LOCUS       NM_018656              17722 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 35 member E3 (SLC35E3),
            transcript variant 1, mRNA.
ACCESSION   NM_018656
VERSION     NM_018656.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 17722)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 17722)
  AUTHORS   Shivakumar,M., Lee,Y., Bang,L., Garg,T., Sohn,K.A. and Kim,D.
  TITLE     Identification of epigenetic interactions between miRNA and DNA
            methylation associated with gene expression as potential prognostic
            markers in bladder cancer
  JOURNAL   BMC Med Genomics 10 (Suppl 1), 30 (2017)
   PUBMED   28589857
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 17722)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   4  (bases 1 to 17722)
  AUTHORS   Hodgson,J.G., Yeh,R.F., Ray,A., Wang,N.J., Smirnov,I., Yu,M.,
            Hariono,S., Silber,J., Feiler,H.S., Gray,J.W., Spellman,P.T.,
            Vandenberg,S.R., Berger,M.S. and James,C.D.
  TITLE     Comparative analyses of gene copy number and mRNA expression in
            glioblastoma multiforme tumors and xenografts
  JOURNAL   Neuro Oncol 11 (5), 477-487 (2009)
   PUBMED   19139420
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124890.8.
            
            On May 29, 2019 this sequence version replaced NM_018656.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.119165.1,
                                           SRR1803616.313376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398004.4/ ENSP00000381089.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               AC124890.8         59514-60117
            605-715             AC124890.8         61268-61378
            716-874             AC124890.8         65370-65528
            875-957             AC124890.8         72495-72577
            958-17722           AC124890.8         78042-94806
FEATURES             Location/Qualifiers
     source          1..17722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..17722
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="solute carrier family 35 member E3"
                     /db_xref="GeneID:55508"
                     /db_xref="HGNC:HGNC:20864"
                     /db_xref="MIM:620355"
     exon            1..604
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1144
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 35, member E2; bladder
                     cancer-overexpressed gene 1 protein"
                     /codon_start=1
                     /product="solute carrier family 35 member E3 isoform 1"
                     /protein_id="NP_061126.2"
                     /db_xref="CCDS:CCDS41808.1"
                     /db_xref="GeneID:55508"
                     /db_xref="HGNC:HGNC:20864"
                     /db_xref="MIM:620355"
                     /translation="MALLVDRVRGHWRIAAGLLFNLLVSICIVFLNKWIYVYHGFPNM
                     SLTLVHFVVTWLGLYICQKLDIFAPKSLPPSRLLLLALSFCGFVVFTNLSLQNNTIGT
                     YQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVKFNFLGMVFAA
                     LGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVAVPFFEPVFGEGGIFGP
                     WSVSALLMVLLSGVIAFMVNLSIYWIIGNTSPVTYNMFGHFKFCITLFGGYVLFKDPL
                     SINQALGILCTLFGILAYTHFKLSEQEGSRSKLAQRP"
     exon            605..715
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..874
