LOCUS       NM_001290264            6434 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens solute carrier family 35 member E2B (SLC35E2B),
            transcript variant 1, mRNA.
ACCESSION   NM_001290264
VERSION     NM_001290264.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6434)
  AUTHORS   Swierkowska,J., Karolak,J.A., Gambin,T., Rydzanicz,M.,
            Frajdenberg,A., Mrugacz,M., Podfigurna-Musielak,M., Stankiewicz,P.,
            Lupski,J.R. and Gajecka,M.
  TITLE     Variants in FLRT3 and SLC35E2B identified using exome sequencing in
            seven high myopia families from Central Europe
  JOURNAL   Adv Med Sci 66 (1), 192-198 (2021)
   PUBMED   33711669
  REMARK    GeneRIF: Variants in FLRT3 and SLC35E2B identified using exome
            sequencing in seven high myopia families from Central Europe.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB450858.1, CR936618.1, BG328537.1, AK125619.1, DA794179.1,
            FO704657.2 and BQ446951.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001290264.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936618.1, SRR7346977.2509845.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617444.5/ ENSP00000481694.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               DB450858.1         11-281
            272-363             CR936618.1         1-92
            364-425             BG328537.1         213-274
            426-821             CR936618.1         155-550
            822-1769            AK125619.1         337-1284
            1770-1999           DA794179.1         415-644
            2000-6127           FO704657.2         33807-37934         c
            6128-6434           BQ446951.1         18-324              c
FEATURES             Location/Qualifiers
     source          1..6434
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..6434
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /note="solute carrier family 35 member E2B"
                     /db_xref="GeneID:728661"
                     /db_xref="HGNC:HGNC:33941"
                     /db_xref="MIM:619315"
     exon            1..347
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            348..765
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1234
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     CDS             913..2130
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /codon_start=1
                     /product="solute carrier family 35 member E2B"
                     /protein_id="NP_001277193.1"
                     /db_xref="CCDS:CCDS44041.1"
                     /db_xref="GeneID:728661"
                     /db_xref="HGNC:HGNC:33941"
                     /db_xref="MIM:619315"
                     /translation="MSSSVKTPALEELVPGSEEKPKGRSPLSWGSLFGHRSEKIVFAK
                     SDGGTDENVLTVTITETTVIESDLGVWSSRALLYLTLWFFFSFCTLFLNKYILSLLGG
                     EPSMLGAVQMLSTTVIGCVKTLVPCCLYQHKARLSYPPNFLMTMLFVGLMRFATVVLG
                     LVSLKNVAVSFAETVKSSAPIFTVIMSRMILGEYTGLLVNLSLIPVMGGLALCTATEI
