LOCUS       NM_001370479            3520 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens solute carrier family 35 member B3 (SLC35B3),
            transcript variant 11, mRNA.
ACCESSION   NM_001370479 XM_005249158
VERSION     NM_001370479.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Kamiyama,S., Ichimiya,T., Ikehara,Y., Takase,T., Fujimoto,I.,
            Suda,T., Nakamori,S., Nakamura,M., Nakayama,F., Irimura,T.,
            Nakanishi,H., Watanabe,M., Narimatsu,H. and Nishihara,S.
  TITLE     Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate
            transporters in human colorectal carcinoma
  JOURNAL   Glycobiology 21 (2), 235-246 (2011)
   PUBMED   20978009
  REMARK    GeneRIF: PAPS transporters play a role in the proliferation of
            colorectal carcinoma cells themselves and take part in a
            desmoplastic reaction to support cancer growth by controlling their
            sulfation status.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Li,D., Song,Y.M. and Zhan,Q.M.
  TITLE     [Specifically up-regulated non-coding RNA gene HULC in tumor cell
            lines and its effects on the expression of neighboring gene
            SLC35B3]
  JOURNAL   Zhonghua Yi Xue Za Zhi 90 (44), 3156-3159 (2010)
   PUBMED   21211351
  REMARK    GeneRIF: The specifically up-regulated non-coding gene HULC in
            HepG2 cell line has some effects on the expression of its
            neighboring gene SLC35B3.
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Goren,A., Ram,O., Amit,M., Keren,H., Lev-Maor,G., Vig,I., Pupko,T.
            and Ast,G.
  TITLE     Comparative analysis identifies exonic splicing regulatory
            sequences--The complex definition of enhancers and silencers
  JOURNAL   Mol Cell 22 (6), 769-781 (2006)
   PUBMED   16793546
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Kamiyama,S., Sasaki,N., Goda,E., Ui-Tei,K., Saigo,K., Narimatsu,H.,
            Jigami,Y., Kannagi,R., Irimura,T. and Nishihara,S.
  TITLE     Molecular cloning and characterization of a novel
            3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2
  JOURNAL   J Biol Chem 281 (16), 10945-10953 (2006)
   PUBMED   16492677
  REMARK    GeneRIF: PAPST2 is a PAPS transporter gene involved in the
            synthesis of sulfated glycoconjugates in the colon
REFERENCE   6  (bases 1 to 3520)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355815.9.
            
            On Nov 23, 2022 this sequence version replaced NM_001370479.1.
            
            Summary: This gene is a member of the solute carrier family. The
            encoded protein is involved in the transport of 3-prime
            phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or
            the cytosol to the Golgi lumen. This gene has been reported to be
            expressed preferentially in the human colon tissues. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Dec 2013].
            
            Transcript Variant: This variant (11), as well as variant 10,
            encodes isoform 3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.4040853.1,
                                           SRR14038191.4054693.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000710437.1/ ENSP00000518269.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-203               AL355815.9         44644-44846         c
            204-497             AL355815.9         39165-39458         c
            498-619             AL355815.9         37238-37359         c
            620-774             AL355815.9         31771-31925         c
            775-882             AL355815.9         30022-30129         c
            883-980             AL355815.9         28881-28978         c
            981-1073            AL355815.9         26703-26795         c
