LOCUS       NM_178148               2022 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens solute carrier family 35 member B2 (SLC35B2),
            transcript variant 1, mRNA.
ACCESSION   NM_178148
VERSION     NM_178148.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2022)
  AUTHORS   Guasto,A., Dubail,J., Aguilera-Albesa,S., Paganini,C., Vanhulle,C.,
            Haouari,W., Gorria-Redondo,N., Aznal-Sainz,E., Boddaert,N.,
            Planas-Serra,L., Schluter,A., Velez-Santamaria,V., Verdura,E.,
            Bruneel,A., Rossi,A., Huber,C., Pujol,A. and Cormier-Daire,V.
  TITLE     Biallelic variants in SLC35B2 cause a novel chondrodysplasia with
            hypomyelinating leukodystrophy
  JOURNAL   Brain 145 (10), 3711-3722 (2022)
   PUBMED   35325049
  REMARK    GeneRIF: Biallelic variants in SLC35B2 cause a novel
            chondrodysplasia with hypomyelinating leukodystrophy.
REFERENCE   2  (bases 1 to 2022)
  AUTHORS   Uezato,A., Jitoku,D., Shimazu,D., Yamamoto,N., Kurumaji,A.,
            Iwayama,Y., Toyota,T., Yoshikawa,T., Haroutunian,V., Bentea,E.,
            Meller,J., Sullivan,C.R., Meador-Woodruff,J.H., McCullumsmith,R.E.
            and Nishikawa,T.
  TITLE     Differential genetic associations and expression of PAPST1/SLC35B2
            in bipolar disorder and schizophrenia
  JOURNAL   J Neural Transm (Vienna) 129 (7), 913-924 (2022)
   PUBMED   35501530
  REMARK    GeneRIF: Differential genetic associations and expression of
            PAPST1/SLC35B2 in bipolar disorder and schizophrenia.
REFERENCE   3  (bases 1 to 2022)
  AUTHORS   Guo,D., Yu,X., Wang,D., Li,Z., Zhou,Y., Xu,G., Yuan,B., Qin,Y. and
            Chen,M.
  TITLE     SLC35B2 Acts in a Dual Role in the Host Sulfation Required for EV71
            Infection
  JOURNAL   J Virol 96 (9), e0204221 (2022)
   PUBMED   35420441
  REMARK    GeneRIF: SLC35B2 Acts in a Dual Role in the Host Sulfation Required
            for EV71 Infection.
REFERENCE   4  (bases 1 to 2022)
  AUTHORS   Guo,X.Y., Gao,X.D. and Fujita,M.
  TITLE     Sulfation of a FLAG tag mediated by SLC35B2 and TPST2 affects
            antibody recognition
  JOURNAL   PLoS One 16 (5), e0250805 (2021)
   PUBMED   33951064
  REMARK    GeneRIF: Sulfation of a FLAG tag mediated by SLC35B2 and TPST2
            affects antibody recognition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2022)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2022)
  AUTHORS   Xu,Q.F., Pan,Y.W., Li,L.C., Zhou,Z., Huang,Q.L., Pang,J.C.,
            Zhu,X.P., Ren,Y., Yang,H., Ohgaki,H. and Lv,S.Q.
  TITLE     MiR-22 is frequently downregulated in medulloblastomas and inhibits
            cell proliferation via the novel target PAPST1
  JOURNAL   Brain Pathol 24 (6), 568-583 (2014)
   PUBMED   24576181
  REMARK    GeneRIF: Results suggest that frequently downregulated miR-22
            expression is associated with cell proliferation in
            medulloblastomas, and this may be at least in part via PAPST1,
            which is a novel target of miR-22
REFERENCE   7  (bases 1 to 2022)
  AUTHORS   Kamiyama,S., Ichimiya,T., Ikehara,Y., Takase,T., Fujimoto,I.,
            Suda,T., Nakamori,S., Nakamura,M., Nakayama,F., Irimura,T.,
            Nakanishi,H., Watanabe,M., Narimatsu,H. and Nishihara,S.
