LOCUS       NM_007001               1623 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 35 member D2 (SLC35D2),
            transcript variant 1, mRNA.
ACCESSION   NM_007001 XM_372131
VERSION     NM_007001.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1623)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   2  (bases 1 to 1623)
  AUTHORS   Lee,Y., Yoon,K.A., Joo,J., Lee,D., Bae,K., Han,J.Y. and Lee,J.S.
  TITLE     Prognostic implications of genetic variants in advanced non-small
            cell lung cancer: a genome-wide association study
  JOURNAL   Carcinogenesis 34 (2), 307-313 (2013)
   PUBMED   23144319
REFERENCE   3  (bases 1 to 1623)
  AUTHORS   Sesma,J.I., Esther,C.R. Jr., Kreda,S.M., Jones,L., O'Neal,W.,
            Nishihara,S., Nicholas,R.A. and Lazarowski,E.R.
  TITLE     Endoplasmic reticulum/golgi nucleotide sugar transporters
            contribute to the cellular release of UDP-sugar signaling molecules
  JOURNAL   J Biol Chem 284 (18), 12572-12583 (2009)
   PUBMED   19276090
  REMARK    GeneRIF: HFRC1 was overexpressed in human bronchial epithelial
            cells and was shown to localize in the Golgi and to enhance the
            surface expression of N-acetylglucosamine-rich glycans.
REFERENCE   4  (bases 1 to 1623)
  AUTHORS   Ishida,N., Kuba,T., Aoki,K., Miyatake,S., Kawakita,M. and Sanai,Y.
  TITLE     Identification and characterization of human Golgi nucleotide sugar
            transporter SLC35D2, a novel member of the SLC35 nucleotide sugar
            transporter family
  JOURNAL   Genomics 85 (1), 106-116 (2005)
   PUBMED   15607426
REFERENCE   5  (bases 1 to 1623)
  AUTHORS   Suda,T., Kamiyama,S., Suzuki,M., Kikuchi,N., Nakayama,K.,
            Narimatsu,H., Jigami,Y., Aoki,T. and Nishihara,S.
  TITLE     Molecular cloning and characterization of a human multisubstrate
            specific nucleotide-sugar transporter homologous to Drosophila
            fringe connection
  JOURNAL   J Biol Chem 279 (25), 26469-26474 (2004)
   PUBMED   15082721
  REMARK    GeneRIF: HFRC1 takes part in the synthesis of heparan sulfate by
            regulating the level of UDP-GlcNAc, a donor substrate for the
            heparan sulfate synthases
REFERENCE   6  (bases 1 to 1623)
  AUTHORS   Ishida,N. and Kawakita,M.
  TITLE     Molecular physiology and pathology of the nucleotide sugar
            transporter family (SLC35)
  JOURNAL   Pflugers Arch 447 (5), 768-775 (2004)
   PUBMED   12759756
  REMARK    Review article
REFERENCE   7  (bases 1 to 1623)
  AUTHORS   Herman,T. and Horvitz,H.R.
  TITLE     Three proteins involved in Caenorhabditis elegans vulval
            invagination are similar to components of a glycosylation pathway
  JOURNAL   Proc Natl Acad Sci U S A 96 (3), 974-979 (1999)
   PUBMED   9927678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160269.14, AB106537.1 and AJ005866.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007001.2.