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..957
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..17722
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2299..2304
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="hexamer: AATAAA"
     polyA_site      2322
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="major polyA site"
     regulatory      4681..4686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="hexamer: AATAAG"
     polyA_site      4697
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
     regulatory      4911..4916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="hexamer: AATAAA"
     polyA_site      4931
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
     regulatory      9452..9457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="hexamer: AATAAA"
     polyA_site      9466
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
     polyA_site      9478
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
     regulatory      17701..17706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
                     /note="hexamer: AATAAA"
     polyA_site      17722
                     /gene="SLC35E3"
                     /gene_synonym="BLOV1"
ORIGIN      
        1 gtcctagctg gcttacaggg cggcggcggg gtgtgtgtcc tctgttaaga gtgctactcg
       61 cccggggttg atctgtgcat gccactcctg ggtcagacgg tgaggtcggc gtctgcgagg
      121 acgcggcggt ggagtagaag ggcagccgga gacaggcccg gcgccccttc cgaggctaga
      181 cggccccagc ttcgcgggga tcatggcatt gctggtggac cgagtgcggg gccactggcg
      241 aatcgccgcc gggctcctgt tcaacctgct ggtgtccatc tgcattgtgt tcctcaacaa
      301 atggatttat gtgtaccacg gcttccccaa catgagcctg accctggtgc acttcgtggt
      361 cacctggctg ggcttgtata tctgccagaa gctggacatc tttgccccca aaagtctgcc
      421 gccctccagg ctcctcctcc tggccctcag cttctgtggc tttgtggtct tcactaacct
      481 ttctctgcag aacaacacca taggcaccta tcagctggcc aaggccatga ccacgccggt
      541 gatcatagcc atccagacct tctgctacca gaaaaccttc tccaccagaa tccagctcac
      601 gctgattcct ataactttag gtgtaatcct aaattcttat tacgatgtga agtttaattt
      661 ccttggaatg gtgtttgctg ctcttggtgt tttagttaca tccctttatc aagtgtgggt
      721 aggagccaaa cagcatgaat tacaagtgaa ctcaatgcag ctgctgtact accaggctcc
      781 gatgtcatct gccatgttgc tggttgctgt gcccttcttt gagccagtgt ttggagaagg
      841 aggaatattt ggtccctggt cagtttctgc tttgcttatg gtgctgctat ctggagtaat
      901 agctttcatg gtgaacttat caatttattg gatcattggg aacacttcac ctgtcaccta
      961 taacatgttc ggacacttca agttctgcat tactttattc ggaggatatg ttttatttaa
     1021 ggatccactg tccattaatc aggcccttgg cattttatgt acattatttg gcattctcgc
     1081 ctatacccac tttaagctca gtgaacagga aggaagtagg agtaaactgg cacaacgtcc
     1141 ttaattgggt ttttgtggag aaaagaatgt tgtcccaaga agataaaaaa tattgttaag
     1201 tgtgcaagtt attaaaaaaa aaaaattggg ccaggcacgg tggctcacgc ctgtaatccc
     1261 agcactttgg gaggccaagg ccagcggatc acttgaggtc aggagttcga gaccagcctg
     1321 accaacatgg agaaaccctg tctcaactaa taatacaaaa ttagccaggc gtggtggcgc
     1381 atgcctgtaa tcccagctac tcgggaggct gaggcaggag aatcacttga acccgggagg
     1441 cggcggttgc agtgagccga gatcgtacca ttgcactcca gcctgggcaa caagagcgaa
     1501 actccatttc aaaaaaaaaa aattggtgac agactcaatg atggaatgat ttgtcggaat
     1561 taacacaaag cagattttat tcatataatg actttttttt aagagtctct tttttaaaaa
     1621 aacttaattc tctaaaaccg aaatggttca tgcttctttt taaaaatgat tgtataaaat