            1074-1185           AL355815.9         26185-26296         c
            1186-1255           AL355815.9         24209-24278         c
            1256-3520           AL355815.9         20736-23000         c
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.3"
     gene            1..3520
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /note="solute carrier family 35 member B3"
                     /db_xref="GeneID:51000"
                     /db_xref="HGNC:HGNC:21601"
                     /db_xref="MIM:610845"
     exon            1..203
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..497
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1406
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /note="isoform 3 is encoded by transcript variant 11; 3'
                     phosphoadenosine 5' phosphosulfate transporter 2;
                     adenosine 3'-phospho 5'-phosphosulfate transporter 2; PAPS
                     transporter 2; solute carrier family 35 (adenosine
                     3'-phospho 5'-phosphosulfate transporter), member B3"
                     /codon_start=1
                     /product="adenosine 3'-phospho 5'-phosphosulfate
                     transporter 2 isoform 3"
                     /protein_id="NP_001357408.1"
                     /db_xref="CCDS:CCDS93854.1"
                     /db_xref="GeneID:51000"
                     /db_xref="HGNC:HGNC:21601"
                     /db_xref="MIM:610845"
                     /translation="MDLKFNNSRKYISITVPSKTQTMSPHIKSVDDVVVLGMNLSKFN
                     KLTQFFICVAGVFVFYLIYGYLQELIFSVEGFKSCGWYLTLVQFAFYSIFGLIELQLI
                     QDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQG
                     KRYNVADVSAAICMSLGLIWFTLADSTTAPNFNLTGVVLISLALCADAVIGNVQEKAM
                     KLHNASNSEMVLYSYSIGFVYILLGLTCTSGLGPAVTFCAKNPVRTYGYAFLFSLTGY
                     FGISFVLALIKIFGALIAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFL
                     NVYSKNMDKIRLPSLYDLINKSVEARKSRTLAQTV"
     exon            498..619
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..774
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..882
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            883..980
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1073
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1185
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1255
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..3520
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1859..1864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /note="hexamer: AATAAA"
     polyA_site      1887
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /note="major polyA site"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /note="hexamer: AATATA"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
                     /note="hexamer: TATAAA"
     polyA_site      3509
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
     polyA_site      3520
                     /gene="SLC35B3"
                     /gene_synonym="C6orf196; CGI-19; PAPST2"
ORIGIN      
        1 acataggcgg aagtggcctg cgggcgccgg agttgagagt gctttccggg gaggcgaccg
       61 ccgcggtgga aagtgcagga gtgggcgagg aggaggagga agaggaggtg atggcgacgg
      121 accaggggag ggggagatgc tccgtctagc tcagacgcca cgcaggctgc cgtcaccctt
      181 ccgggtgaca taccggcctt ggggacttga cacagcaagc aaaagacata cagaacataa
      241 cagtccagga aaccaacaaa aataactctg aaagcattga atgcagcaaa ataacaatgg
      301 atctcaagtt caacaattcc aggaaatata tttctatcac tgtgccatcc aaaacccaaa
      361 caatgtcacc acacatcaag tcagttgacg acgttgtggt acttggcatg aatctcagca
      421 agtttaacaa acttactcag tttttcatat gtgttgctgg agtttttgta ttttacctaa
      481 tttatgggta tttacaggaa ttaatatttt cagtggaggg ttttaagtcc tgtggctggt
