LOCUS       NM_032826               6676 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens solute carrier family 35 member B4 (SLC35B4), mRNA.
ACCESSION   NM_032826
VERSION     NM_032826.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6676)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6676)
  AUTHORS   Liu,J., Zhao,X., Wang,K., Zhang,X., Yu,Y., Lv,Y., Zhang,S.,
            Zhang,L., Guo,Y., Li,Y., Yang,A., Zhang,R. and Li,J.
  TITLE     A novel YAP1/SLC35B4 regulatory axis contributes to proliferation
            and progression of gastric carcinoma
  JOURNAL   Cell Death Dis 10 (6), 452 (2019)
   PUBMED   31175271
  REMARK    GeneRIF: A novel YAP1/SLC35B4 axis promotes gastric cancer (GC)
            development and progression, and this axis could be a potential
            candidate for prognosis and therapeutics in GC.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6676)
  AUTHORS   Bazan,B., Wiktor,M., Maszczak-Seneczko,D., Olczak,T., Kaczmarek,B.
            and Olczak,M.
  TITLE     Lysine at position 329 within a C-terminal dilysine motif is
            crucial for the ER localization of human SLC35B4
  JOURNAL   PLoS One 13 (11), e0207521 (2018)
   PUBMED   30458018
  REMARK    GeneRIF: Our data showed that knock-out of the SLC35B4 gene does
            not affect major UDP-Xyl- and UDP-GlcNAc-dependent glycosylation
            pathways.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6676)
  AUTHORS   Huang,E.Y., Chang,Y.J., Huang,S.P., Lin,V.C., Yu,C.C., Huang,C.Y.,
            Yin,H.L., Chang,T.Y., Lu,T.L. and Bao,B.Y.
  TITLE     A common regulatory variant in SLC35B4 influences the recurrence
            and survival of prostate cancer
  JOURNAL   J Cell Mol Med 22 (7), 3661-3670 (2018)
   PUBMED   29682886
  REMARK    GeneRIF: SLC35B4 single nucleotide polymorphism rs1646724 was
            associated with recurrence in patients with localized disease and
            survival in patients with advanced prostate cancer.
REFERENCE   5  (bases 1 to 6676)
  AUTHORS   Wex,B., Safi,R.M., Antonios,G., Zgheib,P.Z., Awad,D.B.,
            Kobeissy,F.H., Mahfouz,R.A., El-Sabban,M.M. and Yazbek,S.N.
  TITLE     SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose
            Stimulation and Downregulates Hsp60 among Other Proteins in HepG2
            Liver Cell Lines
  JOURNAL   Molecules 23 (6), 1350 (2018)
   PUBMED   29867058
  REMARK    GeneRIF: Glucose levels activate SLC35B4 expression. This triggers
            a downstream effect via Hsp60 and other proteins. We hypothesize
            that the downstream effect on the proteins is mediated via altering
            the glycosylation pattern inside liver cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6676)
  AUTHORS   Yazbek,S.N., Buchner,D.A., Geisinger,J.M., Burrage,L.C.,
            Spiezio,S.H., Zentner,G.E., Hsieh,C.W., Scacheri,P.C.,
            Croniger,C.M. and Nadeau,J.H.
  TITLE     Deep congenic analysis identifies many strong, context-dependent
            QTLs, one of which, Slc35b4, regulates obesity and glucose
            homeostasis
  JOURNAL   Genome Res 21 (7), 1065-1073 (2011)
   PUBMED   21507882
  REMARK    GeneRIF: Decreased SLC35B4 expression led to increased
            gluconeogenesis in HepG2 cells.
REFERENCE   7  (bases 1 to 6676)
  AUTHORS   Maszczak-Seneczko,D., Olczak,T. and Olczak,M.
  TITLE     Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4
            transporters
  JOURNAL   Acta Biochim Pol 58 (3), 413-419 (2011)
   PUBMED   21918738
  REMARK    GeneRIF: subcellular localization of SLC35B4
REFERENCE   8  (bases 1 to 6676)
  AUTHORS   Kobayashi,T., Sleeman,J.E., Coughtrie,M.W. and Burchell,B.