     1681 gtatggaatg gttagcctgg tgtggtggtg cacacctgta atcccagcta cttgggagac
     1741 tgagacatga gaatcgcttg agcctgggag gcggaggttg caatgagcca agatcgtacc
     1801 actgcactcc agcctgggcg acagagcaag acactgtctc tctctctctc tccatatata
     1861 tatgtgtgtg tgtgtatata tatatatatg tgtgtgtgtg tgtgtgtata catatataca
     1921 catatataca cacacacata catatacatg tgtatatata taccatccca tatatatgtg
     1981 ggatatatat atatatatat atggatatgg ttatatatat gggatggttt ggttggtccc
     2041 agcaaagtat atgaaaatta aagttctgtg ataatgacaa aggaattgct gttactgtac
     2101 tgcaaatatg ctgtgggttc tcggtgttca aactcttcta aggaaggaca cacagtagct
     2161 ctctgcttgc tgatagatgg tttcccagtg tgagatttgt tattttgatc agagtattca
     2221 aatcagaatt taaatctagt gtttctattt tagtttagct tcctgattta tataaatgaa
     2281 atctcattta taaagtataa taaagatgac tgtaagacaa aatccaattc taaaagtatg
     2341 atttttttct agtagaaaat tgatgtaaga aatcatacat tattcataca tttataggtc
     2401 atctctttga gttttcagtg aactatagaa actatatgga gttaaaaaac aaaacggcag
     2461 ccaatctcag tggctcacac ctgtaatccc agcactttgg aaggttgagg caggcagatc
     2521 acctgaggtt gggagttcaa gaccagtctg accaacatgg aggaatcccg tctctactaa
     2581 aaatacaaaa ttagccaggc atggtggcac atgcctgtaa tcccagctgc tcgggaggct
     2641 gaggcaggag aatcgcttga acccaggagg cagaggttgt ggtgagccga gatcatgcca
     2701 ttgctctcca gcctgggcaa caagagtgaa actccatctc aaaaaaaaaa aaaaaaaata
     2761 gccctatgtt taaatggctc aaagaaaaga ctataaatgg aattgaacat gtttgttagc
     2821 tgtttgagca ttttatattg gtaaattttt tattttctta ttttttgtct tacagtcgac
     2881 caggctggaa tgcagtggca caatcatggc tcactgcagc ctcagcctcc tgggctcaag
     2941 caatcctcct gcctcaacct ccccagtagc tgggactaca ggtgcacacc aacatacctg
     3001 gctgattttt atattttttg tagagacaga gttttgccat gttgctcagg ctgatctcaa
     3061 actcttgagc tcaagccatc tgtctgcctc agcctctcga agtgctggga ttacaggcct
     3121 gagccaccac acctggccag taatttctta atcctacctc cctgcttcta ttgcctagcc
     3181 cgtacatttg aggcttccat ggagctttct gtggtactga aacacttgga gtgaactgca
     3241 aacttggagt gaactacatc caacctttct aaggtggctg gggaaaattc ttgtacagca
     3301 agttgggaca aaatagccat atagaaacag ccatataaga tcccaatata gaaaaattgg
     3361 gatattagag gaaatacatg atttccattt atggagtgct acatgtttgc aaaatgtatt
     3421 tctgcttttc atcttcttga catctgaata ttaaaagcag ttgttgataa tttcatataa
     3481 taaattgaga catatcatta ctcttgtaat aattcatttt ctaaatgtta tttatcaact
     3541 ttcatggaga aaacaactct taggagaaca aagaccagcc cgggcaacat ggcaaaaccc
     3601 tgtctgcaaa aaatacaaaa attagccggg cctagtggca cgtgcctgta gctccatcta
     3661 ctcaggaggc tgaggtggga ggattgcttg agcccagaag atgcaggttg cagtgagccg
     3721 agatcatgcc actgcacttc agcctgggcg acagactgga ctctgtctcg ggaaaaaaaa
     3781 aaaaaaaaaa agggaagagc gacaaaatat accttttgat aagacagtaa attttatgtt
     3841 ttgtgttttt taacacaata aaaatatata tacacacata taatatacct ttggggtttt
     3901 taggattttt ttttcctgga ctctgaaatg agaagcctcg ctgaaaatct gttttggaga
     3961 attccagttt gtcagtcagt ctcttgtgta attagtacgt gtggcttcct tctttgtttt
     4021 aaatattctt tggttcttct cattttacaa agatatatat tttttgtgct aaggacagag
     4081 caattagttt ttaccagata agcctcgggt attatgtttg tctaagaaac attctctgtg
     4141 tatgtttaaa ttgtaattat ttcccaaaag ctgaggaaaa tgtttcagca cagtgaggat
     4201 ttgacgtctg cactgagaac agctgagttt atttgtgcca tttagaaatt cgtaactgta
     4261 ggctgggcgc agtggcttac gcctataatc ccagcacttt gagaggccaa ggcgggtgga
     4321 tcacctgagg tcaggagttt gagaccagcc tggccaacat ggcgaaacac tgtctctact
