LOCUS       NM_015945               5820 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens solute carrier family 35 member C2 (SLC35C2),
            transcript variant 2, mRNA.
ACCESSION   NM_015945
VERSION     NM_015945.12
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5820)
  AUTHORS   Lu,L., Varshney,S., Yuan,Y., Wei,H.X., Tanwar,A., Sundaram,S.,
            Nauman,M., Haltiwanger,R.S. and Stanley,P.
  TITLE     In vivo evidence for GDP-fucose transport in the absence of
            transporter SLC35C1 and putative transporter SLC35C2
  JOURNAL   J Biol Chem 299 (12), 105406 (2023)
   PUBMED   38270391
  REMARK    GeneRIF: In vivo evidence for GDP-fucose transport in the absence
            of transporter SLC35C1 and putative transporter SLC35C2.
REFERENCE   2  (bases 1 to 5820)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5820)
  AUTHORS   Lu,L., Hou,X., Shi,S., Korner,C. and Stanley,P.
  TITLE     Slc35c2 promotes Notch1 fucosylation and is required for optimal
            Notch signaling in mammalian cells
  JOURNAL   J Biol Chem 285 (46), 36245-36254 (2010)
   PUBMED   20837470
REFERENCE   4  (bases 1 to 5820)
  AUTHORS   Leach,R.E., Duniec-Dmuchowski,Z.M., Pesole,G., Tanaka,T.S.,
            Ko,M.S., Armant,D.R. and Krawetz,S.A.
  TITLE     Identification, molecular characterization, and tissue expression
            of OVCOV1
  JOURNAL   Mamm Genome 13 (11), 619-624 (2002)
   PUBMED   12461647
REFERENCE   5  (bases 1 to 5820)
  AUTHORS   Lash,G.E., Postovit,L.M., Matthews,N.E., Chung,E.Y., Canning,M.T.,
            Pross,H., Adams,M.A. and Graham,C.H.
  TITLE     Oxygen as a regulator of cellular phenotypes in pregnancy and
            cancer
  JOURNAL   Can J Physiol Pharmacol 80 (2), 103-109 (2002)
   PUBMED   11934252
  REMARK    Review article
REFERENCE   6  (bases 1 to 5820)
  AUTHORS   Leach,R., Duniec-Dmuchowski,Z., Tanaka,T., Ko,M.S. and Krawetz,S.A.
  TITLE     Assignment of OVCOV1 (alias CGI-15) to human chromosome 20 band
            q13.1-->q13.2 by fluorescent in situ hybridization
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 252-253 (2001)
   PUBMED   11856893
  REMARK    GeneRIF: Assignment of OVCOV1 (alias CGI-15) to human chromosome 20
            band q13.1-->q13.2 by fluorescent in situ hybridization
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA820126.1, BC014191.2,
            AK222928.1, BM666377.1 and AL133227.15.
            
            On Nov 22, 2018 this sequence version replaced NM_015945.11.
            
            Summary: This gene encodes a member of the triose-phosphate
            transporter protein family. This gene is regulated by oxygen
            tension, is induced in hypoxic trophoblast cells, and is
            overexpressed in ovarian cancer. Alternative splicing results in
            multiple transcript variants. A pseudogene of this gene has been
            defined on the X chromosome. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 7 encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.127856.1,
                                           SRR1803614.5640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372230.10/ ENSP00000361304.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DA820126.1         34-56
            24-720              BC014191.2         1-697
            721-2068            AK222928.1         694-2041
            2069-2276           BM666377.1         17-224              c