  TITLE     Molecular and functional characterization of microsomal
            UDP-glucuronic acid uptake by members of the nucleotide sugar
            transporter (NST) family
  JOURNAL   Biochem J 400 (2), 281-289 (2006)
   PUBMED   16965264
REFERENCE   9  (bases 1 to 6676)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 6676)
  AUTHORS   Ashikov,A., Routier,F., Fuhlrott,J., Helmus,Y., Wild,M.,
            Gerardy-Schahn,R. and Bakker,H.
  TITLE     The human solute carrier gene SLC35B4 encodes a bifunctional
            nucleotide sugar transporter with specificity for UDP-xylose and
            UDP-N-acetylglucosamine
  JOURNAL   J Biol Chem 280 (29), 27230-27235 (2005)
   PUBMED   15911612
  REMARK    GeneRIF: Transport capabilities for UDP-Glc and UDP-Xyl were
            determined with Golgi vesicles isolated from transformed cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB052892.1 and AC008154.6.
            
            On Nov 22, 2018 this sequence version replaced NM_032826.4.
            
            Summary: Glycosyltransferases, such as SLC35B4, transport
            nucleotide sugars from the cytoplasm where they are synthesized, to
            the Golgi apparatus where they are utilized in the synthesis of
            glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005
            [PubMed 15911612]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279868.3157.1,
                                           SRR1803612.237699.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378509.9/ ENSP00000367770.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1246              AB052892.1         122-1367
            1247-6671           AC008154.6         73849-79273         c
            6672-6676           AC008154.6         73844-73848         c
FEATURES             Location/Qualifiers
     source          1..6676
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..6676
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="solute carrier family 35 member B4"
                     /db_xref="GeneID:84912"
                     /db_xref="HGNC:HGNC:20584"
                     /db_xref="MIM:610923"
     exon            1..256
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1175
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="UDP-xylose and UDP-N-acetylglucosamine transporter;
                     UDP-Xylose/N-Acetylglucosamine transporter; YEA4 homolog;
                     solute carrier family 35
                     (UDP-xylose/UDP-N-acetylglucosamine transporter), member
                     B4"
                     /codon_start=1
                     /product="nucleotide sugar transporter SLC35B4"
                     /protein_id="NP_116215.1"
                     /db_xref="CCDS:CCDS34756.1"
                     /db_xref="GeneID:84912"
                     /db_xref="HGNC:HGNC:20584"
                     /db_xref="MIM:610923"
                     /translation="MRPALAVGLVFAGCCSNVIFLELLARKHPGCGNIVTFAQFLFIA
                     VEGFLFEADLGRKPPAIPIRYYAIMVTMFFTVSVVNNYALNLNIAMPLHMIFRSGSLI
                     ANMILGIIILKKRYSIFKYTSIALVSVGIFICTFMSAKQVTSQSSLSENDGFQAFVWW
                     LLGIGALTFALLMSARMGIFQETLYKRFGKHSKEALFYNHALPLPGFVFLASDIYDHA
                     VLFNKSELYEIPVIGVTLPIMWFYLLMNIITQYVCIRGVFILTTECASLTVTLVVTLR