     4381 aaaaatacaa aaattagctg ggcatggtgg cgggcgcctg taattccagc tactcgggag
     4441 gctgagacag gagaatcact tgaaccaggg agtcggaggt tgcagtgagc cgagactgcg
     4501 ccattgcaca ccagcctggg tgacgagagt gaaactctgt ctcaaaaaaa gaaaaaaaaa
     4561 aagaaatttt taaccgtaaa tagaacttgg ggagggtgtt atataatata tgtgtcagta
     4621 ggaaggcagt aagaagattg gagtaagaca ggatggggtt acatgtatat aaatgaataa
     4681 aataagtact gctaaaactt gagtctgata aacttttttg ccccgaagat aatcatccca
     4741 ctgaaaagaa aactctgggg aaaatatgcc agatactagg accaagcacg gagacaaacc
     4801 agatacagtg ctttcaaaga aaacatgctt gctgtccttt gttaccagtg taattgtaat
     4861 tattgtttat tctgtgttaa gtgactgaat ttcaattttt accttttaaa aataaagaga
     4921 acctcttttt acttctgtat tgcatatgag agctgatgga agaaggatgg catctgtgta
     4981 acatatgcat ggtaacgctg acgtgttcag ctgttcatat ttggcctgtc caaataagca
     5041 gaaatgaatg aaacaaaatt ccatctcctt ttagaaataa cataaaggag aaatctatct
     5101 ctgtgaaatg aagtaagcat tcttctgttt cactttttaa aatactttta aaatcttgct
     5161 gttttcaacc tattaatgac tttttgaaat tgtatttcaa agcagaaaca ttaggttggg
     5221 tatggtggct cacgcctgta atcccagcac tttgggaagc tgaggtgggc agatcacctg
     5281 aggtcaggag ttcaagacca gcctggccaa tatggtgaaa ccttgtctct actaaaaata
     5341 caaaaattag ccaggtgtgg tgttgcatgc ctgtagtccc agctacttgg gaggctgagg
     5401 caggagaatg gcttgaaccc gggaggcgga ggttgcagtg agccgagatc acgccactgc
     5461 actccagcct gggcaacaga gcaagactcc atctcaataa taataataat aataacaaag
     5521 cagcaacatt aatcaagcac tctgtattca ctccgtcagt aaatactgtc gggtgaatga
     5581 ctgcagaatg gccaaaggtg agagtttgat taaaagaaag gagaccttgg ccgggcacgg
     5641 tggctcacgc ctgtaatccc aacactttgg gaggctgagg tgggtggatc acctgaggtc
     5701 aggagttcga gaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacaaaa
     5761 aaattagctg ggcgtggtgg tggatgcctg taatcccagc tacttgggag gctgaggctg
     5821 gagaatccct tgaacttggg aggcggaggt ttcagtgagc caagatcatg ccattgcact
     5881 gcagcctggg caacaagagc aaaactgtct caaataaata aataataaaa gaaaggagac
     5941 cggatttatt agatgtggtc cgttttgtct ttctgttccc aaacttaaac tggattatac
     6001 ctgctaatat caggaatata atgataattg cattcattca acaaaaattt attgagcata
     6061 tactgtgtgc caggtactgt cctaggcatt atggatataa aacagttttt atgtagagac
     6121 agtcctatat ttcctgtgat cttaaggaac atttgtctag tattagagat aggactaatt
     6181 aaacaaaaac aagacaagaa taattaaaca gcaaactcaa tgaatgctaa agggaacatc
     6241 gttctgtgag cacataacaa aagaatctgg cccaggcttg gcacttgtgg agggagtcca
     6301 tgaggaaagt ttgagctgca gtcatagata catagaagtt agctagctag gcagagggag
     6361 ggtattgcat tctggaaaga gggaatagca catacaaatg cctagtggtt ggaggaattg
     6421 tgatgctttt aaagaactgt aaaaaggatg gagtctggag actaaatttg ggagtgggga
     6481 gacatggtgt gtcctgcacc tggaaatgta gatagacctc aggccataca atacctggag
     6541 gctatggtaa gcatctttag taagagcaag ggggagtgtt gtgagcactg tcacagtaaa
     6601 tttctttttt tgaaattagt ggaggagaac cagagagatg ccaggagacc agttagttgg
     6661 gagatgactg tagttagaga tggtggtagc ttcaaaggta gtggaatgag ataagtggaa
     6721 ataattgagt agctggagtc aactggactg gagatggatt ggaaatggag ggcatgagaa
     6781 ggggtgaagt taaggatcac acttcagctg ggcacagtgg ctcatgcctg taatcccagc
     6841 actttgggag gctgaggtgg gtggattgct tgagtccagg agttcgagac cagcctgggc
     6901 aaacatgatg aaaccccatc tctacaaaga atacaaaatt agctgggcat ggtggtgtgg
     6961 gcctgtggtc ccagctactc aggaggctga ggcgggagga tctcctgagc ccaggagttt