            2277-5820           AL133227.15        27793-31336         c
FEATURES             Location/Qualifiers
     source          1..5820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.12"
     gene            1..5820
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="solute carrier family 35 member C2"
                     /db_xref="GeneID:51006"
                     /db_xref="HGNC:HGNC:17117"
                     /db_xref="MIM:619530"
     exon            1..55
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            56..432
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     CDS             313..1410
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="isoform a is encoded by transcript variant 2;
                     ovarian cancer-overexpressed gene 1 protein; solute
                     carrier family 35 (GDP-fucose transporter), member C2"
                     /codon_start=1
                     /product="solute carrier family 35 member C2 isoform a"
                     /protein_id="NP_057029.8"
                     /db_xref="CCDS:CCDS13396.1"
                     /db_xref="GeneID:51006"
                     /db_xref="HGNC:HGNC:17117"
                     /db_xref="MIM:619530"
                     /translation="MGRWALDVAFLWKAVLTLGLVLLYYCFSIGITFYNKWLTKSFHF
                     PLFMTMLHLAVIFLFSALSRALVQCSSHRARVVLSWADYLRRVAPTALATALDVGLSN
                     WSFLYVTVSLYTMTKSSAVLFILIFSLIFKLEELRAALVLVVLLIAGGLFMFTYKSTQ
                     FNVEGFALVLGASFIGGIRWTLTQMLLQKAELGLQNPIDTMFHLQPLMFLGLFPLFAV
                     FEGLHLSTSEKIFRFQDTGLLLRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAG
                     IFKEVCTLLLAAHLLGDQISLLNWLGFALCLSGISLHVALKALHSRGDGGPKALKGLG
                     SSPDLELLLRSSQREEGDNEEEEYFVAQGQQ"
     exon            433..583
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            584..647
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..720
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..889
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..973
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1149
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1279
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..5820
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1839..1844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="hexamer: AATAAA"
     polyA_site      1858
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="major polyA site"
     regulatory      2048..2053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="hexamer: AATAAA"
     polyA_site      2075
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="hexamer: ATTAAA"
     polyA_site      2266
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
     regulatory      5796..5801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
                     /note="hexamer: ATTAAA"
     polyA_site      5820
                     /gene="SLC35C2"
                     /gene_synonym="BA394O2.1; C20orf5; CGI-15; OVCOV1;
                     SLC35H1"
ORIGIN      
        1 atccggcctc gcacttccgg tggggagatt ccggcctgga gctcccaggg ccgagcagac
       61 cttgggacct gtgagcgctg catccaatta accatgggaa gggtcagcac cagccaccag
      121 ccccttaggt gaggactctg cctggggctc tgctgatggt tccgaatcat ggagctgcag
      181 agagctcctc cagcctggag acgttcttgg tgaaagctgt ggtctaactc caccggctct
      241 tcctgcacat tgtattcaag aggggtgcct gcccccgctg actcaggagc tccggtgctg
      301 cagccgccac gaatggggag gtgggccctc gatgtggcct ttttgtggaa ggcggtgttg