                     KFVSLIFSILYFQNPFTLWHWLGTLFVFIGTLMYTEVWNNLGTTKSEPQKDSKKN"
     exon            257..370
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            371..473
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..523
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            524..605
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            606..666
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            667..776
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            777..852
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            853..928
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     exon            929..6676
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5581..5586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="hexamer: AATAAA"
     polyA_site      5602
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="major polyA site"
     regulatory      6287..6292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="hexamer: AATAAA"
     polyA_site      6309
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
     regulatory      6653..6658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="hexamer: AATAAA"
     polyA_site      6676
                     /gene="SLC35B4"
                     /gene_synonym="YEA; YEA4"
                     /note="major polyA site"
ORIGIN      
        1 cttggcagcg tcggtgttgg ccgcgggaga aggggagacc gcggcggccc ccagtgagag
       61 cggctttcca ggacggtgcg atgtgctgcg cagcgaagag gcaggaggcc ggcttcctgg
      121 ggtagcggta caggcgggcg cttactctgt gcgcttgctt ccccaaccct gcaccggcca
      181 tgcgcccggc cttggcggtg ggcctggtgt tcgcaggctg ctgcagtaac gtgatcttcc
      241 tagagctcct ggcccggaag catccaggat gtgggaacat tgtgacattt gcacaatttt
      301 tatttattgc tgtggaaggc ttcctctttg aagctgattt gggaaggaag ccaccagcta
      361 tcccaataag gtactatgcc ataatggtga ccatgttctt caccgtgagc gtggtgaaca
      421 actatgccct gaatctcaac attgccatgc ccctgcatat gatatttaga tccggttctc
      481 taattgccaa catgattcta ggaattatca ttttgaagaa aagatacagt atattcaaat
      541 atacctccat tgccctggtg tctgtgggga tatttatttg cacttttatg tcagcaaagc
      601 aggtgacttc ccagtccagc ttgagtgaga atgatggatt ccaggcattt gtgtggtggt
      661 tactaggtat tggggcattg acttttgctc ttctgatgtc agcaaggatg gggatattcc
      721 aagagactct ctacaaacga tttgggaaac actccaagga ggctttgttt tataatcacg
      781 cccttccact tccgggtttc gtcttcttgg cttctgatat ttatgaccat gcagttctat
      841 tcaataagtc tgagttatat gaaattcccg tcatcggagt gaccctgccc atcatgtggt
      901 tctacctcct catgaacatc atcactcagt acgtgtgcat ccggggtgtg tttatcctca
      961 ccacagaatg cgcctccctc accgtcacgc tcgtcgtgac cctacgcaaa tttgtgagcc
     1021 tcatcttttc catcttgtac ttccagaacc ccttcaccct gtggcactgg ctgggcacct
     1081 tgtttgtctt cattgggacc ttaatgtaca cagaggtgtg gaacaaccta gggaccacaa
     1141 aaagtgagcc tcagaaggac agcaagaaga actgaggcct gtctggagta cgtagaccag
     1201 tgtcgtcgtg agggtgggac cctgtgaagg tctgaccacc gtttcgcttt tgttaatgcc
     1261 gagctacccg cagtgctgag ccagccgtgc aaaaggaaat cttcaggagg ggacttctca
     1321 cgttgctcag actgacacat gtagactaaa tagaaacccc tcagccctaa aatagaaaaa
     1381 agaacagttc tggactattg aacagcccat tcatttattt ctgttttgtt taccgacata
     1441 ttcagtatta ttcttgtttt ctgaattctg agtctcctga acaaaaggct tactatccat