     7021 gaggcttcag tgcgccatga tcacgccact gcactctagc ctgggtgaca gagtgagtcc
     7081 ctgtctcaac aacaacaaaa aatcacacat gtctgatttg cgcagcttga tagagaatgg
     7141 tgccattctc tgaactagga aacacaagaa gaggactgag gagagggatg aggcagagga
     7201 atattatggg ccttcttgat actgagatat ccaattaaag atgttggcca ggcatggtgg
     7261 ctcaggcttg taatcccagc actttgggaa gctgaggcag tcagatcact tcagatcagg
     7321 agtttgagac cagcctgacc aacatggtga aaccccgtct ctactaaaag tacaaaaatt
     7381 agctgtgtgc ggtggtgcat gcctataatc ccagctactt aggaggctga ggcaggagaa
     7441 tcgcttgaat ctgggaggca gaagctgcag tgatctgaga ttgcaccact gcactccagc
     7501 ctgggtgaca gagagagact ctatctcaga aaaaaaaaaa aaagatgtta atcaaataat
     7561 tagtttatag aggcccagaa ctcaggaaaa tgtttagttg aggtggagat aaaacaggag
     7621 tttctggggt atgcctgata aggaggaaaa cagaccaaga tgagcttgct gaagaagata
     7681 gcataaagca agaacagact ataactgaag ttgaggaact ctggtataca atgatagaac
     7741 ataatgctgc aaaagaaaca gagaaggaac aaagaggtgg gaggaaaatg ggccgggcac
     7801 tgtggcttat gcctgtaatc ccaacatttt tgagaggcca agctgggtgg atctcttgag
     7861 ctcaggagtt caagaccagc ctgggcatca tggcaaaacc ctgtctctac aaaaaataca
     7921 ataattaata gtttcgaaag aaagaaacct gccaagcaaa agtccggtct cagcccggga
     7981 gctagtagca tgcagtggaa caggtctcac ctggacggca gcactgggac ttccagtcca
     8041 gactctgcca ttcactggta tagcctttgg caaagccttt gggcagcttg ctcaaatctt
     8101 acttctcagt ttcttcacct ataaaatgag ggctttgatc caaataattt ccaggggact
     8161 gtccagctcc aaaatcccct gattctgctt tttcagatta aaattataat ttctcatttg
     8221 cttataataa aagtagattg aataaattaa tcagaagggt ttggtttgtt tgaccttttt
     8281 tttaatttta atttttattt tttatttttt gagacagagt ttcctctgtc tcccaggctt
     8341 ggttgttgtg gctcaatctc agttcactgc aacctccgcc tcccgggttc aagcgattct
     8401 cccgcctctg cctcccgagt agctgagatt acaggcaccc accatcatgc ccagctaatt
     8461 ttttgtattt ttgtagagac agggtatcac catgttggcc aggctggtct tgaactcctg
     8521 acctcaggta ctccgcccac ctcagcctcc caaagtgctg ggattacagg tgtgagccac
     8581 cacgcctggc ctgtttgacc tttataagat caattttttt gttcacaagc atttctttac
     8641 tcatagatac catttttata acttatatga gacgcattta atgtaatcat attactttct
     8701 tatattagaa gataggattt cttctgatgt atcgaagtta ctttatactt catatgaagt
     8761 cattaggagg tgaattattg ccaattcaat gaattattta tgagtattag gggaatgttt
     8821 ttgttatgct gcttttaatt tggaaagcag catatcactc aaactatagt aattcacatt
     8881 tttccattta actaaaaatg tctcgtaact actatgccac aagaacaagc atggatactt
     8941 atttaaccag ccaagactat gcatttctaa atatttattt ttttcggtta tccgtagact
     9001 tttccttttg aaatccaacg atctgtatca accacgtctt cattttcctt ttcctgtttg
     9061 tcttactctc cccccaaaaa gagtcagttt cctgttttct caatttctca gtttaaaatt
     9121 agagccctat ggcaggtgcc atgtacagct gcaaaggtgg caagaagccc tgagaaagct
     9181 caagaagcag gtcaaggggg tgggtaagga agatgggacg ttcaagcaga aacaaaaaga
     9241 ggagctaaaa gtgaaagcca ccccgccacc agccctcacc agtcacaggt ggaattaaag
     9301 aaatctggca aaaaataaat tttgttatcc gtgcttgggg cggtgaccct tgaccccatt
     9361 cctatttaaa catctggatt ctctgccata acatcttttg ccacctatag ctacaataaa
     9421 gtgtcgtctt ggagtctgtt gtacatttaa gaataaactt ttgtaaggaa gtaaaaaaga
     9481 gtctacagtt cagtgcagga tagggatggg tgggccttaa ttcaggaggt gggaggctca
     9541 aaatcaatta ctctgttgag gagatggaat ctcctggaat ctcaaaaagg atttccttta
     9601 ggaatcatca gactcatccg actcgtcaag tctttctctg cttggagttt tgttttgttt
     9661 ttattttgtt ttgttttgga gataggttct ccctctgtca cccaggctgg agtgcagtgg