      361 accctggggc tggtgcttct ctactactgc ttctccatcg gcatcacctt ctacaacaag
      421 tggctgacaa agagcttcca tttccccctc ttcatgacga tgctgcacct ggccgtgatc
      481 ttcctcttct ccgccctgtc cagggcgctg gttcagtgct ccagccacag ggcccgtgtg
      541 gtgctgagct gggccgacta cctcagaaga gtggctccca cagctctggc gacggcgctt
      601 gacgtgggct tgtccaactg gagcttcctg tatgtcaccg tctcgctgta cacaatgacc
      661 aaatcctcag ctgtcctctt catcttgatc ttctctctga tcttcaagct ggaggagctg
      721 cgcgcggcac tggtcctggt ggtcctcctc atcgccgggg gtctcttcat gttcacctac
      781 aagtccacac agttcaacgt ggagggcttc gccttggtgc tgggggcctc gttcatcggt
      841 ggcattcgct ggaccctcac ccagatgctc ctgcagaagg ctgaactcgg cctccagaat
      901 cccatcgaca ccatgttcca cctgcagcca ctcatgttcc tggggctctt ccctctcttt
      961 gctgtatttg aaggtctcca tttgtccaca tctgagaaaa tcttccgttt ccaggacaca
     1021 gggctgctcc tgcgggtact tgggagcctc ttccttggcg ggattctcgc ctttggtttg
     1081 ggcttctctg agttcctcct ggtctccaga acctccagcc tcactctctc cattgccggc
     1141 atttttaagg aagtctgcac tttgctgttg gcagctcatc tgctgggcga tcagatcagc
     1201 ctcctgaact ggctgggctt cgccctctgc ctctcgggaa tatccctcca cgttgccctc
     1261 aaagccctgc attccagagg tgatggtggc cccaaggcct tgaaggggct gggctccagc
     1321 cccgacctgg agctgctgct ccggagcagc cagcgggagg aaggtgacaa tgaggaggag
     1381 gagtactttg tggcccaggg gcagcagtga ccagccaggg caaatggctt agaagcaggc
     1441 cactccccag cctgctgcca gcactcactg tgctcaagcc gccagggctc atcatggtag
     1501 ctgggagctg tggacgggag tcaccaggtg gtggggccaa gccagggact catgactttt
     1561 gcccctccct tcagagcctg gtcacacaag gggcgagcac caggccagcc tgggactggc
     1621 cagagctggg cccaagctgc gctggaatcg cagcaggaga ggggagtggg ctggttcttc
     1681 ccaccacttc ccaggctctg acagccgaga ctcatttcca aggcacagca gctttctaaa
     1741 gggactgagt ttggactggg ttttggacct ccaggggctg gagcttcatc acctgggcag
     1801 tgtcttttct cagagagcag gtttctttat agtttggaaa taaatggttc acggtccact
     1861 ggccgccttg tgttgctgga gacgtggggg cagggagggg acagtgtggg cctggcctct
     1921 cctttccttt ccctgcctgg agccttcttc aaatgtctgg tcttaagcca ggcctccttc
     1981 attttctcgc tcctgttaga acaccagtcc cctccccagt ggggccccac tgcacctgct
     2041 ggcaggaaat aaatgaatgt ttactgagta ctgcattctg gagaccttac atgttttcac
     2101 agcctagttt gaatactggc tttgtcacta gctgtgtgac cctaagcaaa tgacctaacc
     2161 tgtctgtgcc gtagtttttt aatctgtgaa atggggataa tgtctatctc agagtccttt
     2221 tgaagattga gtcattatta gtaacagatt aaatgttata taagcatttc ttttaatcct
     2281 tttaacaact aagagactaa agcctggaaa agataaagag ctgcttaagt ggccgggctg
     2341 aggttcacat ccaagtctgt gtacgtctgt gtgtgcacgt gctgcacgtg acatccacac
     2401 agcctcctgg aacttcatgg gcccctgggg cttgggcttt ccactcctcc ttggccaagt
     2461 cccacgtctt ctctagactg caggcctctc tcaaatgagg aagggagggg gcaagacccc
     2521 agctctgatg tgctgtggac tgagtctact cctgtaaact ggttcccggg ccatgggaga
     2581 cccccccggc ccttggggac aaagctttcc aggcgaagtg ctcctaggca ctcacagcag
     2641 gtggcgccat tgcaccacac tggctcccag agcccagctg ccctgccacg gctatccaga
     2701 caccggcaga aaaggggtgc ttggaagagg acagtgggta tccatgggtg gggacaagga
     2761 tagggcttgt tctaaaattg tttccatcag gttggagtca ctaaagctcg ttcggttaag
     2821 cccaggagaa ctttaatact ttaaaaatgg gtctgcaaac ttcctgtaaa gggccagata
     2881 gtaaatattt ggggtttggg gaccatatgg cgtctgttgc agctactctg ccatcgtagc
     2941 acaaaagcag ccatagatga cacagaccca gggtgtggct gtcccagtga aaccccattt
     3001 acaaaagtag gatccagctt gctggctgaa gtttaccagc aggagaaccc tcaagaattc