     1501 ggtcttggaa aagattgtcc cttctcttgc tgttgtaatg catctctgct acagcagtca
     1561 ttgtcatcct gtgaccttat cccttttgtc tcccatcacc ttttccttct tcagcagcac
     1621 ctcacagtca gtcagacgct gcaggcacca ctatcaccag gagtggccaa gtaaaccgag
     1681 acaccagtaa cagcagggct ggacttcctc cagcgttttg ggaaggaaag agatgttccc
     1741 ctgagctgat tcccagtgac agtgcagcaa gactagtggg actcctcttt cccacatttt
     1801 gctttttttt ttttctatgc aaaagtcaga tgcttctatc cattgctttc tgtgattagg
     1861 gcggccctgc agcatatctc acagcagaca cagtgttcat aacaaagaaa ggttgtgccg
     1921 ggcacggtgg ctcacacctg taatcccagc cctttgggag gctgaggtgg gtgtatcact
     1981 tgaggtcagg agttcaagac caatctggcc aacatggtga aaccccatct ctactaaaaa
     2041 tacgaaaatt agctgggtgt gatggcgcat gcctgtaatc ccagctactt gggaggctga
     2101 ggcaggagaa tcacttgaac ccgggagatg aaggttgcag tgagctgagg tcgtgctact
     2161 gcactcccgc ctgggtgaca gagtgagact ctatctcaaa aaaaaaaaaa aaaaagaaag
     2221 gttgttatgg actggacacc cctgaagccc attgcctagg ccacagtggt gacggcagga
     2281 tggccctgct cagcaccgca agagccatgg ctgtccctgt tggcccagcc gggcactcac
     2341 agggcagaag ggtgggtctc aagtgggagg ataaggcttc accaccagga gattcccctc
     2401 tgcccgatga ctctgttaag agtcacgacc catcaaggga atgcatagat ggagatatat
     2461 agtgtgtgat gtgtaaatca ggtcaaacct caacgacaat tgaaagttgt tattgtccta
     2521 tgaggtatct tagcattctc gatgggtatt gaggatggtt ggatgtgctt tattgtgtgt
     2581 ggaaacatgc ctctctttgc taatcatttc agaggtccag ttttcctttc actggacaat
     2641 cttgaatagg aggaacgctg ttgctgtaat atgcgtagct tctgtgtgct cttgtgtagt
     2701 ctgtgtgtga tcaaagggca cggaagtggc tgcactttca catccctttt ctttacttag
     2761 ctggaacctt acataccagt acatgctcct ctgtaagcag ctgaactcac cggccacttc
     2821 tctgtttgcc tatagacaaa gactgtgtgt gtgtgtgtgt atgtatgtgt gtgtgtgtgg
     2881 tgcacacatt gtgttcttaa actgagacgt ggctctgcag gtctcctggg ctcattccat
     2941 ggtgtggtat gtttattcca ctgtccagag ctattctctg atggatttga gcaacagcag
     3001 tggagataaa tgtcctagag tcaccaggtc gcttggagaa gtcatttaag ctgcctcggg
     3061 tttttgttac ttaaaatgtg gatattattt ctccacctaa atcactgagt ttacagagta
     3121 ataatgtgtt gctctggaca ttgacagctt tctagagcca gtaatgggct cttctgaagg
     3181 atgctgaatt agaagtgaac ctattcatag gatcaaaagc cacttgcttt gaaatatgta
     3241 gagttcctca gaattgacgg tgctagaaat atccaagtgt taaataacct tttaaaagca
     3301 acaaaagcta cttttttctt accacttaat agaagaacct gtccctagag gcgacttcat
     3361 tgctatggat ctggagtctc tgaactctta ataggatgca gcctcacata cataatgtca
     3421 cccattttat gttgatgaaa acattacaag ttttcttcat tgggtatgtg ttgatgttca
     3481 cagacagtac ttgggcccat taggttttcg cgtctggtct tagagcatgt gtattcatct
     3541 cagcgtgaat acctcagcca gtcttatgaa taggaggcta tgtatgggca gggaatagat
     3601 tagattagaa cactcgcaca agatgaccac atatagaagc agaaagcccc aaattccctg
     3661 ggaactgttt tttctctagt agctgaatat aaggaaatat gtctaatgga caccagttaa
     3721 tactttttaa aactactctt taaaaaaaaa atacgttccc cttggttaac tgatttttta
     3781 atccagggtg gacatttttt caacctttat taaaaagaca aataaactat tttgtagaag
     3841 atcagactcc tacttaactg gaagagaaat gtctattaaa tgtctctcct ctttctctgg
     3901 gtcaagacca tgtaatttta tgcttcagag atgaagatac tgtttgttta caaagagttt
     3961 agtttttaag acatccaaaa ctctatgcta gagcaaaaat caaatagcaa aggacactag
     4021 ccagaaaata cagtgtgtgt gtgtgcacct gtgtgcctgc tgaacaactt gacagtgtaa