     9721 tgcaatcaca gctcactgca gcctcgaatt cctaggctca agtgatcctc ccacctcagc
     9781 ctcctgagta gctgggacta caggtgtgca ccaacaggcc cagataattt tattttttgt
     9841 agagacgggg tcttgctatg ttgccaggct ggtctccaac tcctggcctc aagtgatcct
     9901 cttgctctgc ctcccgaagt gctaaaatta cagctgtgaa acaccgcgcc tggagtttaa
     9961 aagcaagatt aacctttttg gactggagtt cttagagaat tatggtgtga ctcattgacc
    10021 atatttgtta ggatcagcat ttttatatga tttaacacaa aatgttacag aaaaaagtgc
    10081 aaaaatgttg taaggcacag ttggtttcct aagcaaatgc ccattcctat tctttgttca
    10141 tctccactct agaggctaga aatactaaat tctcttttta cctcgttgcc ttgtagaggg
    10201 atgatcatat gacatttcac caatggcaca taattcaaag tctgctgagg atttctaggg
    10261 tatcctgatt aaaagggaca gatgtggctg gtagtgtcta ttaccacctc cttcctgcct
    10321 taaatgtagc tgcggatgtc tagaattgtg ctaatcagct tatgactata aaagagaggt
    10381 gaagagagcc agatctgaaa gtggtgagcc gaccaggcac agtggcacac ctgtaacccc
    10441 agcactttgg gaggccgagg gaggaggatc atttgagccc aggagtttga gaccagcctg
    10501 ggcaacattg caaaacctgt tctctgtgaa taacttaaaa attagtcagg tggccaggcg
    10561 tagtggttca cacctgcaat ctcagcactt tggaaggctg aggtgggtgg atcacctgag
    10621 gtcaggagtt cgagaccagc ctgaccaaca tggagaaacc ctgtctctac taaaaataca
    10681 aaattagctg ggcgtagtgg cttatgcctg taaccccagc tactcggcag gctgagacag
    10741 gagaatcgct tgaaccaggg aggcagaggt tgcagtgagc tgagaccacg ccattgcact
    10801 ccagcctggg caacaagagt gaaactccat ctcaaaaaaa aaaaaattag gtatattggt
    10861 gtgcacctgt ggtctcagct actcaggaag ctgaagcagg aggattgcct gatcctggga
    10921 ggttgaggct gcagtgagcc atgatcatgc cactgcacta tatgctgggc aacagaggga
    10981 gaccctgtct caaaaacaaa caaaacaaac aaaaataagc aaaaaaaaaa aagtgttgag
    11041 cagctaaaac aatgccgtta gatgccctat ctcttaaaaa aaaaaaaaaa aagataaaat
    11101 aaaagaaatt gggtcttgtg gccaggtgcg gtggctcacg cataatccca acactttggg
    11161 aggctgaggt gggtggatca cttgagccca gtagtttgag accagcctgg ccaacacgtc
    11221 ttcttgttct agatgaaaag taaaccccta tttggcttac tcacttaaaa aaataataat
    11281 aattagagac agggtgttgc tatgttgccc tggctggtct cactcctggg ttcaagtgat
    11341 cctcctgcct cagcctccca aagtgctgat attacaggcg tgagcaacca tgccagcctg
    11401 gcttagccac ttttaattat tactcgtagc tgcaagaatg ccaatgagca tttggggtaa
    11461 aaaggggcaa gaatggagga cctgctctgt ctgtcggact ttggaactca ggaagcaaca
    11521 actaagcgta ctcgttgtct tagtccattt tgtgttgcat agaacagaat acctgaaact
    11581 gggtcattta taaagaaaag gaatttattt cttacaatag tggagactga gaagtccaag
    11641 gtacagggtc cacatctggt gagagacttc ttgttcctgg gaactctctg cagagaccca
    11701 aggtggcaga gggcctcacg tggtgaggga cttgagcatg gtagctcagg tctctcttcc
    11761 tcttcttata aaggcaccag tctcactggg cagagccttc atgacccagt caccttttaa
    11821 aggcgccatc tctcaatatt gccacattgg ggatgtttcc agatgagttt tggaggagac
    11881 aaatattcaa actacagcac tggttaaaaa taaaaatagg gcctggcgtg gtggctcacg
    11941 cctgtcatcc cagcagtttg ggaggctgag gcagatggat cacctgaggt caggagttcg
    12001 agaccagcct ggccaacatg gtgaaacccc gtctctacta aaaatataaa aattagccag
    12061 gcatgctggc gtgtgcctgt aatcccagct gctcaggagg ctgaggcagg agaatggctt
    12121 gaacccgaga ggcagaggtt gcagtaagct ggaatcacac tattacactc cagcctgggt
    12181 gacaagagcg aaactctgtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaggccaga
    12241 cttggtagct aacacctgta atcccagcac tttgggaggc caaggcagga ggatcacttg
    12301 aggtcaggag ttggagacca gcctggccaa catggtgaaa ccccgtttct accaaaaata
