LOCUS       NM_005827               1615 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens solute carrier family 35 member B1 (SLC35B1),
            transcript variant 1, mRNA.
ACCESSION   NM_005827
VERSION     NM_005827.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Schwarzbaum,P.J., Schachter,J. and Bredeston,L.M.
  TITLE     The broad range di- and tri-nucleotide exchanger SLC35B1 displays
            asymmetrical affinities for ATP transport across the ER membrane
  JOURNAL   J Biol Chem 298 (4), 101537 (2022)
   PUBMED   35041824
  REMARK    GeneRIF: The broad range di- and tri-nucleotide exchanger SLC35B1
            displays asymmetrical affinities for ATP transport across the ER
            membrane.
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Ondo,K., Arakawa,H., Nakano,M., Fukami,T. and Nakajima,M.
  TITLE     SLC35B1 significantly contributes to the uptake of UDPGA into the
            endoplasmic reticulum for glucuronidation catalyzed by
            UDP-glucuronosyltransferases
  JOURNAL   Biochem Pharmacol 175, 113916 (2020)
   PUBMED   32179043
  REMARK    GeneRIF: SLC35B1 significantly contributes to the uptake of UDPGA
            into the endoplasmic reticulum for glucuronidation catalyzed by
            UDP-glucuronosyltransferases.
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Klein,M.C., Zimmermann,K., Schorr,S., Landini,M., Klemens,P.A.W.,
            Altensell,J., Jung,M., Krause,E., Nguyen,D., Helms,V., Rettig,J.,
            Fecher-Trost,C., Cavalie,A., Hoth,M., Bogeski,I., Neuhaus,H.E.,
            Zimmermann,R., Lang,S. and Haferkamp,I.
  TITLE     AXER is an ATP/ADP exchanger in the membrane of the endoplasmic
            reticulum
  JOURNAL   Nat Commun 9 (1), 3489 (2018)
   PUBMED   30154480
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Song,Z.
  TITLE     Roles of the nucleotide sugar transporters (SLC35 family) in health
            and disease
  JOURNAL   Mol Aspects Med 34 (2-3), 590-600 (2013)
   PUBMED   23506892
  REMARK    Review article
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Suzuki,Y., Tsunoda,T., Sese,J., Taira,H., Mizushima-Sugano,J.,
            Hata,H., Ota,T., Isogai,T., Tanaka,T., Nakamura,Y., Suyama,A.,
            Sakaki,Y., Morishita,S., Okubo,K. and Sugano,S.
  TITLE     Identification and characterization of the potential promoter
            regions of 1031 kinds of human genes
  JOURNAL   Genome Res 11 (5), 677-684 (2001)
   PUBMED   11337467
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Ishida,N., Miura,N., Yoshioka,S. and Kawakita,M.
  TITLE     Molecular cloning and characterization of a novel isoform of the
            human UDP-galactose transporter, and of related complementary DNAs
            belonging to the nucleotide-sugar transporter gene family
  JOURNAL   J Biochem 120 (6), 1074-1078 (1996)
   PUBMED   9010752
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Lennon,G., Auffray,C., Polymeropoulos,M. and Soares,M.B.
  TITLE     The I.M.A.G.E. Consortium: an integrated molecular analysis of
            genomes and their expression
  JOURNAL   Genomics 33 (1), 151-152 (1996)
   PUBMED   8617505
REFERENCE   10 (bases 1 to 1615)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015795.20, AU099388.1,
            D87989.1, BM476321.1 and AI252816.1.
            
            On May 17, 2019 this sequence version replaced NM_005827.3.
