctttgtt tttataactg
     2461 gtaaaaacaa gaaaagattc tcatcaaaat gaaaatataa aattaatcat ttctcaccaa
     2521 agagtatgcc tgggagcctc cagctgttaa aagacaatgc tattactact tcttatcaaa
     2581 aatctgtaat gccctgtgat ttttatgata cttcttcaat acaaagtgtt aatatgtgtc
     2641 atcagtataa taacaaccaa caaaatgcca ctttcagaaa actgtatgta aattttttgt
     2701 aacaatgtaa aaaagaaatg gggagtaagt gttcacatca ttaaaaggct ttgaattcat
     2761 ggaaataca
//