    12361 caaaaattag ccgggcatgg tgacgtgtgc ctggcagagg tttcagtgag ccgagatcat
    12421 gccattacac tccagcctgg gtgacaagag caaaactctg tctcacaaaa aaaaaaaaaa
    12481 ggccaggcat gatgactcac gcctgtaatc ccagcgattt gggaggccga ggcaggtgga
    12541 tcacttgagg tcaggagttg gagaccagcc tggccaacat ggtgaaaccc aatctctact
    12601 aaaaatacaa aaattagctg gacgtggtgg caggcgcctg taatcccagc tactcactca
    12661 ggaggctgag gcaggaaact cacatgaacc ctggagacgt aggttgcagt gagctgagat
    12721 cacatcactg cactccagcc tgggagacag agtgagactc cgtctcaaaa aaaaaaaaag
    12781 aaaagaaaaa ttagtcagct gtgatggtgt gcacctgtag tcccagctac tctgaaagct
    12841 aaggcacgag aatcgcttga acctgggagg cggaggttgc agtgagctga gatcatgcca
    12901 ctgcactcca gcctggatga cagaatgaaa ctgtgtctca aaaagaaaaa aaaaaacaaa
    12961 aactagtagc tagccccacc cccgccattt ttccagactc cagagagtgg ggtgtgtgga
    13021 agacagggac tggtctggtg gcatgtagat tcataaatgg cgtccaaacc tggagctgtt
    13081 gctggcttgg aatgaatgaa ccagttccag ccaggaacag actttcccac caagtgggag
    13141 gtggtctacc tgcccttcac catcatcttt gtgctctctg acactggtca tcctcagtta
    13201 cccaatatac ccctcgcccc agccccatcc ctagtcaccc ctcattccta gtagtacccc
    13261 cagttctgct tcaatttgat tcagcagatc aagaaagcac tatcaccaat ggtcgcaagg
    13321 tcatgcttaa gtcttggaac tggccatcag tgtgaaagtt caacaggtat tcagtaagca
    13381 gatctaggaa aaactcactc taataacgtt ccaggaattt cctaagacca tagtgggaga
    13441 cagctgcatc agaggcctcc cagtgccata ggaccatgga cattggtgag caactgtgtg
    13501 ctgggaggaa atggctgctt attggcatgg agttattgaa tgcagaactt ttcagccaag
    13561 cacagtgcta ttcttctgaa atcataacat catgaggaca tccactgctt gtactcaaat
    13621 agcattcctc acaggaatgt cacacctgtg actctctcat acctccaaaa tctcactgct
    13681 gttctgaaac gcaagagatt ttgccaagga aatgctgaca ttccttctgt ccactcctct
    13741 ccccacactg cactgtgtgg ccccagagag gaaagacaag ggctgttacc atggagttct
    13801 tgaatttcat tatttatctc ccaacacaac tttggcctca ccctcttccc cagcgtgaag
    13861 acgcacaacc caagtgggac agtctgaatt tccccaccct caggtgtcag agaatcagag
    13921 gaagtcatgc tgcttatcta gaatctgcta gaaatggagt tcacccaaag aatgaccatc
    13981 acagaattta tgaactactc ctagatcatg caattaataa gtcctctagc ccagtaccac
    14041 tcaaggtagg gtctgggccc cagtaccagt ccataaacag tttgctgccg gctgggtgtg
    14101 gtggctcatg cctataatcc cagcactttg ggaggccaag gtgggcggat cacttgagat
    14161 caggagttta agaccagcct ggccaacatg gtgaatcccc gtctctataa aaagtacaaa
    14221 aattagccag gtatggtggt atgtgcctgt gatcccagct actcgggagg ctgaggtggg
    14281 aggatcaccc aagcccaggg aggtcgaggc tgcaatgagc caccgtgatg gtgaactgca
    14341 ctccagcttg agtgacagag tgagatcctg tctcaaaaaa aagggcgggg tgcggggatt
    14401 ttgggtagta atatcaatag cagacaaaat agaatttgag gcaaaaagtg ttaataggat
    14461 caagattttt ttttttaaag aacaatccac cacaaacata gcaatcatga acaacccaga
    14521 aaacagcatg aaaattaaaa ggaaaattga gattttaaat acttctaata gaggtgatag
    14581 agcaggcagc agggaagtta gtaaccttgt ctaataggtt atctgtactc aacaagccta
    14641 gaacacacac tcctttcaag tacctgagga atgtttataa cagtaaagat gaacagagat
    14701 catattataa atagttggaa gatttatttt ttattttgtt ttttagaaac agggtcttgc
    14761 cggccaggcg tggtgactca tgcctgtaat ctcagcactt tgcaaggccg aagcgggtgg
    14821 atcacctgag gtcaggagtt tgagaccagc ctagccaaca tggcgaaacc tcgtctctac
    14881 taaaaataca aaaattagct gggcgtagta gtgggtgcct ataatcccag ctacttggga
    14941 ggctgaggca ggagaattgc ttgaaccggg agggtagagg ttgcagtgaa ccatggtcgc
    15001 accacttcac tccagcctgg acaaaagagc aaaactccat ctccaaaaaa aaaaaagaaa