     3061 tcgagtccaa cttccacttc tgcagcagga gactgaagcc aggagggggc ggtgactagc
     3121 ccgaggccct cagagcctcc gtgctcagga gtcagaccga gatctgcctc taattcagat
     3181 tcccagcaca gactcagcag gcggaggtgg agcaccaagg gcgcttggaa gcggcctctt
     3241 atctggctcc tgcacctctg ccccccttgg attccgcaag ctcagaggcc aagattaaag
     3301 gaggctcgtg ctccagctgg atgatgtggg aagagccagc caaggagggg ggccagggcc
     3361 tcctccgtct tagaggctgc ttgggatgca ggctgcttgg gcggcagggg gagtctgcca
     3421 gagccccgct ggctcaggtg gatgagagct tcctgtctgc tcccccactg cccgcctccc
     3481 agcacaggga gcaagcgttg ctgtctggtg cagtaattac aaggtgcaga gcgggggccc
     3541 ttacctcgca catgttgggt tcaatgacag cccttcattt agcagcaatt accagctgaa
     3601 cctaaaggag ggctccctct cctcccccac ccagcccacc caatcgcctg gcctcccagg
     3661 ccagacagcg tccacctcgg cattgagccc tagaaccacc catgctgtct gcagccattg
     3721 catctcaggg ctgcagcatc accatggcaa cgcggtgctt gcacaggttg aggggaagct
     3781 gaggatgtga cttgtctctc caaggctgtg gtgtctgtcc ccacacagcc ccagctccga
     3841 ggcttctgca gaaggggcgg agagaggact gacctgcagg ttcgagtttc aagtgcttac
     3901 ctgcccacca cctctcccag gggcccacag tggaaggaag gttaatggct ccaatatgtg
     3961 aggacgtcca cagttggtgt tgtggtggcg gtgagaatgg gctgcagttt gcctgtggga
     4021 gggacctgag ccatcaggca gggcccggca taccttcatc ttcactccgg tacccttttc
     4081 tgccttgagg gctcaaggga ttgtctccat ctgtttctgc tttatcctgc tgtgaaaaac
     4141 ctgaaaatcc cagtggcttg agagtagtta catggcacca agagaattct cctcatggta
     4201 cttgctgcag cttcctgcat cacacactag tgatggactg agggtgggga ctcccaggcc
     4261 atccatttag gtcgacagca ttcagtgagt actggctaca tggcagacac tgccggactt
     4321 ggggacagag acattcattt ttggagtcag ccttcctccc agcccaggaa agtgatgagg
     4381 cagtgggctg gggaatgggg aagaaagaac agaaaagacc gttcactggg caccatctag
     4441 gcctttgcca taggttattt aatctgtaac agcccggtgc agtaaggact gattgtattt
     4501 ctttcctagc tgtggaaact aagttccaag tggttaagca taacgatggc taaggataca
     4561 acctgcagac gccgtagagt gagagacgtg tctctctttg ctgtgattag ctgcgtgctt
     4621 ttggacacgt tgctgatctt ctccgagcct gtttccttgt ctctacagaa ggaataataa
     4681 tacatacacc tgaaggaagc tactgtgaag gtgaaataaa ataatgtagg taaagcacac
     4741 agtgctcggc tcatagtcat caccactcag gaaatggagc aggaaggacg tcacataact
     4801 cgcccagatg agaggaggag ccagcgttgg agctctggcc ttccaagatc cccatctctg
     4861 ctgcagtgtc tggtactgag catgcactta acagatgctt tttttttttt ttttttgaca
     4921 tggagttttt gctcttattg cccaggctgg agtgcaatgg cacgatcttg gctcgctgca
     4981 acctccacct cccgggttca agtgattctc ctgtctcagc ttcccaagta gctgggatta
     5041 caggcaccca ccaccatgcc tggctaattt tttgtatgtt tagtacaggg agctctaaag
     5101 ctgagatgcc tttcagagtt gtcccaagtt ggggtgagag gttcatggct ttacgccaca
     5161 gcattttttg tatttttagt attttgtatt tttgtatttc agtacatgtt ggccaggccg
     5221 gtcttgaact cctgacctca ggtaatccac ctgccttgac ctcccaaagt gctgggatta
     5281 caggtgtgag ccatcgcacc cggcccagat gcttgttttt tgaaggaatt tccactagcg
     5341 gaaactaaag tggggatttt acaggttcta acttccaaat gacttgccct gtaagaaggg
     5401 gctgctccct cccaccaccg cccattcctg ccagcctccg gtctcccagc catcccatgg
     5461 agttttcacc ctaactgcac agccctgaca tcagccacgt cccttcaccc ctgctttgta
     5521 gtaaccaatt agcttaacgt ctgttcccat ggttatttag tttcgttggc aactaacata
     5581 cttcccagaa acaggccagc atctcccagt cccaccacca tcctgctggt ggggccgtcc
     5641 tcttctggat gtcagatgag aactctcctg ctggggaaca acagaaggac agaacataga
     5701 accagaggaa aatgcattca aatgcattcc atcagtgttt ctggacagtc tacaatgtgc
     5761 cctggccggt gatcgctgct ggagatatcg aagtcattaa aacatggtct ctgtcctcaa
//