      541 accttacctt agtgcagttt gccttttact ccatatttgg cctaatagaa cttcagctta
      601 ttcaggacaa aaggaggaga ataccaggaa aaacctacat gataatagct tttctaactg
      661 tgggtactat ggggttatca aacacttcct tgggctacct gaattaccct acccaagtca
      721 tcttcaagtg ctgcaaattg attcctgtta tgctaggagg agtttttatt caaggaaagc
      781 gttataatgt tgcagatgtg tctgctgcca tatgtatgag ccttggcctg atatggttta
      841 ccctcgctga cagcacaact gcaccaaatt tcaacctgac gggtgtggtg cttatttccc
      901 tggcactatg tgcagatgcc gtcattggaa atgttcaaga gaaagctatg aaacttcata
      961 atgcttctaa ttctgaaatg gtattgtatt cgtattcaat tggttttgta tacattttac
     1021 tgggattgac atgcactagt ggattaggcc ctgcagtaac attttgtgca aagaatccag
     1081 ttcggaccta tggttatgcg ttcctttttt ccctcactgg atattttgga atctcctttg
     1141 ttctggcttt gattaaaatt tttggtgcac ttattgctgt aacagtgaca acaggaagaa
     1201 aagcaatgac cattgtactt tcgtttatat tctttgctaa accattcacg tttcagtatg
     1261 tatggtctgg tttgttagtt gtccttggta tatttcttaa tgtttacagc aaaaatatgg
     1321 ataaaataag actaccatca ctgtatgatt tgataaacaa atcagtggaa gcaagaaagt
     1381 caaggacgct ggcacagact gtatagacag tgattgtcct atttaaaata gaattttaag
     1441 ggaacaatca tcaattaatt aactttccaa agggactgat aaaaaccaaa ggatctggag
     1501 gcattgctat cccatttgtg gacagatttc atatgaagtt gttttgcggt gtcagccttt
     1561 tcttcagagc atttgtttga ctgacttcca aagcaatcaa gagagccacg tctagcagac
     1621 tttacaataa aatgtcaata tgaaggactg taattcctag cagtttattg agaatttcac
     1681 tggaaatgga ccatgtgttg caagactaat tggctataat tatatcctat caaagaaatc
     1741 gatacgtaat agcagattgt tttatattca ttccattttg atggtgttat ttaaattgat
     1801 tctctgttat aagagtaaac tgatgagttg aagtctggag agaataacat tcattataaa
     1861 taaaattatt ctgtgatctt ttttcaagat gtgttaatag aattttgtta taaagagaga
     1921 aatggaagtt ggagtaaggc ttaacatgaa ctttaaaact tgagttttct ctgatttaaa
     1981 attattcttt agagcaggag ctcccaacca cccaggccgt ggactggtac cagtccgtgg
     2041 cctgttagga accagaccac gcaacaagag gtgagaggct gacaagtgag cattaccatc
     2101 tgagctccac ttcctgtcag atcagcagca gcgttagatt ctcatagcag cgggaaccct
     2161 gttatgaacc gcatatgcaa ggggtttggg ttgtacactc cttttgagaa tctaatgcct
     2221 gatgatctga agtggaacag tttcatagtt ttatcctgaa accatcccct gtcccagtcc
     2281 atggaaaaat tgtcttccac gaaactagtc cctactgcca aaagggttgg ggaccactga
     2341 tttagagaag acatgcttta agttttatgt agaatatagg caaggtagta aaaacagaca
     2401 tcattctgca tcatgtaagt atgtgtagta agaaaaattt gctacagttt gcccaagtaa
     2461 tcccaaagga atcatgattg gatttttttt aattgaagaa aaagtaattg atgtctcaaa
     2521 attataataa aataattata aaattatcct agttttttcc ataaaagtaa gatttaattt
     2581 ggaagtttga ggacaaaata ggataaattt aagaaacaca agtagagtta gcaaatttgg
     2641 acaatatttt ccgccttagc acattcaggc tgctatataa aataccataa gtgggtagct
     2701 cataaacaat ggaaatttat ttcccacagt tctgatgtct ggaagtccaa gatggaggtg
     2761 ctggcagatt tggtgagagc ctgctttctg gttcacagaa ggagccttct cattatgtcc
     2821 ttatatgatg aagggccaaa caagctccct tgggtgctaa tcccattttc aaggactctg
     2881 ccctcatgac cttatcacct cccaaaaggc cccaccactt aatacaatca ctttgggagt
     2941 taggatttca acaaatgaat ctcaggggga cacaaacatt cagaccatag gaatgttgca
     3001 tgcatagttt tgagtctaaa ttcaaagatt tgggcactta tttttagcag tgatttttag
     3061 aattgcttct attgtatttt ttaaaaatac tgttattctt cgttttcaat ataaataata
     3121 ctggtttaaa aagcttagtg ctcttgggga cactgtttat attttgtgag tataatatac
     3181 ttggaatagt taatctcatt cttaaaattc cattgtattc tgatggctat ttaatctgtt
     3241 atgtgcatat gcaggtacaa cagagcctgt atcatggagg ggtccagcat gaggaattcg
     3301 gactggtttt catttgccca tttgctgaaa tacagccatt gttttttccc aagtggtaat
     3361 catttaaaat ttttcctggc ttaagataga cgggatctta atgcatactt cattatgctg
     3421 ccttaaactt ttaagaagaa aaggatttgt acttgaaaga aaaacttgtc aactttctca
     3481 aatctttgat aaaatataaa tttgacttat caaagcctta
//