    15061 agaaactgag tcttatggct ggatgcagtg gctcacgcct gtaatcccag cactttggga
    15121 ggccaaggta ggtgaatcac ttgagcccag gagtttgaga ccaacctggc caacatggcg
    15181 aaactccatc tctactaaaa atacaaaagt tagttgggcg tggtggtgtg cccctgtaat
    15241 cccagctact caggaggctg aggcaggaga attgcttgaa cccaggaggt ggaggttgca
    15301 atgagccact gcactccaga ctgcattcca gcctgggcga cagaacaaga ctctgtctca
    15361 aaaacaaaaa caaaaacaaa aaactaggtc tttctctgtg gccgacgctg gagtgcagtg
    15421 cctttttgca ggcacaatca tagtgcactg cagccctgaa ctccttggct caagtaatcc
    15481 tcctgcctca gcctcctgag taactgggac tataggtatg ccctaccatg tgtggctata
    15541 tttggtaggt tttaaatgaa aagatttttg ttttctgtac atttatttaa atttaaaaag
    15601 tatttaagcc atctttaaga aacttaatgt tgagaatgtt ctagaatagt gagtcattag
    15661 atttcaaaat attggtattg aaccagatgg tcttgtggct tcaaagaagt ctctgaagtc
    15721 actccaggtg atattaaaag tacagtgcta ggactgtctg acccaaaata tgtggctgga
    15781 accagaaagg atataagcat ggtttgagaa ggaaaaaaag cttaacaagg gggaattgag
    15841 gaagccattt gcaaaacttc acaggaaagt taaatgaatg aatgaataaa atgtgattaa
    15901 taaatatggg ggccaggtac agtggcctgc atctgtaatc ccagtgtttt gggaggccaa
    15961 ggcaggaggt gcacttgagg ccaggagttc aagacctgag caacacagca agacccccgt
    16021 ctctataaaa aattttataa aattagccgg gcatggtggt agacacctgt agtcccagct
    16081 acttgggaag atgaggcaga ggattgcctg agcccaggag tttgaggtta tagtgagcca
    16141 tgactgtgcc actgcactcc agcctgggca acaaagtgag accctgactc taaaagtaaa
    16201 attaaattaa attaaaaata agtggataaa tatgggttat gctgtgaagc atagagggag
    16261 ggatgaagag ggacatttta agccacttct ctggccccag tttctaacat tatttctaaa
    16321 atgcaggata tctggttatc ccaaaccagt tatattttta tttaaatttg ctcaaaattt
    16381 ttatttttaa atcttaacaa tttctaaaat cacacttttt aatttatttt gtattttttt
    16441 gagacagggt cttactttgt cacccaggct ggagtgcagg ggcacaaaca tggctcactg
    16501 cagcctcgac ctcccagcct caagtgatac tcccgcctca gcctcccaag tagctgggac
    16561 tacaggcatg caccaccaca cctggctaat ttttttatat tttgtttgta gagatggggt
    16621 ttcaccatgt tgccctgtct agtcttgaaa ccttgagctc aagagatctg cccaccttgg
    16681 cctctcaaag tgctgggatt acaggcgtga gccgtcctgc ctggcctagt cacacttttt
    16741 tttttttttt tttttttgga gacagagttt cactcttgtt gcccaggctg gagtgcaatg
    16801 gcatgatctg gactcaccgc aacctccgcc tcctgggttc aagcgattct cctgcctcag
    16861 ccacccaagt agctgggatt ataggcatgc accactatgc ccggctaatt ttgtattttt
    16921 agtagagaca gggcttctcc atgatggtca ggctggtctc gaactcctga cctcaggtga
    16981 tctgcccgcc tcggcctccc agtgttggga ttataggcat gagccaccgc gcccagctag
    17041 tcacgctttt tagtcaagat ttttaaaaat gtctgcatgc ttttctgaga gccttacctc
    17101 tcttgtgatt tgaagcattt tctccaccag gcctaaggct gaaggaatgt agtttgctgc
    17161 ccttcagtct atgacaagga ggtctgtttc ctccaacgcc tgccttttag acagagtgtt
    17221 gattcacagg gaacagaggc agacctgggg ctgacactga atgaatgcta ctcacagcag
    17281 taaggggaaa agtgggaaag tcttgtttat gctgtggctg atgtggatgt ctttggggaa
    17341 gaaaaattca ggatgagttt attgagagca ttatttttga aagtataaga tttgtgattg
    17401 taatataaac ttaaatcact ttgggaatga atttaaaaaa tctatgtgac acaaattaat
    17461 catcattctc attgtaaatt tggcaaagta tttgtaatta ggaatatctg tcatactggc
    17521 actgggcaaa ttattctgaa tgttcccatg ctgaagattc tctcaaaaag ggaaaaaaca
    17581 agatcctttg tttgtataag tacaatcagt ttgctgaata aaacctttat agctacaatt
    17641 ataacaggat tgtttctaca ttttagcttg gagatcccat gactactctg ttttgctaat
    17701 aataaaccaa tacagtgcta ca
//