                     SFNVLGFSAALSTNIMDCLQNVFSKKLLSGDKYRFSAPELQFYTSAAAVAMLVPARVF
                     FTDVPVIGRSGKSFSYNQDVVLLLLTDGVLFHLQSVTAYALMGKISPVTFSVASTVKH
                     ALSIWLSVIVFGNKITSLSAVGTALVTVGVLLYNKARQHQQEALQSLAAATGRAPDDT
                     VEPLLPQDPRQHP"
     exon            1235..1370
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1498
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1619
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1673
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1746
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1892
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..6434
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3603..3608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /note="hexamer: GATAAA"
     polyA_site      3624
                     /gene="SLC35E2B"
                     /gene_synonym="SLC35E2"
                     /note="major polyA site"
ORIGIN      
        1 agaacggccc gggcggaacc aacgggcagc cgcgggggcg ttgtgggccg cggcgcgttt
       61 ccccggctcc gtggctctgg ggcactgagg agcggcgccc gcggggcagc gaggagcccg
      121 atgcagggtt ctgcgcgtca tttccggtcc cgcgggcgcc ccgtgaagcc cacctggatc
      181 cgccagcgct gtgccactcc ccagtgccga gctccgagct gtctccgcgg cctcgcgccc
      241 ggcccctcca ccgcgcgcct ctcaggcccc gcccgccagc gtccctttgt tgtgaaggcg
      301 ccggggccta gcgctatgcc tgcggcggag actgcatcag gctctcgtcc tcgggctcca
      361 cccggggagc tgtgcccaga cagcagaagg gaaggatgtc acttctgaga tgaggttcag
      421 aaaggtctgg gctcctgtcc tggctgctct ctcccactcc ctgatgagct tgctggatga
      481 aagctcctgt caggctgtgg ggcgtcctgt ggagaagctg gcaagaaact ggtgggggcc
      541 ctttccacct atagccagca aggaactgaa cccagccagc gtccacctga gtgagctcag
      601 aggtgggcct cagccccagt tgagccttcg gatgaggtca cagccctggt ccatggtgtg
      661 actgcagctt caggagggac cttaagccag aggtgcctgg ctaagcttcc cgcagattgc
      721 tgccccacag gagccaacat caaaagcatt tgttgttttg aggtgcgtct gcttctgcgc
      781 tttgcctggg agaggccctg gtggcctcgt tcctggcgcc cggagtccct gctgcggccc
      841 cacccccggg cggtcacggt gacccatgct gcccagcctg gaggtaaaat cgttcgtggc
      901 tgtggcttca gcatgtcgtc ctcggtgaaa accccagcac tggaagagct ggttcctggc
      961 tccgaagaga agccgaaagg caggtcgcct ctcagctggg gctctctgtt tggtcaccga
     1021 agtgagaaga ttgtttttgc caagagcgac ggcggcacag atgagaacgt actgaccgtc
     1081 accatcacgg agaccacggt catcgagtca gacttgggtg tgtggagctc gcgggcgctg
     1141 ctctacctca cgctgtggtt cttcttcagc ttctgcacgc tcttcctcaa caagtacatc
     1201 ctgtccctgc tgggaggcga gcccagcatg ctaggtgcgg tgcagatgct gtccaccacg
     1261 gttatcgggt gtgtgaaaac cctcgttcct tgctgtttgt atcagcacaa ggcccggctt
     1321 tcctacccac ccaacttcct tatgacgatg ctgtttgtgg gtctgatgag gtttgcaact
     1381 gtggttttgg gtttggtcag cctgaaaaat gtggcggttt cgtttgctga gacggtgaag
     1441 agctccgccc ccatcttcac ggtgatcatg tctcggatga ttctggggga gtacacaggg
     1501 ctgctggtca acctctccct catcccagtc atgggcgggc tggcgctgtg cacggccact
     1561 gagatcagct tcaatgtcct ggggttctcg gccgcactgt ccaccaacat catggactgt