            
            Summary: This gene encodes a nucleotide sugar transporter which is
            a member of solute carrier family 35. The transporters in this
            family are highly conserved hydrophobic proteins with multiple
            transmembrane domains. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293563.1, SRR3476690.674548.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000240333.12/
                                                ENSP00000240333.8
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC015795.20        54484-54496         c
            14-44               AU099388.1         5-35
            45-1230             D87989.1           1-1186
            1231-1272           BM476321.1         628-669
            1273-1615           AI252816.1         2-344               c
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..1615
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /note="solute carrier family 35 member B1"
                     /db_xref="GeneID:10237"
                     /db_xref="HGNC:HGNC:20798"
                     /db_xref="MIM:610790"
     exon            1..235
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1100
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UDP-galactose transporter related; UDP-galactose
                     transporter-related protein 1; ATP/ADP exchanger in the ER
                     membrane; ATP/ADP exchanger ER; endoplasmic reticulum
                     ATP/ADP translocase"
                     /codon_start=1
                     /product="solute carrier family 35 member B1 isoform 1"
                     /protein_id="NP_005818.3"
                     /db_xref="CCDS:CCDS11552.3"
                     /db_xref="GeneID:10237"
                     /db_xref="HGNC:HGNC:20798"
                     /db_xref="MIM:610790"
                     /translation="MASSSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGA
                     KQETFTFALTLVFIQCVINAVFAKILIQFFDTARVDRTRSWLYAACSISYLGAMVSSN
                     SALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKK
                     VVGIEEHTVGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGM
                     GILFTGELWEFLSFAERYPAIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTR
                     KFFTILASVILFANPISPMQWVGTVLVFLGLGLDAKFGKGAKKTSH"
     exon            236..339
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..470
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..501
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..659
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..786
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..893
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1047
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1615
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1218..1223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /note="hexamer: AATAAA"
     polyA_site      1237
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /note="major polyA site"
     polyA_site      1272
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /note="major polyA site"
     regulatory      1598..1603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1615
                     /gene="SLC35B1"
                     /gene_synonym="AXER; UGTREL1"
ORIGIN      
        1 agcggtcgca tgcagctcct atgaggcccc tgccgccggt cggcgatgtc cggctggagc
       61 tgtcgcctcc gccgccgctg ctgccggtgc cggttgtgag cgggtctcca gtcggctcct
      121 ctgggcgtct catggcctct agcagctccc tggtgcccga ccggctgcgc ctgccgctct
      181 gcttcctggg tgtctttgtc tgctattttt actatgggat cctgcaggaa aagataacaa
      241 gaggaaagta tggggaagga gccaagcagg agacgttcac ctttgcctta actttggtct
      301 tcattcaatg tgtgatcaat gctgtgtttg ccaagatctt gatccagttt tttgacactg
      361 ccagggtgga tcgtacccgg agctggctct atgctgcctg ttctatctcc tatctgggtg
      421 ccatggtctc cagcaattca gcactacagt ttgtcaacta cccaactcag gtccttggta
      481 aatcctgcaa gccaatccca gtcatgctcc ttggggtgac cctcttgaag aagaagtacc
      541 cgttggccaa gtacctgtgt gtgctgttaa ttgtggctgg agtggccctt ttcatgtaca
      601 aacccaagaa agttgttggg atagaagaac acacagtcgg ctatggagag ctactcttgc
      661 tattatcgct gaccctggat ggactgactg gtgtttccca ggaccacatg cgggctcatt
      721 accaaacagg ctccaaccac atgatgctga acatcaacct ttggtcgaca ttgctgctgg
      781 gaatgggaat cctgttcact ggggagctct gggagttctt gagctttgct gaaaggtacc
      841 ctgccatcat ctataacatc ctgctctttg ggctgaccag tgccctgggt cagagcttca
      901 tctttatgac ggttgtgtat tttggtcccc tgacctgctc catcatcact acaactcgaa
      961 agttcttcac aattttggcc tctgtgatcc tcttcgccaa tcccatcagc cccatgcagt
     1021 gggtgggcac tgtgcttgtg ttcctgggtc ttggtcttga tgccaagttt gggaaaggag
     1081 ctaagaagac atcccactag gaagagagag actacctcca catcaagaat atttaagtta
     1141 ttatctcaaa cagtgacatc tcttgggaaa atggacttaa taggaatatg ggactgagtt
     1201 ccagtctttt ttaataaaat aaaatcaagc aaaatcacat attctaaaaa atgcacttgg
     1261 attttaacaa gacagagtgg tggtttttgt tcttcatgcc ctggagcagt ctatggtaaa
     1321 taaaagaggg agggaagagg cagagctgga tgttcattac ccaggctgct cctctcacgg
     1381 gtgtggttag catggttgag tgggcgattc ctccaagaac ctgaggatta tagggaggaa
     1441 ctctgtgaga tcgcagaatt gtgctaatgg cttctgttcc gatgggtgag gcttgtcccg
     1501 ttagagctgg tcccattaga ggacgggtgg ctgtccatta gagccagaga atgtaaaagt
     1561 cacttcctct cctaaagctc ctgtgggcaa atatttcatt aaaaaaacaa agttg
//