            
            Summary: Nucleotide sugars, which are synthesized in the cytosol or
            the nucleus, are high-energy donor substrates for
            glycosyltransferases located in the lumen of the endoplasmic
            reticulum and Golgi apparatus. Translocation of nucleotide sugars
            from the cytosol into the lumen compartment is mediated by specific
            nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004
            [PubMed 15082721]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB122077.1, SRR1803617.409249.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253270.13/ ENSP00000253270.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL160269.14        4343-4410
            69-1091             AB106537.1         1-1023
            1092-1623           AJ005866.1         787-1318
FEATURES             Location/Qualifiers
     source          1..1623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.32"
     gene            1..1623
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /note="solute carrier family 35 member D2"
                     /db_xref="GeneID:11046"
                     /db_xref="HGNC:HGNC:20799"
                     /db_xref="MIM:609182"
     exon            1..235
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1091
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /note="isoform a is encoded by transcript variant 1;
                     UDP-N-acetylglucosamine transporter;
                     UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose
                     transporter; fringe connection; SQV7-like protein; homolog
                     of Fringe connection protein 1; UDP-galactose
                     transporter-related protein 8; nucleotide sugar
                     transporter SLC35D2; solute carrier family 35
                     (UDP-GlcNAc/UDP-glucose transporter), member D2"
                     /codon_start=1
                     /product="nucleotide sugar transporter SLC35D2 isoform a"
                     /protein_id="NP_008932.2"
                     /db_xref="CCDS:CCDS6717.1"
                     /db_xref="GeneID:11046"
                     /db_xref="HGNC:HGNC:20799"
                     /db_xref="MIM:609182"
                     /translation="MTAGGQAEAEGAGGEPGAARLPSRVARLLSALFYGTCSFLIVLV
                     NKALLTTYGFPSPIFLGIGQMAATIMILYVSKLNKIIHFPDFDKKIPVKLFPLPLLYV
                     GNHISGLSSTSKLSLPMFTVLRKFTIPLTLLLETIILGKQYSLNIILSVFAIILGAFI
                     AAGSDLAFNLEGYIFVFLNDIFTAANGVYTKQKMDPKELGKYGVLFYNACFMIIPTLI
                     ISVSTGDLQQATEFNQWKNVVFILQFLLSCFLGFLLMYSTVLCSYYNSALTTAVVGAI
                     KNVSVAYIGILIGGDYIFSLLNFVGLNICMAGGLRYSFLTLSSQLKPKPVGEENICLD
                     LKS"
     exon            236..269
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            270..356
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            357..424
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            425..496
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            497..565
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            566..668
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            669..761
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            762..829
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            830..908
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            909..991
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1623
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1606..1611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="SLC35D2"
                     /gene_synonym="hfrc; HFRC1; SQV7L; UGTrel8"
                     /note="major polyA site"
ORIGIN      
        1 ctcttccccg gcccggccgg gcgggaccag tgcgcagccg gggctggcgg gcggcggggt
       61 ccgcggggcc gcaggagatg acggccggcg gccaggccga ggccgagggc gctggcgggg
      121 agcccggcgc ggcgcggctg ccctcgcggg tggcccggct gctgtcggcg ctcttctacg
      181 ggacctgctc cttcctcatc gtgcttgtca acaaggcgct gctgaccacc tacggtttcc
      241 cgtcaccaat tttccttgga attggacaga tggcagccac cataatgata ctatatgtgt
      301 ccaagctaaa caaaatcatt cacttccctg attttgataa gaaaattcct gtaaagctgt
      361 ttcctctgcc tctcctctac gttggaaacc acataagtgg attatcaagc acaagtaaat
      421 taagcctacc gatgttcacc gtgctcagga aattcaccat tccacttacc ttacttctgg
      481 aaaccatcat acttgggaag cagtattcac tcaacatcat cctcagtgtc tttgccatta
      541 ttctcggggc tttcatagca gctgggtctg accttgcttt taacttagaa ggctatattt
      601 ttgtattcct gaatgatatc ttcacagcag caaatggagt ttataccaaa cagaaaatgg
      661 acccaaagga gctagggaaa tacggagtac ttttctacaa tgcctgcttc atgattatcc
      721 caactcttat tattagtgtc tccactggag acctgcaaca ggctactgaa ttcaaccaat
      781 ggaagaatgt tgtgtttatc ctacagtttc ttctttcctg ttttttgggg tttctgctga
      841 tgtactccac ggttctgtgc agctattaca attcagccct gacgacagca gtggttggag
      901 ccatcaagaa tgtatccgtt gcctacattg ggatattaat cggtggagac tacattttct
      961 ctttgttaaa ctttgtaggg ttaaatattt gcatggcagg gggcttgaga tattcctttt
     1021 taacactgag cagccagtta aaacctaaac ctgtgggtga agaaaacatc tgtttggatt
     1081 tgaagagcta aagagtctgc agcaggattg gagactgact tgtgactgcg ggctgggggg
     1141 gcattcccag taggaatgtg aagccagagg tttcggattc gtgacatcca ccccctgggc
     1201 aagtgagagc atctgcaaaa tgcaaagaga actacctcat atgcaggatg agccaatggc
     1261 agtctcaaga aatgtactcg ggcgacacct tacctgtgga aagcaaatct tttcaaaata
     1321 agccactggg actcggtagg tggagcccca gctgctcttc tagggaccta tggggccttc
     1381 gtggcatctc tgtgctgtgt gctggggagg aggttgatgt aatggtgact cttttctgat
     1441 cagcaccttg gccgtgattc ccaaggtccc agccaaagca aagggccagt tgtttcagtt
     1501 taaacagaca tgtctttagt ctaataaaat tagttaactg ccagtaaagt tatttgttag
     1561 ctttgatgaa agctatgttg gtatctttcc ctaatcatca aagtaaataa aaaatcattt
     1621 cta
//