     1621 ttgcaaaatg ttttttcaaa aaagctgctc agcggggaca aatacaggtt ctcggccccg
     1681 gagctgcagt tctacaccag cgccgctgcg gtggccatgc tcgtcccggc ccgggttttc
     1741 tttacggacg tcccagtgat cgggaggagt gggaagagct tcagctacaa ccaggacgtg
     1801 gtgctgctgc ttctgacaga cggagtcctg ttccaccttc agagcgtcac ggcgtacgcc
     1861 ctcatgggga aaatctcccc ggtgactttc agcgtcgcca gcaccgtgaa acatgccttg
     1921 tccatctggc tcagcgtaat cgttttcggc aacaagatca ccagcttgtc ggccgttggc
     1981 acagccctgg tgaccgttgg ggtcctgctc tacaacaaag ccaggcaaca ccagcaggag
     2041 gcgctgcaga gcctggctgc agccactggc cgggccccag acgacacagt ggagccgctg
     2101 cttccacagg accccaggca gcatccctga gagcaggaag ctgccagctg ctgctgtcct
     2161 cgtgacactg catcccccag aaatgggcag ggacgccctc ctccatggcc ctgctggggt
     2221 gcaggacatg gggagctaag ttggccattg cctgcggctt tctcggtttg tcggtgaaga
     2281 ccagcagaaa ctcaaactgg ggattccagg tatcagcttc ctggagtaga gaccagacca
     2341 gtagctgact gtgtccgccg agcccatccc cgtgtaatgt gaaaacagcc tctgaggctc
     2401 ccatgctggg ggtgcccact tcctctctgg gcgacacccc agggtccacc gggagccaga
     2461 ggtgggtcca gtgccaacga gagccgctcc ctgccacagc caagagagcc ctcggcttcc
     2521 cacaccagcc atcgaaggcc ctgaggccct ggaccggcgg cagactggcc ctgggcatga
     2581 ggccacagag cagggccgaa gggaggggac agagggccct ggaaggaagg gtctcctgct
     2641 gccacggtgg gcactcagaa cttctcccca cctgacccag ggctgtgggc atcctcagac
     2701 tatcccagag gcatcgcaag cctcaagctg cagcattgca cggcactcaa gggctatgac
     2761 cacggaggcc gttcagtcgc ttctgtttag aggaaggccc cctacctctt ccacaccctg
     2821 ccctcctatc ccttccacac cctgggctgc gtgagctccc cgcaacccca gggcaccctg
     2881 ccctcctacc tgtgggggtt tccagccctg aggttgagga caaacctctc gtgtttaact
     2941 tgggaggaga tgtgtacgtt ccttttcttt tttggactct gagtatgagg caggctgttc
     3001 tgaggtcccc gtggggtgag cctgtctgtc ctccctcaga gcccactgtt cctatcatca
     3061 tctagcacct gtccggttcc ccacgtgagc cttgggcagg acgctgcagt gttgatggtt
     3121 tgggttacgt ggcgtttacc tgggcgccgt ccttactgaa aaaggaaacg tccacactga
     3181 atgtttctgg ggcgcgtggt gtgtgtcagg cgcccaccct gtcccactct ccccaaggga
     3241 cagtagtacg gcacactggg gccaccagcc agctcaactc atcctcctgt gtcacgcacc
     3301 cccgagggcg caggaggcct gaggagtggc tactggagcc gtgtgttagg cagaggcttc
     3361 tgaccatgtc tgagctcttt acccccaatc tcgcagctgg cggattccca tgcccggtgc
     3421 agcctgttgc cagccagcct ttgagaccca gagctccagg gcttgtcaga ggcagcatgg
     3481 ggctccagtg gtcccgagtc tcatttccct gcctgctctt taggcctttg gcacccatgg
     3541 tcacttcact ggctttccat ttggcttctc acctgggaaa tacaaaaata gcccctcctg
     3601 aagataaaat cattcagaaa cagagcaata attctgactc attaacttct acctactcaa
     3661 aaaagtctgc catgatgatg gaccgaagtg aggcttttta acccacaagt aaccttttta
     3721 tttttttgag acagtcttgc tctgtctgtc acccaggctg gagtacagtg gcatgatctt
     3781 ggctcactgc agcctcgact tcctgggctc aaatgatcct cccacctcag cctcccatgt
     3841 ggctggaacc acaggcacgt gccaccatgc ctggctattt ttttgttgag ctgggctctc
     3901 gctttgttgc ccaggctggt cttgaactcc tcggctcaag caatccttcc cactcagcct
     3961 cctgtagtgt cgagaatata ggcgtgggct actacacctg cttcagccgc ttctataaaa
