LOCUS       NM_001008783            2343 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens solute carrier family 35 member D3 (SLC35D3), mRNA.
ACCESSION   NM_001008783 XM_294017
VERSION     NM_001008783.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Qian,C., Wu,Z., Sun,R., Yu,H., Zeng,J., Rao,Y. and Li,Y.
  TITLE     Localization, proteomics, and metabolite profiling reveal a
            putative vesicular transporter for UDP-glucose
  JOURNAL   Elife 10, e65417 (2021)
   PUBMED   34269178
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Zhang,Z., Hao,C.J., Li,C.G., Zang,D.J., Zhao,J., Li,X.N., Wei,A.H.,
            Wei,Z.B., Yang,L., He,X., Zhen,X.C., Gao,X., Speakman,J.R. and
            Li,W.
  TITLE     Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine
            signaling in striatal D1 neurons
  JOURNAL   PLoS Genet 10 (2), e1004124 (2014)
   PUBMED   24550737
  REMARK    GeneRIF: Our results suggest that the SLC35D3 gene, close to the
            D6S1009 locus, is a candidate gene for MetS, which is involved in
            metabolic control in the central nervous system by regulating
            dopamine signaling.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK316095.1, AK295424.1, BC067217.1 and BE669463.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001008783.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087842.1, SRR1803614.17469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331858.5/ ENSP00000333591.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AK316095.1         61-151
            92-1506             AK295424.1         1-1415
            1507-1940           BC067217.1         800-1233
            1941-2343           BE669463.1         4-406               c
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..2343
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /note="solute carrier family 35 member D3"
                     /db_xref="GeneID:340146"
                     /db_xref="HGNC:HGNC:15621"
                     /db_xref="MIM:612519"
     exon            1..567
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1379
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /note="frc, fringe-like 1; fringe connection-like protein
                     1"
                     /codon_start=1
                     /product="solute carrier family 35 member D3"
                     /protein_id="NP_001008783.1"
                     /db_xref="CCDS:CCDS34544.1"
                     /db_xref="GeneID:340146"
                     /db_xref="HGNC:HGNC:15621"
                     /db_xref="MIM:612519"
                     /translation="MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLV
                     QCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLP
                     MYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVT
                     GVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFP
                     GWKDPAMVCIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSD
                     VEPTSLFIAGVVVNTLGSIIYCVAKFMETRKQSNYEDLEAQPRGEEAQLSGDQLPFVM
                     EELPGEGGNGRSEGGEAAGGPAQESRQEVRGSPRGVPLVAGSSEEGSRRSLKDAYLEV
                     WRLVRGTRYMKKDYLIENEELPSP"
     exon            568..2343
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2297..2302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /note="hexamer: AATAAA"
     regulatory      2317..2322
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2322
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
                     /note="major polyA site"
     polyA_site      2343
                     /gene="SLC35D3"
                     /gene_synonym="FRCL1"
ORIGIN      
        1 agccggcgcc ccctgccctt cgccgccgcg ctgggcgggc gcccccgccg ccctcactcc
       61 gctgctcccg gctcctcgcg cgcaggtcgc ggagctccgc caccgctggg tgcggcgagg
      121 ccggcgcgat gcggcagctg tgccggggcc gcgtgctggg catctcggtg gccatcgcgc
      181 acggggtctt ctcgggctcc ctcaacatct tgctcaagtt cctcatcagc cgctaccagt
      241 tctccttcct gaccctggtg cagtgcctga ccagctccac cgcggcgctg agcctggagc
      301 tgctgcggcg cctcgggctc atcgccgtgc cccccttcgg tctgagcctg gcgcgctcct
      361 tcgcgggggt cgcggtgctc tccacgctgc agtccagcct cacgctctgg tccctgcgcg
      421 gcctcagcct gcccatgtac gtggtcttca agcgctgcct gcccctggtc accatgctca
      481 tcggcgtcct ggtgctcaag aacggcgcgc cctcgccagg ggtgctggcg gcggtgctca
      541 tcaccacctg cggcgccgcc ctggcaggag ccggcgacct gacgggcgac cccatcgggt
      601 acgtcacggg agtgctggcg gtgctggtgc acgctgccta cctggtgctc atccagaagg
      661 ccagcgcaga caccgagcac gggccgctca ccgcgcagta cgtcatcgcc gtctctgcca
      721 ccccgctgct ggtcatctgc tccttcgcca gcaccgactc catccacgcc tggaccttcc
      781 cgggctggaa ggacccggcc atggtctgca tcttcgtggc ctgcatcctg atcggctgcg
      841 ccatgaactt caccacgctg cactgcacct acatcaattc ggccgtgacc accagcttcg
      901 tgggtgtggt gaagagcatc gccaccatca cggtgggcat ggtggccttc agcgacgtgg
      961 agcccacctc tctgttcatt gccggcgtgg tggtgaacac cctgggctct atcatttact
     1021 gtgtggccaa gttcatggag accagaaagc aaagcaacta cgaggacctg gaggcccagc
     1081 ctcggggaga ggaggcgcag ctaagtggag accagctgcc gttcgtgatg gaggagctgc
     1141 ccggggaggg aggaaatggc cggtcagaag gtggggaggc agcaggtggc cccgctcagg
     1201 agagcaggca agaggtcagg ggcagccccc gaggagtccc gctggtggct gggagctctg
     1261 aagaagggag caggaggtcg ttaaaagatg cttacctcga ggtatggagg ttggttaggg
     1321 gaaccaggta tatgaagaag gattatttga tagaaaacga ggagttaccc agtccttgag
     1381 aaggaggtgc atgtacgtac ctatgtgcat acacttattt tatatgttag aaatgacgtg
     1441 ttttaatgag aggcctcccc gttttattct ttgaggagtg gggaagggaa gaaaagaaag
     1501 aagctgaaag gtactgacac agagcaacaa aattagcacc tgtgtgaatt atttagtgtg
     1561 acttcacctg aggcatcaca gagacaaaag aatgtgaagc tacttaacaa agtaaggcaa
     1621 cgtttctgct tcagactcct ggcacattta ctttttgtca ttataaccat aactaaatat
     1681 ctgcatgtac caagagtccc taagccaccc cctccaaaga tggagtgtag aaatgatgac
     1741 agcacttagt aagttcaaag atgacattca gggatgcatt ttttgatgat agaactacag
     1801 tttttatcgc cagctgggca aagagtatat tgctgaaatg atatataaat atattgaatt
     1861 gatgtttact gtttatagtc atctgaaata tcatatttac tctgattcta ctcacttgtt
     1921 ttttaaaaat aagtgtccta ttattgtatt atatattgat agaaactgtt aaagctattt
     1981 tgaaaatatg agttcttagc tttaatcatg aagtctgaag tttgctttca gtaattattt
     2041 taaaagttgt tttggttcat tgctttataa tatttattat tgaatgccaa acctgttctt
     2101 ttttttactg tgtccaatat tctttcaagc aaatgcaatg gctggaatat aattcagaat
     2161 taactgaaac ccagccagaa gagggaccac ctgtaaagca agtcctttca agtttcactg
     2221 cacatcccaa accatgttac aaaaagagca actgctatat tcacattatg atatttttct
     2281 atcttaaatt tgtcaaaata aagtatgagt ctaactatta aaggatacat tgttagaaat
     2341 tta
//