  TITLE     Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate
            transporters in human colorectal carcinoma
  JOURNAL   Glycobiology 21 (2), 235-246 (2011)
   PUBMED   20978009
  REMARK    GeneRIF: PAPS transporters play a role in the proliferation of
            colorectal carcinoma cells themselves and take part in a
            desmoplastic reaction to support cancer growth by controlling their
            sulfation status.
REFERENCE   8  (bases 1 to 2022)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2022)
  AUTHORS   Kamiyama,S., Suda,T., Ueda,R., Suzuki,M., Okubo,R., Kikuchi,N.,
            Chiba,Y., Goto,S., Toyoda,H., Saigo,K., Watanabe,M., Narimatsu,H.,
            Jigami,Y. and Nishihara,S.
  TITLE     Molecular cloning and identification of 3'-phosphoadenosine
            5'-phosphosulfate transporter
  JOURNAL   J Biol Chem 278 (28), 25958-25963 (2003)
   PUBMED   12716889
  REMARK    GeneRIF: PAPS1 has roles in PAPS transport and post-translational
            sulfation
REFERENCE   10 (bases 1 to 2022)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY044970.1, AB106538.1, AK075456.1 and AK223028.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178148.3.
            
            Summary: Sulfotransferases (e.g., SULT4A1; MIM 608359) use an
            activated form of sulfate, 3-prime-phosphoadenosine
            5-prime-phosphosulfate (PAPS), as a common sulfate donor for
            sulfation of glycoproteins, proteoglycans, and glycolipids in the
            endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in
            the microsomal membrane and transports PAPS from the cytosol, where
            it is synthesized, into the Golgi lumen (Kamiyama et al., 2003
            [PubMed 12716889]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.967173.1,
                                           SRR5189667.407982.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153347, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393812.4/ ENSP00000377401.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               HY044970.1         45-153
            110-1417            AB106538.1         1-1308
            1418-2016           AK075456.1         1390-1988
            2017-2022           AK223028.1         1712-1717
FEATURES             Location/Qualifiers
     source          1..2022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2022
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /note="solute carrier family 35 member B2"
                     /db_xref="GeneID:347734"
                     /db_xref="HGNC:HGNC:16872"
                     /db_xref="MIM:610788"
     exon            1..129
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1417
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /note="isoform a is encoded by transcript variant 1;
                     3'-phosphoadenosine 5'-phosphosulfate transporter;
                     adenosine 3'-phospho 5'-phosphosulfate transporter 1; PAPS
                     transporter 1; putative MAPK-activating protein PM15;
                     putative NF-kappa-B-activating protein 48; solute carrier
                     family 35 (adenosine 3'-phospho 5'-phosphosulfate
                     transporter), member B2"
                     /codon_start=1
                     /product="adenosine 3'-phospho 5'-phosphosulfate
                     transporter 1 isoform a"
                     /protein_id="NP_835361.1"
                     /db_xref="CCDS:CCDS34462.1"
                     /db_xref="GeneID:347734"
                     /db_xref="HGNC:HGNC:16872"
                     /db_xref="MIM:610788"
                     /translation="MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAA
                     GYASFMVPGYLLVQYFRRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAE
                     TTPMWQALKLLFCATGLQVSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNR
                     VLALIVAGLSCVLCKQPRHGAPMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKAS
                     KVIPVMLMGKLVSRRSYEHWEYLTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLA
                     GYIAFDSFTSNWQDALFAYKMSSVQMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRH
                     SEFAAHALLLSICSACGQLFIFYTIGQFGAAVFTIIMTLRQAFAILLSCLLYGHTVTV
                     VGGLGVAVVFAALLLRVYARGRLKQRGKKAVPVESPVQKV"
     exon            130..323
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /inference="alignment:Splign:2.1.0"
     exon            324..478
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..2022
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2004..2009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /note="hexamer: ATTAAA"
     polyA_site      2022
                     /gene="SLC35B2"
                     /gene_synonym="HLD26; PAPST1; SLL; UGTrel4"
                     /note="major polyA site"
ORIGIN      
        1 acttccgctg gccgctggct cgctggccgc tcctggaggc ggcggcggga gcgcaggggg
       61 cgcgcggccc ggggactcgc attccccggt tccccctcca ccccacgcgg cctggaccat
      121 ggacgccaga tggtgggcag tggtggtgct ggctgcgttc ccctccctag gggcaggtgg
      181 ggagactccc gaagcccctc cggagtcatg gacccagcta tggttcttcc gatttgtggt
      241 gaatgctgct ggctatgcca gctttatggt acctggctac ctcctggtgc agtacttcag
      301 gcggaagaac tacctggaga ccggtagggg cctctgcttt cccctggtga aagcttgtgt
      361 gtttggcaat gagcccaagg cctctgatga ggttcccctg gcgccccgaa cagaggcggc
      421 agagaccacc ccgatgtggc aggccctgaa gctgctcttc tgtgccacag ggctccaggt
      481 gtcttatctg acttggggtg tgctgcagga aagagtgatg acccgcagct atggggccac
      541 agccacatca ccgggtgagc gctttacgga ctcgcagttc ctggtgctaa tgaaccgagt
      601 gctggcactg attgtggctg gcctctcctg tgttctctgc aagcagcccc ggcatggggc
      661 acccatgtac cggtactcct ttgccagcct gtccaatgtg cttagcagct ggtgccaata
      721 cgaagctctt aagttcgtca gcttccccac ccaggtgctg gccaaggcct ctaaggtgat
      781 ccctgtcatg ctgatgggaa agcttgtgtc tcggcgcagc tacgaacact gggagtacct
      841 gacagccacc ctcatctcca ttggggtcag catgtttctg ctatccagcg gaccagagcc
      901 ccgcagctcc ccagccacca cactctcagg cctcatctta ctggcaggtt atattgcttt
      961 tgacagcttc acctcaaact ggcaggatgc cctgtttgcc tataagatgt catcggtgca
     1021 gatgatgttt ggggtcaatt tcttctcctg cctcttcaca gtgggctcac tgctagaaca
     1081 gggggcccta ctggagggaa cccgcttcat ggggcgacac agtgagtttg ctgcccatgc
     1141 cctgctactc tccatctgct ccgcatgtgg ccagctcttc atcttttaca ccattgggca
     1201 gtttggggct gccgtcttca ccatcatcat gaccctccgc caggcctttg ccatccttct
     1261 ttcctgcctt ctctatggcc acactgtcac tgtggtggga gggctggggg tggctgtggt
     1321 ctttgctgcc ctcctgctca gagtctacgc gcggggccgt ctaaagcaac ggggaaagaa
     1381 ggctgtgcct gttgagtctc ctgtgcagaa ggtttgaggg tggaaagggc ctgaggggtg
     1441 aagtgaaata ggaccctccc accatcccct tctgctgtaa cctctgaggg agctggctga
     1501 aagggcaaaa tgcaggtgtt ttctcagtat cacagaccag ctctgcagca ggggattggg
     1561 gagcccagga ggcagccttc ccttttgcct taagtcaccc atcttccagt aagcagttta
     1621 ttctgagccc cgggggtaga cagtcctcag tgaggggttt tggggagttt ggggtcaaga
     1681 gagcataggt aggttccagt tactcttccc acaagttccc ttaagtcttg ccctagctgt
     1741 gctctgccac cttccagact cactcccctc tgcaaatacc tgcatttctt accctggtga
     1801 gaaaagcaca agcggtgtag gctccaatgc tgctttccca ggagggtgaa gatggtgctg
     1861 tgctgaggaa aggggatgca gagccctgcc cagcaccacc acctcctatg ctcctggatc
     1921 cctaggctct gttccatgag cctgttgcag gttttggtac tttagaaatg taactttttg
     1981 ctcttataat tttattttat taaattaaat tactgcagtg ga
//