     4081 cagataaggt aactgaagat ggtggatatt tgaattgtat tagcttaatg tctacatatc
     4141 tttggccaaa actctattgt catattagaa acatgttatc tttttcatgt ttattagtaa
     4201 tttatttttg attctttgtt ttctttttcg tccaactaaa acaactgtaa tgtacttgat
     4261 acatttatat caagttctaa agtatttaga caaatccaaa tactttgttt ttagtttttt
     4321 cctcctttcc atcctgttaa ccacagtgaa acgctgcagt attttgattt ggtcagtgct
     4381 acggaggaag accatgaaag ctgaattggt ctgtgccacc cagagtaaac ctcttctctt
     4441 cttctggaaa gatggcgtga tgtttttcaa ggattctaat aaatatcccg cagtcatctc
     4501 ctgagcagct ttcctctgtt tcacttcaga actccttccc ccactttctt cactccagtt
     4561 tcttcacttg cagcgttttc tgctaagaaa gacttatcat cttgtatctg tttatgcctc
     4621 tcttctttgg ggcccctgga tgtttttgtg gatttttaca gagtatttat atctgcacag
     4681 cgtgtatttt gttatacatt cttacaagca ttgatattgg ggggtacatt cataatagtg
     4741 agaatatctg gcagaatgtg tgaatgccat atctgtagat gacgatgaat gtgaagggtt
     4801 aatgtagaaa tgtttgttta ttctgttaca gctcaaaatg gaggctgaga atctctacca
     4861 ccattccctt ctctatttga gaatctctac caccattccc ttctctattt gggaaacaat
     4921 actctcttat tttgctattt ttaccttccc attaactggc ttcactcaac agtgccagat
     4981 acctatggag aggggaagta aaacacctta ggtcaggaat aataaaccaa tgagttagct
     5041 cagggccggt ggacatgttc actggtggac cagttggcat tgacctaaac ggacagagaa
     5101 atgcacatgg aggagaacta cgttgaaatc aagatcctat gtctgttgta ttttctcttt
     5161 gcctggagta aatagcatta taagtcattc cacccttatt agataaccaa agcatattgg
     5221 tctcaatagc tttctcctga aaaatgtgat tgaatcttac ctgtagcagt tcactcttaa
     5281 ggttgaaaga actgtcaata tagataaaat ccattcctta ttattattga ttggtgtgac
     5341 atttgaaaat gtgtctaaac aatatttgta agtaaaagaa ccagtcataa gcctcaaatg
     5401 tgttcagtgt gtaccaagct ggaatgggag actggcccct cttggcttta aagtagcatg
     5461 ttgtcttttt ctagcagctt cttcctagta gacattccag ggatgggagg ggccagggat
     5521 catgtcttac tcatttctgt atcgccagcc cctggcatag tgtctggctt atgttatgtg
     5581 aataaatgaa tgcttgccaa gatctcttct tccctcaagt ttctggaaaa cctgagggtt
     5641 cgtgatacct gttcccactc ctcatcagcg ggttggcaag aaagcaaata aggggaaaca
     5701 tttttaacat tccaagcaag agaaggaaga acgactattg ggaggaggta caccagagat
     5761 tgctcagtgt gcagcctgct acctcacttt tggctctgga ttgcctggtg gtagaaggga
     5821 agagtattat gtagttagca ccttacatat ttgatgctca ggaagaaagt gcaagaagat
     5881 ccctaataga acattaaaga ttcttaaaag tttttgaagt aggctgcttg gggtgaccag
     5941 ccccaccctt acatctccat agttggtaca gttagcttgt agcagctgaa gctgatgcct
     6001 ggagatcact gtctgttggt ctgatctcag tatcatactg agacacctcc cctgagcctt
     6061 acctacttaa attggtaacc gtcctaccaa aatttgtcaa ttttaatcaa gtgaggcaag
     6121 ttgcaaggga gccagagata cgtgaaaaaa gaaaagcaga aatactgata ctttctaaga
     6181 aagaagttgt aataatttct ttggcacatt gacttactga tatcttttga aatgcataga
     6241 tgactcttgt gaaccaaaga gagcagtagt ggttattccc cggcgcaata aaaatgcctt
     6301 tgtgtatcac ttgcgattgc cagtcatttc tgtgccagtt gctttcattc cagagaatgg
     6361 cctcattctc caaaaaaaga tgatgatttt agaagtagga tttcctaaca aattatgtgg
     6421 tggggaggga cggcggggat tttattcatc ccgtctgagc tcttcataca gtattaccat
     6481 taggttttaa gaacaaagat gggggaggag ggagtagaaa gctgagagta cgtagaacag
     6541 ctacaagaca ttagtgggta ttcagatttt gagctgtgta aatatcaaac atcggcttcc
     6601 agccttaaga gttatttgag cagagagtta aggaggaatg ggagattttg tgaataaaat
     6661 gttttgccaa actgaa
//