     4021 ccgctgacct gtgtgtggag gacaggccag gtgtgtgctc actgcgctgc gaagatgttt
     4081 tgtcacgtga ctttccccgg atttccattt ctttttttct gctttcctca aaaactaata
     4141 gaagactggg tgcggtggct cacgcctcta atcgcagcac tttgggaggc agcagctggc
     4201 ggatcacaag gccaggagtt cgagaccagc ctggccaaca tgatgaaacc ctgtctctac
     4261 caaaaataca aaaattagct gggtgcgatg gtgggtgcct gtaatcccag atactcagga
     4321 ggctgaggca ggagaattgt ttgaaccccg gagatggagg ttgcagtgag ccaagatcgt
     4381 gccattgcac tccagcctgg gcaacagggc aagattccgt ctcaaaaaca aacactatta
     4441 gaaaatgccc tggaggtggc ggggagttgt tgatttgtga ggacagattg aaagcaactc
     4501 ccagggtggc cttgtccacc tccccgtcga gaatgtggct gccggcctct ttgaagattg
     4561 tggtctggca taaggagagg tgcaggcgcc tggttctgag caccttggaa tttccagccg
     4621 cacagcatct ggtgccctcc cctccaccct cacaaggagc tgccatcctg tttggatttt
     4681 ctgtttgtgg accagaaaca aacgtttttc caaaggatta gcaaataggg taatttcctg
     4741 tgtaacgctg ctctggggcc tcttcctcat cctggcagaa ggagcctgga gcccatgagg
     4801 cagccagcac tgtgcccttg ctcagtcgtg ctgtcccctc cctctccctc agtctcctct
     4861 ccatgcccaa gtcagtttcc agccgctggt cttcatggca ttcccagcac agccgggcac
     4921 caagaggcaa aacccaaggc ctggcttggc cgtgttaacg attgtacaga cattttttaa
     4981 aataactttg tgtaatactt ttctggaata gtaagttctt gttgaactgt cacaggtgag
     5041 cttctaggaa cacaccaggt gtggttactt ccactgggtg tgtccatggt cgtggtctgt
     5101 gcttttgtaa acgaacagaa cacttgaacc acctcccgaa ttgggtcatc ggcttcttta
     5161 cgttgatact taagagattt gcagctctct ttcaaggaaa cttcccctac tgaaaggcat
     5221 aaaaaggtta aaaaagaaaa tccgagagtc ccaattccct gtataacagc attaaaataa
     5281 tctgcctgcc tggaaagatg agaacactgt tgcacaaccc aaaatgtgtc tttaatttgt
     5341 gaaaaattac catggtgagt cagacagtca ttttaaacag ctgaacagag actatcatca
     5401 gcaaatagag ctcagctttg tagctgcctt taaaatcctt gtcccaaatc cggtgagctc
     5461 tgcttgctgc cgccgcgctc ctgggtgatc actcagacgg gtcagtggga ataacaggcc
     5521 aacaagacag ctttttacat gtgtccaaag gatggccttt cgaaggcctg gaagtatttc
     5581 actgttggaa gaagtaaaca agaatgacat tccagatgga aatagaattc tctctcttgc
     5641 ctttgaccaa catggtacta aggggtttct tctttcccaa tgtatgtacg tgccctgctg
     5701 ggggccttac tttatagaat gagagcatcc gagcttccct aatgaatctg gctagttctg
     5761 tgtctggctg aggatacagg agtgggacat ccactctcgg atccctcaga gcacagaaac
     5821 cttcagcttt gctgtctctg aagtatttcc tccagtttcc ctgcgggccc ctatgtttga
     5881 gtttgatggc tgctggatcc tcactcaacg aaaactcggt tggaaactgt tccgcctggc
     5941 agtccttttt tgttgttttc catctcattt cccttccatc tgaaagtggc attcagctga
     6001 cttgctcatt tagactgttc acggagtctg aatctgccaa cgtggtgttg gaggctccac
     6061 cttgaaaagg gccacagtca gggcaacttt ccccatacag gaaaacttga aaattacatc
     6121 aacagtctac gtcacagcca aattatattt cctttatacc aaacaaaact atggagaact
     6181 aaaagtacat cacacaaaac gtttatagtg ttttgcatgt gacctatttc agtatttata
     6241 taactagatt agtgctttct agcaaacggt tctgttaatt agcgagtcac tgttgattct
     6301 gctgtggtgg taagttgata ccgtgtaact aatcccgtgg atgcctcctc gttatttttg
     6361 tccaaacgaa gcagccgtgg tagtagctgt ctatgattct tgctcagcaa agtaaaataa
     6421 atgttaaata tgga
//
